{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=L-methylfolate",
    "query": {
      "intervention": "L-methylfolate"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 27,
    "total_pages": 3,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=L-methylfolate&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-03T18:34:36.013Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02223299",
      "title": "Pilot Study: Combining Nutritional Supplements With Standard Antidepressant to Treat Depression.",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Depression"
      ],
      "interventions": [
        {
          "name": "L-tyrosine",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "L-Tryptophan",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "deplin",
          "type": "DRUG"
        },
        {
          "name": "Placebo A",
          "type": "OTHER"
        },
        {
          "name": "Placebo B",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT",
        "DRUG",
        "OTHER"
      ],
      "sponsor": "John D. Dingell VA Medical Center",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 0,
      "start_date": "2015-11",
      "completion_date": "2015-11",
      "has_results": false,
      "last_update_posted_date": "2020-02-21",
      "last_synced_at": "2026-09-03T18:34:36.013Z",
      "location_count": 1,
      "location_summary": "Detroit, Michigan",
      "locations": [
        {
          "city": "Detroit",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02223299"
    },
    {
      "nct_id": "NCT01381354",
      "title": "Nutrition, Neuromuscular Electrical Stimulation (NMES) and Secondary Progressive Multiple Sclerosis (SPMS)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Multiple Sclerosis"
      ],
      "interventions": [
        {
          "name": "Progressive exercise",
          "type": "OTHER"
        },
        {
          "name": "Neuromuscular electrical stimulation delivered using the electrical therapy device EMPI 300 PV",
          "type": "DEVICE"
        },
        {
          "name": "Modified paleolithic diet",
          "type": "OTHER"
        },
        {
          "name": "Omega 3 fatty acids",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Full Spectrum vitamin",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Essential - hydroxytyrosol",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Maltodextrin fiber supplement",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Mineral boost (magnesium)",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Niacinamide",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Methyl B12",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Taurine",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "creatine",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "thiamine",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "riboflavin",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "N acetylcysteine",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "alpha lipoic acid",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "L acetyl carnitine",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "methyl folate",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "coenzyme Q",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "meditation",
          "type": "BEHAVIORAL"
        },
        {
          "name": "self massage",
          "type": "BEHAVIORAL"
        },
        {
          "name": "learning",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Coconut oil",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DEVICE",
        "DIETARY_SUPPLEMENT",
        "BEHAVIORAL"
      ],
      "sponsor": "University of Iowa",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 38,
      "start_date": "2010-10",
      "completion_date": "2016-05",
      "has_results": false,
      "last_update_posted_date": "2018-06-26",
      "last_synced_at": "2026-09-03T18:34:36.013Z",
      "location_count": 1,
      "location_summary": "Iowa City, Iowa",
      "locations": [
        {
          "city": "Iowa City",
          "state": "Iowa"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01381354"
    },
    {
      "nct_id": "NCT00321152",
      "title": "A Study of 6(S)-5-MTHF Among Serotonin Reuptake Inhibitor(SSRI)-Resistant Outpatients With Major Depressive Disorder (MDD)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Major Depressive Disorder"
      ],
      "interventions": [
        {
          "name": "6(S)-5-MTHF (a Medical Food)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 150,
      "start_date": "2006-11",
      "completion_date": "2010-06",
      "has_results": false,
      "last_update_posted_date": "2010-06-08",
      "last_synced_at": "2026-09-03T18:34:36.013Z",
      "location_count": 11,
      "location_summary": "San Diego, California • Chicago, Illinois • New Orleans, Louisiana + 8 more",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Chicago",
          "state": "Illinois"
        },
        {
          "city": "New Orleans",
          "state": "Louisiana"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Burlington",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00321152"
    },
    {
      "nct_id": "NCT00933998",
      "title": "Restoration of Cutaneous Sensorum in Patients With Diabetic Peripheral Neuropathy (DPN) Via Metanx®",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Diabetic Peripheral Neuropathy"
      ],
      "interventions": [
        {
          "name": "Metanx® (Oral L-methylfolate, Methylcobalamin and Pyridoxal 5'-phosphate)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Carolina Musculoskeletal Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 20,
      "start_date": "2006-06",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2014-01-29",
      "last_synced_at": "2026-09-03T18:34:36.013Z",
      "location_count": 1,
      "location_summary": "Aiken, South Carolina",
      "locations": [
        {
          "city": "Aiken",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00933998"
    },
    {
      "nct_id": "NCT05673070",
