{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Hybrid+Closed+Loop&page=2",
    "query": {
      "intervention": "Hybrid Closed Loop",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Hybrid+Closed+Loop&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-09-21T19:58:34.005Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04878120",
      "title": "Hybrid Closed-Loop Control With Smart Prandial Insulin Dosing in Type 1 Diabetes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Type 1 Diabetes"
      ],
      "interventions": [
        {
          "name": "Standard HCL System",
          "type": "DEVICE"
        },
        {
          "name": "HCL System with Smart Bolus Calculator",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Virginia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "12 Years to 17 Years"
      },
      "enrollment_count": 25,
      "start_date": "2021-05-14",
      "completion_date": "2022-06-28",
      "has_results": true,
      "last_update_posted_date": "2024-05-30",
      "last_synced_at": "2026-09-21T19:58:34.005Z",
      "location_count": 1,
      "location_summary": "Charlottesville, Virginia",
      "locations": [
        {
          "city": "Charlottesville",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04878120"
    },
    {
      "nct_id": "NCT06177691",
      "title": "Hybrid Closed Loop Therapy and Verapamil for Beta Cell Preservation in New Onset Type 1 Diabetes (CLVer): Extension Study",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Type1 Diabetes"
      ],
      "interventions": [],
      "intervention_types": [],
      "sponsor": "Jaeb Center for Health Research",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "7 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "7 Years to 17 Years"
      },
      "enrollment_count": 77,
      "start_date": "2021-05-07",
      "completion_date": "2025-12-18",
      "has_results": false,
      "last_update_posted_date": "2023-12-20",
      "last_synced_at": "2026-09-21T19:58:34.005Z",
      "location_count": 6,
      "location_summary": "Palo Alto, California • Aurora, Colorado • New Haven, Connecticut + 3 more",
      "locations": [
        {
          "city": "Palo Alto",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Minneapolis",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06177691"
    },
    {
      "nct_id": "NCT04051632",
      "title": "Analysis of Glycemic Control in Type 1 Diabetes Patients Using Hybrid Closed Loop Insulin Pump Therapy (Medtronic 670G)",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Biomedical Technology",
        "Type 1 Diabetes"
      ],
      "interventions": [
        {
          "name": "Medtronic 670G insulin pump",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Boston Children's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": null,
      "eligibility": {
        "minimum_age": "5 Years",
        "maximum_age": "25 Years",
        "sex": "ALL",
        "summary": "5 Years to 25 Years"
      },
      "enrollment_count": 96,
      "start_date": "2018-06-13",
      "completion_date": "2019-07-30",
      "has_results": false,
      "last_update_posted_date": "2019-08-09",
      "last_synced_at": "2026-09-21T19:58:34.005Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04051632"
    },
    {
      "nct_id": "NCT07226583",
      "title": "Using a Personalized Decision Support Tool to Help People With Type 1 Diabetes Manage Exercise",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Type 1 Diabetes Mellitus",
        "Exercise Physiology"
      ],
      "interventions": [
        {
          "name": "Standard-of-Care Guidance (SoC)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Usual Care (UC)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "netIOB & Exercise Toolkit (NEXT)",
          "type": "DEVICE"
        },
        {
          "name": "Continuous Glucose Monitoring",
          "type": "DEVICE"
        },
        {
          "name": "Continuous Ketone Monitoring",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DEVICE"
      ],
      "sponsor": "Stanford University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 20,
      "start_date": "2026-10",
      "completion_date": "2027-02",
      "has_results": false,
      "last_update_posted_date": "2026-08-12",
      "last_synced_at": "2026-09-21T19:58:34.005Z",
      "location_count": 1,
      "location_summary": "Palo Alto, California",
      "locations": [
        {
          "city": "Palo Alto",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07226583"
    },
    {
      "nct_id": "NCT03977727",
      "title": "FIasp® vs. Novolog® in Type 1 Diabetics Using 670G Medtronic Pump",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Type 1 Diabetes Mellitus"
      ],
      "interventions": [
        {
          "name": "Fiasp®",
          "type": "DRUG"
        },
        {
          "name": "Novolog®",
          "type": "DRUG"
        },
        {
          "name": "670G hybrid closed loop continuous subcutaneous insulin infusion system",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "Texas Diabetes & Endocrinology, P.A.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 40,
      "start_date": "2019-06-11",
