{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=High+level+nicotine+cigarette",
    "query": {
      "intervention": "High level nicotine cigarette"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 52,
    "total_pages": 6,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=High+level+nicotine+cigarette&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-20T15:02:17.102Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03635333",
      "title": "Effects of E-Cigarette Flavors on Adults TCORS 2.0",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Nicotine Use Disorder"
      ],
      "interventions": [
        {
          "name": "Nicotine",
          "type": "DRUG"
        },
        {
          "name": "Flavor",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "21 Years to 50 Years"
      },
      "enrollment_count": 130,
      "start_date": "2019-05-14",
      "completion_date": "2023-07-12",
      "has_results": true,
      "last_update_posted_date": "2025-12-19",
      "last_synced_at": "2026-09-20T15:02:17.102Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03635333"
    },
    {
      "nct_id": "NCT06395415",
      "title": "Development of a Mobile Health Intervention for Electronic Cigarette Use Among Young Adults",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Electronic Nicotine Delivery Systems",
        "Tobacco Products",
        "Cigarette Smoking"
      ],
      "interventions": [
        {
          "name": "EQUIP",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Standard Care",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "26 Years",
        "sex": "ALL",
        "summary": "18 Years to 26 Years"
      },
      "enrollment_count": 46,
      "start_date": "2025-04-25",
      "completion_date": "2026-08",
      "has_results": false,
      "last_update_posted_date": "2026-04-27",
      "last_synced_at": "2026-09-20T15:02:17.102Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06395415"
    },
    {
      "nct_id": "NCT06614504",
      "title": "Nicotine Regulation for Dual Users of E-cigarettes and Cigarettes",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Tobacco Use Disorder"
      ],
      "interventions": [
        {
          "name": "Varying the nicotine content of cigarettes",
          "type": "OTHER"
        },
        {
          "name": "Varying the nicotine content of e-cigarettes",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Vermont",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 308,
      "start_date": "2024-11-01",
      "completion_date": "2028-09-30",
      "has_results": false,
      "last_update_posted_date": "2025-06-27",
      "last_synced_at": "2026-09-20T15:02:17.102Z",
      "location_count": 2,
      "location_summary": "Providence, Rhode Island • Burlington, Vermont",
      "locations": [
        {
          "city": "Providence",
          "state": "Rhode Island"
        },
        {
          "city": "Burlington",
          "state": "Vermont"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06614504"
    },
    {
      "nct_id": "NCT05932745",
      "title": "Effects of Novel E-cigarette Constituents on Adults TCORS 3.0",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nicotine Use Disorder"
      ],
      "interventions": [
        {
          "name": "E-liquid coolant (No WS-3) for non-menthol (1)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (No WS-3) for low (0.1%) menthol (1)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (No WS-3) for high (2.0%) menthol (1)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (Low [0.1%] WS-3) for non-menthol (2)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (Low [0.1%] WS-3) for low (0.1%) menthol (2)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (Low [0.1%] WS-3) for high (2.0%) menthol (2)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (High [2.0%] WS-3) for non-menthol (3)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (High [2.0%] WS-3) for low (0.1%) menthol (3)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (High [2.0%] WS-3) for high (2.0%) menthol (3)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (Low [0.1%] WS-23) for non-menthol (4)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (Low [0.1%] WS-23) for low (0.1%) menthol (4)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (Low [0.1%] WS-23) for high (2.0%) menthol (4)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (High [2.0%] WS-23) for non-menthol (5)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (High [2.0%] WS-23) for low (0.1%) menthol (5)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (High [2.0%] WS-23) for high (2.0%) menthol (5)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (4% WS-23) for non-menthol (6)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (4% WS-23) for low (0.1%) menthol (6)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (4% WS-23) for high (2.0%) menthol (6)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 66,
      "start_date": "2025-06-20",
      "completion_date": "2026-08",
      "has_results": false,
      "last_update_posted_date": "2026-06-16",
      "last_synced_at": "2026-09-20T15:02:17.102Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05932745"
    },
    {
      "nct_id": "NCT05335915",
      "title": "Acute Pharmacokinetic and Pharmacodynamic Effects of \"Tobacco-Free\" Oral Nicotine Pouches in Smokers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Nicotine Withdrawal",
        "Nicotine Addiction",
        "Drug Effect"
      ],
      "interventions": [
        {
          "name": "Nicotine",
          "type": "OTHER"
        },
        {
          "name": "Cigarette",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 71,
      "start_date": "2022-07-27",
      "completion_date": "2025-08-29",
      "has_results": true,
      "last_update_posted_date": "2026-07-23",
      "last_synced_at": "2026-09-20T15:02:17.102Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05335915"
    },
    {
      "nct_id": "NCT05370313",
      "title": "The Impact of Innovative Tax Proposals on Purchase Patterns",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cigarette Smoking"
