{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Hylan+F-+20",
    "query": {
      "intervention": "Hylan F- 20"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 13,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Hylan+F-+20&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-04T07:55:20.123Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00398866",
      "title": "A Study of Hyaluronan for the Treatment of Osteoarthritis in the Thumb",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Osteoarthritis"
      ],
      "interventions": [
        {
          "name": "Synvisc (Hylan G-F20; hyaluronan injection)",
          "type": "DRUG"
        },
        {
          "name": "Bupivicaine (local anesthesia injection)",
          "type": "DRUG"
        },
        {
          "name": "Kenalog (triamcinolone; corticosteroid injection)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Hospital for Special Surgery, New York",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "45 Years",
        "maximum_age": "95 Years",
        "sex": "ALL",
        "summary": "45 Years to 95 Years"
      },
      "enrollment_count": 200,
      "start_date": "2006-08",
      "completion_date": "2013-03",
      "has_results": true,
      "last_update_posted_date": "2017-07-07",
      "last_synced_at": "2026-09-04T07:55:20.123Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00398866"
    },
    {
      "nct_id": "NCT02029703",
      "title": "Optimization of Synvisc-One for Knee OA",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Knee Osteoarthritis"
      ],
      "interventions": [
        {
          "name": "Synvisc-One Injection",
          "type": "DEVICE"
        },
        {
          "name": "Sham Injection",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "OTHER"
      ],
      "sponsor": "Elaine Husni",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 42,
      "start_date": "2012-08",
      "completion_date": "2015-11",
      "has_results": true,
      "last_update_posted_date": "2017-04-21",
      "last_synced_at": "2026-09-04T07:55:20.123Z",
      "location_count": 1,
      "location_summary": "Weston, Florida",
      "locations": [
        {
          "city": "Weston",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02029703"
    },
    {
      "nct_id": "NCT00131326",
      "title": "A Study of the Safety and Efficacy of Synvisc and Depo-Medrol in Patients With Osteoarthritis of the Hip",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Osteoarthritis, Hip",
        "Musculoskeletal Diseases"
      ],
      "interventions": [
        {
          "name": "Synvisc (hylan G-F 20)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Genzyme, a Sanofi Company",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "35 Years and older"
      },
      "enrollment_count": null,
      "start_date": "2003-11",
      "completion_date": "2006-04",
      "has_results": false,
      "last_update_posted_date": "2017-07-31",
      "last_synced_at": "2026-09-04T07:55:20.123Z",
      "location_count": 32,
      "location_summary": "Birmingham, Alabama • Huntsville, Alabama • Scottsdale, Arizona + 29 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Huntsville",
          "state": "Alabama"
        },
        {
          "city": "Scottsdale",
          "state": "Arizona"
        },
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00131326"
    },
    {
      "nct_id": "NCT00971074",
      "title": "Study of Viscosupplementation for the Treatment of Knee Pain After Menisectomy",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Arthralgia"
      ],
      "interventions": [
        {
          "name": "Hylan G-F 20",
          "type": "DRUG"
        },
        {
          "name": "Sham Injection",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Grant Jones",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 0,
      "start_date": "2009-12",
      "completion_date": "2011-12",
      "has_results": false,
      "last_update_posted_date": "2021-02-25",
      "last_synced_at": "2026-09-04T07:55:20.123Z",
      "location_count": 1,
      "location_summary": "Columbus, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00971074"
    },
    {
      "nct_id": "NCT01625013",
      "title": "Synvisc-One for Younger, Active Patients With Osteoarthritis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Osteoarthritis"
      ],
      "interventions": [
        {
          "name": "Synvisc-One (G-F 20)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Anthony Luke",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "30 Years to 50 Years"
      },
      "enrollment_count": 51,
      "start_date": "2011-11",
      "completion_date": "2019-08-07",
      "has_results": true,
      "last_update_posted_date": "2021-05-07",
      "last_synced_at": "2026-09-04T07:55:20.123Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01625013"
    },
    {
      "nct_id": "NCT01618708",
