{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Lidocaine%2FKetamine", "query": { "intervention": "Lidocaine/Ketamine" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 33, "total_pages": 4, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Lidocaine%2FKetamine&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-24T13:33:37.960Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01983020", "title": "Peri-Operative Lidocane, Ketamine, or Lidocane and Ketamine Combination, Infusion for Patients Undergoing Spine Surgery", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Postoperative Pain" ], "interventions": [ { "name": "Lidocaine", "type": "DRUG" }, { "name": "Ketamine", "type": "DRUG" }, { "name": "Saline", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Beth Israel Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 46, "start_date": "2011-04", "completion_date": "2013-01", "has_results": true, "last_update_posted_date": "2017-05-15", "last_synced_at": "2026-09-24T13:33:37.960Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT01983020" }, { "nct_id": "NCT05688943", "title": "Comparative Analysis of Spinal Anesthesia Versus General Anesthesia for vNOTES", "overall_status": "ENROLLING_BY_INVITATION", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Anesthesia", "Tubal Ligation" ], "interventions": [ { "name": "Spinal Anesthesia", "type": "PROCEDURE" }, { "name": "General Anesthesia", "type": "PROCEDURE" } ], "intervention_types": [ "PROCEDURE" ], "sponsor": "University of Kansas Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "21 Years", "maximum_age": null, "sex": "FEMALE", "summary": "21 Years and older · Female only" }, "enrollment_count": 20, "start_date": "2023-03-01", "completion_date": "2026-07-15", "has_results": false, "last_update_posted_date": "2025-06-05", "last_synced_at": "2026-09-24T13:33:37.960Z", "location_count": 1, "location_summary": "Kansas City, Kansas", "locations": [ { "city": "Kansas City", "state": "Kansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT05688943" }, { "nct_id": "NCT04084548", "title": "Perioperative Lidocaine and Ketamine in Abdominal Surgery", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Postoperative Pain" ], "interventions": [ { "name": "Lidocaine and ketamine", "type": "DRUG" }, { "name": "Lidocaine", "type": "DRUG" }, { "name": "Ketamine", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "The Cleveland Clinic", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 420, "start_date": "2019-10-15", "completion_date": "2025-12", "has_results": false, "last_update_posted_date": "2025-05-21", "last_synced_at": "2026-09-24T13:33:37.960Z", "location_count": 1, "location_summary": "Weston, Florida", "locations": [ { "city": "Weston", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT04084548" }, { "nct_id": "NCT00720330", "title": "Lidocaine and Ketamine Versus Standard Care on Acute and Chronic Pain", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Pain", "Nausea" ], "interventions": [ { "name": "ropivacaine", "type": "DRUG" }, { "name": "Lidocaine/Ketamine", "type": "DRUG" }, { "name": "placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "The Cleveland Clinic", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "MALE", "summary": "18 Years to 75 Years · Male only" }, "enrollment_count": 12, "start_date": "2008-07", "completion_date": "2010-02", "has_results": true, "last_update_posted_date": "2019-03-12", "last_synced_at": "2026-09-24T13:33:37.960Z", "location_count": 1, "location_summary": "Mayfield Heights, Ohio", "locations": [ { "city": "Mayfield Heights", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT00720330" }, { "nct_id": "NCT00721110", "title": "Lidocaine and Ketamine in Abdominal Surgery", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Abdominal Hysterectomy (& Wertheim)" ], "interventions": [ { "name": "Lidocaine", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Ketamine", "type": "DRUG" }, { "name": "Ketamine + Lidocaine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "The Cleveland Clinic", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "FEMALE", "summary": "18 Years to 75 Years · Female only" }, "enrollment_count": 64, "start_date": "2008-07", "completion_date": "2012-07", "has_results": true, "last_update_posted_date": "2017-07-26", "last_synced_at": "2026-09-24T13:33:37.960Z", "location_count": 1, "location_summary": "Mayfield Heights, Ohio", "locations": [ { "city": "Mayfield Heights", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT00721110" }, { "nct_id": "NCT04176419", "title": "Perioperative Analgesia on Postoperative Opioid Usage and Pain Control in H&N Cancer Surgery", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Postoperative Pain Control", "Opioid Consumption" ], "interventions": [ { "name": "Ketamine", "type": "DRUG" }, { "name": "Placebo Ketamine", "type": "DRUG" }, { "name": "Lidocaine", "type": "DRUG" }, { "name": "Placebo Lidocaine", "type": "DRUG" }, { "name": "Acetaminophen", "type": "DRUG" }, { "name": "Placebo Acetaminophen", "type": "DRUG" }, { "name": "Gabapentin", "type": "DRUG" }, { "name": "Placebo Gabapentin", "type": "DRUG" }, { "name": "Celecoxib", "type": "DRUG" }, { "name": "Placebo