      "completion_date": "2020-04-20",
      "has_results": true,
      "last_update_posted_date": "2020-09-29",
      "last_synced_at": "2026-09-21T19:58:34.005Z",
      "location_count": 1,
      "location_summary": "Austin, Texas",
      "locations": [
        {
          "city": "Austin",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03977727"
    },
    {
      "nct_id": "NCT03774186",
      "title": "Pregnancy Intervention With a Closed-Loop System (PICLS) Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Type 1 Diabetes Mellitus",
        "Pregnancy in Diabetes"
      ],
      "interventions": [
        {
          "name": "Hybrid closed-loop therapy",
          "type": "DEVICE"
        },
        {
          "name": "Sensor-augmented pump therapy",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Colorado, Denver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 45 Years · Female only"
      },
      "enrollment_count": 24,
      "start_date": "2019-03-21",
      "completion_date": "2022-03-08",
      "has_results": true,
      "last_update_posted_date": "2023-11-28",
      "last_synced_at": "2026-09-21T19:58:34.005Z",
      "location_count": 2,
      "location_summary": "Aurora, Colorado • Columbus, Ohio",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03774186"
    },
    {
      "nct_id": "NCT03804983",
      "title": "Safety and Efficacy of Initializing the Control-IQ Artificial Pancreas System Using Total Daily Insulin",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Type 1 Diabetes Mellitus"
      ],
      "interventions": [
        {
          "name": "Hybrid Closed Loop (HCL)",
          "type": "DEVICE"
        },
        {
          "name": "Control-IQ with MyTDI",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Virginia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "12 Years to 18 Years"
      },
      "enrollment_count": 22,
      "start_date": "2019-01-15",
      "completion_date": "2019-02-16",
      "has_results": true,
      "last_update_posted_date": "2024-08-01",
      "last_synced_at": "2026-09-21T19:58:34.005Z",
      "location_count": 1,
      "location_summary": "Charlottesville, Virginia",
      "locations": [
        {
          "city": "Charlottesville",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03804983"
    },
    {
      "nct_id": "NCT05537233",
      "title": "ADJUnct Semaglutide Treatment in Type 1 Diabetes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Type 1 Diabetes",
        "Obesity"
      ],
      "interventions": [
        {
          "name": "Semaglutide",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Viral N. Shah",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 115,
      "start_date": "2023-04-11",
      "completion_date": "2024-08-06",
      "has_results": true,
      "last_update_posted_date": "2025-09-03",
      "last_synced_at": "2026-09-21T19:58:34.005Z",
      "location_count": 4,
      "location_summary": "Aurora, Colorado • West Des Moines, Iowa • Detroit, Michigan + 1 more",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "West Des Moines",
          "state": "Iowa"
        },
        {
          "city": "Detroit",
          "state": "Michigan"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05537233"
    },
    {
      "nct_id": "NCT07293715",
      "title": "Permissive Versus Strict Intrapartum Glucose Management in Type 1 Diabetes (PRISM-T1D)",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Pregnancy, High Risk",
        "Type 1 Diabetes"
      ],
      "interventions": [
        {
          "name": "Insulin",
          "type": "DRUG"
        },
        {
          "name": "DEXCOM Continuous Glucose Monitor",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "Ohio State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 44,
      "start_date": "2026-02-25",
      "completion_date": "2027-06",
      "has_results": false,
      "last_update_posted_date": "2026-04-29",
      "last_synced_at": "2026-09-21T19:58:34.005Z",
      "location_count": 1,
      "location_summary": "Columbus, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07293715"
    },
    {
      "nct_id": "NCT04614623",
      "title": "Defining the Role of Management Factors in Outcome Disparity in Pediatric T1D",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Type1diabetes"
      ],
      "interventions": [
        {
          "name": "AHCL pump",
          "type": "DEVICE"
        },
        {
          "name": "Video conferencing Application",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Children's Hospital New Orleans, LA",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "10 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "10 Years to 17 Years"
      },
      "enrollment_count": 120,
      "start_date": "2020-11-01",
      "completion_date": "2022-12-31",
      "has_results": false,
      "last_update_posted_date": "2020-11-04",
      "last_synced_at": "2026-09-21T19:58:34.005Z",
      "location_count": 1,
      "location_summary": "New Orleans, Louisiana",
      "locations": [
        {
          "city": "New Orleans",
          "state": "Louisiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04614623"
    }
  ]
}