      "title": "Use of Ritual Prenatal Multivitamins for Pregnancy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Pregnancy Related",
        "Nutrition, Healthy"
      ],
      "interventions": [
        {
          "name": "Ritual Epre Multivitamin-mineral supplement",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "control MVI",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "City University of New York",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 80,
      "start_date": "2023-10-15",
      "completion_date": "2024-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-05-19",
      "last_synced_at": "2026-09-03T18:34:36.013Z",
      "location_count": 2,
      "location_summary": "Brooklyn, New York",
      "locations": [
        {
          "city": "Brooklyn",
          "state": "New York"
        },
        {
          "city": "Brooklyn",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05673070"
    },
    {
      "nct_id": "NCT00853879",
      "title": "An Exploratory, Randomized, Blinded, Placebo-Controlled Trial of Folic Acid and L-methylfolate in Parkinson's Disease",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Parkinson's Disease"
      ],
      "interventions": [
        {
          "name": "Folic Acid, Vitamin B6, Vitamin B12",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "B6, B12, L-methylfolate",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "B6, B12, Placebo",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Northwell Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "30 Years and older"
      },
      "enrollment_count": 150,
      "start_date": "2006-12",
      "completion_date": "2010-06",
      "has_results": false,
      "last_update_posted_date": "2015-05-15",
      "last_synced_at": "2026-09-03T18:34:36.013Z",
      "location_count": 1,
      "location_summary": "Manhasset, New York",
      "locations": [
        {
          "city": "Manhasset",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00853879"
    },
    {
      "nct_id": "NCT01360996",
      "title": "Low Dose OC Therapy in Women With Polycystic Ovary Syndrome (PCOS): Impact of BMI on Hyperandrogenism",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Polycystic Ovary Syndrome"
      ],
      "interventions": [
        {
          "name": "3 mg DRSP/20 μg EE",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Woman's",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": "35 Years",
        "sex": "FEMALE",
        "summary": "16 Years to 35 Years · Female only"
      },
      "enrollment_count": 64,
      "start_date": "2011-08",
      "completion_date": "2015-02",
      "has_results": true,
      "last_update_posted_date": "2017-03-31",
      "last_synced_at": "2026-09-03T18:34:36.013Z",
      "location_count": 1,
      "location_summary": "Baton Rouge, Louisiana",
      "locations": [
        {
          "city": "Baton Rouge",
          "state": "Louisiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01360996"
    },
    {
      "nct_id": "NCT00348933",
      "title": "Dietary Supplements for the Treatment of Angelman Syndrome",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Angelman Syndrome",
        "Nervous System Diseases"
      ],
      "interventions": [
        {
          "name": "Betaine",
          "type": "DRUG"
        },
        {
          "name": "Creatine",
          "type": "DRUG"
        },
        {
          "name": "Metafolin",
          "type": "DRUG"
        },
        {
          "name": "Vitamin B12",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of California, San Diego",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Day",
        "maximum_age": "5 Years",
        "sex": "ALL",
        "summary": "1 Day to 5 Years"
      },
      "enrollment_count": 90,
      "start_date": "2006-07",
      "completion_date": "2010-02",
      "has_results": true,
      "last_update_posted_date": "2012-09-24",
      "last_synced_at": "2026-09-03T18:34:36.013Z",
      "location_count": 4,
      "location_summary": "San Diego, California • Boston, Massachusetts • Greenwood, South Carolina + 1 more",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Greenwood",
          "state": "South Carolina"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00348933"
    },
    {
      "nct_id": "NCT01369030",
      "title": "Deplin® P.L.U.S. Program (Progress Through Learning Understanding & Support)",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Major Depressive Disorder"
      ],
      "interventions": [
        {
          "name": "Deplin®",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Pamlab, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 554,
      "start_date": "2010-11",
      "completion_date": "2012-04",
      "has_results": true,
      "last_update_posted_date": "2014-06-03",
      "last_synced_at": "2026-09-03T18:34:36.013Z",
      "location_count": 2,
      "location_summary": "Greensboro, North Carolina • Nashville, Tennessee",
      "locations": [
        {
          "city": "Greensboro",
          "state": "North Carolina"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01369030"
    },
    {
      "nct_id": "NCT04095052",
      "title": "Food and Alcohol Behavior Study: Meaningful Enhancement",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Folate Deficiency"
      ],
      "interventions": [
        {
          "name": "Methyl Folate",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Oklahoma State University Center for Health Sciences",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "24 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 24 Years · Female only"
      },
      "enrollment_count": 20,
      "start_date": "2019-08-14",
      "completion_date": "2024-08-14",
      "has_results": false,
      "last_update_posted_date": "2023-08-16",
      "last_synced_at": "2026-09-03T18:34:36.013Z",
      "location_count": 1,
      "location_summary": "Tulsa, Oklahoma",
      "locations": [
        {
          "city": "Tulsa",
          "state": "Oklahoma"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04095052"
    }
  ]
}