      ],
      "interventions": [
        {
          "name": "Market Price Condition (control)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Tobacco Parity Tax Condition",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Nicotine-Content Tax Condition",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Harm-Reduction Tax Condition",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Modified Risk Tobacco Product (MRTP) Tax Condition",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Virginia Polytechnic Institute and State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 285,
      "start_date": "2023-04-11",
      "completion_date": "2025-06-10",
      "has_results": false,
      "last_update_posted_date": "2025-09-18",
      "last_synced_at": "2026-09-20T15:02:17.102Z",
      "location_count": 2,
      "location_summary": "Buffalo, New York • Roanoke, Virginia",
      "locations": [
        {
          "city": "Buffalo",
          "state": "New York"
        },
        {
          "city": "Roanoke",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05370313"
    },
    {
      "nct_id": "NCT06609109",
      "title": "Effect of Cannabis on E-Cigarette Use Behavior",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Cannabis Use",
        "Tobacco Use",
        "Electronic Cigarette Use"
      ],
      "interventions": [
        {
          "name": "THC High Dose",
          "type": "DRUG"
        },
        {
          "name": "THC Low Dose",
          "type": "DRUG"
        },
        {
          "name": "THC 0mg",
          "type": "DRUG"
        },
        {
          "name": "E-Cigarette Full Nicotine",
          "type": "DRUG"
        },
        {
          "name": "E-Cigarette Placebo Nicotine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Johns Hopkins University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 100,
      "start_date": "2025-03-19",
      "completion_date": "2029-10-01",
      "has_results": false,
      "last_update_posted_date": "2026-04-09",
      "last_synced_at": "2026-09-20T15:02:17.102Z",
      "location_count": 1,
      "location_summary": "Baltimore, Maryland",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06609109"
    },
    {
      "nct_id": "NCT02415270",
      "title": "Switching to Reduced Oxidant or Nicotine Content Cigarettes in Smokers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tobacco Smoking Behavior"
      ],
      "interventions": [
        {
          "name": "Reduced Nicotine Cigarettes",
          "type": "OTHER"
        },
        {
          "name": "Reduced ROS/RNS",
          "type": "OTHER"
        },
        {
          "name": "Control",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Milton S. Hershey Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "21 Years to 65 Years"
      },
      "enrollment_count": 37,
      "start_date": "2016-01",
      "completion_date": "2017-01-01",
      "has_results": false,
      "last_update_posted_date": "2018-07-27",
      "last_synced_at": "2026-09-20T15:02:17.102Z",
      "location_count": 1,
      "location_summary": "Hershey, Pennsylvania",
      "locations": [
        {
          "city": "Hershey",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02415270"
    },
    {
      "nct_id": "NCT04038515",
      "title": "Impact of Flavors on Nicotine Perception and Self-Administration Via E-cigarettes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Nicotine",
        "E-liquid Flavors"
      ],
      "interventions": [
        {
          "name": "Nicotine 0 mg/mL",
          "type": "DRUG"
        },
        {
          "name": "Nicotine 6 mg/mL",
          "type": "DRUG"
        },
        {
          "name": "Nicotine 12 mg/mL",
          "type": "DRUG"
        },
        {
          "name": "Nicotine 24 mg/mL",
          "type": "DRUG"
        },
        {
          "name": "'Menthol' flavor",
          "type": "OTHER"
        },
        {
          "name": "'Menthol/Mint' flavor",
          "type": "OTHER"
        },
        {
          "name": "'Green Apple' flavor",
          "type": "OTHER"
        },
        {
          "name": "'Watermelon' flavor",
          "type": "OTHER"
        },
        {
          "name": "'Unflavored'",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "30 Years",
        "sex": "ALL",
        "summary": "18 Years to 30 Years"
      },
      "enrollment_count": 54,
      "start_date": "2022-10-27",
      "completion_date": "2024-06-03",
      "has_results": false,
      "last_update_posted_date": "2024-08-05",
      "last_synced_at": "2026-09-20T15:02:17.102Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04038515"
    },
    {
      "nct_id": "NCT05458895",
      "title": "Evaluating E-Cigarette Nicotine Form, Concentration, and Flavors Among Youth",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "E-cigarette Use"
      ],
      "interventions": [
        {
          "name": "ECIG lab session 1",
          "type": "OTHER"
        },
        {
          "name": "ECIG lab session 2",
          "type": "OTHER"
        },
        {
          "name": "ECIG lab session 3",
          "type": "OTHER"
        },
        {
          "name": "ECIG lab session 4",
          "type": "OTHER"
        },
        {
          "name": "ECIG lab session 5",
          "type": "OTHER"
        },
        {
          "name": "ECIG lab session 6",
          "type": "OTHER"
        },
        {
          "name": "ECIG lab session 7",
          "type": "OTHER"
        },
        {
          "name": "ECIG lab session 8",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Ohio State University Comprehensive Cancer Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "25 Years",
        "sex": "ALL",
        "summary": "21 Years to 25 Years"
      },
      "enrollment_count": 88,
      "start_date": "2021-12-02",
      "completion_date": "2023-08-07",
      "has_results": true,
      "last_update_posted_date": "2024-11-22",
      "last_synced_at": "2026-09-20T15:02:17.102Z",
      "location_count": 1,
      "location_summary": "Columbus, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05458895"
    }
  ]
}