{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Ketone+Ester+Supplement",
    "query": {
      "intervention": "Ketone Ester Supplement"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 22,
    "total_pages": 3,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Ketone+Ester+Supplement&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-26T08:29:14.185Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT07289165",
      "title": "Comparison of Pharmacokinetic Responses to Three Ketone Esters",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Healthy Volunteer"
      ],
      "interventions": [
        {
          "name": "Dietary Supplement containing Tri-betahydroxybutyrin",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Dietary Supplement containing a ketone mono Ester",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Dietary supplement containing a ketone salt",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "NeuroEnergy Ventures, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "30 Years to 70 Years"
      },
      "enrollment_count": 18,
      "start_date": "2025-07-15",
      "completion_date": "2026-02",
      "has_results": false,
      "last_update_posted_date": "2025-12-17",
      "last_synced_at": "2026-09-26T08:29:14.185Z",
      "location_count": 1,
      "location_summary": "Canfield, Ohio",
      "locations": [
        {
          "city": "Canfield",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07289165"
    },
    {
      "nct_id": "NCT06335875",
      "title": "Brain Small Chain Fatty Acid Metabolism in Bipolar Disorder: Ketones",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Bipolar Disorder"
      ],
      "interventions": [
        {
          "name": "Ketone Ester Beverage",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Low Glycemic Index Diet",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT",
        "BEHAVIORAL"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 15,
      "start_date": "2024-06-07",
      "completion_date": "2025-09-03",
      "has_results": false,
      "last_update_posted_date": "2025-12-12",
      "last_synced_at": "2026-09-26T08:29:14.185Z",
      "location_count": 2,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        },
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06335875"
    },
    {
      "nct_id": "NCT03204604",
      "title": "The Brain Ketone Body Challenge Imaging Study",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Alzheimer Disease"
      ],
      "interventions": [
        {
          "name": "Challenge A - low calorie Ensure®",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Challenge B - Ensure® plus ketone esters (KE)",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "PET Scan",
          "type": "PROCEDURE"
        },
        {
          "name": "Cognitive Testing - FCSRT",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Story Recall",
          "type": "BEHAVIORAL"
        },
        {
          "name": "BVRT",
          "type": "BEHAVIORAL"
        },
        {
          "name": "CogState One Card Learning",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT",
        "PROCEDURE",
        "BEHAVIORAL"
      ],
      "sponsor": "Wake Forest University Health Sciences",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "50 Years to 85 Years"
      },
      "enrollment_count": 0,
      "start_date": "2016-08-08",
      "completion_date": "2019-03",
      "has_results": false,
      "last_update_posted_date": "2019-03-19",
      "last_synced_at": "2026-09-26T08:29:14.185Z",
      "location_count": 1,
      "location_summary": "Winston-Salem, North Carolina",
      "locations": [
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03204604"
    },
    {
      "nct_id": "NCT05545501",
      "title": "Ketone Ester and Salt (KEAS) in Young Adults",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Salt; Excess",
        "Hypertension"
      ],
      "interventions": [
        {
          "name": "No Salt, No β-OHB",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "High Salt, No β-OHB",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "High Salt, High β-OHB",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Indiana University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "19 Years",
        "maximum_age": "39 Years",
        "sex": "ALL",
        "summary": "19 Years to 39 Years"
      },
      "enrollment_count": 35,
      "start_date": "2023-03-24",
      "completion_date": "2027-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-08-19",
      "last_synced_at": "2026-09-26T08:29:14.185Z",
      "location_count": 1,
      "location_summary": "Bloomington, Indiana",
      "locations": [
        {
          "city": "Bloomington",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05545501"
    },
    {
      "nct_id": "NCT06078683",
      "title": "Effects of Ketone Ester Consumption on Exercise Tolerance and Cardiac Function",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Type 2 Diabetes",
        "Ketone Body Metabolism",
        "Ketones, Metabolism"
      ],
      "interventions": [
        {
          "name": "Ketone Ester Acute",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo Acute",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Ohio State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 30,
      "start_date": "2023-06-06",
      "completion_date": "2027-08-31",
      "has_results": false,
      "last_update_posted_date": "2026-04-03",
      "last_synced_at": "2026-09-26T08:29:14.185Z",
      "location_count": 1,
      "location_summary": "Columbus, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06078683"
    },
    {
      "nct_id": "NCT05519644",
      "title": "Strategies to Augment Ketosis: Ketone Conferred Resiliency Against Sleep Restriction",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Sleep Deprivation"
      ],
      "interventions": [
        {
          "name": "Sleep Deprivation",
          "type": "OTHER"
        },
        {
          "name": "Heart Rate",
          "type": "OTHER"
