{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=High+Nicotine+e-cigarette",
    "query": {
      "intervention": "High Nicotine e-cigarette"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 33,
    "total_pages": 4,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=High+Nicotine+e-cigarette&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-10T15:37:16.745Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06395415",
      "title": "Development of a Mobile Health Intervention for Electronic Cigarette Use Among Young Adults",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Electronic Nicotine Delivery Systems",
        "Tobacco Products",
        "Cigarette Smoking"
      ],
      "interventions": [
        {
          "name": "EQUIP",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Standard Care",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "26 Years",
        "sex": "ALL",
        "summary": "18 Years to 26 Years"
      },
      "enrollment_count": 46,
      "start_date": "2025-04-25",
      "completion_date": "2026-08",
      "has_results": false,
      "last_update_posted_date": "2026-04-27",
      "last_synced_at": "2026-09-10T15:37:16.745Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06395415"
    },
    {
      "nct_id": "NCT04058717",
      "title": "Low Nicotine Cigarettes Plus Electronic Cigarettes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tobacco Dependence"
      ],
      "interventions": [
        {
          "name": "Normal Nicotine Content research cigarettes",
          "type": "OTHER"
        },
        {
          "name": "High Nicotine e-cigarette",
          "type": "OTHER"
        },
        {
          "name": "Very Low Nicotine Content research cigarettes",
          "type": "OTHER"
        },
        {
          "name": "Zero Nicotine e-cigarette",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Milton S. Hershey Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "21 Years to 70 Years"
      },
      "enrollment_count": 88,
      "start_date": "2021-06-01",
      "completion_date": "2024-08-12",
      "has_results": true,
      "last_update_posted_date": "2025-09-11",
      "last_synced_at": "2026-09-10T15:37:16.745Z",
      "location_count": 1,
      "location_summary": "Hershey, Pennsylvania",
      "locations": [
        {
          "city": "Hershey",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04058717"
    },
    {
      "nct_id": "NCT02482233",
      "title": "The END Perioperative Smoking Pilot Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Smoking",
        "Nicotine Addiction",
        "Surgery"
      ],
      "interventions": [
        {
          "name": "ENDD (NJOY)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "NRT (NicoDerm CQ)",
          "type": "DRUG"
        },
        {
          "name": "telephone counseling",
          "type": "BEHAVIORAL"
        },
        {
          "name": "brief advice",
          "type": "BEHAVIORAL"
        },
        {
          "name": "brochure",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DRUG"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2015-08",
      "completion_date": "2016-09",
      "has_results": true,
      "last_update_posted_date": "2022-03-09",
      "last_synced_at": "2026-09-10T15:37:16.745Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02482233"
    },
    {
      "nct_id": "NCT05423340",
      "title": "Effect of E-Liquid Flavor on Respiratory Symptoms in People Using Electronic Nicotine Delivery Systems",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Electronic Cigarette Use"
      ],
      "interventions": [
        {
          "name": "E-cigarette Flavor",
          "type": "OTHER"
        },
        {
          "name": "Tobacco Free Nicotine Pouch",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Roswell Park Cancer Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "21 Years to 55 Years"
      },
      "enrollment_count": 163,
      "start_date": "2022-06-12",
      "completion_date": "2024-10-03",
      "has_results": true,
      "last_update_posted_date": "2026-06-04",
      "last_synced_at": "2026-09-10T15:37:16.745Z",
      "location_count": 1,
      "location_summary": "Buffalo, New York",
      "locations": [
        {
          "city": "Buffalo",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05423340"
    },
    {
      "nct_id": "NCT04258852",
      "title": "Understanding Factors That Influence Electronic Cigarette Nicotine Delivery Through PET Imaging of Beta-2 Nicotinic Acetylcholine Receptors",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Electronic Cigarette Use"
      ],
      "interventions": [
        {
          "name": "Low strength nicotine e-liquid",
          "type": "DRUG"
        },
        {
          "name": "High strength nicotine e-liquid",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "21 Years to 55 Years"
      },
      "enrollment_count": 0,
      "start_date": "2022-12-30",
      "completion_date": "2025-02-01",
      "has_results": false,
      "last_update_posted_date": "2024-02-16",
      "last_synced_at": "2026-09-10T15:37:16.745Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04258852"
    },
    {
      "nct_id": "NCT06602492",
      "title": "Compensatory Behavior of E-cig Users in Response to Reduced Nicotine E-liquids",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Healthy",
        "Nicotine Addiction",
        "Electronic Cigarette Use"
      ],
      "interventions": [
        {
          "name": "Lower nicotine e-liquid",
          "type": "DRUG"
