{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Ketamine+%2B+methadone", "query": { "intervention": "Ketamine + methadone" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 11, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Ketamine+%2B+methadone&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-25T01:54:22.005Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT02252432", "title": "The Effects of Ketamine and Methadone on Postoperative Pain for Laminectomy", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Laminectomy" ], "interventions": [ { "name": "Ketamine", "type": "DRUG" }, { "name": "Methadone", "type": "DRUG" }, { "name": "Ketamine + methadone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Cedars-Sinai Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 13, "start_date": "2013-02", "completion_date": "2023-01", "has_results": true, "last_update_posted_date": "2024-02-29", "last_synced_at": "2026-09-25T01:54:22.005Z", "location_count": 1, "location_summary": "Los Angeles, California", "locations": [ { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02252432" }, { "nct_id": "NCT02958566", "title": "Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Colon Cancer", "Colon Diverticulosis", "Colonic Neoplasms", "Colonic Diverticulitis", "Pain, Postoperative", "Ileus", "Ileus Paralytic", "Ileus; Mechanical", "Constipation Drug Induced", "Constipation", "Rectum Cancer", "Rectum Neoplasm" ], "interventions": [ { "name": "Acetaminophen", "type": "DRUG" }, { "name": "Gabapentin", "type": "DRUG" }, { "name": "Orphenadrine", "type": "DRUG" }, { "name": "Lidocaine", "type": "DRUG" }, { "name": "Marcaine", "type": "DRUG" }, { "name": "Ketamine", "type": "DRUG" }, { "name": "Methadone", "type": "DRUG" }, { "name": "Tramadol", "type": "DRUG" }, { "name": "Ketorolac", "type": "DRUG" }, { "name": "Morphine Sulfate", "type": "DRUG" }, { "name": "Fentanyl", "type": "DRUG" }, { "name": "Dilaudid", "type": "DRUG" }, { "name": "Hydrocodone-Acetaminophen Tab 5-325 MG", "type": "DRUG" }, { "name": "HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Illinois College of Medicine at Peoria", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 80, "start_date": "2017-01", "completion_date": "2018-12", "has_results": false, "last_update_posted_date": "2017-03-20", "last_synced_at": "2026-09-25T01:54:22.005Z", "location_count": 1, "location_summary": "Peoria, Illinois", "locations": [ { "city": "Peoria", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT02958566" }, { "nct_id": "NCT02989597", "title": "Intraoperative Methadone Administration for Improved Pain Control in Spinal Fusion Patients", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Pain, Postoperative" ], "interventions": [ { "name": "Methadone Hydrochloride", "type": "DRUG" }, { "name": "Standard pain regimen", "type": "OTHER" }, { "name": "Spinal Fusion Surgery", "type": "PROCEDURE" }, { "name": "Dexamethasone", "type": "DRUG" }, { "name": "Ketamine", "type": "DRUG" }, { "name": "Remifentanil", "type": "DRUG" }, { "name": "Sufentanil", "type": "DRUG" } ], "intervention_types": [ "DRUG", "OTHER", "PROCEDURE" ], "sponsor": "Montefiore Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 10, "start_date": "2017-07-29", "completion_date": "2020-11-10", "has_results": true, "last_update_posted_date": "2023-05-22", "last_synced_at": "2026-09-25T01:54:22.005Z", "location_count": 1, "location_summary": "The Bronx, New York", "locations": [ { "city": "The Bronx", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT02989597" }, { "nct_id": "NCT02827526", "title": "Methadone and Ketamine for Spinal Surgery", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Pain" ], "interventions": [ { "name": "Ketamine", "type": "DRUG" }, { "name": "Control", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Endeavor Health", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 130, "start_date": "2016-07", "completion_date": "2021-02", "has_results": false, "last_update_posted_date": "2021-12-21", "last_synced_at": "2026-09-25T01:54:22.005Z", "location_count": 1, "location_summary": "Evanston, Illinois", "locations": [ { "city": "Evanston", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT02827526" }, { "nct_id": "NCT06943859", "title": "Ketamine for Opioid Use Disorder", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Opioid Use Disorder" ], "interventions": [ { "name": "Treatment with Ketamine", "type": "DRUG" }, { "name": "Treatment with Very Low Dose Ketamine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Maryland, Baltimore", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 50, "start_date": "2026-02-04", "completion_date": "2029-08-31", "has_results": false, "last_update_posted_date": "2026-08-31", "last_synced_at": "2026-09-25T01:54:22.005Z", "location_count": 1, "location_summary": "Baltimore, Maryland", "locations": [ { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT06943859" }, { "nct_id": "NCT00892606", "title": "Methadone Versus Morphine for Orthopedic Surgery Patients", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Fracture", "Pain, Postoperative" ], "interventions": [ { "name": "Methadone", "type": "DRUG" }, { "name": "Morphine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Louisville", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 