{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Intermediate+nicotine+level+cigarette",
    "query": {
      "intervention": "Intermediate nicotine level cigarette"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 48,
    "total_pages": 5,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Intermediate+nicotine+level+cigarette&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-17T22:23:56.904Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT07213947",
      "title": "Comparison of Demand and Substitution for Nicotine Pouches as a Function of Nicotine Dosage",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tobacco Use",
        "Nicotine Pouch Self-Administration"
      ],
      "interventions": [
        {
          "name": "Nicotine Pouch Dosage",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "William Middleton",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 1360,
      "start_date": "2025-12-04",
      "completion_date": "2026-01-02",
      "has_results": false,
      "last_update_posted_date": "2026-05-01",
      "last_synced_at": "2026-09-17T22:23:56.904Z",
      "location_count": 1,
      "location_summary": "Lexington, Kentucky",
      "locations": [
        {
          "city": "Lexington",
          "state": "Kentucky"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07213947"
    },
    {
      "nct_id": "NCT07564648",
      "title": "Impact of Novel vs. Usual Brand Menthol Cigarettes on Abuse Liability",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cigarette Addiction",
        "Tobacco Use Disorder"
      ],
      "interventions": [
        {
          "name": "Biospecimen Collection",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Questionnaire Administration",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Cigarette Purchase Task",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Cross-Price Elasticity Task",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Daily Diary Surveys",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Progressive Ratio Task",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Ohio State University Comprehensive Cancer Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 48,
      "start_date": "2026-07-27",
      "completion_date": "2029-09-30",
      "has_results": false,
      "last_update_posted_date": "2026-07-22",
      "last_synced_at": "2026-09-17T22:23:56.904Z",
      "location_count": 1,
      "location_summary": "Columbus, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07564648"
    },
    {
      "nct_id": "NCT02416011",
      "title": "Smoking Cessation Self-Help for Dual Users of Tobacco Cigarettes and E-Cigarettes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking Cessation"
      ],
      "interventions": [
        {
          "name": "GENERIC",
          "type": "BEHAVIORAL"
        },
        {
          "name": "eTARGET",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "H. Lee Moffitt Cancer Center and Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 2896,
      "start_date": "2015-03-31",
      "completion_date": "2019-06-30",
      "has_results": true,
      "last_update_posted_date": "2022-02-23",
      "last_synced_at": "2026-09-17T22:23:56.904Z",
      "location_count": 1,
      "location_summary": "Tampa, Florida",
      "locations": [
        {
          "city": "Tampa",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02416011"
    },
    {
      "nct_id": "NCT07476144",
      "title": "Nicotine Pouch Pharmacokinetics Abuse Liability",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Smoking Behaviors"
      ],
      "interventions": [
        {
          "name": "Participants will place the pouch between their top lip and their gum for 30 minutes as per use instructions.",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "JT International SA",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "22 Years to 65 Years"
      },
      "enrollment_count": 55,
      "start_date": "2026-01-08",
      "completion_date": "2026-10",
      "has_results": false,
      "last_update_posted_date": "2026-08-19",
      "last_synced_at": "2026-09-17T22:23:56.904Z",
      "location_count": 2,
      "location_summary": "Knoxville, Tennessee • San Antonio, Texas",
      "locations": [
        {
          "city": "Knoxville",
          "state": "Tennessee"
        },
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07476144"
    },
    {
      "nct_id": "NCT07598136",
      "title": "A Study to Determine the Effects of ENDS Flavor Availability on Abstinence Within Smokers",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking",
        "Tobacco"
      ],
      "interventions": [
        {
          "name": "P2613422",
          "type": "OTHER"
        },
        {
          "name": "P2611222",
          "type": "OTHER"
        },
        {
          "name": "P2615522",
          "type": "OTHER"
        },
        {
          "name": "P2615122",
          "type": "OTHER"
        },
        {
          "name": "P2615422",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "RAI Services Company",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "21 Years to 65 Years"
      },
      "enrollment_count": 1280,
      "start_date": "2026-05-14",
      "completion_date": "2027-01-21",
      "has_results": false,
      "last_update_posted_date": "2026-06-03",
