{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=High+tidal+Volume&page=2",
    "query": {
      "intervention": "High tidal Volume",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=High+tidal+Volume&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-09-21T20:42:12.672Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT05467228",
      "title": "Laryngeal Vibro-tactile Stimulation as a Non-invasive Symptomatic Treatment for Spasmodic Dysphonia",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Adductor Spasmodic Dysphonia",
        "Abductor Spastic Dysphonia",
        "Laryngeal Dystonia"
      ],
      "interventions": [
        {
          "name": "vibro-tactile stimulation (VTS)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Minnesota",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2026-08",
      "completion_date": "2026-08-01",
      "has_results": false,
      "last_update_posted_date": "2025-05-16",
      "last_synced_at": "2026-09-21T20:42:12.672Z",
      "location_count": 1,
      "location_summary": "Minneapolis, Minnesota",
      "locations": [
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05467228"
    },
    {
      "nct_id": "NCT03445689",
      "title": "Oxygenation Instability and Maturation of Control of Breathing in Premature Infants",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Infant,Premature"
      ],
      "interventions": [
        {
          "name": "Assessment of oxygenation instability",
          "type": "OTHER"
        },
        {
          "name": "Determination of mechanisms of hypoxemia episodes",
          "type": "OTHER"
        },
        {
          "name": "Assessment of respiratory instability",
          "type": "OTHER"
        },
        {
          "name": "apneic threshold of CO2",
          "type": "OTHER"
        },
        {
          "name": "Assessment of peripheral chemoreceptor function",
          "type": "OTHER"
        },
        {
          "name": "Assessment of central chemo-receptor function",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Miami",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 70,
      "start_date": "2018-09-04",
      "completion_date": "2023-11-01",
      "has_results": false,
      "last_update_posted_date": "2025-03-18",
      "last_synced_at": "2026-09-21T20:42:12.672Z",
      "location_count": 1,
      "location_summary": "Miami, Florida",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03445689"
    },
    {
      "nct_id": "NCT03657368",
      "title": "Ventilation Strategy During General Anesthesia for Orthopedic Surgery: A Quality Improvement Project",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Orthopedic Surgery",
        "Ventilation"
      ],
      "interventions": [
        {
          "name": "Low tidal Volume",
          "type": "PROCEDURE"
        },
        {
          "name": "High tidal Volume",
          "type": "PROCEDURE"
        },
        {
          "name": "Low PEEP",
          "type": "PROCEDURE"
        },
        {
          "name": "High PEEP",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "The Cleveland Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 2860,
      "start_date": "2018-09-03",
      "completion_date": "2020-10-23",
      "has_results": true,
      "last_update_posted_date": "2025-08-27",
      "last_synced_at": "2026-09-21T20:42:12.672Z",
      "location_count": 1,
      "location_summary": "Cleveland, Ohio",
      "locations": [
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03657368"
    },
    {
      "nct_id": "NCT05388708",
      "title": "ARDS in Children and ECMO Initiation Strategies Impact on Neurodevelopment (ASCEND)",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Acute Respiratory Distress Syndrome",
        "Extracorporeal Membrane Oxygenation"
      ],
      "interventions": [
        {
          "name": "ECMO support",
          "type": "DEVICE"
        },
        {
          "name": "PROSpect protocolized therapies",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "14 Days",
        "maximum_age": "20 Years",
        "sex": "ALL",
        "summary": "14 Days to 20 Years"
      },
      "enrollment_count": 550,
      "start_date": "2021-02-04",
      "completion_date": "2027-09-30",
      "has_results": false,
      "last_update_posted_date": "2026-07-14",
      "last_synced_at": "2026-09-21T20:42:12.672Z",
      "location_count": 72,
      "location_summary": "Birmingham, Alabama • Phoenix, Arizona • Little Rock, Arkansas + 62 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Loma Linda",
          "state": "California"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05388708"
    },
    {
      "nct_id": "NCT00412308",
      "title": "A Comparison of High vs. Low Tidal Volumes in Ventilator Weaning for Individuals With Cervical Spinal Cord Injuries",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Spinal Cord Injury",
        "Respiratory Insufficiency"
      ],
      "interventions": [
        {
          "name": "Tidal volume used in mechanical ventilation",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Craig Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 34,
      "start_date": "2006-12",
      "completion_date": "2010-08",
      "has_results": false,
