{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Lower+FiO2",
    "query": {
      "intervention": "Lower FiO2"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 17,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Lower+FiO2&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-10T08:39:02.871Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01681225",
      "title": "EPVent 2- A Phase II Study of Mechanical Ventilation Directed by Transpulmonary Pressures",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acute Respiratory Distress Syndrome"
      ],
      "interventions": [
        {
          "name": "Esophageal-pressure guided mechanical ventilation",
          "type": "OTHER"
        },
        {
          "name": "High PEEP mechanical ventilation",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Beth Israel Deaconess Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "16 Years and older"
      },
      "enrollment_count": 202,
      "start_date": "2012-10-31",
      "completion_date": "2018-10-19",
      "has_results": false,
      "last_update_posted_date": "2019-12-03",
      "last_synced_at": "2026-09-10T08:39:02.871Z",
      "location_count": 10,
      "location_summary": "La Jolla, California • Stanford, California • Orlando, Florida + 6 more",
      "locations": [
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "Stanford",
          "state": "California"
        },
        {
          "city": "Orlando",
          "state": "Florida"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01681225"
    },
    {
      "nct_id": "NCT07442669",
      "title": "Utilization of Lung Ultrasound Score in Decision for Minimally Invasive Surfactant Administration",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Respiratory Distress Syndrome, Newborn",
        "Respiratory Distress Syndrome in Premature Infant"
      ],
      "interventions": [
        {
          "name": "Lung ultrasound",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Hackensack Meridian Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "27 Weeks",
        "maximum_age": "34 Weeks",
        "sex": "ALL",
        "summary": "27 Weeks to 34 Weeks"
      },
      "enrollment_count": 100,
      "start_date": "2026-08-18",
      "completion_date": "2028-08-17",
      "has_results": false,
      "last_update_posted_date": "2026-08-19",
      "last_synced_at": "2026-09-10T08:39:02.871Z",
      "location_count": 1,
      "location_summary": "Hackensack, New Jersey",
      "locations": [
        {
          "city": "Hackensack",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07442669"
    },
    {
      "nct_id": "NCT04452188",
      "title": "Targeting Normoxia in Neonates With Cyanotic Congenital Heart Disease in the Intra-operative and Immediate Post-operative Period",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypoplastic Left Heart Syndrome",
        "Total Anomalous Pulmonary Venous Return",
        "Truncus Arteriosus",
        "Pulmonary Atresia With Ventricular Septal Defect",
        "Transposition of the Great Arteries",
        "Double Outlet Right Ventricle, Subpulmonary VSD",
        "Tetralogy of Fallot",
        "Double Outlet Right Ventricle With Subaortic Ventricular Septal Defect and Pulmonary Stenosis",
        "Cardiopulmonary Bypass"
      ],
      "interventions": [
        {
          "name": "Normoxia (with controlled re-oxygenation)",
          "type": "OTHER"
        },
        {
          "name": "Standard of care ventilation",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Michigan",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "29 Days",
        "sex": "ALL",
        "summary": "Up to 29 Days"
      },
      "enrollment_count": 29,
      "start_date": "2021-01-18",
      "completion_date": "2023-04-20",
      "has_results": true,
      "last_update_posted_date": "2024-06-18",
      "last_synced_at": "2026-09-10T08:39:02.871Z",
      "location_count": 1,
      "location_summary": "Ann Arbor, Michigan",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04452188"
    },
    {
      "nct_id": "NCT06373289",
      "title": "Pulmonary Hypertension and Oxygen Saturation Targeting in Preterm Infants",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Bronchopulmonary Dysplasia",
        "Pulmonary Hypertension"
      ],
      "interventions": [
        {
          "name": "higher oxygen saturation target using Nellcor pulse oximetry sensors",
          "type": "DEVICE"
        },
        {
          "name": "lower oxygen saturation target using Nellcor pulse oximetry sensors",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "1 Month",
        "maximum_age": "5 Months",
        "sex": "ALL",
        "summary": "1 Month to 5 Months"
      },
      "enrollment_count": 39,
      "start_date": "2026-09-15",
      "completion_date": "2029-12-01",
      "has_results": false,
      "last_update_posted_date": "2026-08-26",
      "last_synced_at": "2026-09-10T08:39:02.871Z",
      "location_count": 2,
      "location_summary": "Birmingham, Alabama • New Haven, Connecticut",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "New Haven",
          "state": "Connecticut"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06373289"
    },
    {
      "nct_id": "NCT07224243",
      "title": "Impact of Intraoperative Oxygenation Practices on Patient Outcomes",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Surgeries Undergoing General Anesthesia"
      ],
      "interventions": [
        {
          "name": "Lower FiO2",
          "type": "OTHER"
        },
        {
          "name": "Intermediate FiO2",
          "type": "OTHER"
        },
        {
          "name": "Higher FiO2",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Frederic T Billings IV",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 54000,
      "start_date": "2025-12-01",
      "completion_date": "2028-04",
      "has_results": false,
