{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Ketone+Monoester",
    "query": {
      "intervention": "Ketone Monoester"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 12,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Ketone+Monoester&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-14T21:25:55.185Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06108076",
      "title": "Acute and Chronic Effects of Oral Ketones in Subjects With HFrEF and Diabetes",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Type 2 Diabetes",
        "Heart Failure, Reduced Ejection Fraction"
      ],
      "interventions": [
        {
          "name": "Ketone Monoester (KE)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "The University of Texas Health Science Center at San Antonio",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 10,
      "start_date": "2024-01-16",
      "completion_date": "2026-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-01-21",
      "last_synced_at": "2026-09-14T21:25:55.185Z",
      "location_count": 1,
      "location_summary": "San Antonio, Texas",
      "locations": [
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06108076"
    },
    {
      "nct_id": "NCT07166965",
      "title": "Ketone and Hawthorn Extract Supplementation in Congestive Heart Failure",
      "overall_status": "ENROLLING_BY_INVITATION",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Congestive Heart Failure(CHF)"
      ],
      "interventions": [
        {
          "name": "Hawthorn supplement",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Ketones",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo Control",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT",
        "OTHER"
      ],
      "sponsor": "Thomas Jefferson University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 45,
      "start_date": "2025-11-15",
      "completion_date": "2029-09",
      "has_results": false,
      "last_update_posted_date": "2025-11-18",
      "last_synced_at": "2026-09-14T21:25:55.185Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07166965"
    },
    {
      "nct_id": "NCT06610344",
      "title": "BHB & CAR-T for Lymphomas",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Large B-cell Lymphoma"
      ],
      "interventions": [
        {
          "name": "R-1,3-Butanediol",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Abramson Cancer Center at Penn Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 5,
      "start_date": "2025-01-07",
      "completion_date": "2027-09-15",
      "has_results": false,
      "last_update_posted_date": "2026-02-23",
      "last_synced_at": "2026-09-14T21:25:55.185Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06610344"
    },
    {
      "nct_id": "NCT05390385",
      "title": "Acceptability and Tolerability of Ketone Supplements and Effects of BHB Concentrations in Young Adults",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Exogenous Ketosis"
      ],
      "interventions": [
        {
          "name": "KE1 5g",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "KE1 10g",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "KE4 5g",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "KE 10g",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo drink",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT",
        "OTHER"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "25 Years",
        "sex": "ALL",
        "summary": "18 Years to 25 Years"
      },
      "enrollment_count": 14,
      "start_date": "2022-09-23",
      "completion_date": "2023-08-15",
      "has_results": false,
      "last_update_posted_date": "2023-08-16",
      "last_synced_at": "2026-09-14T21:25:55.185Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05390385"
    },
    {
      "nct_id": "NCT05798260",
      "title": "T-Cell Mitochondrial Respiration Response to Ketone Monoester Supplement in Healthy Volunteers and COVID-19",
      "overall_status": "WITHDRAWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "COVID-19 Acute Respiratory Distress Syndrome"
      ],
      "interventions": [
        {
          "name": "Agilent Seahorse XF Cell Mito Stress Test",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 0,
      "start_date": "2024-06-30",
      "completion_date": "2024-10-31",
      "has_results": false,
      "last_update_posted_date": "2024-06-03",
      "last_synced_at": "2026-09-14T21:25:55.185Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05798260"
    },
    {
      "nct_id": "NCT07546409",
      "title": "Effects of Exogenous Ketones on Cognitive Function in Older Adults With Prediabetes?",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Prediabetes",
        "Healthy (Controls)"
      ],
      "interventions": [
        {
          "name": "Ketone Monoester (KE)",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "60 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "60 Years to 75 Years"
      },
      "enrollment_count": 20,
      "start_date": "2025-05-20",
      "completion_date": "2027-05-31",
      "has_results": false,
      "last_update_posted_date": "2026-07-02",
      "last_synced_at": "2026-09-14T21:25:55.185Z",
      "location_count": 2,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07546409"
    },
    {
      "nct_id": "NCT05501366",
      "title": "Strategies to Augment Ketosis: Optimization of Ketone Delivery Strategies",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Ketosis"
      ],
      "interventions": [
        {
          "name": "Ketone Supplement",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Beverage Tolerability Questionnaire (BTQ) and satiety visual analogue scale",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Blood Draw",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Breath Reading",
          "type": "OTHER"
        },
        {
          "name": "Heart Rate Variability",
          "type": "OTHER"
        },
        {
          "name": "CGM/CKM",
          "type": "OTHER"
        },
        {
          "name": "DXA",
          "type": "RADIATION"
        },
        {
          "name": "Urine Analysis",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT",
        "BEHAVIORAL",
        "BIOLOGICAL",
        "OTHER",
        "RADIATION"
      ],
      "sponsor": "Ohio State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "20 Years",
        "maximum_age": "30 Years",
        "sex": "MALE",
        "summary": "20 Years to 30 Years · Male only"
      },
      "enrollment_count": 14,
      "start_date": "2023-06-05",
      "completion_date": "2027-09",
      "has_results": false,
      "last_update_posted_date": "2026-05-29",
      "last_synced_at": "2026-09-14T21:25:55.185Z",
      "location_count": 1,
      "location_summary": "Columbus, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05501366"
    },
    {
      "nct_id": "NCT07051655",
      "title": "The Effects of Exogenous Ketones on Cognitive Function",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Placebo - Control",
        "Ketone Monoester"
      ],
      "interventions": [
        {
          "name": "Ketone Monoester (KE)",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "19 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "19 Years to 55 Years"
      },
      "enrollment_count": 45,
      "start_date": "2025-12-01",
      "completion_date": "2027-07-31",
      "has_results": false,
      "last_update_posted_date": "2026-07-13",
      "last_synced_at": "2026-09-14T21:25:55.185Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07051655"
    },
    {
      "nct_id": "NCT07063732",
      "title": "Ketone Monoester Supplements, High Altitude, and Brain Blood Flow During Exercise",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "High Altitude Hypoxia",
        "Exercise"
      ],
      "interventions": [
        {
          "name": "Ketone Monoester (KME)",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "McMaster University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "35 Years",
        "sex": "ALL",
        "summary": "18 Years to 35 Years"
      },
      "enrollment_count": 14,
      "start_date": "2025-05-28",
      "completion_date": "2025-08-31",
      "has_results": false,
      "last_update_posted_date": "2025-07-14",
      "last_synced_at": "2026-09-14T21:25:55.185Z",
      "location_count": 1,
      "location_summary": "Bishop, California",
      "locations": [
        {
          "city": "Bishop",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07063732"
    },
    {
      "nct_id": "NCT05338307",
      "title": "Preliminary Investigation of β-hydroxybutyrate Supplementation in Colorectal Cancer Prevention",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Colorectal Cancer"
      ],
      "interventions": [
        {
          "name": "R-1,3-Butanediol",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Abramson Cancer Center at Penn Medicine",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2022-05-13",
      "completion_date": "2027-06-30",
      "has_results": false,
      "last_update_posted_date": "2026-08-12",
      "last_synced_at": "2026-09-14T21:25:55.185Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05338307"
    }
  ]
}