      "last_synced_at": "2026-09-17T22:23:56.904Z",
      "location_count": 7,
      "location_summary": "Maitland, Florida • Atlanta, Georgia • St Louis, Missouri + 4 more",
      "locations": [
        {
          "city": "Maitland",
          "state": "Florida"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "St Louis",
          "state": "Missouri"
        },
        {
          "city": "Raleigh",
          "state": "North Carolina"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07598136"
    },
    {
      "nct_id": "NCT01387516",
      "title": "Motivation and Skills for Detained Teen Smokers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Motivational Intervention",
        "Nicotine Anonymous",
        "Cognitive Behavior Therapy",
        "Relaxation Therapy"
      ],
      "interventions": [
        {
          "name": "Motivational Intervention",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Relaxation Therapy",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Cognitive Behavioral Therapy",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Self-Help Programming",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Rhode Island",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "13 Years",
        "maximum_age": "19 Years",
        "sex": "ALL",
        "summary": "13 Years to 19 Years"
      },
      "enrollment_count": 314,
      "start_date": "2007-07",
      "completion_date": "2014-05",
      "has_results": true,
      "last_update_posted_date": "2025-04-30",
      "last_synced_at": "2026-09-17T22:23:56.904Z",
      "location_count": 1,
      "location_summary": "Cranston, Rhode Island",
      "locations": [
        {
          "city": "Cranston",
          "state": "Rhode Island"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01387516"
    },
    {
      "nct_id": "NCT03651869",
      "title": "Effects of Nicotine in Tobacco Smokers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Smoking, Tobacco",
        "Smoking (Tobacco) Addiction"
      ],
      "interventions": [
        {
          "name": "Cigarette 1",
          "type": "DRUG"
        },
        {
          "name": "Cigarette 2",
          "type": "DRUG"
        },
        {
          "name": "Patch 1",
          "type": "DRUG"
        },
        {
          "name": "Patch 2",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Southern California",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 221,
      "start_date": "2019-02-04",
      "completion_date": "2023-03-23",
      "has_results": false,
      "last_update_posted_date": "2023-07-13",
      "last_synced_at": "2026-09-17T22:23:56.904Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03651869"
    },
    {
      "nct_id": "NCT06372899",
      "title": "Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "E-cigarette Use",
        "Cigarette Smoking",
        "Harm Reduction",
        "Tobacco Use"
      ],
      "interventions": [
        {
          "name": "E-cigarettes",
          "type": "OTHER"
        },
        {
          "name": "Oral nicotine pouches",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Abramson Cancer Center at Penn Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 200,
      "start_date": "2024-10-02",
      "completion_date": "2028-03-31",
      "has_results": false,
      "last_update_posted_date": "2026-03-12",
      "last_synced_at": "2026-09-17T22:23:56.904Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06372899"
    },
    {
      "nct_id": "NCT01633567",
      "title": "Culturally Targeted & Individually Tailored Smoking Cessation Study: LGBT Smokers",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cigarette Smoking"
      ],
      "interventions": [
        {
          "name": "Culturally Targeted Cessation Program",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Non-Targeted Cessation Program",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Illinois at Chicago",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 400,
      "start_date": "2012-05",
      "completion_date": "2016-01",
      "has_results": false,
      "last_update_posted_date": "2017-05-04",
      "last_synced_at": "2026-09-17T22:23:56.904Z",
      "location_count": 1,
      "location_summary": "Chicago, Illinois",
      "locations": [
        {
          "city": "Chicago",
          "state": "Illinois"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01633567"
    },
    {
      "nct_id": "NCT00308763",
      "title": "Nicotine Patch and Bupropion to Reduce Smoking Rates in Younger, Low-Income, and Minority Individuals",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tobacco Use Disorder"
      ],
      "interventions": [
        {
          "name": "Nicotine Patch",
          "type": "DRUG"
        },
        {
          "name": "Sustained Release Bupropion",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of Tennessee",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "18 Years to 45 Years"
      },
      "enrollment_count": 594,
      "start_date": "2004-01",
      "completion_date": "2008-12",
      "has_results": false,
      "last_update_posted_date": "2014-05-21",
      "last_synced_at": "2026-09-17T22:23:56.904Z",
      "location_count": 1,
      "location_summary": "Memphis, Tennessee",
      "locations": [
        {
          "city": "Memphis",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00308763"
    }
  ]
}