{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Major+surgery", "query": { "intervention": "Major surgery" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 803, "total_pages": 81, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Major+surgery&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-08T21:47:22.617Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT03896568", "title": "MSC-DNX-2401 in Treating Patients With Recurrent High-Grade Glioma", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "IDH1 wt Allele", "Recurrent Anaplastic Astrocytoma", "Recurrent Glioblastoma", "Recurrent Gliosarcoma", "Recurrent Malignant Glioma" ], "interventions": [ { "name": "Oncolytic Adenovirus Ad5-DNX-2401", "type": "BIOLOGICAL" }, { "name": "Therapeutic Conventional Surgery", "type": "PROCEDURE" } ], "intervention_types": [ "BIOLOGICAL", "PROCEDURE" ], "sponsor": "M.D. Anderson Cancer Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 36, "start_date": "2019-02-12", "completion_date": "2027-09-30", "has_results": false, "last_update_posted_date": "2026-07-15", "last_synced_at": "2026-09-08T21:47:22.617Z", "location_count": 1, "location_summary": "Houston, Texas", "locations": [ { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT03896568" }, { "nct_id": "NCT02058979", "title": "Pharmacokinetics of Bolus Versus Continuous Cefazolin Infusion in Patients Undergoing Major Surgery", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Plasma Concentration of Antibiotics" ], "interventions": [ { "name": "BOLUS INFUSION (Ancef)", "type": "DRUG" }, { "name": "CONTINUOUS INFUSION (Ancef)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Virginia", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 20, "start_date": "2014-11", "completion_date": "2016-06", "has_results": false, "last_update_posted_date": "2016-10-26", "last_synced_at": "2026-09-08T21:47:22.617Z", "location_count": 1, "location_summary": "Charlottesville, Virginia", "locations": [ { "city": "Charlottesville", "state": "Virginia" } ], "official_url": "https://clinicaltrials.gov/study/NCT02058979" }, { "nct_id": "NCT05660408", "title": "RNA Lipid Particles Targeting Pediatric Recurrent Intracranial Malignancies and Other systEmic Solid Tumors", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Recurrent Pulmonary Osteosarcoma", "Recurrent High-grade Glioma" ], "interventions": [ { "name": "pp65 RNA LP (DP1)", "type": "BIOLOGICAL" }, { "name": "pp65/tumor mRNA RNA-LP (DP2)", "type": "BIOLOGICAL" }, { "name": "Surgical Biopsy/Resection", "type": "PROCEDURE" } ], "intervention_types": [ "BIOLOGICAL", "PROCEDURE" ], "sponsor": "University of Florida", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "3 Years", "maximum_age": "39 Years", "sex": "ALL", "summary": "3 Years to 39 Years" }, "enrollment_count": 36, "start_date": "2025-03-12", "completion_date": "2035-10", "has_results": false, "last_update_posted_date": "2026-03-09", "last_synced_at": "2026-09-08T21:47:22.617Z", "location_count": 1, "location_summary": "Gainesville, Florida", "locations": [ { "city": "Gainesville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT05660408" }, { "nct_id": "NCT05362526", "title": "High Flow vs Conventional Oxygen in Head and Neck Surgery", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Pulmonary Disease" ], "interventions": [ { "name": "High flow humidification", "type": "DEVICE" }, { "name": "Conventional cool mist aerosol humidification", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "University of Florida", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "100 Years", "sex": "ALL", "summary": "18 Years to 100 Years" }, "enrollment_count": 56, "start_date": "2022-07-01", "completion_date": "2024-07-01", "has_results": true, "last_update_posted_date": "2025-11-03", "last_synced_at": "2026-09-08T21:47:22.617Z", "location_count": 1, "location_summary": "Jacksonville, Florida", "locations": [ { "city": "Jacksonville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT05362526" }, { "nct_id": "NCT00061568", "title": "Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital Anemias", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Congenital Hemolytic Anemia", "Sickle Cell Disease" ], "interventions": [ { "name": "Peripheral blood hematopoietic progenitor cell (PBPC) transplant", "type": "PROCEDURE" }, { "name": "Alemtuzumab", "type": "DRUG" }, { "name": "Peripheral blood hematopoietic progenitor cell Apheresis", "type": "PROCEDURE" }, { "name": "Sirolimus", "type": "DRUG" } ], "intervention_types": [ "PROCEDURE", "DRUG" ], "sponsor": "National Heart, Lung, and Blood Institute (NHLBI)", "sponsor_class": "NIH", "healthy_volunteers": true, "eligibility": { "minimum_age": "2 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "2 Years to 80 Years" }, "enrollment_count": 130, "start_date": "2004-07-16", "completion_date": "2026-01-31", "has_results": true, "last_update_posted_date": "2024-02-29", "last_synced_at": "2026-09-08T21:47:22.617Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00061568" }, { "nct_id": "NCT02526368", "title": "Pilot Study of (MR) Imaging With