{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Manual+titration",
    "query": {
      "intervention": "Manual titration"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-06T23:59:24.596Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00631748",
      "title": "Quetiapine for the Reduction of Cocaine Use",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Cocaine Dependence",
        "Cocaine Abuse",
        "Cocaine Addiction",
        "Drug Abuse",
        "Substance Abuse"
      ],
      "interventions": [
        {
          "name": "quetiapine fumarate",
          "type": "DRUG"
        },
        {
          "name": "Matched Placebo",
          "type": "DRUG"
        },
        {
          "name": "Cognitive-behavioral Therapy",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL"
      ],
      "sponsor": "Seattle Institute for Biomedical and Clinical Research",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 60,
      "start_date": "2008-02",
      "completion_date": "2010-07",
      "has_results": true,
      "last_update_posted_date": "2014-03-31",
      "last_synced_at": "2026-09-06T23:59:24.596Z",
      "location_count": 1,
      "location_summary": "Tacoma, Washington",
      "locations": [
        {
          "city": "Tacoma",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00631748"
    },
    {
      "nct_id": "NCT06367387",
      "title": "Pain Self-Management and Patient-Oriented Dosing for Pain and in Retention Opioid Treatment",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Opioid Use Disorder",
        "Chronic Pain"
      ],
      "interventions": [
        {
          "name": "Patient-Oriented Dosing (POD)",
          "type": "DRUG"
        },
        {
          "name": "Pain Self-Management (PSM)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Usual Care",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Standard Buprenorphine Dosing Condition",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL"
      ],
      "sponsor": "Erin Winstanley",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 273,
      "start_date": "2024-05-28",
      "completion_date": "2026-10-31",
      "has_results": false,
      "last_update_posted_date": "2026-08-18",
      "last_synced_at": "2026-09-06T23:59:24.596Z",
      "location_count": 13,
      "location_summary": "Baltimore, Maryland • Dundalk, Maryland • Hagerstown, Maryland + 6 more",
      "locations": [
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Dundalk",
          "state": "Maryland"
        },
        {
          "city": "Hagerstown",
          "state": "Maryland"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06367387"
    },
    {
      "nct_id": "NCT06572449",
      "title": "Study to Assess Safety and Effectiveness of Slowly Increasing Dose and Food Effect of KarXT in Participants With Schizophrenia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Schizophrenia"
      ],
      "interventions": [
        {
          "name": "KarXT",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Karuna Therapeutics, Inc., a Bristol Myers Squibb company",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 173,
      "start_date": "2024-10-28",
      "completion_date": "2025-03-13",
      "has_results": true,
      "last_update_posted_date": "2026-06-22",
      "last_synced_at": "2026-09-06T23:59:24.596Z",
      "location_count": 6,
      "location_summary": "Los Alamitos, California • Riverside, California • Hollywood, Florida + 3 more",
      "locations": [
        {
          "city": "Los Alamitos",
          "state": "California"
        },
        {
          "city": "Riverside",
          "state": "California"
        },
        {
          "city": "Hollywood",
          "state": "Florida"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Decatur",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06572449"
    },
    {
      "nct_id": "NCT06374225",
      "title": "Strategy to Avoid Excessive Oxygen Using an Autonomous Oxygen Titration Intervention",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Critical Illness",
        "Wounds and Injury",
        "Disease Attributes",
        "Pathologic Processes"
      ],
      "interventions": [
        {
          "name": "Automated Titration (O2matic)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "University of Colorado, Denver",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 300,
      "start_date": "2024-04-29",
      "completion_date": "2026-01-09",
      "has_results": false,
      "last_update_posted_date": "2026-04-29",
      "last_synced_at": "2026-09-06T23:59:24.596Z",
      "location_count": 4,
      "location_summary": "Aurora, Colorado • Winston-Salem, North Carolina • Portland, Oregon + 1 more",
      "locations": [
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        },
        {
          "city": "Nashville",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06374225"
    },
    {
      "nct_id": "NCT02675400",
      "title": "Treatments for Fathers With ADHD and Their At-Risk Children (Fathers Too)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Attention Deficit/Hyperactivity Disorder (ADHD)"
      ],
      "interventions": [
        {
          "name": "Vyvanse",
          "type": "DRUG"
        },
        {
          "name": "Behavioral Parent Training",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Methylphenidate",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL"
      ],
      "sponsor": "Seattle Children's Hospital",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": "55 Years",
        "sex": "MALE",
        "summary": "21 Years to 55 Years · Male only"
      },
      "enrollment_count": 19,
      "start_date": "2015-12",
      "completion_date": "2018-08-31",
      "has_results": false,
      "last_update_posted_date": "2018-09-12",
      "last_synced_at": "2026-09-06T23:59:24.596Z",
      "location_count": 1,
      "location_summary": "Seattle, Washington",
      "locations": [
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02675400"
    },
    {
      "nct_id": "NCT07740291",
      "title": "Tirzepatide Impact Assessment Study",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Obesity & Overweight",
        "Cardiometabolic Health Indicators",
        "Addiction",
