{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Higher+SpO2+Target",
    "query": {
      "intervention": "Higher SpO2 Target"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-03T23:03:51.784Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04707729",
      "title": "ROX Index for the Timing of Intubation in Nasal High Flow",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acute Hypoxemic Respiratory Failure"
      ],
      "interventions": [
        {
          "name": "ROX index algorithm",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Hospital Universitari Vall d'Hebron Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "120 Years",
        "sex": "ALL",
        "summary": "18 Years to 120 Years"
      },
      "enrollment_count": 630,
      "start_date": "2020-12-09",
      "completion_date": "2025-06-30",
      "has_results": false,
      "last_update_posted_date": "2024-08-15",
      "last_synced_at": "2026-09-03T23:03:51.784Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04707729"
    },
    {
      "nct_id": "NCT05729048",
      "title": "Starling/CRRT Observational Study",
      "overall_status": "WITHDRAWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Hemodynamic Monitoring"
      ],
      "interventions": [
        {
          "name": "Starling",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Baxter Healthcare Corporation",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "95 Years",
        "sex": "ALL",
        "summary": "18 Years to 95 Years"
      },
      "enrollment_count": 0,
      "start_date": "2023-07-15",
      "completion_date": "2025-03-14",
      "has_results": false,
      "last_update_posted_date": "2023-07-14",
      "last_synced_at": "2026-09-03T23:03:51.784Z",
      "location_count": 1,
      "location_summary": "Lexington, Kentucky",
      "locations": [
        {
          "city": "Lexington",
          "state": "Kentucky"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05729048"
    },
    {
      "nct_id": "NCT03537937",
      "title": "Pragmatic Investigation of optimaL Oxygen Targets Trial",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Respiratory Failure"
      ],
      "interventions": [
        {
          "name": "Lower SpO2 Target",
          "type": "OTHER"
        },
        {
          "name": "Intermediate SpO2 Target",
          "type": "OTHER"
        },
        {
          "name": "Higher SpO2 Target",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Vanderbilt University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 2541,
      "start_date": "2018-07-01",
      "completion_date": "2022-01-31",
      "has_results": true,
      "last_update_posted_date": "2023-09-25",
      "last_synced_at": "2026-09-03T23:03:51.784Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03537937"
    },
    {
      "nct_id": "NCT04648293",
      "title": "Starling Registry Study",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Hemodynamic Monitoring"
      ],
      "interventions": [
        {
          "name": "Starling",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Baxter Healthcare Corporation",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "95 Years",
        "sex": "ALL",
        "summary": "18 Years to 95 Years"
      },
      "enrollment_count": 1207,
      "start_date": "2020-11-16",
      "completion_date": "2024-02-21",
      "has_results": false,
      "last_update_posted_date": "2024-04-16",
      "last_synced_at": "2026-09-03T23:03:51.784Z",
      "location_count": 9,
      "location_summary": "Denver, Colorado • Quincy, Illinois • Kansas City, Kansas + 5 more",
      "locations": [
        {
          "city": "Denver",
          "state": "Colorado"
        },
        {
          "city": "Quincy",
          "state": "Illinois"
        },
        {
          "city": "Kansas City",
          "state": "Kansas"
        },
        {
          "city": "St Louis",
          "state": "Missouri"
        },
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04648293"
    },
    {
      "nct_id": "NCT04381923",
      "title": "COVIDNOCHE Trial (HFNO Versus CPAP Helmet) in COVID-19 Pneumonia",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Severe Acute Respiratory Syndrome Coronavirus 2",
        "Hypoxemic Respiratory Failure",
        "Pneumonia, Viral",
        "COVID"
      ],
      "interventions": [
        {
          "name": "Helmet Continuous Positive Airway Pressure (CPAP)",
          "type": "DEVICE"
        },
        {
          "name": "High Flow Nasal Oxygen (HFNO)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2021-11-15",
      "completion_date": "2022-12-15",
      "has_results": false,
      "last_update_posted_date": "2022-04-05",
      "last_synced_at": "2026-09-03T23:03:51.784Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04381923"
    },
    {
      "nct_id": "NCT07536984",
      "title": "Examination of Personalized SpO2 Targets",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acute Respiratory Failure"