Pyruvate (13C) to Detect High Grade Prostate Cancer", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "EARLY_PHASE1" ], "conditions": [ "Prostate Cancer", "Localized Prostate Carcinoma" ], "interventions": [ { "name": "Hyperpolarized 13C-Pyruvate", "type": "DRUG" }, { "name": "Hyperpolarized 13C,15N2-urea", "type": "DRUG" }, { "name": "Magnetic Resonance Spectroscopic Imaging", "type": "PROCEDURE" } ], "intervention_types": [ "DRUG", "PROCEDURE" ], "sponsor": "Ivan de Kouchkovsky, MD", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "MALE", "summary": "18 Years and older · Male only" }, "enrollment_count": 80, "start_date": "2016-03-22", "completion_date": "2026-12-31", "has_results": false, "last_update_posted_date": "2026-04-30", "last_synced_at": "2026-09-08T21:47:22.617Z", "location_count": 1, "location_summary": "San Francisco, California", "locations": [ { "city": "San Francisco", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02526368" }, { "nct_id": "NCT03823534", "title": "Post-Op Pain Control for Prophylactic Intramedullary Nailing.", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Bone Metastases", "Lymphoma", "Multiple Myeloma", "Opioid Use", "Pain" ], "interventions": [ { "name": "Ketorolac", "type": "DRUG" }, { "name": "Normal saline", "type": "DRUG" }, { "name": "Acetaminophen", "type": "DRUG" }, { "name": "Oxycodone Acetaminophen", "type": "DRUG" }, { "name": "Morphine", "type": "DRUG" }, { "name": "Hydrocodone/Acetaminophen", "type": "DRUG" }, { "name": "Oxycodone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "St. Louis University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 60, "start_date": "2019-02-20", "completion_date": "2027-03-31", "has_results": false, "last_update_posted_date": "2026-04-22", "last_synced_at": "2026-09-08T21:47:22.617Z", "location_count": 1, "location_summary": "St Louis, Missouri", "locations": [ { "city": "St Louis", "state": "Missouri" } ], "official_url": "https://clinicaltrials.gov/study/NCT03823534" }, { "nct_id": "NCT00589602", "title": "T-Cell Depletion, Donor Hematopoietic Stem Cell Transplant (HSCT), and T-Cell Infusions in Treating Patients With Hematologic Cancer or Other Diseases", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Chronic Myeloproliferative Disorders", "Leukemia", "Lymphoma", "Multiple Myeloma and Malignant Plasma Cell Neoplasms", "Myelodysplastic Syndromes", "Precancerous/Nonmalignant Condition", "Secondary Myelofibrosis" ], "interventions": [ { "name": "peripheral blood lymphocyte therapy", "type": "PROCEDURE" }, { "name": "allogeneic hematopoietic stem cell transplantation", "type": "PROCEDURE" }, { "name": "peripheral blood stem cell transplantation", "type": "PROCEDURE" }, { "name": "total-body irradiation (TBI)", "type": "RADIATION" } ], "intervention_types": [ "PROCEDURE", "RADIATION" ], "sponsor": "The Cleveland Clinic", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 13, "start_date": "2004-01", "completion_date": "2014-12", "has_results": true, "last_update_posted_date": "2017-05-30", "last_synced_at": "2026-09-08T21:47:22.617Z", "location_count": 1, "location_summary": "Cleveland, Ohio", "locations": [ { "city": "Cleveland", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT00589602" }, { "nct_id": "NCT00144729", "title": "Conditioning Regimens for Patients With Severe Aplastic Anemia Transplanted With Marrow From an Unrelated Donor", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Anemia, Aplastic" ], "interventions": [ { "name": "Bone marrow transplant", "type": "PROCEDURE" } ], "intervention_types": [ "PROCEDURE" ], "sponsor": "Fred Hutchinson Cancer Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": "55 Years", "sex": "ALL", "summary": "Up to 55 Years" }, "enrollment_count": 85, "start_date": "1993-05", "completion_date": "2007-07", "has_results": false, "last_update_posted_date": "2008-04-30", "last_synced_at": "2026-09-08T21:47:22.617Z", "location_count": 1, "location_summary": "Seattle, Washington", "locations": [ { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT00144729" }, { "nct_id": "NCT07166172", "title": "Prospective Registry for Long-term Outcomes Following FETO in Severe Left and Right CDH", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Congenital Diaphragmatic Hernia", "Congenital Abnormalities", "Neonatal Diseases and Abnormalities", "Hernia, DIaphragmatic, Congenital", "Internal Hernia", "Hernia", "Pathological Conditions, Anatomical", "Pathological Conditions, Signs and Symptoms" ], "interventions": [ { "name": "Fetal Treatment Arm (FETO Group)", "type": "DEVICE" } ], "intervention_types": [ "DEVICE" ], "sponsor": "Johns Hopkins University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "FEMALE", "summary": "18 Years and older · Female only" }, "enrollment_count": 80, "start_date": "2025-06-23", "completion_date": "2031-12-01", "has_results": false, "last_update_posted_date": "2026-04-23", "last_synced_at": "2026-09-08T21:47:22.617Z", "location_count": 1, "location_summary": "Baltimore, Maryland", "locations": [ { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT07166172" } ] }