{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Lower+PEEP",
    "query": {
      "intervention": "Lower PEEP"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 14,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Lower+PEEP&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-08T13:13:51.369Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02148692",
      "title": "Protective Ventilation With Higher Versus Lower PEEP During General Anesthesia for Surgery in Obese Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Morbid Obesity",
        "Surgery",
        "General Anesthesia"
      ],
      "interventions": [
        {
          "name": "Higher PEEP",
          "type": "PROCEDURE"
        },
        {
          "name": "Lower PEEP",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Technische Universität Dresden",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 2013,
      "start_date": "2014-07",
      "completion_date": "2018-05",
      "has_results": false,
      "last_update_posted_date": "2019-01-03",
      "last_synced_at": "2026-09-08T13:13:51.369Z",
      "location_count": 2,
      "location_summary": "Boston, Massachusetts • Rochester, Minnesota",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02148692"
    },
    {
      "nct_id": "NCT06976554",
      "title": "Mechanical Ventilator Weaning in Chronically Ventilated Patients",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Mechanical Ventilation Complication"
      ],
      "interventions": [
        {
          "name": "weaning",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of California, Los Angeles",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 51,
      "start_date": "2023-09-01",
      "completion_date": "2025-07-29",
      "has_results": false,
      "last_update_posted_date": "2025-08-03",
      "last_synced_at": "2026-09-08T13:13:51.369Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06976554"
    },
    {
      "nct_id": "NCT00793013",
      "title": "Airway Pressure Release Ventilation (APRV) Compared to ARDSnet Ventilation",
      "overall_status": "WITHDRAWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Acute Lung Injury",
        "Adult Respiratory Distress Syndrome",
        "Kidney Injury"
      ],
      "interventions": [
        {
          "name": "Volume-Cycled Assist-Control (AC) mode",
          "type": "DEVICE"
        },
        {
          "name": "Airway Pressure Release Ventilation (APRV) mode",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Tennessee, Chattanooga",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "18 Years to 85 Years"
      },
      "enrollment_count": 0,
      "start_date": "2020-11-02",
      "completion_date": "2020-11-02",
      "has_results": false,
      "last_update_posted_date": "2020-11-04",
      "last_synced_at": "2026-09-08T13:13:51.369Z",
      "location_count": 1,
      "location_summary": "Chattanooga, Tennessee",
      "locations": [
        {
          "city": "Chattanooga",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00793013"
    },
    {
      "nct_id": "NCT03951064",
      "title": "Providing Optimal PEEP During Mechanical Ventilation for Obese Patients Using Esophageal Balloon",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Obesity, Morbid",
        "Ventilator-Induced Lung Injury",
        "Respiratory Failure"
      ],
      "interventions": [
        {
          "name": "Esophageal balloon",
          "type": "DEVICE"
        },
        {
          "name": "Intervention Spontaneous Breathing Trial (SBT) and Extubation",
          "type": "PROCEDURE"
        },
        {
          "name": "Control Spontaneous Breathing Trial and Extubation",
          "type": "PROCEDURE"
        },
        {
          "name": "Intervention Weaning after Tracheostomy",
          "type": "PROCEDURE"
        },
        {
          "name": "Control Weaning after Tracheostomy",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DEVICE",
        "PROCEDURE"
      ],
      "sponsor": "University of North Carolina, Chapel Hill",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 6,
      "start_date": "2021-03-31",
      "completion_date": "2022-12-06",
      "has_results": true,
      "last_update_posted_date": "2024-06-05",
      "last_synced_at": "2026-09-08T13:13:51.369Z",
      "location_count": 2,
      "location_summary": "Chapel Hill, North Carolina • Greenville, North Carolina",
      "locations": [
        {
          "city": "Chapel Hill",
          "state": "North Carolina"
        },
        {
          "city": "Greenville",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03951064"
    },
    {
      "nct_id": "NCT04372953",
      "title": "Positive End-Expiratory Pressure (PEEP) Levels During Resuscitation of Preterm Infants at Birth (The POLAR Trial).",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Lung Injury",
        "Preterm Birth"
      ],
      "interventions": [
        {
          "name": "Positive End-Expiratory Pressure (PEEP)",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Murdoch Childrens Research Institute",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "23 Weeks",
        "maximum_age": "28 Weeks",
        "sex": "ALL",
        "summary": "23 Weeks to 28 Weeks"
      },
      "enrollment_count": 906,
      "start_date": "2021-05-04",
      "completion_date": "2028-05-30",
      "has_results": false,
      "last_update_posted_date": "2026-02-19",
      "last_synced_at": "2026-09-08T13:13:51.369Z",
      "location_count": 4,
      "location_summary": "Little Rock, Arkansas • San Diego, California • Indianapolis, Indiana + 1 more",
      "locations": [
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Indianapolis",
          "state": "Indiana"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04372953"
    },
    {
      "nct_id": "NCT01681225",
      "title": "EPVent 2- A Phase II Study of Mechanical Ventilation Directed by Transpulmonary Pressures",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acute Respiratory Distress Syndrome"
      ],
      "interventions": [
        {
          "name": "Esophageal-pressure guided mechanical ventilation",
          "type": "OTHER"
        },
        {
          "name": "High PEEP mechanical ventilation",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Beth Israel Deaconess Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "16 Years and older"
      },
