{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Low+nicotine&page=2",
    "query": {
      "intervention": "Low nicotine",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Low+nicotine&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-09-24T07:49:08.172Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT07095140",
      "title": "Studying the Effects of Nicotine Concentration and Flavor on Alcohol Use in Young Adults",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Alcohol-Related Carcinoma"
      ],
      "interventions": [
        {
          "name": "Ecological Momentary Assessment",
          "type": "OTHER"
        },
        {
          "name": "Monitoring",
          "type": "OTHER"
        },
        {
          "name": "Nicotine Oral Pouch",
          "type": "DRUG"
        },
        {
          "name": "Survey Administration",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DRUG"
      ],
      "sponsor": "Ohio State University Comprehensive Cancer Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "30 Years",
        "sex": "ALL",
        "summary": "21 Years to 30 Years"
      },
      "enrollment_count": 20,
      "start_date": "2025-09-03",
      "completion_date": "2027-12-31",
      "has_results": false,
      "last_update_posted_date": "2025-11-26",
      "last_synced_at": "2026-09-24T07:49:08.172Z",
      "location_count": 1,
      "location_summary": "Columbus, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07095140"
    },
    {
      "nct_id": "NCT05707871",
      "title": "Cardiovascular Effects of Very Low Nicotine Content Cigarettes",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Tobacco Use"
      ],
      "interventions": [
        {
          "name": "SPECTRUM cigarettes",
          "type": "DRUG"
        },
        {
          "name": "usual brand of Cigarettes",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Wake Forest University Health Sciences",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 49,
      "start_date": "2023-04-04",
      "completion_date": "2026-12",
      "has_results": false,
      "last_update_posted_date": "2026-08-28",
      "last_synced_at": "2026-09-24T07:49:08.172Z",
      "location_count": 1,
      "location_summary": "Winston-Salem, North Carolina",
      "locations": [
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05707871"
    },
    {
      "nct_id": "NCT04047836",
      "title": "Vaping High vs. Low Nicotine E-Liquid",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cardiovascular Risk Factor",
        "Nicotine Dependence"
      ],
      "interventions": [
        {
          "name": "Low Nicotine E-Liquid",
          "type": "OTHER"
        },
        {
          "name": "Medium or High Nicotine E-Liquid",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "21 Years to 70 Years"
      },
      "enrollment_count": 0,
      "start_date": "2023-06-01",
      "completion_date": "2023-12-31",
      "has_results": false,
      "last_update_posted_date": "2023-08-22",
      "last_synced_at": "2026-09-24T07:49:08.172Z",
      "location_count": 2,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04047836"
    },
    {
      "nct_id": "NCT01964807",
      "title": "Cardiovascular Assessment of the Effects of Tobacco and Nicotine Delivery Products",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Adverse Effect of Other Agents Primarily Affecting the Cardiovascular System, Initial Encounter"
      ],
      "interventions": [
        {
          "name": "Cigarette, NIDA test type with 16.6 mg nicotine",
          "type": "OTHER"
        },
        {
          "name": "Cigarette, NIDA test type with <0.45 mg nicotine",
          "type": "OTHER"
        },
        {
          "name": "Electronic cigarette with 18 mg/ml nicotine",
          "type": "OTHER"
        },
        {
          "name": "Electronic Cigarette with no nicotine",
          "type": "OTHER"
        },
        {
          "name": "Moist snuff",
          "type": "OTHER"
        },
        {
          "name": "Sham Smoking",
          "type": "OTHER"
        },
        {
          "name": "Secondhand cigarette smoke (SHS)",
          "type": "OTHER"
        },
        {
          "name": "Conditioned, filtered air",
          "type": "OTHER"
        },
        {
          "name": "Sham Moist Snuff",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of California, San Francisco",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 81,
      "start_date": "2013-11-03",
      "completion_date": "2021-05-31",
      "has_results": false,
      "last_update_posted_date": "2021-12-27",
      "last_synced_at": "2026-09-24T07:49:08.172Z",
      "location_count": 1,
      "location_summary": "San Francisco, California",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01964807"
    },
    {
      "nct_id": "NCT05458895",
      "title": "Evaluating E-Cigarette Nicotine Form, Concentration, and Flavors Among Youth",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "E-cigarette Use"
      ],
      "interventions": [
        {
          "name": "ECIG lab session 1",
          "type": "OTHER"
        },
        {
          "name": "ECIG lab session 2",
          "type": "OTHER"
        },
        {
          "name": "ECIG lab session 3",
          "type": "OTHER"
        },
        {
          "name": "ECIG lab session 4",
          "type": "OTHER"
        },
        {
          "name": "ECIG lab session 5",
          "type": "OTHER"
        },
        {
          "name": "ECIG lab session 6",
          "type": "OTHER"
        },
        {
          "name": "ECIG lab session 7",
          "type": "OTHER"
        },
        {
          "name": "ECIG lab session 8",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Ohio State University Comprehensive Cancer Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "25 Years",
        "sex": "ALL",
        "summary": "21 Years to 25 Years"
      },
      "enrollment_count": 88,
      "start_date": "2021-12-02",
      "completion_date": "2023-08-07",
      "has_results": true,