Celecoxib", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Case Comprehensive Cancer Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 30, "start_date": "2020-01-17", "completion_date": "2021-06-23", "has_results": false, "last_update_posted_date": "2024-11-12", "last_synced_at": "2026-09-24T13:33:37.960Z", "location_count": 1, "location_summary": "Cleveland, Ohio", "locations": [ { "city": "Cleveland", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT04176419" }, { "nct_id": "NCT07120763", "title": "Pain Control Alternatives in Pediatric Patients With Distal Radius Fractures", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Distal Radius Fracture Reduction", "Pain Control", "Pediatric Fractures" ], "interventions": [ { "name": "Ketamine + Lidocaine", "type": "DRUG" }, { "name": "Ketamine group", "type": "DRUG" }, { "name": "Fentanyl (Nasalfent, Fentanyl Citrate Nasal Spray)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "State University of New York at Buffalo", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "3 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "3 Years to 17 Years" }, "enrollment_count": 50, "start_date": "2025-08-22", "completion_date": "2027-08-22", "has_results": false, "last_update_posted_date": "2025-10-10", "last_synced_at": "2026-09-24T13:33:37.960Z", "location_count": 1, "location_summary": "Buffalo, New York", "locations": [ { "city": "Buffalo", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT07120763" }, { "nct_id": "NCT02958566", "title": "Multimodal Narcotic Limited Perioperative Pain Control With Colorectal Surgery", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Colon Cancer", "Colon Diverticulosis", "Colonic Neoplasms", "Colonic Diverticulitis", "Pain, Postoperative", "Ileus", "Ileus Paralytic", "Ileus; Mechanical", "Constipation Drug Induced", "Constipation", "Rectum Cancer", "Rectum Neoplasm" ], "interventions": [ { "name": "Acetaminophen", "type": "DRUG" }, { "name": "Gabapentin", "type": "DRUG" }, { "name": "Orphenadrine", "type": "DRUG" }, { "name": "Lidocaine", "type": "DRUG" }, { "name": "Marcaine", "type": "DRUG" }, { "name": "Ketamine", "type": "DRUG" }, { "name": "Methadone", "type": "DRUG" }, { "name": "Tramadol", "type": "DRUG" }, { "name": "Ketorolac", "type": "DRUG" }, { "name": "Morphine Sulfate", "type": "DRUG" }, { "name": "Fentanyl", "type": "DRUG" }, { "name": "Dilaudid", "type": "DRUG" }, { "name": "Hydrocodone-Acetaminophen Tab 5-325 MG", "type": "DRUG" }, { "name": "HYDROCODONE/ACETAMINOPHEN 5 Mg-325 Mg ORAL TABLET", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Illinois College of Medicine at Peoria", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 80, "start_date": "2017-01", "completion_date": "2018-12", "has_results": false, "last_update_posted_date": "2017-03-20", "last_synced_at": "2026-09-24T13:33:37.960Z", "location_count": 1, "location_summary": "Peoria, Illinois", "locations": [ { "city": "Peoria", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT02958566" }, { "nct_id": "NCT05279898", "title": "Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Postoperative Delirium", "Hemodynamic Instability", "Pain", "Neurocognitive Dysfunction" ], "interventions": [ { "name": "EEG Monitoring", "type": "DEVICE" }, { "name": "Ropivacaine", "type": "DRUG" }, { "name": "Ketamine", "type": "DRUG" }, { "name": "Remifentanil", "type": "DRUG" }, { "name": "Dexmedetomidine", "type": "DRUG" }, { "name": "Rocuronium", "type": "DRUG" }, { "name": "Propofol", "type": "DRUG" } ], "intervention_types": [ "DEVICE", "DRUG" ], "sponsor": "Beth Israel Deaconess Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "60 Years", "maximum_age": null, "sex": "ALL", "summary": "60 Years and older" }, "enrollment_count": 70, "start_date": "2023-02-28", "completion_date": "2024-12-31", "has_results": true, "last_update_posted_date": "2025-11-26", "last_synced_at": "2026-09-24T13:33:37.960Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT05279898" }, { "nct_id": "NCT02410460", "title": "Anesthetics in Rhytidoplasty - A Comparison Study", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Rhytidoplasty" ], "interventions": [ { "name": "clonidine", "type": "DRUG" }, { "name": "glycopyrrolate", "type": "DRUG" }, { "name": "propofol", "type": "DRUG" }, { "name": "ketamine", "type": "DRUG" }, { "name": "marcaine", "type": "DRUG" }, { "name": "scopolamine", "type": "DRUG" }, { "name": "midazolam", "type": "DRUG" }, { "name": "ondansetron", "type": "DEVICE" }, { "name": "metoclopramide", "type": "DRUG" }, { "name": "lidocaine", "type": "DRUG" }, { "name": "famotidine", "type": "DRUG" }, { "name": "desflurane", "type": "DRUG" }, { "name": "sevoflurane", "type": "DRUG" } ], "intervention_types": [ "DRUG", "DEVICE" ], "sponsor": "Mercy Facial Plastic Surgery Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "FEMALE", "summary": "18 Years and older · Female only" }, "enrollment_count": 30, "start_date": "2013-09", "completion_date": "2014-06", "has_results": false, "last_update_posted_date": "2015-04-07", "last_synced_at": "2026-09-24T13:33:37.960Z", "location_count": 1, "location_summary": "Springfield, Missouri", "locations": [ { "city": "Springfield", "state": "Missouri" } ], "official_url": "https://clinicaltrials.gov/study/NCT02410460" } ] }