        },
        {
          "name": "Sleep Monitoring",
          "type": "OTHER"
        },
        {
          "name": "Diet",
          "type": "OTHER"
        },
        {
          "name": "Exercise Performance",
          "type": "OTHER"
        },
        {
          "name": "Surveys, McGill Pain Questionnaire, Shortened Profile of Mood States, Pittsburg Sleep Index",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Cognitive performance",
          "type": "OTHER"
        },
        {
          "name": "Marksmanship Performance",
          "type": "OTHER"
        },
        {
          "name": "Quick Board",
          "type": "OTHER"
        },
        {
          "name": "Advanced Medical Technologies Inc, Jump Test",
          "type": "OTHER"
        },
        {
          "name": "CGM/CKM",
          "type": "OTHER"
        },
        {
          "name": "Blood Draw",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Ketone Supplement",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "OTHER",
        "BEHAVIORAL",
        "BIOLOGICAL",
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Ohio State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "18 Years to 40 Years"
      },
      "enrollment_count": 60,
      "start_date": "2023-06-20",
      "completion_date": "2026-09",
      "has_results": false,
      "last_update_posted_date": "2026-06-01",
      "last_synced_at": "2026-09-26T08:29:14.185Z",
      "location_count": 1,
      "location_summary": "Columbus, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05519644"
    },
    {
      "nct_id": "NCT05501366",
      "title": "Strategies to Augment Ketosis: Optimization of Ketone Delivery Strategies",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Ketosis"
      ],
      "interventions": [
        {
          "name": "Ketone Supplement",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Beverage Tolerability Questionnaire (BTQ) and satiety visual analogue scale",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Blood Draw",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Breath Reading",
          "type": "OTHER"
        },
        {
          "name": "Heart Rate Variability",
          "type": "OTHER"
        },
        {
          "name": "CGM/CKM",
          "type": "OTHER"
        },
        {
          "name": "DXA",
          "type": "RADIATION"
        },
        {
          "name": "Urine Analysis",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT",
        "BEHAVIORAL",
        "BIOLOGICAL",
        "OTHER",
        "RADIATION"
      ],
      "sponsor": "Ohio State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "30 Years",
        "sex": "MALE",
        "summary": "20 Years to 30 Years · Male only"
      },
      "enrollment_count": 14,
      "start_date": "2023-06-05",
      "completion_date": "2027-09",
      "has_results": false,
      "last_update_posted_date": "2026-05-29",
      "last_synced_at": "2026-09-26T08:29:14.185Z",
      "location_count": 1,
      "location_summary": "Columbus, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05501366"
    },
    {
      "nct_id": "NCT06645847",
      "title": "Targeting Aging With a Ketone Ester for Function in Frailty",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Frail Elderly",
        "Aging",
        "Immune Function",
        "Muscle Function"
      ],
      "interventions": [
        {
          "name": "Ketone ester",
          "type": "OTHER"
        },
        {
          "name": "Placebo Comparator: Non-ketone placebo",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Buck Institute for Research on Aging",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "65 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "65 Years and older"
      },
      "enrollment_count": 180,
      "start_date": "2025-04-17",
      "completion_date": "2028-04-01",
      "has_results": false,
      "last_update_posted_date": "2026-09-09",
      "last_synced_at": "2026-09-26T08:29:14.185Z",
      "location_count": 3,
      "location_summary": "Novato, California • Farmington, Connecticut • Columbus, Ohio",
      "locations": [
        {
          "city": "Novato",
          "state": "California"
        },
        {
          "city": "Farmington",
          "state": "Connecticut"
        },
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06645847"
    },
    {
      "nct_id": "NCT05551754",
      "title": "Acute Effects of Ketone Supplement on Responses to Alcohol Challenge in Healthy Volunteers",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Alcohol Drinking"
      ],
      "interventions": [
        {
          "name": "Ketone Supplement",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Alcohol Beverage",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT",
        "OTHER"
      ],
      "sponsor": "University of Pennsylvania",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "21 Years to 50 Years"
      },
      "enrollment_count": 10,
      "start_date": "2022-10-20",
      "completion_date": "2027-07",
      "has_results": false,
      "last_update_posted_date": "2026-08-06",
      "last_synced_at": "2026-09-26T08:29:14.185Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05551754"
    },
    {
      "nct_id": "NCT07711990",
      "title": "Effects of Acute Ketone Supplementation on the Brain",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Brain Health"
      ],
      "interventions": [
        {
          "name": "Ketone Ester Drink",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Christopher Crabtree",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "45 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "45 Years to 65 Years"
      },
      "enrollment_count": 24,
      "start_date": "2026-06-15",
      "completion_date": "2029-12",
      "has_results": false,
      "last_update_posted_date": "2026-07-17",
      "last_synced_at": "2026-09-26T08:29:14.185Z",
      "location_count": 1,
      "location_summary": "Columbus, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07711990"
    }
  ]
}