      "last_update_posted_date": "2024-11-22",
      "last_synced_at": "2026-09-24T07:49:08.172Z",
      "location_count": 1,
      "location_summary": "Columbus, Ohio",
      "locations": [
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05458895"
    },
    {
      "nct_id": "NCT04634071",
      "title": "Tobacco Treatment Optimization and Preferences During Concurrent Cancer Treatment",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Smoking Cessation",
        "Cancer, Treatment-Related"
      ],
      "interventions": [
        {
          "name": "Varenicline",
          "type": "DRUG"
        },
        {
          "name": "Bupropion",
          "type": "DRUG"
        },
        {
          "name": "Long-acting nicotine replacement therapy",
          "type": "DRUG"
        },
        {
          "name": "Low-intensity counseling",
          "type": "BEHAVIORAL"
        },
        {
          "name": "High-intensity counseling",
          "type": "BEHAVIORAL"
        },
        {
          "name": "No nicotine replacement therapy",
          "type": "OTHER"
        },
        {
          "name": "Nicotine Replacement Products",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL",
        "OTHER"
      ],
      "sponsor": "Joseph Valentino, MD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 126,
      "start_date": "2021-01-12",
      "completion_date": "2026-01-02",
      "has_results": false,
      "last_update_posted_date": "2026-02-02",
      "last_synced_at": "2026-09-24T07:49:08.172Z",
      "location_count": 3,
      "location_summary": "Bowling Green, Kentucky • Lexington, Kentucky • Owensboro, Kentucky",
      "locations": [
        {
          "city": "Bowling Green",
          "state": "Kentucky"
        },
        {
          "city": "Lexington",
          "state": "Kentucky"
        },
        {
          "city": "Owensboro",
          "state": "Kentucky"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04634071"
    },
    {
      "nct_id": "NCT04419922",
      "title": "A Digital Smoking Cessation Intervention for Adults With Substance Use Disorder",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Tobacco Use Disorder",
        "Substance Use Disorders"
      ],
      "interventions": [
        {
          "name": "Smartphone Contingency Management Intervention",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "BrightView LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 100,
      "start_date": "2020-04-02",
      "completion_date": "2021-01-15",
      "has_results": false,
      "last_update_posted_date": "2020-06-09",
      "last_synced_at": "2026-09-24T07:49:08.172Z",
      "location_count": 1,
      "location_summary": "Cincinnati, Ohio",
      "locations": [
        {
          "city": "Cincinnati",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04419922"
    },
    {
      "nct_id": "NCT02599571",
      "title": "Effects of Nicotine Reduction on Smoking Behavior in ADHD Smokers",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Nicotine Dependence",
        "ADHD"
      ],
      "interventions": [
        {
          "name": "Very low nicotine content cigarettes",
          "type": "OTHER"
        },
        {
          "name": "Conventional nicotine content cigarettes",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Duke University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "18 Years to 40 Years"
      },
      "enrollment_count": 71,
      "start_date": "2016-03-30",
      "completion_date": "2019-09-12",
      "has_results": false,
      "last_update_posted_date": "2020-01-27",
      "last_synced_at": "2026-09-24T07:49:08.172Z",
      "location_count": 2,
      "location_summary": "Durham, North Carolina • Pittsburgh, Pennsylvania",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        },
        {
          "city": "Pittsburgh",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02599571"
    },
    {
      "nct_id": "NCT07010601",
      "title": "Tobacco Product Susceptibility and Substitutability by Rurality and Alcohol Use",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Alcohol Use",
        "E-cigarette Use",
        "Cigarette Use"
      ],
      "interventions": [
        {
          "name": "Experimental Tobacco Marketplace",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Hypothetical Novel Nicotine Product Purchase Tasks",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Mark J Rzeszutek, PhD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 737,
      "start_date": "2025-08-18",
      "completion_date": "2025-08-20",
      "has_results": false,
      "last_update_posted_date": "2025-09-23",
      "last_synced_at": "2026-09-24T07:49:08.172Z",
      "location_count": 1,
      "location_summary": "Lexington, Kentucky",
      "locations": [
        {
          "city": "Lexington",
          "state": "Kentucky"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07010601"
    },
    {
      "nct_id": "NCT07771725",
      "title": "Impact of Sweeteners on the Addictive Threshold of Nicotine",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Smoking ( Cigarette)"
      ],
      "interventions": [
        {
          "name": "Nicotine 0.05 mg/pulse and 0.1 mg/pulse",
          "type": "DRUG"
        },
        {
          "name": "Saline Placebo (0.5mL injection)",
          "type": "DRUG"
        },
        {
          "name": "sucralose",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Sugar syrup (Placebo)",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Yale University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "59 Years",
        "sex": "ALL",
        "summary": "21 Years to 59 Years"
      },
      "enrollment_count": 36,
      "start_date": "2026-09-01",
      "completion_date": "2029-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-08-31",
      "last_synced_at": "2026-09-24T07:49:08.172Z",
      "location_count": 1,
      "location_summary": "West Haven, Connecticut",
      "locations": [
        {
          "city": "West Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07771725"
    }
  ]
}