{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=KarXT+%28xanomeline+and+trospium%29", "query": { "intervention": "KarXT (xanomeline and trospium)" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 34, "total_pages": 4, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=KarXT+%28xanomeline+and+trospium%29&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-10-04T20:50:31.377Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT05304767", "title": "An Extension Study to Assess Long-Term Safety and Tolerability of Adjunctive KarXT in Subjects With Inadequately Controlled Symptoms of Schizophrenia", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Schizophrenia" ], "interventions": [ { "name": "Xanomeline and Trospium Chloride Capsules", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Karuna Therapeutics, Inc., a Bristol Myers Squibb company", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 290, "start_date": "2022-03-07", "completion_date": "2026-03-25", "has_results": false, "last_update_posted_date": "2026-07-31", "last_synced_at": "2026-10-04T20:50:31.377Z", "location_count": 56, "location_summary": "Phoenix, Arizona • Little Rock, Arkansas • Anaheim, California + 44 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Anaheim", "state": "California" }, { "city": "Bellflower", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05304767" }, { "nct_id": "NCT07284745", "title": "A Study of KarXT + KarX-EC for Treatment of Irritability in Children and Adolescents With Autism", "overall_status": "NOT_YET_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Irritability Associated With Autism Spectrum Disorder" ], "interventions": [ { "name": "KarXT", "type": "DRUG" }, { "name": "KarX-EC", "type": "DRUG" }, { "name": "KarXT + KarX-EC Matching Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Bristol-Myers Squibb", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "5 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "5 Years to 17 Years" }, "enrollment_count": 176, "start_date": "2026-09-11", "completion_date": "2029-08-06", "has_results": false, "last_update_posted_date": "2026-08-24", "last_synced_at": "2026-10-04T20:50:31.377Z", "location_count": 29, "location_summary": "Dothan, Alabama • Phoenix, Arizona • Anaheim, California + 25 more", "locations": [ { "city": "Dothan", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Anaheim", "state": "California" }, { "city": "Glendale", "state": "California" }, { "city": "Redlands", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT07284745" }, { "nct_id": "NCT05145413", "title": "A Study to Assess Efficacy and Safety of Adjunctive KarXT in Subjects With Inadequately Controlled Symptoms of Schizophrenia", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Schizophrenia" ], "interventions": [ { "name": "Xanomeline and Trospium Chloride Capsules", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Karuna Therapeutics, Inc., a Bristol Myers Squibb company", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 396, "start_date": "2021-11-12", "completion_date": "2025-03-19", "has_results": true, "last_update_posted_date": "2026-05-05", "last_synced_at": "2026-10-04T20:50:31.377Z", "location_count": 79, "location_summary": "Phoenix, Arizona • Little Rock, Arkansas • Anaheim, California + 61 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Anaheim", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05145413" }, { "nct_id": "NCT04659174", "title": "An Extension Study to Assess Long-term Safety, Tolerability, and Efficacy of KarXT in Adult Patients With Schizophrenia (EMERGENT-4)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Schizophrenia" ], "interventions": [ { "name": "Xanomeline and Trospium Chloride Capsules", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Karuna Therapeutics, Inc., a Bristol Myers Squibb company", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 152, "start_date": "2021-02-01", "completion_date": "2023-10-03", "has_results": true, "last_update_posted_date": "2024-10-28", "last_synced_at": "2026-10-04T20:50:31.377Z", "location_count": 34, "location_summary": "Bentonville, Arkansas • Little Rock, Arkansas • Anaheim, California + 27 more", "locations": [ { "city": "Bentonville", "state": "Arkansas" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Anaheim", "state": "California" }, { "city": "Bellflower", "state": "California" }, { "city": "Bellflower", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04659174" }, { "nct_id": "NCT03697252", "title": "A Study to Assess Safety and Efficacy of KarXT in Adult Patients With Schizophrenia", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Schizophrenia" ], "interventions": [ { "name": "Xanomeline and Trospium Chloride Capsules", "type": "DRUG" }, { "name": "Placebo Capsules", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Karuna Therapeutics, Inc., a Bristol Myers Squibb company", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "60 Years", "sex": "ALL", "summary": "18 Years to 60 Years" }, "enrollment_count": 182, "start_date": "2018-09-18", "completion_date": "2019-09-04", "has_results": true, "last_update_posted_date": "2020-10-26", "last_synced_at": "2026-10-04T20:50:31.377Z", "location_count": 12, "location_summary": "Little Rock, Arkansas • Lemon Grove, California • Long Beach, California + 9 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Lemon Grove", "state": "California" }, { "city": "Long Beach", "state": "California" }, { "city": "Orange", "state": "California" }, { "city": "San Diego", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03697252" }, { "nct_id": "NCT05511363", "title": "A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Disease (ADEPT-1)", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Psychosis Associated With Alzheimer's Disease" ], "interventions": [ { "name": "KarXT", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Karuna Therapeutics, Inc., a Bristol Myers Squibb company", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "55 Years", "maximum_age": "90 Years", "sex": "ALL", "summary": "55 Years to 90 Years" }, "enrollment_count": 410, "start_date": "2022-08-23", "completion_date": "2026-10-05", "has_results": false, "last_update_posted_date": "2026-08-17", "last_synced_at": "2026-10-04T20:50:31.377Z", "location_count": 59, "location_summary": "Homewood, Alabama • Phoenix, Arizona • Encino, California + 38 more", "locations": [ { "city": "Homewood", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Encino", "state": "California" }, { "city": "Irvine", "state": "California" }, { "city": "Orange", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05511363" }, { "nct_id": "NCT07221877", "title": "A Study to Evaluate the Effect of KarXT on Urological Safety", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Schizophrenia" ], "interventions": [ { "name": "Xanomeline/trospium chloride", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Bristol-Myers Squibb", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 60, "start_date": "2026-01-20", "completion_date": "2027-12-30", "has_results": false, "last_update_posted_date": "2026-06-03", "last_synced_at": "2026-10-04T20:50:31.377Z", "location_count": 13, "location_summary": "Little Rock, Arkansas • Bellflower, California • Garden Grove, California + 9 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Bellflower", "state": "California" }, { "city": "Garden Grove", "state": "California" }, { "city": "Orange", "state": "California" }, { "city": "Lauderhill", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT07221877" }, { "nct_id": "NCT07118215", "title": "A Study to Evaluate the Effects of KarXT on the Drug Levels of Midazolam, Fexofenadine, and Digoxin", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy Volunteers" ], "interventions": [ { "name": "KarXT", "type": "DRUG" }, { "name": "Midazolam", "type": "DRUG" }, { "name": "Fexofenadine", "type": "DRUG" }, { "name": "Digoxin", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Karuna Therapeutics, Inc., a Bristol Myers Squibb company", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 62, "start_date": "2025-09-29", "completion_date": "2026-06-25", "has_results": false, "last_update_posted_date": "2026-07-22", "last_synced_at": "2026-10-04T20:50:31.377Z", "location_count": 1, "location_summary": "Lenexa, Kansas", "locations": [ { "city": "Lenexa", "state": "Kansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT07118215" }, { "nct_id": "NCT05980949", "title": "Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Psychosis Associated With Alzheimer's Disease" ], "interventions": [ { "name": "KarXT", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Karuna Therapeutics, Inc., a Bristol Myers Squibb company", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "55 Years", "maximum_age": "90 Years", "sex": "ALL", "summary": "55 Years to 90 Years" }, "enrollment_count": 1000, "start_date": "2023-07-11", "completion_date": "2027-09-07", "has_results": false, "last_update_posted_date": "2026-09-29", "last_synced_at": "2026-10-04T20:50:31.377Z", "location_count": 147, "location_summary": "Homewood, Alabama • Chandler, Arizona • Gilbert, Arizona + 92 more", "locations": [ { "city": "Homewood", "state": "Alabama" }, { "city": "Chandler", "state": "Arizona" }, { "city": "Chandler", "state": "Arizona" }, { "city": "Chandler", "state": "Arizona" }, { "city": "Gilbert", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT05980949" }, { "nct_id": "NCT04659161", "title": "A Study to Assess Efficacy and Safety of KarXT in Acutely Psychotic Hospitalized Adult Patients With Schizophrenia (EMERGENT-2)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Schizophrenia", "Schizophrenia; Psychosis" ], "interventions": [ { "name": "Xanomeline and Trospium Chloride Capsules", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Karuna Therapeutics, Inc., a Bristol Myers Squibb company", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 252, "start_date": "2020-12-16", "completion_date": "2022-05-24", "has_results": true, "last_update_posted_date": "2023-12-12", "last_synced_at": "2026-10-04T20:50:31.377Z", "location_count": 22, "location_summary": "Little Rock, Arkansas • Bellflower, California • Culver City, California + 19 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Bellflower", "state": "California" }, { "city": "Culver City", "state": "California" }, { "city": "Glendale", "state": "California" }, { "city": "Lemon Grove", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04659161" } ] }