{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Hydrocodon%2FAcetaminophen", "query": { "intervention": "Hydrocodon/Acetaminophen" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 115, "total_pages": 12, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Hydrocodon%2FAcetaminophen&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-09T03:57:57.955Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT03879408", "title": "Naproxen Sodium/Acetaminophen Proof of Concept Dosing Study", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Pain" ], "interventions": [ { "name": "440 mg naproxen sodium with 1000 mg acetaminophen", "type": "DRUG" }, { "name": "220 mg naproxen sodium with 650 mg acetaminophen", "type": "DRUG" }, { "name": "10 mg hydrocodone + 650 mg acetaminophen", "type": "DRUG" }, { "name": "440 mg naproxen sodium", "type": "DRUG" }, { "name": "Placebo tablet", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "17 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "17 Years to 50 Years" }, "enrollment_count": 290, "start_date": "2019-05-28", "completion_date": "2019-11-13", "has_results": true, "last_update_posted_date": "2022-12-05", "last_synced_at": "2026-09-09T03:57:57.955Z", "location_count": 1, "location_summary": "Salt Lake City, Utah", "locations": [ { "city": "Salt Lake City", "state": "Utah" } ], "official_url": "https://clinicaltrials.gov/study/NCT03879408" }, { "nct_id": "NCT03823534", "title": "Post-Op Pain Control for Prophylactic Intramedullary Nailing.", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Bone Metastases", "Lymphoma", "Multiple Myeloma", "Opioid Use", "Pain" ], "interventions": [ { "name": "Ketorolac", "type": "DRUG" }, { "name": "Normal saline", "type": "DRUG" }, { "name": "Acetaminophen", "type": "DRUG" }, { "name": "Oxycodone Acetaminophen", "type": "DRUG" }, { "name": "Morphine", "type": "DRUG" }, { "name": "Hydrocodone/Acetaminophen", "type": "DRUG" }, { "name": "Oxycodone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "St. Louis University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 60, "start_date": "2019-02-20", "completion_date": "2027-03-31", "has_results": false, "last_update_posted_date": "2026-04-22", "last_synced_at": "2026-09-09T03:57:57.955Z", "location_count": 1, "location_summary": "St Louis, Missouri", "locations": [ { "city": "St Louis", "state": "Missouri" } ], "official_url": "https://clinicaltrials.gov/study/NCT03823534" }, { "nct_id": "NCT05553366", "title": "Evaluation of Efficacy and Safety of VX-548 for Acute Pain After a Bunionectomy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Acute Pain" ], "interventions": [ { "name": "SUZ", "type": "DRUG" }, { "name": "HB/APAP", "type": "DRUG" }, { "name": "Placebo (matched to SUZ)", "type": "DRUG" }, { "name": "Placebo (matched to HB/APAP)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vertex Pharmaceuticals Incorporated", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 1075, "start_date": "2022-10-03", "completion_date": "2023-12-15", "has_results": true, "last_update_posted_date": "2025-08-01", "last_synced_at": "2026-09-09T03:57:57.955Z", "location_count": 21, "location_summary": "Sheffield, Alabama • Phoenix, Arizona • Little Rock, Arkansas + 18 more", "locations": [ { "city": "Sheffield", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Anaheim", "state": "California" }, { "city": "Bakersfield", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05553366" }, { "nct_id": "NCT02153177", "title": "The Effect of NSAIDs After a Rotator Cuff Repair Surgery.", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Rotator Cuff Tear" ], "interventions": [ { "name": "Rotator cuff repair", "type": "PROCEDURE" }, { "name": "Ibuprofen, Hydrocodone/Acetaminophen, Omeprazole", "type": "DRUG" }, { "name": "Hydrocodone/Acetaminophen", "type": "DRUG" } ], "intervention_types": [ "PROCEDURE", "DRUG" ], "sponsor": "University of Chicago", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "45 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "45 Years to 75 Years" }, "enrollment_count": 0, "start_date": "2015-01", "completion_date": "2018-12", "has_results": false, "last_update_posted_date": "2023-02-23", "last_synced_at": "2026-09-09T03:57:57.955Z", "location_count": 1, "location_summary": "Chicago, Illinois", "locations": [ { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT02153177" }, { "nct_id": "NCT01053637", "title": "Pain and Anxiety Management With Oral Narcotic for Pediatric Suture Repair", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Children", "Lacerations", "Procedures", "Child", "Pain" ], "interventions": [ { "name": "hydrocodone/acetaminophen", "type": "DRUG" }, { "name": "Sugar water", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Baylor College of Medicine", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "2 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "2 Years to 17 Years" }, "enrollment_count": 85, "start_date": "2009-02", "completion_date": "2015-05", "has_results": true, "last_update_posted_date": "2021-08-25", "last_synced_at": "2026-09-09T03:57:57.955Z", "location_count": 1, "location_summary": "Houston, Texas", "locations": [ { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT01053637" }, { "nct_id": "NCT04240626", "title": "Multimodal