{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Malaria+challenge&page=2", "query": { "intervention": "Malaria challenge", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 10, "total_pages": 1, "next_page_url": null, "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Malaria+challenge&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-09-29T02:32:27.651Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01540474", "title": "Trial of a Falciparum Malaria Protein (FMP012), E. Coli-expressed PfCelTOS, in Healthy Malaria-Naive Adults", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Malaria" ], "interventions": [ { "name": "Group 1: 10 ug FMP012 with 2 ug GLA-SE", "type": "BIOLOGICAL" }, { "name": "Group 2: 10 ug FMP012 with 5 ug GLA-SE", "type": "BIOLOGICAL" }, { "name": "50 ug FMP012 with 5 ug GLA-SE or 2 ug GLA-SE", "type": "BIOLOGICAL" }, { "name": "Controlled group-Challenged Only: no vaccination", "type": "OTHER" } ], "intervention_types": [ "BIOLOGICAL", "OTHER" ], "sponsor": "U.S. Army Medical Research and Development Command", "sponsor_class": "FED", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 36, "start_date": "2012-02", "completion_date": "2012-12", "has_results": true, "last_update_posted_date": "2021-06-08", "last_synced_at": "2026-09-29T02:32:27.651Z", "location_count": 1, "location_summary": "Silver Spring, Maryland", "locations": [ { "city": "Silver Spring", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT01540474" }, { "nct_id": "NCT02780154", "title": "PfSPZ Challenge in Non-immune Adults in Baltimore, USA", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Plasmodium Falciparum Infection" ], "interventions": [ { "name": "PfSPZ (7G8) Challenge", "type": "BIOLOGICAL" }, { "name": "PfSPZ (NF54) Challenge", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "ALL", "summary": "18 Years to 45 Years" }, "enrollment_count": 30, "start_date": "2016-08-25", "completion_date": "2016-12-15", "has_results": false, "last_update_posted_date": "2019-01-28", "last_synced_at": "2026-09-29T02:32:27.651Z", "location_count": 1, "location_summary": "Baltimore, Maryland", "locations": [ { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT02780154" }, { "nct_id": "NCT03014258", "title": "A Systems Biology Approach to Malaria Immunity", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Plasmodium Falciparum Infection" ], "interventions": [ { "name": "NF54 P. falciparum malaria challenge", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 27, "start_date": "2017-06-07", "completion_date": "2019-07-19", "has_results": false, "last_update_posted_date": "2021-06-08", "last_synced_at": "2026-09-29T02:32:27.651Z", "location_count": 1, "location_summary": "Baltimore, Maryland", "locations": [ { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT03014258" }, { "nct_id": "NCT01994525", "title": "Immunization Via Mosquito Bite With Radiation-attenuated Sporozoites", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Malaria" ], "interventions": [ { "name": "PfRAS", "type": "BIOLOGICAL" }, { "name": "Placebo", "type": "BIOLOGICAL" }, { "name": "Challenge", "type": "OTHER" } ], "intervention_types": [ "BIOLOGICAL", "OTHER" ], "sponsor": "U.S. Army Medical Research and Development Command", "sponsor_class": "FED", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 54, "start_date": "2014-01-24", "completion_date": "2017-02", "has_results": false, "last_update_posted_date": "2019-09-17", "last_synced_at": "2026-09-29T02:32:27.651Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT01994525" }, { "nct_id": "NCT04966871", "title": "Safety, Tolerability and Efficacy of PfSPZ Vaccine Against Heterologous CHMI in US Malaria naïve Adults", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Malaria" ], "interventions": [ { "name": "PfSPZ Vaccine", "type": "BIOLOGICAL" }, { "name": "PfSPZ Challenge (7G8) for CHMI", "type": "BIOLOGICAL" }, { "name": "Normal Saline", "type": "OTHER" } ], "intervention_types": [ "BIOLOGICAL", "OTHER" ], "sponsor": "Sanaria Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 54, "start_date": "2021-09-27", "completion_date": "2022-06-21", "has_results": false, "last_update_posted_date": "2022-07-18", "last_synced_at": "2026-09-29T02:32:27.651Z", "location_count": 