{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Increase+in+the+PEEP+followed+by+decrease+in+the+PEEP",
    "query": {
      "intervention": "Increase in the PEEP followed by decrease in the PEEP"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 4,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-08T13:20:50.496Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT07701850",
      "title": "Mechanical Ventilator Adjustments and Patient Dyspnea",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Respiratory Failure",
        "Dyspnea During Mechanical Ventilation",
        "Mechanical Ventilation"
      ],
      "interventions": [
        {
          "name": "Change to VC/AC",
          "type": "OTHER"
        },
        {
          "name": "Change in Tidal Volume",
          "type": "OTHER"
        },
        {
          "name": "Change in inspiratory flow",
          "type": "OTHER"
        },
        {
          "name": "Change in PEEP",
          "type": "OTHER"
        },
        {
          "name": "Change to PSV",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Beth Israel Deaconess Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2026-09-01",
      "completion_date": "2027-07-01",
      "has_results": false,
      "last_update_posted_date": "2026-07-14",
      "last_synced_at": "2026-09-08T13:20:50.496Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07701850"
    },
    {
      "nct_id": "NCT06512935",
      "title": "Ventilator Pressure and Optimization of Compliance and Hemodynamics",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Bronchopulmonary Dysplasia",
        "Pulmonary Hypertension Due to Lung Diseases and Hypoxia",
        "Extreme Prematurity",
        "Ventilator Lung; Newborn",
        "Ventilation Perfusion Mismatch"
      ],
      "interventions": [
        {
          "name": "Increase in the PEEP followed by decrease in the PEEP",
          "type": "OTHER"
        },
        {
          "name": "Decrease in the PEEP followed by increase in the PEEP",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "7 Days",
        "maximum_age": "30 Days",
        "sex": "ALL",
        "summary": "7 Days to 30 Days"
      },
      "enrollment_count": 24,
      "start_date": "2026-08-01",
      "completion_date": "2027-06-30",
      "has_results": false,
      "last_update_posted_date": "2026-05-11",
      "last_synced_at": "2026-09-08T13:20:50.496Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06512935"
    },
    {
      "nct_id": "NCT02503241",
      "title": "Open Lung Strategy in Critically Ill Morbid Obese Patients",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Obesity",
        "Respiratory Insufficiency",
        "Right-Sided Heart Failure",
        "Pulmonary Atelectasis",
        "Respiratory Mechanics"
      ],
      "interventions": [
        {
          "name": "PEEP INCREMENTAL",
          "type": "PROCEDURE"
        },
        {
          "name": "PEEP DECREMENTAL",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 21,
      "start_date": "2016-04",
      "completion_date": "2022-06-30",
      "has_results": false,
      "last_update_posted_date": "2020-11-17",
      "last_synced_at": "2026-09-08T13:20:50.496Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02503241"
    },
    {
      "nct_id": "NCT07774065",
      "title": "Mechanical Ventilation in Obese Surgical Patients",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Obese"
      ],
      "interventions": [
        {
          "name": "Standard PEEP (8 cmH₂O)",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "The University of Texas Medical Branch, Galveston",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 10,
      "start_date": "2026-07-29",
      "completion_date": "2027-07-31",
      "has_results": false,
      "last_update_posted_date": "2026-08-19",
      "last_synced_at": "2026-09-08T13:20:50.496Z",
      "location_count": 1,
      "location_summary": "Galveston, Texas",
      "locations": [
        {
          "city": "Galveston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07774065"
    }
  ]
}