{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=L-methylfolate&page=2",
    "query": {
      "intervention": "L-methylfolate",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=L-methylfolate&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-09-10T20:34:48.514Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00853879",
      "title": "An Exploratory, Randomized, Blinded, Placebo-Controlled Trial of Folic Acid and L-methylfolate in Parkinson's Disease",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Parkinson's Disease"
      ],
      "interventions": [
        {
          "name": "Folic Acid, Vitamin B6, Vitamin B12",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "B6, B12, L-methylfolate",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "B6, B12, Placebo",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Northwell Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "30 Years and older"
      },
      "enrollment_count": 150,
      "start_date": "2006-12",
      "completion_date": "2010-06",
      "has_results": false,
      "last_update_posted_date": "2015-05-15",
      "last_synced_at": "2026-09-10T20:34:48.514Z",
      "location_count": 1,
      "location_summary": "Manhasset, New York",
      "locations": [
        {
          "city": "Manhasset",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00853879"
    },
    {
      "nct_id": "NCT01001559",
      "title": "Combination Deplin® and Antidepressant Therapy for a Major Depressive Episode (MDE)- a Retrospective Analysis",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Major Depressive Disorder"
      ],
      "interventions": [
        {
          "name": "L-methylfolate",
          "type": "DRUG"
        },
        {
          "name": "Selective serotonin reuptake inhibitor (SSRI)",
          "type": "DRUG"
        },
        {
          "name": "Serotonin and norepinephrine reuptake inhibitor (SNRI)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Pamlab, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 242,
      "start_date": "2009-08",
      "completion_date": "2011-06",
      "has_results": true,
      "last_update_posted_date": "2013-12-19",
      "last_synced_at": "2026-09-10T20:34:48.514Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01001559"
    },
    {
      "nct_id": "NCT01853280",
      "title": "L-methylfolate Supplementation to OROS-Methylphenidate Pharmacotherapy in ADHD Adults",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2",
        "PHASE3"
      ],
      "conditions": [
        "Attention Deficit Hyperactivity Disorder"
      ],
      "interventions": [
        {
          "name": "L-methylfolate",
          "type": "DRUG"
        },
        {
          "name": "OROS-Methylphenidate",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Massachusetts General Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "18 Years to 55 Years"
      },
      "enrollment_count": 47,
      "start_date": "2014-05",
      "completion_date": "2017-09",
      "has_results": true,
      "last_update_posted_date": "2017-11-14",
      "last_synced_at": "2026-09-10T20:34:48.514Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01853280"
    },
    {
      "nct_id": "NCT01368549",
      "title": "Metanx® P.L.U.S. Program (Progress Through Learning, Understanding & Support)",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Diabetic Peripheral Neuropathy"
      ],
      "interventions": [
        {
          "name": "Metanx® (a medical food)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Pamlab, L.L.C.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "18 Years to 80 Years"
      },
      "enrollment_count": 800,
      "start_date": "2011-01",
      "completion_date": "2012-01",
      "has_results": false,
      "last_update_posted_date": "2012-01-11",
      "last_synced_at": "2026-09-10T20:34:48.514Z",
      "location_count": 1,
      "location_summary": "Montgomery, Alabama",
      "locations": [
        {
          "city": "Montgomery",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01368549"
    },
    {
      "nct_id": "NCT01062958",
      "title": "A Retrospective Analysis of Neevo®/Neevo®DHA Compared to a Standard Prenatal Vitamin in Anemia During Pregnancy",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Anemia in Pregnancy",
        "Preeclampsia"
      ],
      "interventions": [
        {
          "name": "Neevo® (a medical food)",
          "type": "OTHER"
        },
        {
          "name": "Prenatal vitamins (≤1mg folic acid, 27 - 35mg iron, and ≤12mcg vitamin B12)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Pamlab, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "39 Years",
        "sex": "FEMALE",
        "summary": "21 Years to 39 Years · Female only"
      },
      "enrollment_count": 100,
      "start_date": "2009-12",
      "completion_date": "2010-02",
      "has_results": false,
      "last_update_posted_date": "2013-04-16",
      "last_synced_at": "2026-09-10T20:34:48.514Z",
      "location_count": 3,
      "location_summary": "Sheffield, Alabama • Flowood, Mississippi • Gainesville, Texas",
      "locations": [
        {
          "city": "Sheffield",
          "state": "Alabama"
        },
        {
          "city": "Flowood",
          "state": "Mississippi"
        },
        {
          "city": "Gainesville",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01062958"
    },
    {
      "nct_id": "NCT01193192",
      "title": "A Retrospective Analysis of Neevo® and NeevoDHA® Compared to a Standard Prenatal Vitamin in Anemia During Pregnancy",