Analgesia Effect on Post Surgical Patient", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Obesity, Morbid", "Surgery", "Bariatric Surgery Candidate" ], "interventions": [ { "name": "Neurontin", "type": "DRUG" }, { "name": "Dilaudid Injectable Product", "type": "DRUG" }, { "name": "Marcaine Injectable Product", "type": "DRUG" }, { "name": "Oxycodone Hydrochloride", "type": "DRUG" }, { "name": "Hycet 7.5Mg-325Mg/15Ml Solution", "type": "DRUG" }, { "name": "Zofran Injection", "type": "DRUG" }, { "name": "Scopolamine patch", "type": "DRUG" }, { "name": "Ativan", "type": "DRUG" }, { "name": "Flexeril Oral Product", "type": "DRUG" }, { "name": "Tylenol Suspension", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of California, Davis", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "35 Years", "maximum_age": "65 Years", "sex": "FEMALE", "summary": "35 Years to 65 Years · Female only" }, "enrollment_count": 60, "start_date": "2021-01-20", "completion_date": "2026-06-24", "has_results": false, "last_update_posted_date": "2025-08-08", "last_synced_at": "2026-09-09T03:57:57.955Z", "location_count": 1, "location_summary": "Sacramento, California", "locations": [ { "city": "Sacramento", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04240626" }, { "nct_id": "NCT03472469", "title": "MAST Trial: Multi-modal Analgesic Strategies in Trauma", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Nonspecific Pain Post Traumatic Injury" ], "interventions": [ { "name": "Acetaminophen IV/PO", "type": "DRUG" }, { "name": "Acetaminophen PO", "type": "DRUG" }, { "name": "Ketorolac", "type": "DRUG" }, { "name": "Celebrex", "type": "DRUG" }, { "name": "Naproxen", "type": "DRUG" }, { "name": "Tramadol", "type": "DRUG" }, { "name": "Pregabalin", "type": "DRUG" }, { "name": "Gabapentin", "type": "DRUG" }, { "name": "Lidocaine", "type": "DRUG" }, { "name": "Opioids", "type": "DRUG" }, { "name": "Regional anesthesia", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "The University of Texas Health Science Center, Houston", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "16 Years", "maximum_age": null, "sex": "ALL", "summary": "16 Years and older" }, "enrollment_count": 1561, "start_date": "2018-04-02", "completion_date": "2019-07-03", "has_results": true, "last_update_posted_date": "2021-06-18", "last_synced_at": "2026-09-09T03:57:57.955Z", "location_count": 1, "location_summary": "Houston, Texas", "locations": [ { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT03472469" }, { "nct_id": "NCT02929589", "title": "Ibuprofen to Decrease Opioid Use and Post-operative Pain Following Unilateral Inguinal Herniorrhaphy", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Pain", "Hernia" ], "interventions": [ { "name": "Ibuprofen", "type": "DRUG" }, { "name": "Opioid Medication", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Ibuprofen + Opioid medication", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Mike O'Callaghan Military Hospital", "sponsor_class": "FED", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 18, "start_date": "2018-07-05", "completion_date": "2021-08-23", "has_results": true, "last_update_posted_date": "2024-03-26", "last_synced_at": "2026-09-09T03:57:57.955Z", "location_count": 1, "location_summary": "Nellis Air Force Base, Nevada", "locations": [ { "city": "Nellis Air Force Base", "state": "Nevada" } ], "official_url": "https://clinicaltrials.gov/study/NCT02929589" }, { "nct_id": "NCT05240755", "title": "Effectiveness of Cannabidiol vs. Narcotics for Post Operative Pain Control in Elective Shoulder Arthroscopic Surgery", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "EARLY_PHASE1" ], "conditions": [ "Post-operative Pain" ], "interventions": [ { "name": "Cannabidiol Oil", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Foundation for Orthopaedic Research and Education", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 40, "start_date": "2022-07-01", "completion_date": "2024-08-20", "has_results": false, "last_update_posted_date": "2025-03-17", "last_synced_at": "2026-09-09T03:57:57.955Z", "location_count": 1, "location_summary": "Tampa, Florida", "locations": [ { "city": "Tampa", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT05240755" }, { "nct_id": "NCT04977336", "title": "A Study Evaluating Efficacy and Safety of VX-548 for Acute Pain After a Bunionectomy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Acute Pain" ], "interventions": [ { "name": "VX-548", "type": "DRUG" }, { "name": "HB/APAP", "type": "DRUG" }, { "name": "Placebo (matched to VX-548)", "type": "DRUG" }, { "name": "Placebo (matched to HB/APAP)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vertex Pharmaceuticals Incorporated", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 274, "start_date": "2021-07-19", "completion_date": "2022-03-04", "has_results": true, "last_update_posted_date": "2025-06-25", "last_synced_at": "2026-09-09T03:57:57.955Z", "location_count": 12, "location_summary": "Sheffield, Alabama • Phoenix, Arizona • Anaheim, California + 9 more", "locations": [ { "city": "Sheffield", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Anaheim", "state": "California" }, { "city": "Pasadena", "state": "California" }, { "city": "Tarzana", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04977336" } ] }