{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=MK-8189", "query": { "intervention": "MK-8189" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 11, "total_pages": 2, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=MK-8189&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-02T10:45:26.631Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT05893862", "title": "A Study To Evaluate The Effect Of A Supratherapeutic Dose Of Elpipodect (MK-8189) On The QTc Interval In Participants With Schizophrenia (MK-8189-019)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Schizophrenia" ], "interventions": [ { "name": "Elpipodect", "type": "DRUG" }, { "name": "Moxifloxacin", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Merck Sharp & Dohme LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "60 Years", "sex": "ALL", "summary": "18 Years to 60 Years" }, "enrollment_count": 107, "start_date": "2023-06-26", "completion_date": "2024-02-22", "has_results": true, "last_update_posted_date": "2026-04-29", "last_synced_at": "2026-09-02T10:45:26.631Z", "location_count": 4, "location_summary": "Glendale, California • Orange, California • Hallandale, Florida + 1 more", "locations": [ { "city": "Glendale", "state": "California" }, { "city": "Orange", "state": "California" }, { "city": "Hallandale", "state": "Florida" }, { "city": "Marlton", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT05893862" }, { "nct_id": "NCT06626464", "title": "A Study of Elpipodect (MK-8189) Human Absorption, Metabolism, and Excretion in Healthy Male Participants (MK-8189-010)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy" ], "interventions": [ { "name": "[14C]Elpipodect", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Merck Sharp & Dohme LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "MALE", "summary": "18 Years to 55 Years · Male only" }, "enrollment_count": 6, "start_date": "2022-05-13", "completion_date": "2022-07-08", "has_results": false, "last_update_posted_date": "2026-04-13", "last_synced_at": "2026-09-02T10:45:26.631Z", "location_count": 1, "location_summary": "Madison, Wisconsin", "locations": [ { "city": "Madison", "state": "Wisconsin" } ], "official_url": "https://clinicaltrials.gov/study/NCT06626464" }, { "nct_id": "NCT03565068", "title": "A Safety, Tolerability, and Pharmacokinetics Study of MK-8189 in Participants With Schizophrenia and in Healthy Participants (MK-8189-007)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Schizophrenia" ], "interventions": [ { "name": "MK-8189", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Background AAP Therapy", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Merck Sharp & Dohme LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "60 Years", "sex": "ALL", "summary": "18 Years to 60 Years" }, "enrollment_count": 75, "start_date": "2018-06-20", "completion_date": "2020-04-03", "has_results": true, "last_update_posted_date": "2021-03-29", "last_synced_at": "2026-09-02T10:45:26.631Z", "location_count": 1, "location_summary": "Glendale, California", "locations": [ { "city": "Glendale", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03565068" }, { "nct_id": "NCT04506905", "title": "Safety, Tolerability, and Pharmacokinetics Study of Elpipodect (MK-8189) in Participants With Schizophrenia and Healthy Participants (MK-8189-011)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Schizophrenia" ], "interventions": [ { "name": "Elpipodect", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Merck Sharp & Dohme LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 63, "start_date": "2020-08-28", "completion_date": "2022-03-22", "has_results": true, "last_update_posted_date": "2026-04-29", "last_synced_at": "2026-09-02T10:45:26.631Z", "location_count": 6, "location_summary": "Rogers, Arkansas • Glendale, California • Long Beach, California + 3 more", "locations": [ { "city": "Rogers", "state": "Arkansas" }, { "city": "Glendale", "state": "California" }, { "city": "Long Beach", "state": "California" }, { "city": "Hallandale", "state": "Florida" }, { "city": "Oakland Park", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT04506905" }, { "nct_id": "NCT05227118", "title": "Elpipodect (MK-8189) Safety and Tolerability in Participants With Alzheimer's Disease With or Without Symptoms of Agitation-Aggression and/or Psychosis (MK-8189-017)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Alzheimer's Disease" ], "interventions": [ { "name": "Elpipodect", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Merck Sharp & Dohme LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "65 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "65 Years to 85 Years" }, "enrollment_count": 29, "start_date": "2022-07-01", "completion_date": "2023-01-10", "has_results": true, "last_update_posted_date": "2026-04-29", "last_synced_at": "2026-09-02T10:45:26.631Z", "location_count": 8, "location_summary": "Santa Ana, California • Cutler Bay, Florida • Hallandale, Florida + 5 more", "locations": [ { "city": "Santa Ana", "state": "California" }, { "city": "Cutler