      "enrollment_count": 202,
      "start_date": "2012-10-31",
      "completion_date": "2018-10-19",
      "has_results": false,
      "last_update_posted_date": "2019-12-03",
      "last_synced_at": "2026-09-08T13:13:51.369Z",
      "location_count": 10,
      "location_summary": "La Jolla, California • Stanford, California • Orlando, Florida + 6 more",
      "locations": [
        {
          "city": "La Jolla",
          "state": "California"
        },
        {
          "city": "Stanford",
          "state": "California"
        },
        {
          "city": "Orlando",
          "state": "Florida"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01681225"
    },
    {
      "nct_id": "NCT05440851",
      "title": "Platform of Randomized Adaptive Clinical Trials in Critical Illness",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Respiratory Insufficiency",
        "Extracorporeal Membrane Oxygenation Complication",
        "Mechanical Ventilation Pressure High"
      ],
      "interventions": [
        {
          "name": "Ultra-Protective Ventilation Facilitated by Extracorporeal Support",
          "type": "OTHER"
        },
        {
          "name": "Lung-Protective Ventilation (LPV)",
          "type": "OTHER"
        },
        {
          "name": "Driving Pressure-Limited Ventilation (DPL)",
          "type": "OTHER"
        },
        {
          "name": "Lung- and Diaphragm-Protective Ventilation and Sedation (LDPVS)",
          "type": "OTHER"
        },
        {
          "name": "Early Cohort corticosteroid dose",
          "type": "DRUG"
        },
        {
          "name": "Extended Cohort corticosteroid dose",
          "type": "DRUG"
        },
        {
          "name": "Usual care without routine corticosteroids",
          "type": "DRUG"
        },
        {
          "name": "Usual care without extending corticosteroids",
          "type": "DRUG"
        },
        {
          "name": "Usual care with fludrocortisone",
          "type": "DRUG"
        },
        {
          "name": "Usual care without fludrocortisone",
          "type": "DRUG"
        },
        {
          "name": "Drug 4 mL:",
          "type": "DRUG"
        },
        {
          "name": "Drug 40 mg:",
          "type": "DRUG"
        },
        {
          "name": "PEEP-20",
          "type": "OTHER"
        },
        {
          "name": "PEEP-AOP",
          "type": "OTHER"
        },
        {
          "name": "PEEP-10",
          "type": "OTHER"
        },
        {
          "name": "VV ECMO-facilitated strategy of earlier awakening, extubation and rehabilitation",
          "type": "OTHER"
        },
        {
          "name": "Electrical impedance tomography (EIT)",
          "type": "OTHER"
        },
        {
          "name": "no treatment / intervention arm is involved.",
          "type": "OTHER"
        },
        {
          "name": "Usual care",
          "type": "OTHER"
        },
        {
          "name": "Early Routine IMT",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DRUG"
      ],
      "sponsor": "University Health Network, Toronto",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 6250,
      "start_date": "2023-04-30",
      "completion_date": "2027-03-31",
      "has_results": false,
      "last_update_posted_date": "2026-05-07",
      "last_synced_at": "2026-09-08T13:13:51.369Z",
      "location_count": 26,
      "location_summary": "Tucson, Arizona • Los Angeles, California • San Diego, California + 19 more",
      "locations": [
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05440851"
    },
    {
      "nct_id": "NCT02354365",
      "title": "Measuring Lung Pressures in Critically Ill Children Who Are on Mechanical Ventilation",
      "overall_status": "UNKNOWN",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Transpulmonary Pressure",
        "Pressure.Rate Product",
        "Guide to Mechanical Ventilator Management",
        "Extubation Readiness"
      ],
      "interventions": [
        {
          "name": "Transpulmonary Pressure measurement",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Children's Hospital Los Angeles",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Week",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "1 Week to 18 Years"
      },
      "enrollment_count": 55,
      "start_date": "2014-02",
      "completion_date": "2024-12-31",
      "has_results": false,
      "last_update_posted_date": "2024-02-15",
      "last_synced_at": "2026-09-08T13:13:51.369Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02354365"
    },
    {
      "nct_id": "NCT02963025",
      "title": "Protective Ventilation With High Versus Low PEEP During One-lung Ventilation for Thoracic Surgery",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "One-Lung Ventilation"
      ],
      "interventions": [
        {
          "name": "PEEP level",
          "type": "PROCEDURE"
        },
        {
          "name": "Use of recruitment maneuvers",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Technische Universität Dresden",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 2200,
      "start_date": "2017-01",
      "completion_date": "2024-08",
      "has_results": false,
      "last_update_posted_date": "2025-09-26",
      "last_synced_at": "2026-09-08T13:13:51.369Z",
      "location_count": 3,
      "location_summary": "Boston, Massachusetts • New York, New York • Cleveland, Ohio",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02963025"
    },
    {
      "nct_id": "NCT07790133",
      "title": "Trial of Total Lung Protective Ventilation in Adult VV-ECMO Patients With Severe ARDS",
      "overall_status": "NOT_YET_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "ARDS (Acute Respiratory Distress Syndrome)",
        "VV ECMO"
      ],
      "interventions": [
        {
          "name": "Mechanical Power Targeted Ventilation",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "University of Virginia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 24,
      "start_date": "2026-09-01",
      "completion_date": "2028-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-09-01",
      "last_synced_at": "2026-09-08T13:13:51.369Z",
      "location_count": 1,
      "location_summary": "Charlottesville, Virginia",
      "locations": [
        {
          "city": "Charlottesville",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07790133"
    }
  ]
}