{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=High-dose+furosemide", "query": { "intervention": "High-dose furosemide" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 15, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=High-dose+furosemide&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-06T09:24:45.212Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01060293", "title": "Dopamine in Acute Decompensated Heart Failure II", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Acute Decompensated Heart Failure" ], "interventions": [ { "name": "High-dose furosemide", "type": "DRUG" }, { "name": "Low-dose furosemide", "type": "DRUG" }, { "name": "Low-dose furosemide combined with low-dose dopamine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Larissa University Hospital", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 161, "start_date": "2009-07", "completion_date": "2013-12", "has_results": false, "last_update_posted_date": "2013-09-11", "last_synced_at": "2026-09-06T09:24:45.212Z", "location_count": 2, "location_summary": "Atlanta, Georgia • Cleveland, Ohio", "locations": [ { "city": "Atlanta", "state": "Georgia" }, { "city": "Cleveland", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT01060293" }, { "nct_id": "NCT02030314", "title": "The Management of Resistant Hypertension in Kidney Transplant Patients Using Chlorthalidone", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Resistant Hypertension in Kidney Transplant Patients" ], "interventions": [ { "name": "Chlorthalidone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Virginia Commonwealth University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 0, "start_date": "2013-07", "completion_date": "2017-04-12", "has_results": false, "last_update_posted_date": "2017-06-15", "last_synced_at": "2026-09-06T09:24:45.212Z", "location_count": 1, "location_summary": "Richmond, Virginia", "locations": [ { "city": "Richmond", "state": "Virginia" } ], "official_url": "https://clinicaltrials.gov/study/NCT02030314" }, { "nct_id": "NCT04615624", "title": "Furosemide vs. Placebo for Severe Antepartum Hypertension", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Pre-Eclampsia", "Hypertension in Pregnancy", "Pregnancy Complications", "Hypertension, Pregnancy-Induced" ], "interventions": [ { "name": "Furosemide", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Melanie Maykin, MD", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "FEMALE", "summary": "18 Years and older · Female only" }, "enrollment_count": 65, "start_date": "2021-01-04", "completion_date": "2022-04-29", "has_results": true, "last_update_posted_date": "2024-04-18", "last_synced_at": "2026-09-06T09:24:45.212Z", "location_count": 1, "location_summary": "Honolulu, Hawaii", "locations": [ { "city": "Honolulu", "state": "Hawaii" } ], "official_url": "https://clinicaltrials.gov/study/NCT04615624" }, { "nct_id": "NCT05440851", "title": "Platform of Randomized Adaptive Clinical Trials in Critical Illness", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Respiratory Insufficiency", "Extracorporeal Membrane Oxygenation Complication", "Mechanical Ventilation Pressure High" ], "interventions": [ { "name": "Ultra-Protective Ventilation Facilitated by Extracorporeal Support", "type": "OTHER" }, { "name": "Lung-Protective Ventilation (LPV)", "type": "OTHER" }, { "name": "Driving Pressure-Limited Ventilation (DPL)", "type": "OTHER" }, { "name": "Lung- and Diaphragm-Protective Ventilation and Sedation (LDPVS)", "type": "OTHER" }, { "name": "Early Cohort corticosteroid dose", "type": "DRUG" }, { "name": "Extended Cohort corticosteroid dose", "type": "DRUG" }, { "name": "Usual care without routine corticosteroids", "type": "DRUG" }, { "name": "Usual care without extending corticosteroids", "type": "DRUG" }, { "name": "Usual care with fludrocortisone", "type": "DRUG" }, { "name": "Usual care without fludrocortisone", "type": "DRUG" }, { "name": "Drug 4 mL:", "type": "DRUG" }, { "name": "Drug 40 mg:", "type": "DRUG" }, { "name": "PEEP-20", "type": "OTHER" }, { "name": "PEEP-AOP", "type": "OTHER" }, { "name": "PEEP-10", "type": "OTHER" }, { "name": "VV ECMO-facilitated strategy of earlier awakening, extubation and rehabilitation", "type": "OTHER" }, { "name": "Electrical impedance tomography (EIT)", "type": "OTHER" }, { "name": "no treatment / intervention arm is involved.", "type": "OTHER" }, { "name": "Usual care", "type": "OTHER" }, { "name": "Early Routine IMT", "type": "OTHER" } ], "intervention_types": [ "OTHER", "DRUG" ], "sponsor": "University Health Network, Toronto", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 6250, "start_date": "2023-04-30", "completion_date": "2027-03-31", "has_results": false, "last_update_posted_date": "2026-05-07", "last_synced_at": "2026-09-06T09:24:45.212Z", "location_count": 26, "location_summary": "Tucson, Arizona • Los Angeles, California • San Diego, California + 19 more", "locations": [ { "city": "Tucson", "state": "Arizona" }, { "city": "Los Angeles", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "San Francisco", "state": "California" }, { "city": "Aurora", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT05440851" }, { "nct_id": "NCT03753204", "title": "Salt-Sensitivity and Immunity Cell