{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=ISMN&page=2", "query": { "intervention": "ISMN", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 10, "total_pages": 1, "next_page_url": null, "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=ISMN&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-09-12T22:04:10.217Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT03171480", "title": "Use of Nitrous Oxide Donor for Labor Induction in Women With PreEclampsia", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Preeclampsia", "Labor, Premature" ], "interventions": [ { "name": "Monoket Pill", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Ohio State University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "42 Years", "sex": "FEMALE", "summary": "18 Years to 42 Years · Female only" }, "enrollment_count": 176, "start_date": "2017-10-30", "completion_date": "2020-07-01", "has_results": true, "last_update_posted_date": "2022-01-04", "last_synced_at": "2026-09-12T22:04:10.217Z", "location_count": 1, "location_summary": "Columbus, Ohio", "locations": [ { "city": "Columbus", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT03171480" }, { "nct_id": "NCT00262470", "title": "Treatment of Orthostatic Intolerance", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Tachycardia", "Chronic Orthostatic Intolerance" ], "interventions": [ { "name": "Acetazolamide", "type": "DRUG" }, { "name": "Atomoxetine", "type": "DRUG" }, { "name": "NO Drug", "type": "OTHER" }, { "name": "Clonidine", "type": "DRUG" }, { "name": "Entacapone", "type": "DRUG" }, { "name": "Entacapone & Propranolol", "type": "DRUG" }, { "name": "Atomoxetine & Propranolol", "type": "DRUG" }, { "name": "Indomethacin", "type": "DRUG" }, { "name": "Mecamylamine", "type": "DRUG" }, { "name": "Isosorbide Dinitrate", "type": "DRUG" }, { "name": "Melatonin", "type": "DIETARY_SUPPLEMENT" }, { "name": "Midodrine", "type": "DRUG" }, { "name": "Modafinil", "type": "DRUG" }, { "name": "Octreotide", "type": "DRUG" }, { "name": "Placebo", "type": "RADIATION" }, { "name": "Propranolol", "type": "DRUG" }, { "name": "Modafinil & Propranolol", "type": "DRUG" }, { "name": "Sertraline", "type": "DRUG" }, { "name": "IV Saline", "type": "PROCEDURE" }, { "name": "Drinking Water", "type": "OTHER" }, { "name": "Breathing Device", "type": "DEVICE" }, { "name": "memantine", "type": "DRUG" }, { "name": "Abdominal binder", "type": "DEVICE" } ], "intervention_types": [ "DRUG", "OTHER", "DIETARY_SUPPLEMENT", "RADIATION", "PROCEDURE", "DEVICE" ], "sponsor": "Satish R. Raj", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 150, "start_date": "1997-04", "completion_date": "2029-12", "has_results": false, "last_update_posted_date": "2025-10-08", "last_synced_at": "2026-09-12T22:04:10.217Z", "location_count": 1, "location_summary": "Nashville, Tennessee", "locations": [ { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT00262470" }, { "nct_id": "NCT07456852", "title": "Vasodilator Therapy With Isosorbide Mononitrate or Diltiazem to Reduce Vasotoxicity in Patients With Gastrointestinal Cancer Receiving Fluoropyrimidine Therapy", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Malignant Digestive System Neoplasm" ], "interventions": [ { "name": "Biospecimen Collection", "type": "PROCEDURE" }, { "name": "Capecitabine", "type": "DRUG" }, { "name": "Diltiazem Hydrochloride", "type": "DRUG" }, { "name": "Electrocardiogram", "type": "PROCEDURE" }, { "name": "Fluorouracil", "type": "DRUG" }, { "name": "Holter Monitoring", "type": "DEVICE" }, { "name": "Isosorbide Mononitrate", "type": "DRUG" }, { "name": "Medical Device Usage and Evaluation", "type": "OTHER" }, { "name": "Placebo Administration", "type": "DRUG" }, { "name": "Questionnaire Administration", "type": "OTHER" } ], "intervention_types": [ "PROCEDURE", "DRUG", "DEVICE", "OTHER" ], "sponsor": "Mayo Clinic", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 60, "start_date": "2026-04-30", "completion_date": "2030-04-30", "has_results": false, "last_update_posted_date": "2026-06-02", "last_synced_at": "2026-09-12T22:04:10.217Z", "location_count": 1, "location_summary": "Rochester, Minnesota", "locations": [ { "city": "Rochester", "state": "Minnesota" } ], "official_url": "https://clinicaltrials.gov/study/NCT07456852" }, { "nct_id": "NCT02053493", "title": "Nitrate's Effect on Activity Tolerance in Heart Failure With Preserved Ejection Fraction", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Heart Failure" ], "interventions": [ { "name": "Isosorbide Mononitrate", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Adrian Hernandez", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "50 Years", "maximum_age": null, "sex": "ALL", "summary": "50 Years and older" }, "enrollment_count": 110, "start_date": "2014-04", "completion_date": "2015-03", "has_results": true, "last_update_posted_date": "2016-11-28", "last_synced_at": "2026-09-12T22:04:10.217Z", "location_count": 22, "location_summary": "Newark, Delaware • Atlanta, Georgia • Chicago, Illinois + 12 more", "locations": [ { "city": "Newark", "state": "Delaware" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Chicago", "state": "Illinois" }, { "city": "Baltimore", "state": "Maryland" }, { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT02053493" }, { "nct_id": "NCT02045459", "title": "Microvascular Disease Exercise Trial", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Coronary Microvascular Disease" ], "interventions": [ { "name": "Exercise Program", "type": "BEHAVIORAL" } ], "intervention_types": [ "BEHAVIORAL" ], "sponsor": "University of Virginia", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "18 Years to 85 Years" }, "enrollment_count": 79, "start_date": "2014-05", "completion_date": "2021-05-17", "has_results": false, "last_update_posted_date": "2021-05-19", "last_synced_at": "2026-09-12T22:04:10.217Z", "location_count": 2, "location_summary": "Charlottesville, Virginia", "locations": [ { "city": "Charlottesville", "state": "Virginia" }, { "city": "Charlottesville", "state": "Virginia" } ], "official_url": "https://clinicaltrials.gov/study/NCT02045459" }, { "nct_id": "NCT01587313", "title": "A Comparison of Various Combinations of BiDil Capsules and BiDil Tablets in Healthy Human Volunteers", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy" ], "interventions": [ { "name": "Isosorbide dinitrate / hydralazine capsules", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Arbor Pharmaceuticals, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "40 Years", "sex": "ALL", "summary": "18 Years to 40 Years" }, "enrollment_count": 36, "start_date": "2012-04", "completion_date": "2012-05", "has_results": false, "last_update_posted_date": "2015-08-06", "last_synced_at": "2026-09-12T22:04:10.217Z", "location_count": 1, "location_summary": "Hackensack, New Jersey", "locations": [ { "city": "Hackensack", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT01587313" }, { "nct_id": "NCT04051957", "title": "Isosorbide Mononitrate For Anti-Vascular Endothelial Growth Factor (VEGF) Induced Kidney Injury", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Kidney Injury", "Proteinuria", "Hypertension" ], "interventions": [ { "name": "Isosorbide Mononitrate", "type": "DRUG" }, { "name": "Placebo oral tablet", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "The University of Texas Health Science Center, Houston", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 9, "start_date": "2019-09-26", "completion_date": "2021-02-12", "has_results": true, "last_update_posted_date": "2022-08-03", "last_synced_at": "2026-09-12T22:04:10.217Z", "location_count": 1, "location_summary": "Houston, Texas", "locations": [ { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT04051957" }, { "nct_id": "NCT01961453", "title": "Effect of Isosorbide Mononitrate on Hypertension to Improve Left Ventricular Hypertrophy, Fibrosis and Myocardial Function", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Hypertension" ], "interventions": [ { "name": "Isosorbide Mononitrate, sustained release", "type": "DRUG" }, { "name": "Placebo capsule", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Corporal Michael J. Crescenz VA Medical Center", "sponsor_class": "FED", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "89 Years", "sex": "ALL", "summary": "18 Years to 89 Years" }, "enrollment_count": 0, "start_date": "2013-08", "completion_date": "2016-01", "has_results": false, "last_update_posted_date": "2016-08-11", "last_synced_at": "2026-09-12T22:04:10.217Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT01961453" }, { "nct_id": "NCT04831892", "title": "The Effect of Isosorbide Diesters Based Moisturizer on Skin Health", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Atopic Dermatitis" ], "interventions": [ { "name": "Moisturizer Containing Isosorbide Diesters and Colloidal Oatmeal", "type": "OTHER" }, { "name": "Moisturizer containing Colloidal Oatmeal only", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Integrative Skin Science and Research", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 34, "start_date": "2021-04-12", "completion_date": "2022-04-30", "has_results": false, "last_update_posted_date": "2022-11-09", "last_synced_at": "2026-09-12T22:04:10.217Z", "location_count": 1, "location_summary": "Sacramento, California", "locations": [ { "city": "Sacramento", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04831892" }, { "nct_id": "NCT00047775", "title": "African-American Heart Failure Trial", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Congestive Heart Failure" ], "interventions": [ { "name": "BiDil", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Nitromed", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 1100, "start_date": "2001-05", "completion_date": "2004-08", "has_results": false, "last_update_posted_date": "2005-06-24", "last_synced_at": "2026-09-12T22:04:10.217Z", "location_count": 7, "location_summary": "Birmingham, Alabama • Little Rock, Arkansas • Washington D.C., District of Columbia + 4 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Aventura", "state": "Florida" }, { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT00047775" } ] }