      ],
      "interventions": [
        {
          "name": "Personalized SpO2 Target",
          "type": "OTHER"
        },
        {
          "name": "Usual Care",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Vanderbilt University Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 3000,
      "start_date": "2026-05-12",
      "completion_date": "2030-01",
      "has_results": false,
      "last_update_posted_date": "2026-05-20",
      "last_synced_at": "2026-09-03T23:03:51.784Z",
      "location_count": 1,
      "location_summary": "Nashville, Tennessee",
      "locations": [
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07536984"
    },
    {
      "nct_id": "NCT05030012",
      "title": "Maintaining Optimal HVNI Delivery Using Automatic Titration of Oxygen in Preterm Infants",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Infant, Premature",
        "Neonatal Respiratory Distress",
        "Oxygen Saturation",
        "Bronchopulmonary Dysplasia"
      ],
      "interventions": [
        {
          "name": "Automated Control",
          "type": "DEVICE"
        },
        {
          "name": "Manual Control",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Vapotherm, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 15,
      "start_date": "2021-09-02",
      "completion_date": "2023-10-19",
      "has_results": true,
      "last_update_posted_date": "2024-06-26",
      "last_synced_at": "2026-09-03T23:03:51.784Z",
      "location_count": 3,
      "location_summary": "Washington D.C., District of Columbia • Salt Lake City, Utah • Seattle, Washington",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Salt Lake City",
          "state": "Utah"
        },
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05030012"
    },
    {
      "nct_id": "NCT03385330",
      "title": "BPD Saturation TARgeting",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Bronchopulmonary Dysplasia",
        "Chronic Lung Disease of Prematurity",
        "Chronic Lung Disease"
      ],
      "interventions": [
        {
          "name": "LOWER oxygen saturation target group",
          "type": "OTHER"
        },
        {
          "name": "HIGHER oxygen saturation target group",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Children's Hospital of Philadelphia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "34 Weeks",
        "maximum_age": "44 Weeks",
        "sex": "ALL",
        "summary": "34 Weeks to 44 Weeks"
      },
      "enrollment_count": 50,
      "start_date": "2018-06-01",
      "completion_date": "2023-09-01",
      "has_results": true,
      "last_update_posted_date": "2024-04-30",
      "last_synced_at": "2026-09-03T23:03:51.784Z",
      "location_count": 3,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03385330"
    },
    {
      "nct_id": "NCT03963622",
      "title": "Careful Ventilation in Acute Respiratory Distress Syndrome (COVID-19 and Non-COVID-19)",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "ARDS"
      ],
      "interventions": [
        {
          "name": "Respiratory Mechanics",
          "type": "OTHER"
        },
        {
          "name": "Standard Ventilation Strategy",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Unity Health Toronto",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 740,
      "start_date": "2020-11-23",
      "completion_date": "2026-09",
      "has_results": false,
      "last_update_posted_date": "2026-01-16",
      "last_synced_at": "2026-09-03T23:03:51.784Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03963622"
    },
    {
      "nct_id": "NCT02330055",
      "title": "Determination of the Predictors of Nocturnal Desaturation in Postpartum Women",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sleep Disordered Breathing",
        "Nocturnal Oxygen Desaturation",
        "Upper Airway Edema"
      ],
      "interventions": [
        {
          "name": "Forty-five degrees elevated upper body position",
          "type": "PROCEDURE"
        },
        {
          "name": "non-elevated upper body position",
          "type": "PROCEDURE"
        },
        {
          "name": "Noninvasive wrist pulse oximeter (WristOx Model 3150)",
          "type": "DEVICE"
        },
        {
          "name": "Stop-Bang questionnaire",
          "type": "OTHER"
        },
        {
          "name": "Epworth Sleepiness Scale",
          "type": "OTHER"
        },
        {
          "name": "P-SAP Score",
          "type": "OTHER"
        },
        {
          "name": "self-reported pain",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 55 Years · Female only"
      },
      "enrollment_count": 99,
      "start_date": "2014-05",
      "completion_date": "2017-12",
      "has_results": true,
      "last_update_posted_date": "2018-07-06",
      "last_synced_at": "2026-09-03T23:03:51.784Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02330055"
    }
  ]
}