{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Linzess&page=2", "query": { "intervention": "Linzess", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 10, "total_pages": 1, "next_page_url": null, "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Linzess&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-09-09T04:08:40.826Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00765882", "title": "Phase III, Randomized, Double-Blind, Placebo-Controlled, Trial of Linaclotide Administered to Patients With Chronic Constipation", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Chronic Constipation" ], "interventions": [ { "name": "Linaclotide 290 micrograms", "type": "DRUG" }, { "name": "Linaclotide 145 micrograms", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Forest Laboratories", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 633, "start_date": "2008-09", "completion_date": "2009-08", "has_results": true, "last_update_posted_date": "2013-01-30", "last_synced_at": "2026-09-09T04:08:40.826Z", "location_count": 100, "location_summary": "Birmingham, Alabama • Huntsville, Alabama • Chandler, Arizona + 89 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Huntsville", "state": "Alabama" }, { "city": "Chandler", "state": "Arizona" }, { "city": "Mesa", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT00765882" }, { "nct_id": "NCT02559817", "title": "A Safety and Efficacy Study of a Range of Linaclotide Doses Administered Orally to Children Ages 7-17 Years, With Irritable Bowel Syndrome With Constipation", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Irritable Bowel Syndrome With Constipation" ], "interventions": [ { "name": "Linaclotide Dose A", "type": "DRUG" }, { "name": "Linaclotide Dose B", "type": "DRUG" }, { "name": "Linaclotide Dose C", "type": "DRUG" }, { "name": "Linaclotide Approved Adult Dose", "type": "DRUG" }, { "name": "Matching Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Forest Laboratories", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "7 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "7 Years to 17 Years" }, "enrollment_count": 101, "start_date": "2015-11-01", "completion_date": "2019-08-30", "has_results": true, "last_update_posted_date": "2020-12-28", "last_synced_at": "2026-09-09T04:08:40.826Z", "location_count": 46, "location_summary": "Hot Springs, Arkansas • Little Rock, Arkansas • Anaheim, California + 39 more", "locations": [ { "city": "Hot Springs", "state": "Arkansas" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Anaheim", "state": "California" }, { "city": "Corona", "state": "California" }, { "city": "Costa Mesa", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02559817" }, { "nct_id": "NCT02465385", "title": "Single-dose Linaclotide for Capsule Endoscopy Preparation", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Crohn's", "Ulcerative Colitis", "Gastrointestinal Bleeding" ], "interventions": [ { "name": "Linaclotide", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Virginia", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 30, "start_date": "2015-02", "completion_date": "2016-06", "has_results": false, "last_update_posted_date": "2016-07-14", "last_synced_at": "2026-09-09T04:08:40.826Z", "location_count": 1, "location_summary": "Charlottesville, Virginia", "locations": [ { "city": "Charlottesville", "state": "Virginia" } ], "official_url": "https://clinicaltrials.gov/study/NCT02465385" }, { "nct_id": "NCT03573908", "title": "A Trial of Linaclotide 290 μg in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Irritable Bowel Syndrome Characterized by Constipation" ], "interventions": [ { "name": "Linaclotide", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Ironwood Pharmaceuticals, Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 614, "start_date": "2018-06-20", "completion_date": "2019-04-10", "has_results": true, "last_update_posted_date": "2020-12-01", "last_synced_at": "2026-09-09T04:08:40.826Z", "location_count": 79, "location_summary": "Huntsville, Alabama • Phoenix, Arizona • Tucson, Arizona + 67 more", "locations": [ { "city": "Huntsville", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "North Little Rock", "state": "Arkansas" }, { "city": "Chula Vista", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03573908" }, { "nct_id": "NCT05760313", "title": "A Study to Assess Adverse Events and Change in Disease Activity in Pediatric Participants (Age 6 Months to <2 Years) With Functional Constipation Who Are Treated With Linaclotide", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Functional Constipation" ], "interventions": [ { "name": "Linaclotide", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AbbVie", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "6 Months", "maximum_age": "23 Months", "sex": "ALL", "summary": "6 Months to 23 Months" }, "enrollment_count": 19, "start_date": "2023-04-27", "completion_date": "2025-06-09", "has_results": true, "last_update_posted_date": "2026-01-06", "last_synced_at": "2026-09-09T04:08:40.826Z", "location_count": 18, "location_summary": "Phoenix, Arizona • Hot Springs, Arkansas • Anaheim, California + 14 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Hot Springs", "state": "Arkansas" }, { "city": "Anaheim", "state": "California" }, { "city": "Corona", "state": "California" }, { "city": "Washington D.C.", "state": "District of Columbia" } ], "official_url": "https://clinicaltrials.gov/study/NCT05760313" }, { "nct_id": "NCT02078323", "title": "Investigation of Linaclotide's Effect on the Bi-directional Brain and Gut