      "last_update_posted_date": "2026-06-10",
      "last_synced_at": "2026-09-10T08:39:02.871Z",
      "location_count": 4,
      "location_summary": "Ann Arbor, Michigan • Omaha, Nebraska • Nashville, Tennessee + 1 more",
      "locations": [
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        },
        {
          "city": "Omaha",
          "state": "Nebraska"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        },
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07224243"
    },
    {
      "nct_id": "NCT02799875",
      "title": "Late Permissive Hypercapnia for Intubated and Ventilated Preterm Infants",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Premature Neonate"
      ],
      "interventions": [
        {
          "name": "Higher permissive hypercapnia",
          "type": "OTHER"
        },
        {
          "name": "Lower Permissive Hypercapnia",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Alabama at Birmingham",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "7 Days",
        "maximum_age": "14 Days",
        "sex": "ALL",
        "summary": "7 Days to 14 Days"
      },
      "enrollment_count": 130,
      "start_date": "2015-12",
      "completion_date": "2021-04",
      "has_results": false,
      "last_update_posted_date": "2021-05-03",
      "last_synced_at": "2026-09-10T08:39:02.871Z",
      "location_count": 1,
      "location_summary": "Birmingham, Alabama",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02799875"
    },
    {
      "nct_id": "NCT04372953",
      "title": "Positive End-Expiratory Pressure (PEEP) Levels During Resuscitation of Preterm Infants at Birth (The POLAR Trial).",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Lung Injury",
        "Preterm Birth"
      ],
      "interventions": [
        {
          "name": "Positive End-Expiratory Pressure (PEEP)",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Murdoch Childrens Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "23 Weeks",
        "maximum_age": "28 Weeks",
        "sex": "ALL",
        "summary": "23 Weeks to 28 Weeks"
      },
      "enrollment_count": 906,
      "start_date": "2021-05-04",
      "completion_date": "2028-05-30",
      "has_results": false,
      "last_update_posted_date": "2026-02-19",
      "last_synced_at": "2026-09-10T08:39:02.871Z",
      "location_count": 4,
      "location_summary": "Little Rock, Arkansas • San Diego, California • Indianapolis, Indiana + 1 more",
      "locations": [
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04372953"
    },
    {
      "nct_id": "NCT07790133",
      "title": "Trial of Total Lung Protective Ventilation in Adult VV-ECMO Patients With Severe ARDS",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "ARDS (Acute Respiratory Distress Syndrome)",
        "VV ECMO"
      ],
      "interventions": [
        {
          "name": "Mechanical Power Targeted Ventilation",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Virginia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 24,
      "start_date": "2026-09-01",
      "completion_date": "2028-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-09-01",
      "last_synced_at": "2026-09-10T08:39:02.871Z",
      "location_count": 1,
      "location_summary": "Charlottesville, Virginia",
      "locations": [
        {
          "city": "Charlottesville",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07790133"
    },
    {
      "nct_id": "NCT03951064",
      "title": "Providing Optimal PEEP During Mechanical Ventilation for Obese Patients Using Esophageal Balloon",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Obesity, Morbid",
        "Ventilator-Induced Lung Injury",
        "Respiratory Failure"
      ],
      "interventions": [
        {
          "name": "Esophageal balloon",
          "type": "DEVICE"
        },
        {
          "name": "Intervention Spontaneous Breathing Trial (SBT) and Extubation",
          "type": "PROCEDURE"
        },
        {
          "name": "Control Spontaneous Breathing Trial and Extubation",
          "type": "PROCEDURE"
        },
        {
          "name": "Intervention Weaning after Tracheostomy",
          "type": "PROCEDURE"
        },
        {
          "name": "Control Weaning after Tracheostomy",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "PROCEDURE"
      ],
      "sponsor": "University of North Carolina, Chapel Hill",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 6,
      "start_date": "2021-03-31",
      "completion_date": "2022-12-06",
      "has_results": true,
      "last_update_posted_date": "2024-06-05",
      "last_synced_at": "2026-09-10T08:39:02.871Z",
      "location_count": 2,
      "location_summary": "Chapel Hill, North Carolina • Greenville, North Carolina",
      "locations": [
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        },
        {
          "city": "Greenville",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03951064"
    },
    {
      "nct_id": "NCT02354365",
      "title": "Measuring Lung Pressures in Critically Ill Children Who Are on Mechanical Ventilation",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Transpulmonary Pressure",
        "Pressure.Rate Product",
        "Guide to Mechanical Ventilator Management",
        "Extubation Readiness"
      ],
      "interventions": [
        {
          "name": "Transpulmonary Pressure measurement",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Children's Hospital Los Angeles",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Week",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "1 Week to 18 Years"
      },
      "enrollment_count": 55,
      "start_date": "2014-02",
      "completion_date": "2024-12-31",
      "has_results": false,
      "last_update_posted_date": "2024-02-15",
      "last_synced_at": "2026-09-10T08:39:02.871Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02354365"
    }
  ]
}