      "title": "A Study of the Safety and Effectiveness of Synvisc-One® (Hylan G-F 20) in Patients With Primary Osteoarthritis of the Hip",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Osteoarthritis, Hip"
      ],
      "interventions": [
        {
          "name": "Synvisc-One (hylan G-F 20)",
          "type": "DEVICE"
        },
        {
          "name": "Placebo",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Genzyme, a Sanofi Company",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "35 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "35 Years and older"
      },
      "enrollment_count": 357,
      "start_date": "2012-09",
      "completion_date": "2015-06",
      "has_results": true,
      "last_update_posted_date": "2016-07-11",
      "last_synced_at": "2026-09-04T07:55:20.123Z",
      "location_count": 45,
      "location_summary": "Burmingham, Alabama • Phoenix, Arizona • Tucson, Arizona + 41 more",
      "locations": [
        {
          "city": "Burmingham",
          "state": "Alabama"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Covina",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01618708"
    },
    {
      "nct_id": "NCT05492851",
      "title": "Trial Comparing Three Single Dose Injections for Knee Osteoarthritis",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Osteoarthritis, Knee"
      ],
      "interventions": [
        {
          "name": "Zilretta",
          "type": "DRUG"
        },
        {
          "name": "Synvisc-One 48 MG in 6 ML Prefilled Syringe",
          "type": "DRUG"
        },
        {
          "name": "Monovisc 88 MG Per 4 ML Prefilled Syringe",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Ohio State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "25 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "25 Years to 85 Years"
      },
      "enrollment_count": 6,
      "start_date": "2022-08-02",
      "completion_date": "2023-01-11",
      "has_results": false,
      "last_update_posted_date": "2023-04-10",
      "last_synced_at": "2026-09-04T07:55:20.123Z",
      "location_count": 2,
      "location_summary": "Columbus, Ohio • Lewis Center, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        },
        {
          "city": "Lewis Center",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05492851"
    },
    {
      "nct_id": "NCT00198029",
      "title": "An Open Label Trial for Treating Carpometacarpal Osteoarthritis of the Thumb: Pilot Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Carpometacarpal Osteoarthritis"
      ],
      "interventions": [
        {
          "name": "Synvisc (hylan G-F20)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Hospital for Special Surgery, New York",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "45 Years",
        "maximum_age": "95 Years",
        "sex": "ALL",
        "summary": "45 Years to 95 Years"
      },
      "enrollment_count": 32,
      "start_date": "2004-10",
      "completion_date": "2009-12",
      "has_results": true,
      "last_update_posted_date": "2017-04-17",
      "last_synced_at": "2026-09-04T07:55:20.123Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00198029"
    },
    {
      "nct_id": "NCT03694821",
      "title": "Knee Injection RCT",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Osteoarthritis"
      ],
      "interventions": [
        {
          "name": "Ketorolac Tromethamine Injection",
          "type": "DRUG"
        },
        {
          "name": "Methylprednisolone Acetate Injection",
          "type": "DRUG"
        },
        {
          "name": "Hylan G-F 20",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "UConn Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 18,
      "start_date": "2018-07-05",
      "completion_date": "2019-07-16",
      "has_results": true,
      "last_update_posted_date": "2020-02-18",
      "last_synced_at": "2026-09-04T07:55:20.123Z",
      "location_count": 1,
      "location_summary": "Farmington, Connecticut",
      "locations": [
        {
          "city": "Farmington",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03694821"
    },
    {
      "nct_id": "NCT01557868",
      "title": "Prediction of Response to Intra-articular Injections of Hyaluronic Acid for Knee Osteoarthritis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Osteoarthritis, Knee"
      ],
      "interventions": [
        {
          "name": "hylan G-F 20",
          "type": "DEVICE"
        },
        {
          "name": "1% sodium hyaluronate",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "American Orthopaedic Society for Sports Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 198,
      "start_date": "2008-10",
      "completion_date": "2012-12",
      "has_results": true,
      "last_update_posted_date": "2014-04-02",
      "last_synced_at": "2026-09-04T07:55:20.123Z",
      "location_count": 1,
      "location_summary": "Portsmouth, Virginia",
      "locations": [
        {
          "city": "Portsmouth",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01557868"
    }
  ]
}