{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Low+Nicotine+E-Liquid",
    "query": {
      "intervention": "Low Nicotine E-Liquid"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 19,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Low+Nicotine+E-Liquid&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-16T09:10:56.439Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06602492",
      "title": "Compensatory Behavior of E-cig Users in Response to Reduced Nicotine E-liquids",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Healthy",
        "Nicotine Addiction",
        "Electronic Cigarette Use"
      ],
      "interventions": [
        {
          "name": "Lower nicotine e-liquid",
          "type": "DRUG"
        },
        {
          "name": "Higher nicotine eliquid",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Rochester Institute of Technology",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 72,
      "start_date": "2021-07-15",
      "completion_date": "2023-11-15",
      "has_results": false,
      "last_update_posted_date": "2024-09-27",
      "last_synced_at": "2026-09-16T09:10:56.439Z",
      "location_count": 1,
      "location_summary": "Rochester, New York",
      "locations": [
        {
          "city": "Rochester",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06602492"
    },
    {
      "nct_id": "NCT04047836",
      "title": "Vaping High vs. Low Nicotine E-Liquid",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cardiovascular Risk Factor",
        "Nicotine Dependence"
      ],
      "interventions": [
        {
          "name": "Low Nicotine E-Liquid",
          "type": "OTHER"
        },
        {
          "name": "Medium or High Nicotine E-Liquid",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "21 Years to 70 Years"
      },
      "enrollment_count": 0,
      "start_date": "2023-06-01",
      "completion_date": "2023-12-31",
      "has_results": false,
      "last_update_posted_date": "2023-08-22",
      "last_synced_at": "2026-09-16T09:10:56.439Z",
      "location_count": 2,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04047836"
    },
    {
      "nct_id": "NCT05327439",
      "title": "Using ANDS to Reduce Harm for Low SES Cigarette Smokers",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking, Cigarette",
        "Nicotine Dependence"
      ],
      "interventions": [
        {
          "name": "Nicotine (electronic cigarette)",
          "type": "OTHER"
        },
        {
          "name": "Nicotine (nicotine pouch)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Brown University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 45,
      "start_date": "2022-03-23",
      "completion_date": "2023-02-09",
      "has_results": false,
      "last_update_posted_date": "2023-01-26",
      "last_synced_at": "2026-09-16T09:10:56.439Z",
      "location_count": 1,
      "location_summary": "Providence, Rhode Island",
      "locations": [
        {
          "city": "Providence",
          "state": "Rhode Island"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05327439"
    },
    {
      "nct_id": "NCT02612701",
      "title": "E-Cigarette Aerosol, Conventional Cigarette Smoke, and Myocardial Perfusion",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Coronary Artery Disease",
        "Myocardial Perfusion"
      ],
      "interventions": [
        {
          "name": "Cigarettes",
          "type": "OTHER"
        },
        {
          "name": "E-cigarettes (nicotine free e-liquid)",
          "type": "OTHER"
        },
        {
          "name": "E-cigarettes (low nicotine e-liquid)",
          "type": "OTHER"
        },
        {
          "name": "E-cigarettes (high nicotine e-liquid)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Cedars-Sinai Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "49 Years",
        "sex": "ALL",
        "summary": "18 Years to 49 Years"
      },
      "enrollment_count": 20,
      "start_date": "2015-10",
      "completion_date": "2020-10",
      "has_results": false,
      "last_update_posted_date": "2021-02-04",
      "last_synced_at": "2026-09-16T09:10:56.439Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02612701"
    },
    {
      "nct_id": "NCT03830892",
      "title": "Effects of E-Cigarette Power and Nicotine Content in Dual Users and Vapers",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Electronic Cigarettes"
      ],
      "interventions": [
        {
          "name": "E-cigarette Lab Session 15 watts, 10 mg nicotine",
          "type": "OTHER"
        },
        {
          "name": "E-cigarette Lab Session 15 watts, 30 mg nicotine",
          "type": "OTHER"
        },
        {
          "name": "E-cigarette Lab Session 30 watts, 10 mg nicotine",
          "type": "OTHER"
        },
        {
          "name": "E-cigarette Lab Session 30 watts, 30 mg nicotine",
          "type": "OTHER"
        },
        {
          "name": "Own Brand Session - E-cigarette",
          "type": "OTHER"
        },
        {
          "name": "Own Brand Session - E-cigarette/Cigarette",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Virginia Commonwealth University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "55 Years",
        "sex": "ALL",
        "summary": "21 Years to 55 Years"
      },
      "enrollment_count": 48,
      "start_date": "2019-01-18",
      "completion_date": "2020-03-06",
      "has_results": true,
      "last_update_posted_date": "2021-06-04",
      "last_synced_at": "2026-09-16T09:10:56.439Z",
      "location_count": 1,
      "location_summary": "Richmond, Virginia",
      "locations": [
        {
          "city": "Richmond",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03830892"
    },
    {
      "nct_id": "NCT03635333",
      "title": "Effects of E-Cigarette Flavors on Adults TCORS 2.0",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Nicotine Use Disorder"
      ],
      "interventions": [
        {
          "name": "Nicotine",