        },
        {
          "name": "Higher nicotine eliquid",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Rochester Institute of Technology",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 72,
      "start_date": "2021-07-15",
      "completion_date": "2023-11-15",
      "has_results": false,
      "last_update_posted_date": "2024-09-27",
      "last_synced_at": "2026-09-10T15:37:16.745Z",
      "location_count": 1,
      "location_summary": "Rochester, New York",
      "locations": [
        {
          "city": "Rochester",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06602492"
    },
    {
      "nct_id": "NCT07167225",
      "title": "Carcinogen and Toxicant Exposure Among Young Adults Who Co-Use Cigarettes, E-cigarettes and Cannabis (Co-Tox Study)",
      "overall_status": "RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Cigarette Smoking-Related Carcinoma",
        "E-Cig Use"
      ],
      "interventions": [
        {
          "name": "Effectiveness of different recruitment approaches",
          "type": "OTHER"
        },
        {
          "name": "Choice of study completion locations",
          "type": "OTHER"
        },
        {
          "name": "Cannabis Engagement Assessment",
          "type": "OTHER"
        },
        {
          "name": "E-cigarette dependence Scale",
          "type": "OTHER"
        },
        {
          "name": "Nicotine dependence Scale",
          "type": "OTHER"
        },
        {
          "name": "Co use practices QUestionnaire",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Roswell Park Cancer Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "25 Years",
        "sex": "ALL",
        "summary": "18 Years to 25 Years"
      },
      "enrollment_count": 150,
      "start_date": "2025-04-03",
      "completion_date": "2028-10-01",
      "has_results": false,
      "last_update_posted_date": "2026-08-26",
      "last_synced_at": "2026-09-10T15:37:16.745Z",
      "location_count": 1,
      "location_summary": "Buffalo, New York",
      "locations": [
        {
          "city": "Buffalo",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07167225"
    },
    {
      "nct_id": "NCT04038515",
      "title": "Impact of Flavors on Nicotine Perception and Self-Administration Via E-cigarettes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Nicotine",
        "E-liquid Flavors"
      ],
      "interventions": [
        {
          "name": "Nicotine 0 mg/mL",
          "type": "DRUG"
        },
        {
          "name": "Nicotine 6 mg/mL",
          "type": "DRUG"
        },
        {
          "name": "Nicotine 12 mg/mL",
          "type": "DRUG"
        },
        {
          "name": "Nicotine 24 mg/mL",
          "type": "DRUG"
        },
        {
          "name": "'Menthol' flavor",
          "type": "OTHER"
        },
        {
          "name": "'Menthol/Mint' flavor",
          "type": "OTHER"
        },
        {
          "name": "'Green Apple' flavor",
          "type": "OTHER"
        },
        {
          "name": "'Watermelon' flavor",
          "type": "OTHER"
        },
        {
          "name": "'Unflavored'",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "30 Years",
        "sex": "ALL",
        "summary": "18 Years to 30 Years"
      },
      "enrollment_count": 54,
      "start_date": "2022-10-27",
      "completion_date": "2024-06-03",
      "has_results": false,
      "last_update_posted_date": "2024-08-05",
      "last_synced_at": "2026-09-10T15:37:16.745Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04038515"
    },
    {
      "nct_id": "NCT07129265",
      "title": "Understanding Vape Marketing Study",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "E-cigarette",
        "Vaping",
        "Tobacco",
        "Nicotine",
        "Adolescent Behavior",
        "Video Information",
        "Digital Education Interventions"
      ],
      "interventions": [
        {
          "name": "Working group",
          "type": "OTHER"
        },
        {
          "name": "Focus group",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Boston Children's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "13 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "13 Years and older"
      },
      "enrollment_count": 46,
      "start_date": "2025-08-04",
      "completion_date": "2027-04-30",
      "has_results": false,
      "last_update_posted_date": "2025-08-19",
      "last_synced_at": "2026-09-10T15:37:16.745Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07129265"
    },
    {
      "nct_id": "NCT07210268",
      "title": "Temporal Interference Methods for Addiction Treatment",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nicotine Use Disorder",
        "Substance Use Disorders"
      ],
      "interventions": [
        {
          "name": "TI-NDBS",
          "type": "DEVICE"
        },
        {
          "name": "Sham TI-NDBS",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Indiana University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "21 Years to 50 Years"
      },
      "enrollment_count": 120,
      "start_date": "2026-01-22",
      "completion_date": "2027-02-27",
      "has_results": false,
      "last_update_posted_date": "2026-07-15",
      "last_synced_at": "2026-09-10T15:37:16.745Z",
      "location_count": 2,
      "location_summary": "Bloomington, Indiana • Indianapolis, Indiana",
      "locations": [
        {
          "city": "Bloomington",
          "state": "Indiana"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07210268"
    }
  ]
}