{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=KarX-EC", "query": { "intervention": "KarX-EC" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 11, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=KarX-EC&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-02T10:32:18.401Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT07011732", "title": "A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease (ADAGIO-1)", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Alzheimer Disease" ], "interventions": [ { "name": "Xanomeline/Trospium Chloride Capsule", "type": "DRUG" }, { "name": "Xanomeline Enteric Capsule", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Bristol-Myers Squibb", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "55 Years", "maximum_age": "90 Years", "sex": "ALL", "summary": "55 Years to 90 Years" }, "enrollment_count": 426, "start_date": "2025-07-10", "completion_date": "2028-12-08", "has_results": false, "last_update_posted_date": "2026-08-11", "last_synced_at": "2026-09-02T10:32:18.401Z", "location_count": 39, "location_summary": "Scottsdale, Arizona • Anaheim, California • La Jolla, California + 31 more", "locations": [ { "city": "Scottsdale", "state": "Arizona" }, { "city": "Anaheim", "state": "California" }, { "city": "La Jolla", "state": "California" }, { "city": "Pomona", "state": "California" }, { "city": "Torrance", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT07011732" }, { "nct_id": "NCT07011745", "title": "A Phase 3 Study to Evaluate the Safety and Efficacy of KarXT + KarX-EC for the Treatment of Agitation Associated With Alzheimer's Disease", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Alzheimer's Disease" ], "interventions": [ { "name": "Xanomeline/Trospium Chloride Capsule", "type": "DRUG" }, { "name": "Xanomeline Enteric Capsule", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Bristol-Myers Squibb", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "55 Years", "maximum_age": "90 Years", "sex": "ALL", "summary": "55 Years to 90 Years" }, "enrollment_count": 426, "start_date": "2025-07-16", "completion_date": "2028-11-13", "has_results": false, "last_update_posted_date": "2026-08-26", "last_synced_at": "2026-09-02T10:32:18.401Z", "location_count": 42, "location_summary": "Chandler, Arizona • Garden Grove, California • Long Beach, California + 35 more", "locations": [ { "city": "Chandler", "state": "Arizona" }, { "city": "Chandler", "state": "Arizona" }, { "city": "Chandler", "state": "Arizona" }, { "city": "Garden Grove", "state": "California" }, { "city": "Long Beach", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT07011745" }, { "nct_id": "NCT06976216", "title": "A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Alzheimer's Disease" ], "interventions": [ { "name": "KarXT", "type": "DRUG" }, { "name": "KarX-EC", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Bristol-Myers Squibb", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "60 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "60 Years to 85 Years" }, "enrollment_count": 586, "start_date": "2025-07-14", "completion_date": "2029-02-23", "has_results": false, "last_update_posted_date": "2026-08-20", "last_synced_at": "2026-09-02T10:32:18.401Z", "location_count": 28, "location_summary": "Long Beach, California • Redlands, California • Basalt, Colorado + 24 more", "locations": [ { "city": "Long Beach", "state": "California" }, { "city": "Redlands", "state": "California" }, { "city": "Basalt", "state": "Colorado" }, { "city": "Washington D.C.", "state": "District of Columbia" }, { "city": "Atlantis", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT06976216" }, { "nct_id": "NCT06937229", "title": "A Study to Evaluate the Long-term Efficacy and Safety of KarXT + KarX-EC for Agitation in Alzheimer's Disease (ADAGIO-3)", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Alzheimer Disease", "Agitation" ], "interventions": [ { "name": "KarXT", "type": "DRUG" }, { "name": "KarX-EC", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Bristol-Myers Squibb", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "55 Years", "maximum_age": "90 Years", "sex": "ALL", "summary": "55 Years to 90 Years" }, "enrollment_count": 650, "start_date": "2025-12-02", "completion_date": "2029-07-20", "has_results": false, "last_update_posted_date": "2026-08-19", "last_synced_at": "2026-09-02T10:32:18.401Z", "location_count": 46, "location_summary": "Chandler, Arizona • Scottsdale, Arizona • Anaheim, California + 40 more", "locations": [ { "city": "Chandler", "state": "Arizona" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Anaheim", "state": "California" }, { "city": "La Jolla", "state": "California" }, { "city": "Long Beach", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06937229" }, { "nct_id": "NCT07424404", "title": "A Study to Evaluate the Long-term Safety and Tolerability of KarXT and KarX-EC for the Treatment of Schizophrenia and Autism-Related Irritability in Adolescents, Respectively", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Schizophrenia", "Autism-Related Irritability" ], "interventions": [ { "name": "KarXT", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Karuna Therapeutics, Inc., a Bristol Myers Squibb company", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "5 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "5 Years to 17 Years" }, "enrollment_count": 400, "start_date": "2026-04-07", "completion_date": "2030-03-08", "has_results": false, "last_update_posted_date": "2026-08-28", "last_synced_at": "2026-09-02T10:32:18.401Z", "location_count": 51, "location_summary": "Dothan, Alabama • Phoenix, Arizona • Anaheim, California + 43 more", "locations": [ { "city": "Dothan", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Anaheim", "state": "California" }, { "city": "Anaheim", "state": "California" }, { "city": "Chino", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT07424404" }, { "nct_id": "NCT07285798", "title": "A Study of KarXT + KarX-EC for Treatment of Irritability in Children and Adolescents With Autism Spectrum Disorder", "overall_status": "NOT_YET_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Irritability Associated With Autism Spectrum Disorder" ], "interventions": [ { "name": "KarXT", "type": "DRUG" }, { "name": "KarX-EC", "type": "DRUG" }, { "name": "KarXT + KarX-EC Matching Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Bristol-Myers Squibb", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "5 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "5 Years to 17 Years" }, "enrollment_count": 176, "start_date": "2026-09-11", "completion_date": "2029-08-06", "has_results": false, "last_update_posted_date": "2026-08-24", "last_synced_at": "2026-09-02T10:32:18.401Z", "location_count": 23, "location_summary": "Phoenix, Arizona • Glendale, California • Los Angeles, California + 19 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Glendale", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Orange", "state": "California" }, { "city": "San Diego", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT07285798" }, { "nct_id": "NCT06976203", "title": "A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Alzheimer's Disease" ], "interventions": [ { "name": "KarXT", "type": "DRUG" }, { "name": "KarX-EC", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Bristol-Myers Squibb", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "60 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "60 Years to 85 Years" }, "enrollment_count": 586, "start_date": "2025-07-21", "completion_date": "2029-02-23", "has_results": false, "last_update_posted_date": "2026-08-12", "last_synced_at": "2026-09-02T10:32:18.401Z", "location_count": 30, "location_summary": "Fullerton, California • Irvine, California • Los Angeles, California + 27 more", "locations": [ { "city": "Fullerton", "state": "California" }, { "city": "Irvine", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Palo Alto", "state": "California" }, { "city": "San Diego", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06976203" }, { "nct_id": "NCT06605950", "title": "A Study to Assess the Safety, Tolerability and Pharmacokinetics (PK) of Xanomeline With Trospium Chloride Versus KarXT in Healthy Adult and Elderly Participants of Japanese Ethnicity and to Assess the Effect of Omeprazole on the PK of Xanomeline With Trospium Chloride in Healthy Adult Participants", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy Volunteers" ], "interventions": [ { "name": "KarXT", "type": "DRUG" }, { "name": "KarX-EC", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Omeprazole", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Karuna Therapeutics, Inc., a Bristol Myers Squibb company", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "19 Years", "maximum_age": "90 Years", "sex": "ALL", "summary": "19 Years to 90 Years" }, "enrollment_count": 78, "start_date": "2024-10-01", "completion_date": "2025-05-31", "has_results": false, "last_update_posted_date": "2025-07-04", "last_synced_at": "2026-09-02T10:32:18.401Z", "location_count": 1, "location_summary": "Anaheim, California", "locations": [ { "city": "Anaheim", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT06605950" }, { "nct_id": "NCT06853171", "title": "Safety, Tolerability, and Pharmacokinetics of KarXT and Dual-burst Release of Xanomeline With Immediate-release Trospium Chloride in Adolescents With Psychiatric Disorders", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Psychiatric Disorders" ], "interventions": [ { "name": "KarXT", "type": "DRUG" }, { "name": "KarX-EC", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Bristol-Myers Squibb", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "13 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "13 Years to 17 Years" }, "enrollment_count": 24, "start_date": "2025-04-29", "completion_date": "2025-07-22", "has_results": false, "last_update_posted_date": "2025-08-06", "last_synced_at": "2026-09-02T10:32:18.401Z", "location_count": 4, "location_summary": "Little Rock, Arkansas • Orange, California • Decatur, Georgia + 1 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Orange", "state": "California" }, { "city": "Decatur", "state": "Georgia" }, { "city": "Overland Park", "state": "Kansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT06853171" }, { "nct_id": "NCT06947941", "title": "A Study to Evaluate Safety and Efficacy of KarXT + KarX-EC as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-5)", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Alzheimer Disease", "Psychosis" ], "interventions": [ { "name": "KarXT", "type": "DRUG" }, { "name": "KarX-EC", "type": "DRUG" }, { "name": "KarXT + KarX-EC Arm Matching Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Bristol-Myers Squibb", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "55 Years", "maximum_age": "90 Years", "sex": "ALL", "summary": "55 Years to 90 Years" }, "enrollment_count": 325, "start_date": "2026-03-25", "completion_date": "2028-03-20", "has_results": false, "last_update_posted_date": "2026-06-30", "last_synced_at": "2026-09-02T10:32:18.401Z", "location_count": 6, "location_summary": "Gilbert, Arizona • Chino, California • Naples, Florida + 2 more", "locations": [ { "city": "Gilbert", "state": "Arizona" }, { "city": "Chino", "state": "California" }, { "city": "Naples", "state": "Florida" }, { "city": "Naples", "state": "Florida" }, { "city": "Cleveland", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT06947941" } ] }