          "type": "DRUG"
        },
        {
          "name": "Flavor",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "21 Years to 50 Years"
      },
      "enrollment_count": 130,
      "start_date": "2019-05-14",
      "completion_date": "2023-07-12",
      "has_results": true,
      "last_update_posted_date": "2025-12-19",
      "last_synced_at": "2026-09-16T09:10:56.439Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03635333"
    },
    {
      "nct_id": "NCT03844672",
      "title": "Impact of E-cigarette Characteristics on Reinforcement and Tobacco Use Patterns",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Smoking",
        "Tobacco Use"
      ],
      "interventions": [
        {
          "name": "Low Power",
          "type": "BEHAVIORAL"
        },
        {
          "name": "High Power",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Low Concentration",
          "type": "BEHAVIORAL"
        },
        {
          "name": "High Concentration",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Medical University of South Carolina",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 93,
      "start_date": "2019-04-01",
      "completion_date": "2023-11-09",
      "has_results": true,
      "last_update_posted_date": "2024-10-24",
      "last_synced_at": "2026-09-16T09:10:56.439Z",
      "location_count": 1,
      "location_summary": "Charleston, South Carolina",
      "locations": [
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03844672"
    },
    {
      "nct_id": "NCT06448351",
      "title": "Manipulating E-Cigarette Nicotine to Promote Public Health",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Tobacco-Related Carcinoma"
      ],
      "interventions": [
        {
          "name": "Biospecimen Collection",
          "type": "PROCEDURE"
        },
        {
          "name": "Carbon Monoxide Measurement",
          "type": "PROCEDURE"
        },
        {
          "name": "Vaping session",
          "type": "OTHER"
        },
        {
          "name": "Survey Administration",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "OTHER"
      ],
      "sponsor": "Ohio State University Comprehensive Cancer Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "21 Years to 65 Years"
      },
      "enrollment_count": 375,
      "start_date": "2024-05-20",
      "completion_date": "2028-08-31",
      "has_results": false,
      "last_update_posted_date": "2026-08-14",
      "last_synced_at": "2026-09-16T09:10:56.439Z",
      "location_count": 1,
      "location_summary": "Columbus, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06448351"
    },
    {
      "nct_id": "NCT04092101",
      "title": "Low Nicotine Content Cigarettes in Vulnerable Populations: Opioid Use Disorder",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Tobacco Use Disorder"
      ],
      "interventions": [
        {
          "name": "Cigarettes with varying nicotine content",
          "type": "OTHER"
        },
        {
          "name": "E-Cigarettes",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Vermont",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "21 Years to 70 Years"
      },
      "enrollment_count": 326,
      "start_date": "2020-10-18",
      "completion_date": "2023-11-27",
      "has_results": true,
      "last_update_posted_date": "2025-03-30",
      "last_synced_at": "2026-09-16T09:10:56.439Z",
      "location_count": 2,
      "location_summary": "Baltimore, Maryland • Burlington, Vermont",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Burlington",
          "state": "Vermont"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04092101"
    },
    {
      "nct_id": "NCT05932745",
      "title": "Effects of Novel E-cigarette Constituents on Adults TCORS 3.0",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nicotine Use Disorder"
      ],
      "interventions": [
        {
          "name": "E-liquid coolant (No WS-3) for non-menthol (1)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (No WS-3) for low (0.1%) menthol (1)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (No WS-3) for high (2.0%) menthol (1)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (Low [0.1%] WS-3) for non-menthol (2)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (Low [0.1%] WS-3) for low (0.1%) menthol (2)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (Low [0.1%] WS-3) for high (2.0%) menthol (2)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (High [2.0%] WS-3) for non-menthol (3)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (High [2.0%] WS-3) for low (0.1%) menthol (3)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (High [2.0%] WS-3) for high (2.0%) menthol (3)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (Low [0.1%] WS-23) for non-menthol (4)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (Low [0.1%] WS-23) for low (0.1%) menthol (4)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (Low [0.1%] WS-23) for high (2.0%) menthol (4)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (High [2.0%] WS-23) for non-menthol (5)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (High [2.0%] WS-23) for low (0.1%) menthol (5)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (High [2.0%] WS-23) for high (2.0%) menthol (5)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (4% WS-23) for non-menthol (6)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (4% WS-23) for low (0.1%) menthol (6)",
          "type": "OTHER"
        },
        {
          "name": "E-liquid coolant (4% WS-23) for high (2.0%) menthol (6)",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 66,
      "start_date": "2025-06-20",
      "completion_date": "2026-08",
      "has_results": false,
      "last_update_posted_date": "2026-06-16",
      "last_synced_at": "2026-09-16T09:10:56.439Z",
      "location_count": 1,
      "location_summary": "New Haven, Connecticut",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05932745"
    }
  ]
}