1, "location_summary": "Seattle, Washington", "locations": [ { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT04966871" }, { "nct_id": "NCT00385047", "title": "A Study to Determine Whether 2 Investigational Malaria Vaccines Are Safe, Protective Against Malaria in Adults", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Malaria" ], "interventions": [ { "name": "Group A FMP2.1/AS01B", "type": "BIOLOGICAL" }, { "name": "Group B FMP2.1/AS02A", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "U.S. Army Medical Research and Development Command", "sponsor_class": "FED", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 41, "start_date": "2006-09", "completion_date": "2007-09", "has_results": false, "last_update_posted_date": "2015-06-08", "last_synced_at": "2026-09-29T02:32:27.651Z", "location_count": 1, "location_summary": "Silver Spring, Maryland", "locations": [ { "city": "Silver Spring", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00385047" }, { "nct_id": "NCT01366534", "title": "Safety, Immunogenicity and Efficacy Against of a Combined Malaria Vaccine in Healthy Malaria-naïve Adults", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Malaria" ], "interventions": [ { "name": "Crucell's replication deficient adenovirus type 35 circumsporozoite malaria vaccine (Ad35.CS.01)", "type": "BIOLOGICAL" }, { "name": "GSK Biologicals' malaria vaccine 257049 (2 doses)", "type": "BIOLOGICAL" }, { "name": "GSK Biologicals' malaria vaccine 257049 (3 doses)", "type": "BIOLOGICAL" }, { "name": "Sporozoite challenge", "type": "OTHER" } ], "intervention_types": [ "BIOLOGICAL", "OTHER" ], "sponsor": "GlaxoSmithKline", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 67, "start_date": "2011-08-10", "completion_date": "2012-07-03", "has_results": true, "last_update_posted_date": "2019-06-18", "last_synced_at": "2026-09-29T02:32:27.651Z", "location_count": 1, "location_summary": "Silver Spring, Maryland", "locations": [ { "city": "Silver Spring", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT01366534" }, { "nct_id": "NCT00408369", "title": "Prophylactic Antimalarial Activity of DB289 in Volunteers", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Prophylactic Activity Against Malaria" ], "interventions": [ { "name": "DB289", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Immtech Pharmaceuticals, Inc", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "ALL", "summary": "18 Years to 45 Years" }, "enrollment_count": 19, "start_date": "2006-11", "completion_date": "2007-11", "has_results": false, "last_update_posted_date": "2008-01-29", "last_synced_at": "2026-09-29T02:32:27.651Z", "location_count": 1, "location_summary": "Baltimore, Maryland", "locations": [ { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00408369" }, { "nct_id": "NCT01024686", "title": "Phase 1/2a Trial of Pf GAP p52-/p36- Sporozoite Malaria Vaccine", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Malaria" ], "interventions": [ { "name": "p52-/p36- GAP Vaccine", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL" ], "sponsor": "Seattle Children's Hospital", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 6, "start_date": "2010-03", "completion_date": "2011-06", "has_results": true, "last_update_posted_date": "2019-10-28", "last_synced_at": "2026-09-29T02:32:27.651Z", "location_count": 1, "location_summary": "Silver Spring, Maryland", "locations": [ { "city": "Silver Spring", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT01024686" }, { "nct_id": "NCT04268420", "title": "A Trial For The Study of Falciparum Malaria Protein 013 Administered Via Intramuscular Injection in Healthy Adults", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Vaccine Reaction" ], "interventions": [ { "name": "FMP013", "type": "DRUG" }, { "name": "ALFQ", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "U.S. Army Medical Research and Development Command", "sponsor_class": "FED", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 46, "start_date": "2020-03-20", "completion_date": "2023-12", "has_results": false, "last_update_posted_date": "2023-01-10", "last_synced_at": "2026-09-29T02:32:27.651Z", "location_count": 1, "location_summary": "Silver Spring, Maryland", "locations": [ { "city": "Silver Spring", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT04268420" } ] }