{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Lithium+treatment", "query": { "intervention": "Lithium treatment" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 123, "total_pages": 13, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Lithium+treatment&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-04T03:26:48.521Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01754883", "title": "Lithium Augmentation for Hyperarousal Symptoms of Post Traumatic Stress Disorder: Pilot Study", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Combat Posttraumatic Stess Disorder", "Mild Traumatic Brain Injury" ], "interventions": [ { "name": "Lithium Carbonate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "VA Eastern Colorado Health Care System", "sponsor_class": "FED", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 0, "start_date": "2011-01", "completion_date": "2014-01", "has_results": false, "last_update_posted_date": "2016-01-07", "last_synced_at": "2026-09-04T03:26:48.521Z", "location_count": 1, "location_summary": "Denver, Colorado", "locations": [ { "city": "Denver", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT01754883" }, { "nct_id": "NCT00581009", "title": "The Role of Dopamine Metabolism in the Antidepressant Effects of Sleep Deprivation and Sertraline in Depressed Patients", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Major Depressive Disorder", "Bipolar Disorder" ], "interventions": [ { "name": "chronobiological augmentation", "type": "OTHER" }, { "name": "sertraline, lithium", "type": "DRUG" }, { "name": "one night of sleep deprivation and two FDG PET scans", "type": "RADIATION" } ], "intervention_types": [ "OTHER", "DRUG", "RADIATION" ], "sponsor": "University of California, Irvine", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 49, "start_date": "2001-05-30", "completion_date": "2011-12-09", "has_results": true, "last_update_posted_date": "2024-10-17", "last_synced_at": "2026-09-04T03:26:48.521Z", "location_count": 2, "location_summary": "Irvine, California • La Jolla, California", "locations": [ { "city": "Irvine", "state": "California" }, { "city": "La Jolla", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00581009" }, { "nct_id": "NCT00276965", "title": "Bipolar II Depression: Lithium, SSRI, or the Combination", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Bipolar Disorder", "Depression" ], "interventions": [ { "name": "Sertraline", "type": "DRUG" }, { "name": "Lithium carbonate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Lindner Center of HOPE", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 139, "start_date": "2006-09", "completion_date": "2012-07", "has_results": false, "last_update_posted_date": "2013-05-10", "last_synced_at": "2026-09-04T03:26:48.521Z", "location_count": 3, "location_summary": "Los Angeles, California • Palo Alto, California • Mason, Ohio", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "Palo Alto", "state": "California" }, { "city": "Mason", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT00276965" }, { "nct_id": "NCT00602537", "title": "Antidepressant Therapy in Treating Bipolar Type II Major Depression", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Bipolar Disorder", "Depression" ], "interventions": [ { "name": "Venlafaxine", "type": "DRUG" }, { "name": "Lithium Carbonate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Pennsylvania", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 140, "start_date": "2007-12", "completion_date": "2013-06", "has_results": true, "last_update_posted_date": "2017-04-25", "last_synced_at": "2026-09-04T03:26:48.521Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT00602537" }, { "nct_id": "NCT00021528", "title": "Sequenced Treatment Alternatives to Relieve Depression (STAR*D)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Depression" ], "interventions": [ { "name": "citalopram", "type": "DRUG" }, { "name": "BuproprionSR", "type": "DRUG" }, { "name": "buspirone", "type": "DRUG" }, { "name": "Lithium", "type": "DRUG" }, { "name": "mirtazapine", "type": "DRUG" }, { "name": "nortriptyline", "type": "DRUG" }, { "name": "sertraline", "type": "DRUG" }, { "name": "tranylcypromine", "type": "DRUG" }, { "name": "VenlafaxineXR", "type": "DRUG" }, { "name": "Cognitive Therapy", "type": "BEHAVIORAL" }, { "name": "T3 (Triiodothyronine)", "type": "DRUG" } ], "intervention_types": [ "DRUG", "BEHAVIORAL" ], "sponsor": "National Institute of Mental Health (NIMH)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 4000, "start_date": "2001-07", "completion_date": "2006-09", "has_results": false, "last_update_posted_date": "2009-09-25", "last_synced_at": "2026-09-04T03:26:48.521Z", "location_count": 41, "location_summary": "Birmingham, Alabama • Tuscaloosa, Alabama • Chula Vista, California + 20 