Bay", "state": "Florida" }, { "city": "Hallandale", "state": "Florida" }, { "city": "Miami", "state": "Florida" }, { "city": "Atlanta", "state": "Georgia" } ], "official_url": "https://clinicaltrials.gov/study/NCT05227118" }, { "nct_id": "NCT05953740", "title": "A Study of MK-5720 in Participants With Schizophrenia (MK-5720-001)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Schizophrenia" ], "interventions": [ { "name": "MK-5720", "type": "DRUG" }, { "name": "Placebo to MK-5720", "type": "DRUG" }, { "name": "MK-8189", "type": "DRUG" }, { "name": "Placebo to MK-8189", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Merck Sharp & Dohme LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "60 Years", "sex": "ALL", "summary": "18 Years to 60 Years" }, "enrollment_count": 17, "start_date": "2023-09-15", "completion_date": "2024-02-15", "has_results": true, "last_update_posted_date": "2025-03-04", "last_synced_at": "2026-09-02T10:45:26.631Z", "location_count": 4, "location_summary": "Glendale, California • Hallandale, Florida • Hollywood, Florida + 1 more", "locations": [ { "city": "Glendale", "state": "California" }, { "city": "Hallandale", "state": "Florida" }, { "city": "Hollywood", "state": "Florida" }, { "city": "Marlton", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT05953740" }, { "nct_id": "NCT06273774", "title": "A Study of Elpipodect (MK-8189) in Participants With Bipolar I Disorder (MK-8189-020)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Bipolar I Disorder" ], "interventions": [ { "name": "Elpipodect", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Merck Sharp & Dohme LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "60 Years", "sex": "ALL", "summary": "18 Years to 60 Years" }, "enrollment_count": 34, "start_date": "2024-04-08", "completion_date": "2024-08-21", "has_results": true, "last_update_posted_date": "2026-04-29", "last_synced_at": "2026-09-02T10:45:26.631Z", "location_count": 3, "location_summary": "Little Rock, Arkansas • Atlanta, Georgia • Marlton, New Jersey", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Marlton", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT06273774" }, { "nct_id": "NCT03055338", "title": "An Active-Controlled Early Phase Study of Elpipodect (MK-8189) in Adults With Schizophrenia (MK-8189-005)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Schizophrenia, Acute Episode" ], "interventions": [ { "name": "Elpipodect", "type": "DRUG" }, { "name": "Risperidone", "type": "DRUG" }, { "name": "Placebo matching MK-8189", "type": "DRUG" }, { "name": "Placebo matching risperidone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Merck Sharp & Dohme LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 224, "start_date": "2017-03-08", "completion_date": "2018-01-09", "has_results": true, "last_update_posted_date": "2026-04-29", "last_synced_at": "2026-09-02T10:45:26.631Z", "location_count": 28, "location_summary": "Little Rock, Arkansas • Rogers, Arkansas • Bellflower, California + 23 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Rogers", "state": "Arkansas" }, { "city": "Bellflower", "state": "California" }, { "city": "Cerritos", "state": "California" }, { "city": "Garden Grove", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03055338" }, { "nct_id": "NCT05406440", "title": "A Study of Elpipodect (MK-8189) in Participants With Schizophrenia (MK-8189-014)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Schizophrenia" ], "interventions": [ { "name": "Elpipodect", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Merck Sharp & Dohme LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 53, "start_date": "2022-07-12", "completion_date": "2023-02-24", "has_results": true, "last_update_posted_date": "2026-04-29", "last_synced_at": "2026-09-02T10:45:26.631Z", "location_count": 3, "location_summary": "Garden Grove, California • Glendale, California • Marlton, New Jersey", "locations": [ { "city": "Garden Grove", "state": "California" }, { "city": "Glendale", "state": "California" }, { "city": "Marlton", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT05406440" }, { "nct_id": "NCT04624243", "title": "Efficacy and Safety of Elpipodect (MK-8189) in Participants With an Acute Episode of Schizophrenia (MK-8189-008)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Schizophrenia" ], "interventions": [ { "name": "Elpipodect", "type": "DRUG" }, { "name": "Risperidone", "type": "DRUG" }, { "name": "Placebo to MK-8189", "type": "DRUG" }, { "name": "Placebo to risperidone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Merck Sharp & Dohme LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 499, "start_date": "2020-12-15", "completion_date": "2024-06-21", "has_results": true, "last_update_posted_date": "2026-04-29", "last_synced_at": "2026-09-02T10:45:26.631Z", "location_count": 35, "location_summary": "Bentonville, Arkansas • Little Rock, Arkansas • Rogers, Arkansas + 27 more", "locations": [ { "city": "Bentonville", "state": "Arkansas" }, { "city": "Little Rock", "state": "Arkansas" }, { "city": "Rogers", "state": "Arkansas" }, { "city": "Bellflower", "state": "California" }, { "city": "Culver City", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04624243" } ] }