      "overall_status": "TERMINATED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Anemia in Pregnancy",
        "Pre-eclampsia"
      ],
      "interventions": [
        {
          "name": "Neevo®",
          "type": "OTHER"
        },
        {
          "name": "Prenatal vitamins",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Pamlab, L.L.C.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "39 Years",
        "sex": "FEMALE",
        "summary": "21 Years to 39 Years · Female only"
      },
      "enrollment_count": 30,
      "start_date": "2010-07",
      "completion_date": "2010-11",
      "has_results": false,
      "last_update_posted_date": "2011-11-23",
      "last_synced_at": "2026-09-10T20:34:48.514Z",
      "location_count": 3,
      "location_summary": "Chickasha, Oklahoma • Norman, Oklahoma",
      "locations": [
        {
          "city": "Chickasha",
          "state": "Oklahoma"
        },
        {
          "city": "Norman",
          "state": "Oklahoma"
        },
        {
          "city": "Norman",
          "state": "Oklahoma"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01193192"
    },
    {
      "nct_id": "NCT02696512",
      "title": "A Study of IBRF Disorders of Consciousness Advanced Care/MultiModal Care Protocol in Severe Disorders of Consciousness",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Brain Injury"
      ],
      "interventions": [
        {
          "name": "Polypharmacy using FDA-approved products",
          "type": "DRUG"
        },
        {
          "name": "Median Nerve Stimulation (MNS)",
          "type": "DEVICE"
        },
        {
          "name": "Nutraceutical Supplementation",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Standard of Care",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE",
        "DIETARY_SUPPLEMENT",
        "OTHER"
      ],
      "sponsor": "International Brain Research Foundation",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 30,
      "start_date": "2016-03",
      "completion_date": "2017-04",
      "has_results": false,
      "last_update_posted_date": "2016-09-02",
      "last_synced_at": "2026-09-10T20:34:48.514Z",
      "location_count": 1,
      "location_summary": "Edison, New Jersey",
      "locations": [
        {
          "city": "Edison",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02696512"
    },
    {
      "nct_id": "NCT01247558",
      "title": "Administrative Claims Analysis of Metanx® in Diabetic Peripheral Neuropathy",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Diabetic Peripheral Neuropathy (DPN)"
      ],
      "interventions": [
        {
          "name": "Metanx® (a medical food)",
          "type": "OTHER"
        },
        {
          "name": "Not treated with Metanx®",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Pamlab, L.L.C.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "25 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "25 Years to 80 Years"
      },
      "enrollment_count": 500,
      "start_date": "2010-11",
      "completion_date": "2011-09",
      "has_results": false,
      "last_update_posted_date": "2012-07-25",
      "last_synced_at": "2026-09-10T20:34:48.514Z",
      "location_count": 1,
      "location_summary": "Wilmington, Delaware",
      "locations": [
        {
          "city": "Wilmington",
          "state": "Delaware"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01247558"
    },
    {
      "nct_id": "NCT00468481",
      "title": "Efficacy and Safety Study for an Oral Contraceptive Containing Folate",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Neural Tube Defects",
        "Contraception",
        "Oral Contraceptives (OC)"
      ],
      "interventions": [
        {
          "name": "Drospirenone/Ethinylestradiol/Methyltetrahydrofolate",
          "type": "DRUG"
        },
        {
          "name": "Drospirenone/Ethinylestradiol (Yaz)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Bayer",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 40 Years · Female only"
      },
      "enrollment_count": 385,
      "start_date": "2007-04",
      "completion_date": "2008-09",
      "has_results": true,
      "last_update_posted_date": "2014-04-23",
      "last_synced_at": "2026-09-10T20:34:48.514Z",
      "location_count": 9,
      "location_summary": "Anaheim, California • San Diego, California • Baltimore, Maryland + 6 more",
      "locations": [
        {
          "city": "Anaheim",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Morrisville",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00468481"
    },
    {
      "nct_id": "NCT01370954",
      "title": "NAC-003 P.L.U.S. Program (Progress Through Learning Understanding & Support)",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Early Memory Loss",
        "Mild Cognitive Impairment",
        "Alzheimer's Disease",
        "Vascular Dementia"
      ],
      "interventions": [
        {
          "name": "CerefolinNAC®",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Pamlab, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "50 Years to 80 Years"
      },
      "enrollment_count": 204,
      "start_date": "2011-05",
      "completion_date": "2012-12",
      "has_results": false,
      "last_update_posted_date": "2013-05-09",
      "last_synced_at": "2026-09-10T20:34:48.514Z",
      "location_count": 1,
      "location_summary": "Hickory, North Carolina",
      "locations": [
        {
          "city": "Hickory",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01370954"
    }
  ]
}