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Tuscaloosa", "state": "Alabama" }, { "city": "Tuscaloosa", "state": "Alabama" }, { "city": "Chula Vista", "state": "California" }, { "city": "Harbor City", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00021528" }, { "nct_id": "NCT03264235", "title": "The Effect of Powered-Knee Exoskeleton Assist on Stair Climbing in Acute CVA", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Stroke, Acute", "Gait Disorders, Neurologic" ], "interventions": [ { "name": "Keeogo", "type": "DEVICE" }, { "name": "Traditional Stair Training", "type": "OTHER" } ], "intervention_types": [ "DEVICE", "OTHER" ], "sponsor": "Shirley Ryan AbilityLab", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 15, "start_date": "2017-08-30", "completion_date": "2023-08-30", "has_results": false, "last_update_posted_date": "2024-01-25", "last_synced_at": "2026-09-04T03:26:48.521Z", "location_count": 2, "location_summary": "Chicago, Illinois", "locations": [ { "city": "Chicago", "state": "Illinois" }, { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT03264235" }, { "nct_id": "NCT00252577", "title": "Genetic Predictors of Lithium Response in Bipolar Disorder", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Bipolar Disorder" ], "interventions": [ { "name": "Lithium treatment", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "VA Office of Research and Development", "sponsor_class": "FED", "healthy_volunteers": false, "eligibility": { "minimum_age": "21 Years", "maximum_age": null, "sex": "ALL", "summary": "21 Years and older" }, "enrollment_count": 130, "start_date": "2005-10", "completion_date": "2016-05", "has_results": true, "last_update_posted_date": "2020-01-29", "last_synced_at": "2026-09-04T03:26:48.521Z", "location_count": 1, "location_summary": "San Diego, California", "locations": [ { "city": "San Diego", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00252577" }, { "nct_id": "NCT05758545", "title": "Trial to Evaluate the Safety and Effectiveness of Treatment With COMS One Device in Subjects With Diabetic Foot Ulcers", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Diabetic Foot Ulcer" ], "interventions": [ { "name": "COMS One device", "type": "DEVICE" }, { "name": "Sham device", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Piomic Medical", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "22 Years", "maximum_age": "90 Years", "sex": "ALL", "summary": "22 Years to 90 Years" }, "enrollment_count": 450, "start_date": "2023-06-19", "completion_date": "2027-06-19", "has_results": false, "last_update_posted_date": "2026-02-17", "last_synced_at": "2026-09-04T03:26:48.521Z", "location_count": 30, "location_summary": "Mesa, Arizona • Tucson, Arizona • Castro Valley, California + 23 more", "locations": [ { "city": "Mesa", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Castro Valley", "state": "California" }, { "city": "Fresno", "state": "California" }, { "city": "Fresno", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT05758545" }, { "nct_id": "NCT00081380", "title": "Efficacy and Safety of Seroquel Plus Mood Stabilizer in the Maintenance of Bipolar I Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Bipolar Disorder" ], "interventions": [ { "name": "Seroquel®, quetiapine fumarate (atypical antipsychotic)", "type": "DRUG" }, { "name": "lithium (mood stabilizer)", "type": "DRUG" }, { "name": "divalproex (mood stabilizer)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AstraZeneca", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 710, "start_date": "2004-03", "completion_date": "2006-09", "has_results": false, "last_update_posted_date": "2008-12-22", "last_synced_at": "2026-09-04T03:26:48.521Z", "location_count": 81, "location_summary": "Birmingham, Alabama • Scottsdale, Arizona • Little Rock, Arkansas + 78 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Anaheim", "state": "California" }, { "city": "Cerritos", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00081380" }, { "nct_id": "NCT01797575", "title": "N-Acetyl Cysteine and Aspirin as an Adjunctive Treatment for Bipolar Disorder", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Bipolar Disorder" ], "interventions": [ { "name": "Aspirin", "type": "DRUG" }, { "name": "N-acetyl-cysteine (NAC)", "type": "DIETARY_SUPPLEMENT" }, { "name": "Sugar Pill", "type": "DRUG" } ], "intervention_types": [ "DRUG", "DIETARY_SUPPLEMENT" ], "sponsor": "The University of Texas Health Science Center, Houston", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 38, "start_date": "2013-01", "completion_date": "2017-02-01", "has_results": true, "last_update_posted_date": "2018-04-30", "last_synced_at": "2026-09-04T03:26:48.521Z", "location_count": 1, "location_summary": "Houston, Texas", "locations": [ { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT01797575" } ] }