        "Eating Disorders",
        "Mental Health"
      ],
      "interventions": [
        {
          "name": "GLP-1 Receptor Agonist Therapy",
          "type": "DRUG"
        },
        {
          "name": "Structured Lifestyle Intervention",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DRUG",
        "BEHAVIORAL"
      ],
      "sponsor": "Texas Tech University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 27,
      "start_date": "2025-01-02",
      "completion_date": "2026-12-07",
      "has_results": false,
      "last_update_posted_date": "2026-07-31",
      "last_synced_at": "2026-09-06T23:59:24.596Z",
      "location_count": 1,
      "location_summary": "Lubbock, Texas",
      "locations": [
        {
          "city": "Lubbock",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07740291"
    },
    {
      "nct_id": "NCT05030012",
      "title": "Maintaining Optimal HVNI Delivery Using Automatic Titration of Oxygen in Preterm Infants",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Infant, Premature",
        "Neonatal Respiratory Distress",
        "Oxygen Saturation",
        "Bronchopulmonary Dysplasia"
      ],
      "interventions": [
        {
          "name": "Automated Control",
          "type": "DEVICE"
        },
        {
          "name": "Manual Control",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Vapotherm, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": null,
        "sex": "ALL",
        "summary": "Not listed"
      },
      "enrollment_count": 15,
      "start_date": "2021-09-02",
      "completion_date": "2023-10-19",
      "has_results": true,
      "last_update_posted_date": "2024-06-26",
      "last_synced_at": "2026-09-06T23:59:24.596Z",
      "location_count": 3,
      "location_summary": "Washington D.C., District of Columbia • Salt Lake City, Utah • Seattle, Washington",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Salt Lake City",
          "state": "Utah"
        },
        {
          "city": "Seattle",
          "state": "Washington"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05030012"
    },
    {
      "nct_id": "NCT05889624",
      "title": "Responding With Evidence and Access for Childhood Headaches",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Headache",
        "Headache Disorders",
        "Headache, Migraine",
        "Migraine",
        "Migraine Disorders",
        "Migraine With Aura",
        "Migraine Without Aura",
        "Chronic Migraine"
      ],
      "interventions": [
        {
          "name": "CBT",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Amitriptyline",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL",
        "DRUG"
      ],
      "sponsor": "Children's Hospital Medical Center, Cincinnati",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "10 Years",
        "maximum_age": "17 Years",
        "sex": "ALL",
        "summary": "10 Years to 17 Years"
      },
      "enrollment_count": 400,
      "start_date": "2023-08-22",
      "completion_date": "2027-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-08-27",
      "last_synced_at": "2026-09-06T23:59:24.596Z",
      "location_count": 15,
      "location_summary": "Birmingham, Alabama • Phoenix, Arizona • San Francisco, California + 12 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        },
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Aurora",
          "state": "Colorado"
        },
        {
          "city": "Wilmington",
          "state": "Delaware"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05889624"
    },
    {
      "nct_id": "NCT07222410",
      "title": "Closed Loop Oxygen Control in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Nasal High Flow in the Hospital",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "COPD"
      ],
      "interventions": [
        {
          "name": "Closed loop oxygen control",
          "type": "DEVICE"
        },
        {
          "name": "Manual titration",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Fisher and Paykel Healthcare",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "22 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "22 Years and older"
      },
      "enrollment_count": 70,
      "start_date": "2026-01-07",
      "completion_date": "2027-11",
      "has_results": false,
      "last_update_posted_date": "2026-06-23",
      "last_synced_at": "2026-09-06T23:59:24.596Z",
      "location_count": 4,
      "location_summary": "Birmingham, Alabama • Des Moines, Iowa • New York, New York + 1 more",
      "locations": [
        {
          "city": "Birmingham",
          "state": "Alabama"
        },
        {
          "city": "Des Moines",
          "state": "Iowa"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07222410"
    },
    {
      "nct_id": "NCT01942356",
      "title": "Evaluation of Closed-loop TIVA Propofol, Sufentanil and Ketamine Guided by BIS Monitor",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acute Cholecystitis",
        "Chronic Cholecystitis"
      ],
      "interventions": [
        {
          "name": "TIVA - Hypotension",
          "type": "PROCEDURE"
        },
        {
          "name": "TIVA - Hypertension",
          "type": "PROCEDURE"
        },
        {
          "name": "TIVA - Bradycardia",
          "type": "PROCEDURE"
        },
        {
          "name": "TIVA - Tachycardia",
          "type": "PROCEDURE"
        },
        {
          "name": "INH - Hypotension",
          "type": "PROCEDURE"
        },
        {
          "name": "INH - Hypertension",
          "type": "PROCEDURE"
        },
        {
          "name": "INH - Bradycardia",
          "type": "PROCEDURE"
        },
        {
          "name": "INH - Tachycardia",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "The University of Texas Health Science Center at San Antonio",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 4,
      "start_date": "2013-09",
      "completion_date": "2014-08",
      "has_results": false,
      "last_update_posted_date": "2015-01-27",
      "last_synced_at": "2026-09-06T23:59:24.596Z",
      "location_count": 1,
      "location_summary": "San Antonio, Texas",
      "locations": [
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01942356"
    }
  ]
}