      "last_update_posted_date": "2011-06-28",
      "last_synced_at": "2026-09-21T20:42:12.672Z",
      "location_count": 1,
      "location_summary": "Englewood, Colorado",
      "locations": [
        {
          "city": "Englewood",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00412308"
    },
    {
      "nct_id": "NCT01003730",
      "title": "The Effects of Different Ventilator Strategies on Inflammation and Injury in Normal Lungs",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acute Respiratory Distress Syndrome"
      ],
      "interventions": [
        {
          "name": "Ventilator settings",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Medicine and Dentistry of New Jersey",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 1,
      "start_date": "2009-03",
      "completion_date": "2010-03",
      "has_results": false,
      "last_update_posted_date": "2015-05-05",
      "last_synced_at": "2026-09-21T20:42:12.672Z",
      "location_count": 1,
      "location_summary": "Newark, New Jersey",
      "locations": [
        {
          "city": "Newark",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01003730"
    },
    {
      "nct_id": "NCT01681225",
      "title": "EPVent 2- A Phase II Study of Mechanical Ventilation Directed by Transpulmonary Pressures",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acute Respiratory Distress Syndrome"
      ],
      "interventions": [
        {
          "name": "Esophageal-pressure guided mechanical ventilation",
          "type": "OTHER"
        },
        {
          "name": "High PEEP mechanical ventilation",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Beth Israel Deaconess Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "16 Years and older"
      },
      "enrollment_count": 202,
      "start_date": "2012-10-31",
      "completion_date": "2018-10-19",
      "has_results": false,
      "last_update_posted_date": "2019-12-03",
      "last_synced_at": "2026-09-21T20:42:12.672Z",
      "location_count": 10,
      "location_summary": "La Jolla, California • Stanford, California • Orlando, Florida + 6 more",
      "locations": [
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "Stanford",
          "state": "California"
        },
        {
          "city": "Orlando",
          "state": "Florida"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01681225"
    },
    {
      "nct_id": "NCT07002437",
      "title": "Hypoxia Pathways for Early Recovery After Spinal Cord Injury",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Spinal Cord Injuries (SCI)"
      ],
      "interventions": [
        {
          "name": "Augmented Acute Intermittent Hypoxia (aAIH)",
          "type": "OTHER"
        },
        {
          "name": "Acute Intermittent Hypercapnic-Hypoxia (AIHH)",
          "type": "OTHER"
        },
        {
          "name": "Sham AIH",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Florida",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 18,
      "start_date": "2025-11-20",
      "completion_date": "2027-07",
      "has_results": false,
      "last_update_posted_date": "2025-12-03",
      "last_synced_at": "2026-09-21T20:42:12.672Z",
      "location_count": 1,
      "location_summary": "Jacksonville, Florida",
      "locations": [
        {
          "city": "Jacksonville",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07002437"
    },
    {
      "nct_id": "NCT03896763",
      "title": "PROSpect: Prone and Oscillation Pediatric Clinical Trial",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acute Respiratory Distress Syndrome in Children"
      ],
      "interventions": [
        {
          "name": "Either supine or prone positioning and either CMV or HFOV",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "2 Weeks",
        "maximum_age": "20 Years",
        "sex": "ALL",
        "summary": "2 Weeks to 20 Years"
      },
      "enrollment_count": 600,
      "start_date": "2019-05-01",
      "completion_date": "2027-01-31",
      "has_results": false,
      "last_update_posted_date": "2026-05-05",
      "last_synced_at": "2026-09-21T20:42:12.672Z",
      "location_count": 28,
      "location_summary": "Birmingham, Alabama • Phoenix, Arizona • Little Rock, Arkansas + 24 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Orange",
          "state": "California"
        },
        {
          "city": "Palo Alto",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03896763"
    },
    {
      "nct_id": "NCT04672538",
      "title": "Fontan Physiology Ventilation Strategy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Anesthesia",
        "Congenital Heart Disease"
      ],
      "interventions": [
        {
          "name": "Low Vt protocol",
          "type": "PROCEDURE"
        },
        {
          "name": "High Vt protocol",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Pittsburgh",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 32,
      "start_date": "2021-03-02",
      "completion_date": "2023-05-15",
      "has_results": false,
      "last_update_posted_date": "2023-05-17",
      "last_synced_at": "2026-09-21T20:42:12.672Z",
      "location_count": 1,
      "location_summary": "Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04672538"
    }
  ]
}