75, "start_date": "2009-01", "completion_date": "2013-12", "has_results": true, "last_update_posted_date": "2017-06-14", "last_synced_at": "2026-09-25T01:54:22.005Z", "location_count": 1, "location_summary": "Louisville, Kentucky", "locations": [ { "city": "Louisville", "state": "Kentucky" } ], "official_url": "https://clinicaltrials.gov/study/NCT00892606" }, { "nct_id": "NCT06868589", "title": "Reducing Pain With Methadone and Ketamine in Liver Transplant", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Liver Transplantation" ], "interventions": [ { "name": "Methadone", "type": "DRUG" }, { "name": "ketamine", "type": "DRUG" }, { "name": "Hydromorphone", "type": "DRUG" }, { "name": "fentanyl", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Lahey Clinic", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 50, "start_date": "2025-06-30", "completion_date": "2026-06-01", "has_results": false, "last_update_posted_date": "2026-08-11", "last_synced_at": "2026-09-25T01:54:22.005Z", "location_count": 2, "location_summary": "Burlington, Massachusetts", "locations": [ { "city": "Burlington", "state": "Massachusetts" }, { "city": "Burlington", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT06868589" }, { "nct_id": "NCT02625181", "title": "Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Postoperative Nausea and Vomiting" ], "interventions": [ { "name": "Automated recommendation at the start of the case", "type": "PROCEDURE" }, { "name": "Automated notification at the start of surgery", "type": "PROCEDURE" }, { "name": "Preoperative recommendations: by email", "type": "PROCEDURE" }, { "name": "Automated notification at the end of surgery", "type": "PROCEDURE" }, { "name": "Anesthesia Information Management System (AIMS)", "type": "DEVICE" }, { "name": "Perioperative Data Warehouse (PDW)", "type": "DEVICE" }, { "name": "General anesthesia", "type": "PROCEDURE" }, { "name": "Elective surgery", "type": "PROCEDURE" }, { "name": "Propofol", "type": "DRUG" }, { "name": "Sevoflurane", "type": "DRUG" }, { "name": "Isoflurane", "type": "DRUG" }, { "name": "Desflurane", "type": "DRUG" }, { "name": "Scopolamine", "type": "DRUG" }, { "name": "Droperidol", "type": "DRUG" }, { "name": "Haloperidol", "type": "DRUG" }, { "name": "Dexamethasone", "type": "DRUG" }, { "name": "Promethazine", "type": "DRUG" }, { "name": "Meclizine", "type": "DRUG" }, { "name": "Aprepitant", "type": "DRUG" }, { "name": "Metoclopramide", "type": "DRUG" }, { "name": "Fentanyl", "type": "DRUG" }, { "name": "Sufentanil", "type": "DRUG" }, { "name": "Alfentanil", "type": "DRUG" }, { "name": "Remifentanil", "type": "DRUG" }, { "name": "Morphine", "type": "DRUG" }, { "name": "Meperidine", "type": "DRUG" }, { "name": "Hydromorphone", "type": "DRUG" }, { "name": "Methadone", "type": "DRUG" }, { "name": "Oxycodone", "type": "DRUG" }, { "name": "Oxymorphone", "type": "DRUG" }, { "name": "Hydrocodone", "type": "DRUG" }, { "name": "Ketamine", "type": "DRUG" }, { "name": "Ondansetron", "type": "DRUG" }, { "name": "Granisetron", "type": "DRUG" }, { "name": "Dolasetron mesylate", "type": "DRUG" }, { "name": "Palonosetron", "type": "DRUG" }, { "name": "Tropisetron", "type": "DRUG" }, { "name": "Ramosetron", "type": "DRUG" } ], "intervention_types": [ "PROCEDURE", "DEVICE", "DRUG" ], "sponsor": "Vanderbilt University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 27034, "start_date": "2016-07", "completion_date": "2017-11-30", "has_results": true, "last_update_posted_date": "2019-03-07", "last_synced_at": "2026-09-25T01:54:22.005Z", "location_count": 1, "location_summary": "Nashville, Tennessee", "locations": [ { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT02625181" }, { "nct_id": "NCT07365800", "title": "The MDK Study: Using a Combination of Methadone-dexmedetomidine-ketamine for Postoperative Pain Control in Patients Undergoing Complex Spine Surgeries.", "overall_status": "ENROLLING_BY_INVITATION", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Spine Surgery" ], "interventions": [ { "name": "Methadone-dexmedetomidine-ketamine combination", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Missouri-Columbia", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "79 Years", "sex": "ALL", "summary": "18 Years to 79 Years" }, "enrollment_count": 248, "start_date": "2026-04-24", "completion_date": "2027-06", "has_results": false, "last_update_posted_date": "2026-06-11", "last_synced_at": "2026-09-25T01:54:22.005Z", "location_count": 1, "location_summary": "Columbia, Missouri", "locations": [ { "city": "Columbia", "state": "Missouri" } ], "official_url": "https://clinicaltrials.gov/study/NCT07365800" }, { "nct_id": "NCT02033707", "title": "Effects of Hallucinogens and Other Drugs on Mood and Performance", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy" ], "interventions": [ { "name": "Hallucinogens and psychoactive substances", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Johns Hopkins University", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "21 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "21 Years to 50 Years" }, "enrollment_count": 20, "start_date": "2014-04", "completion_date": "2019-02", "has_results": false, "last_update_posted_date": "2019-05-16", "last_synced_at": "2026-09-25T01:54:22.005Z", "location_count": 1, "location_summary": "Baltimore, Maryland", "locations": [ { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT02033707" } ] }