{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=High-flow+Oxygen&page=2",
    "query": {
      "intervention": "High-flow Oxygen",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=High-flow+Oxygen&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-09-25T20:24:50.419Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02653638",
      "title": "Blood Brain Flow and Exercise",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Cerebrovascular Circulation"
      ],
      "interventions": [
        {
          "name": "Control",
          "type": "OTHER"
        },
        {
          "name": "Indomethacin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DRUG"
      ],
      "sponsor": "University of Wisconsin, Madison",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "18 Years to 75 Years"
      },
      "enrollment_count": 80,
      "start_date": "2016-06",
      "completion_date": "2019-04",
      "has_results": false,
      "last_update_posted_date": "2019-12-18",
      "last_synced_at": "2026-09-25T20:24:50.419Z",
      "location_count": 1,
      "location_summary": "Madison, Wisconsin",
      "locations": [
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02653638"
    },
    {
      "nct_id": "NCT05495841",
      "title": "OPTiMASK: Comparison of Pre-oxygenation With Standard Face Mask Combined With High Flow Nasal Oxygen With Pre-oxygenation With Standard Face Mask Alone",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Surgery"
      ],
      "interventions": [
        {
          "name": "Pre-oxygenation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Beth Israel Deaconess Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 80,
      "start_date": "2022-08-18",
      "completion_date": "2023-06-30",
      "has_results": false,
      "last_update_posted_date": "2023-11-30",
      "last_synced_at": "2026-09-25T20:24:50.419Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05495841"
    },
    {
      "nct_id": "NCT03066115",
      "title": "Impact of NOS, COX, and ROS Inhibition on Cerebral Blood Flow Regulation",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Hypoxia",
        "Hypercapnia"
      ],
      "interventions": [
        {
          "name": "L-NMMA",
          "type": "DRUG"
        },
        {
          "name": "Ketorolac",
          "type": "DRUG"
        },
        {
          "name": "Ascorbic Acid",
          "type": "DRUG"
        },
        {
          "name": "Intravenous Catheter",
          "type": "PROCEDURE"
        },
        {
          "name": "Transcranial Doppler Ultrasound",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "PROCEDURE"
      ],
      "sponsor": "University of Wisconsin, Madison",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "18 Years to 45 Years"
      },
      "enrollment_count": 0,
      "start_date": "2020-12-01",
      "completion_date": "2021-12-01",
      "has_results": false,
      "last_update_posted_date": "2019-01-10",
      "last_synced_at": "2026-09-25T20:24:50.419Z",
      "location_count": 1,
      "location_summary": "Madison, Wisconsin",
      "locations": [
        {
          "city": "Madison",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03066115"
    },
    {
      "nct_id": "NCT05091723",
      "title": "TD-0903 Pharmacokinetics Study in Healthy Participants With Supplemental Oxygenation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Acute Lung Injury (ALI) Due to Coronavirus Disease-2019 (COVID-19)"
      ],
      "interventions": [
        {
          "name": "Nezulcitinib (TD-0903) Dose A",
          "type": "DRUG"
        },
        {
          "name": "Nezulcitinib (TD-0903) Dose B",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Theravance Biopharma",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 14,
      "start_date": "2021-10-13",
      "completion_date": "2021-11-24",
      "has_results": false,
      "last_update_posted_date": "2021-12-10",
      "last_synced_at": "2026-09-25T20:24:50.419Z",
      "location_count": 1,
      "location_summary": "Cypress, California",
      "locations": [
        {
          "city": "Cypress",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05091723"
    },
    {
      "nct_id": "NCT03464396",
      "title": "Prematurity-Related Ventilatory Control",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Respiratory Control in Premature Infants"
      ],
      "interventions": [
        {
          "name": "Bedside Physiology study",
          "type": "OTHER"
        },
        {
          "name": "Carotid Body Function Test",
          "type": "OTHER"
        },
        {
          "name": "Room Air Challenge",
          "type": "OTHER"
        },
        {
          "name": "Hypoxia Challenge Test",
          "type": "OTHER"
        },
        {
          "name": "Effects of Nasal Cannula Flow",
          "type": "OTHER"
        },
        {
          "name": "Magnetic Resonance Imaging",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Echocardiogram",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "Blood Sample",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Washington University School of Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Day",
        "maximum_age": "28 Days",
        "sex": "ALL",
        "summary": "1 Day to 28 Days"
      },
      "enrollment_count": 177,
      "start_date": "2018-05-14",
      "completion_date": "2022-03-09",
      "has_results": false,