Axis in IBS-C Patients", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Irritable Bowel Syndrome With Constipation (IBS-C)" ], "interventions": [ { "name": "Linaclotide", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Augusta University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "64 Years", "sex": "ALL", "summary": "18 Years to 64 Years" }, "enrollment_count": 39, "start_date": "2014-02", "completion_date": "2018-07-20", "has_results": false, "last_update_posted_date": "2018-07-23", "last_synced_at": "2026-09-09T04:08:40.826Z", "location_count": 1, "location_summary": "Augusta, Georgia", "locations": [ { "city": "Augusta", "state": "Georgia" } ], "official_url": "https://clinicaltrials.gov/study/NCT02078323" }, { "nct_id": "NCT04026113", "title": "Linaclotide Safety and Efficacy in Pediatric Participants, 6 to 17 Years of Age, With Irritable Bowel Syndrome With Constipation (IBS-C) or Functional Constipation (FC)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Functional Constipation", "Irritable Bowel Syndrome With Constipation" ], "interventions": [ { "name": "Linaclotide", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AbbVie", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "6 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "6 Years to 17 Years" }, "enrollment_count": 438, "start_date": "2019-10-01", "completion_date": "2024-05-29", "has_results": true, "last_update_posted_date": "2024-11-26", "last_synced_at": "2026-09-09T04:08:40.826Z", "location_count": 79, "location_summary": "Birmingham, Alabama • Foley, Alabama • Saraland, Alabama + 62 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Foley", "state": "Alabama" }, { "city": "Saraland", "state": "Alabama" }, { "city": "Hot Springs", "state": "Arkansas" }, { "city": "Little Rock", "state": "Arkansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT04026113" }, { "nct_id": "NCT02559570", "title": "A Safety and Efficacy Study of a Range of Linaclotide Doses Administered Orally to Children Ages 6-17 Years Who Fulfill Modified Rome III Criteria for Child/Adolescent Functional Constipation (FC)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Functional Constipation in Children Ages 6-17 Years" ], "interventions": [ { "name": "Placebo", "type": "DRUG" }, { "name": "LIN Dose A", "type": "DRUG" }, { "name": "LIN Dose B", "type": "DRUG" }, { "name": "LIN Dose C", "type": "DRUG" }, { "name": "LIN 145 µg", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Forest Laboratories", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "6 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "6 Years to 17 Years" }, "enrollment_count": 173, "start_date": "2015-11-03", "completion_date": "2018-05-29", "has_results": true, "last_update_posted_date": "2019-06-19", "last_synced_at": "2026-09-09T04:08:40.826Z", "location_count": 60, "location_summary": "Hot Springs, Arkansas • Little Rock, Arkansas • Anaheim, California + 51 more", "locations": [ { "city": "Hot Springs", "state": "Arkansas" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Anaheim", "state": "California" }, { "city": "Corona", "state": "California" }, { "city": "Costa Mesa", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02559570" }, { "nct_id": "NCT04166058", "title": "Long-term Safety of Linaclotide in Pediatric Participants With FC or IBS-C", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Irritable Bowel Syndrome With Constipation", "Functional Constipation" ], "interventions": [ { "name": "Irritable Bowel Syndrome with Constipation (IBS-C) participants (LIN-MD-63 and LIN-MD-64 completers)", "type": "DRUG" }, { "name": "Functional Constipation (FC) participants (LIN-MD-62 and LIN-MD-64 completers)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AbbVie", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "6 Years", "maximum_age": "18 Years", "sex": "ALL", "summary": "6 Years to 18 Years" }, "enrollment_count": 381, "start_date": "2019-11-19", "completion_date": "2025-06-05", "has_results": true, "last_update_posted_date": "2026-01-06", "last_synced_at": "2026-09-09T04:08:40.826Z", "location_count": 65, "location_summary": "Birmingham, Alabama • Foley, Alabama • Saraland, Alabama + 50 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Foley", "state": "Alabama" }, { "city": "Saraland", "state": "Alabama" }, { "city": "Hot Springs", "state": "Arkansas" }, { "city": "Little Rock", "state": "Arkansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT04166058" }, { "nct_id": "NCT02270983", "title": "Phase 2 Randomized, Double-Blind, Placebo-Controlled, Parallel Group Trial of Linaclotide Administered to Patients With Opioid-Induced Constipation Receiving Chronic Opioid Treatment for Non-Cancer Pain", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Opioid-Induced Constipation" ], "interventions": [ { "name": "Linaclotide 145 micrograms", "type": "DRUG" }, { "name": "Linaclotide 290 micrograms", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Forest Laboratories", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 254, "start_date": "2014-10-31", "completion_date": "2015-10-31", "has_results": true, "last_update_posted_date": "2019-04-08", "last_synced_at": "2026-09-09T04:08:40.826Z", "location_count": 77, "location_summary": "Anniston, Alabama • Foley, Alabama • Phoenix, Arizona + 67 more", "locations": [ { "city": "Anniston", "state": "Alabama" }, { "city": "Foley", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "North Little Rock", "state": "Arkansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT02270983" } ] }