Activation", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "High Blood Pressure", "Salt; Excess", "Inflammation" ], "interventions": [ { "name": "Furosemide 40 mg", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vanderbilt University Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "60 Years", "sex": "ALL", "summary": "18 Years to 60 Years" }, "enrollment_count": 20, "start_date": "2021-09-01", "completion_date": "2026-09-15", "has_results": false, "last_update_posted_date": "2025-10-21", "last_synced_at": "2026-09-06T09:24:45.212Z", "location_count": 1, "location_summary": "Nashville, Tennessee", "locations": [ { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT03753204" }, { "nct_id": "NCT01073189", "title": "Intra-Renal Therapy of Diuretic Unresponsive Acute Kidney Injury", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Kidney Failures, Acute" ], "interventions": [ { "name": "Intra-Renal Fenoldopam", "type": "DRUG" }, { "name": "Furosemide", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Southeast Renal Research Institute", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 0, "start_date": "2010-04", "completion_date": "2011-01", "has_results": false, "last_update_posted_date": "2016-03-28", "last_synced_at": "2026-09-06T09:24:45.212Z", "location_count": 1, "location_summary": "Chattanooga, Tennessee", "locations": [ { "city": "Chattanooga", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT01073189" }, { "nct_id": "NCT01860170", "title": "Post-Transplant Bortezomib and High Dose Cyclophosphamide as Graft-Versus-Host Disease (GVHD) Prophylaxis", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Hematological Malignancy" ], "interventions": [ { "name": "Cohort 1-Bortezomib (Velcade ®)", "type": "DRUG" }, { "name": "Cohort 2-Bortezomib (Velcade ®)", "type": "DRUG" }, { "name": "Cohort 3-Bortezomib (Velcade ®)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Corewell Health West", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 28, "start_date": "2012-04", "completion_date": "2018-03", "has_results": true, "last_update_posted_date": "2023-06-02", "last_synced_at": "2026-09-06T09:24:45.212Z", "location_count": 1, "location_summary": "Grand Rapids, Michigan", "locations": [ { "city": "Grand Rapids", "state": "Michigan" } ], "official_url": "https://clinicaltrials.gov/study/NCT01860170" }, { "nct_id": "NCT01474200", "title": "Study of Heart Failure Hospitalizations After Aquapheresis Therapy Compared to Intravenous (IV) Diuretic Treatment", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Heart Failure", "Cardiac Failure", "Acute Decompensated Heart Failure (ADHF)" ], "interventions": [ { "name": "Isolated veno-venous ultrafiltration (AQ)", "type": "DEVICE" }, { "name": "IV Loop Diuretics (LD)", "type": "DRUG" } ], "intervention_types": [ "DEVICE", "DRUG" ], "sponsor": "Nuwellis, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 224, "start_date": "2012-01", "completion_date": "2014-07", "has_results": true, "last_update_posted_date": "2023-08-29", "last_synced_at": "2026-09-06T09:24:45.212Z", "location_count": 38, "location_summary": "Huntsville, Alabama • Scottsdale, Arizona • Los Angeles, California + 28 more", "locations": [ { "city": "Huntsville", "state": "Alabama" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Los Angeles", "state": "California" }, { "city": "San Diego", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01474200" }, { "nct_id": "NCT06036914", "title": "A Study of Ultra High Dose Diuretics to Treat Heart Failure", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Heart Failure; With Decompensation" ], "interventions": [ { "name": "Bumetanide", "type": "DRUG" }, { "name": "Furosemide", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Mayo Clinic", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 20, "start_date": "2023-11-27", "completion_date": "2024-10-08", "has_results": true, "last_update_posted_date": "2026-01-14", "last_synced_at": "2026-09-06T09:24:45.212Z", "location_count": 1, "location_summary": "Rochester, Minnesota", "locations": [ { "city": "Rochester", "state": "Minnesota" } ], "official_url": "https://clinicaltrials.gov/study/NCT06036914" }, { "nct_id": "NCT06218199", "title": "Diuretics vs. Afterload Reduction for Treatment of HeartLogic Alerts", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Heart Failure, Congestive" ], "interventions": [ { "name": "Furosemide", "type": "DRUG" }, { "name": "Torsemide", "type": "DRUG" }, { "name": "Bumetanide", "type": "DRUG" }, { "name": "sacubitril/valsartan", "type": "DRUG" }, { "name": "Hydralazine", "type": "DRUG" }, { "name": "Isosorbide Dinitrate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Heart Center Research, LLC", "sponsor_class": "NETWORK", "healthy_volunteers": false, "eligibility": { "minimum_age": "19 Years", "maximum_age": null, "sex": "ALL", "summary": "19 Years and older" }, "enrollment_count": 80, "start_date": "2021-07-08", "completion_date": "2026-12-31", "has_results": false, "last_update_posted_date": "2024-01-29", "last_synced_at": "2026-09-06T09:24:45.212Z", "location_count": 1, "location_summary": "Huntsville, Alabama", "locations": [ { "city": "Huntsville", "state": "Alabama" } ], "official_url": "https://clinicaltrials.gov/study/NCT06218199" } ] }