      "last_update_posted_date": "2023-01-31",
      "last_synced_at": "2026-09-25T20:24:50.419Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03464396"
    },
    {
      "nct_id": "NCT00434993",
      "title": "Drug Study of Albuterol to Treat Acute Lung Injury",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Respiratory Distress Syndrome, Adult"
      ],
      "interventions": [
        {
          "name": "Albuterol Sulfate",
          "type": "DRUG"
        },
        {
          "name": "Mini-Bronchoalveolar Lavage (BAL)",
          "type": "PROCEDURE"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "PROCEDURE"
      ],
      "sponsor": "National Heart, Lung, and Blood Institute (NHLBI)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "13 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "13 Years and older"
      },
      "enrollment_count": 282,
      "start_date": "2007-08",
      "completion_date": "2008-11",
      "has_results": true,
      "last_update_posted_date": "2017-02-10",
      "last_synced_at": "2026-09-25T20:24:50.419Z",
      "location_count": 40,
      "location_summary": "Fresno, California • Sacramento, California • San Francisco, California + 19 more",
      "locations": [
        {
          "city": "Fresno",
          "state": "California"
        },
        {
          "city": "Sacramento",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Denver",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00434993"
    },
    {
      "nct_id": "NCT03700606",
      "title": "Physiological Changes With High-Flow Nasal Cannula",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Respiratory Distress Syndrome in Premature Infant"
      ],
      "interventions": [
        {
          "name": "High flow nasal cannula",
          "type": "PROCEDURE"
        },
        {
          "name": "Nasal CPAP",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Sharp HealthCare",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "23 Weeks",
        "maximum_age": "28 Weeks",
        "sex": "ALL",
        "summary": "23 Weeks to 28 Weeks"
      },
      "enrollment_count": 80,
      "start_date": "2019-03-15",
      "completion_date": "2022-02-14",
      "has_results": true,
      "last_update_posted_date": "2026-04-17",
      "last_synced_at": "2026-09-25T20:24:50.419Z",
      "location_count": 1,
      "location_summary": "San Diego, California",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03700606"
    },
    {
      "nct_id": "NCT07452406",
      "title": "Protocolized Weaning of High-Flow Nasal Cannula in Adult Patients",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acute Hypoxemic Respiratory Failure",
        "High-Flow Nasal Cannula Therapy"
      ],
      "interventions": [
        {
          "name": "Protocolized HFNC Weaning Strategy",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Usual Care HFNC Weaning",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Rush University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 2000,
      "start_date": "2026-11-01",
      "completion_date": "2028-06-28",
      "has_results": false,
      "last_update_posted_date": "2026-09-25",
      "last_synced_at": "2026-09-25T20:24:50.419Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07452406"
    },
    {
      "nct_id": "NCT01911351",
      "title": "Nitrous Oxide Use in Minor Procedures",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Laceration",
        "Abscess"
      ],
      "interventions": [
        {
          "name": "Nitrous Oxide",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "New York City Health and Hospitals Corporation",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "3 Years",
        "maximum_age": "12 Years",
        "sex": "ALL",
        "summary": "3 Years to 12 Years"
      },
      "enrollment_count": 82,
      "start_date": "2013-07",
      "completion_date": "2014-06",
      "has_results": true,
      "last_update_posted_date": "2016-04-11",
      "last_synced_at": "2026-09-25T20:24:50.419Z",
      "location_count": 1,
      "location_summary": "The Bronx, New York",
      "locations": [
        {
          "city": "The Bronx",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01911351"
    },
    {
      "nct_id": "NCT02858154",
      "title": "Comparison of High Flow Nasal Cannula Therapy to Nasal Oxygen as a Treatment for Obstructive Sleep Apnea in Infants",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Obstructive Sleep Apnea"
      ],
      "interventions": [
        {
          "name": "HFNC",
          "type": "OTHER"
        },
        {
          "name": "Low flow oxygen by nasal cannula",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Children's Hospital Medical Center, Cincinnati",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Day",
        "maximum_age": "12 Months",
        "sex": "ALL",
        "summary": "1 Day to 12 Months"
      },
      "enrollment_count": 9,
      "start_date": "2016-02",
      "completion_date": "2021-07-26",
      "has_results": true,
      "last_update_posted_date": "2022-03-15",
      "last_synced_at": "2026-09-25T20:24:50.419Z",
      "location_count": 2,
      "location_summary": "Kansas City, Kansas • Cincinnati, Ohio",
      "locations": [
        {
          "city": "Kansas City",
          "state": "Kansas"
        },
        {
          "city": "Cincinnati",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02858154"
    }
  ]
}