{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Meal+replacement+and+lifestyle+modification",
    "query": {
      "intervention": "Meal replacement and lifestyle modification"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 19,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Meal+replacement+and+lifestyle+modification&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-27T23:19:25.252Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT01278823",
      "title": "Effect of Bariatric Surgery on Mechanisms of Type 2 Diabetes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Obesity",
        "Type 2 Diabetes"
      ],
      "interventions": [
        {
          "name": "laparoscopic roux en y gastric bypass operation",
          "type": "PROCEDURE"
        },
        {
          "name": "medical management",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "OTHER"
      ],
      "sponsor": "The Cleveland Clinic",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "60 Years",
        "sex": "ALL",
        "summary": "18 Years to 60 Years"
      },
      "enrollment_count": 18,
      "start_date": "2011-01",
      "completion_date": "2017-02-15",
      "has_results": false,
      "last_update_posted_date": "2019-07-11",
      "last_synced_at": "2026-09-27T23:19:25.252Z",
      "location_count": 1,
      "location_summary": "Cleveland, Ohio",
      "locations": [
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01278823"
    },
    {
      "nct_id": "NCT04327141",
      "title": "Low Sugar Protein Pacing, Intermittent Fasting Diet in Men and Women",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Weight Loss",
        "Gut Microbiome",
        "Anti-Aging"
      ],
      "interventions": [
        {
          "name": "P-IF",
          "type": "BEHAVIORAL"
        },
        {
          "name": "HH",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Skidmore College",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "25 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "25 Years to 65 Years"
      },
      "enrollment_count": 40,
      "start_date": "2020-09-03",
      "completion_date": "2024-12-31",
      "has_results": false,
      "last_update_posted_date": "2024-04-08",
      "last_synced_at": "2026-09-27T23:19:25.252Z",
      "location_count": 1,
      "location_summary": "Saratoga Springs, New York",
      "locations": [
        {
          "city": "Saratoga Springs",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04327141"
    },
    {
      "nct_id": "NCT00207519",
      "title": "Liquid Meal Replacements in Conjunction With Lifestyle Intervention in Overweight Adolescents",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Overweight",
        "Obesity"
      ],
      "interventions": [
        {
          "name": "weekly behavioral modification group",
          "type": "BEHAVIORAL"
        },
        {
          "name": "liquid meal replacements",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Boston Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": "18 Years",
        "sex": "ALL",
        "summary": "12 Years to 18 Years"
      },
      "enrollment_count": 40,
      "start_date": "2003-04",
      "completion_date": "2009-01",
      "has_results": false,
      "last_update_posted_date": "2009-02-11",
      "last_synced_at": "2026-09-27T23:19:25.252Z",
      "location_count": 1,
      "location_summary": "Boston, Massachusetts",
      "locations": [
        {
          "city": "Boston",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00207519"
    },
    {
      "nct_id": "NCT03423238",
      "title": "Targeting Obesity to Optimize Health in Cardiac Rehab (TOPCARE)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Obesity",
        "Weight Loss",
        "CHD - Coronary Heart Disease"
      ],
      "interventions": [
        {
          "name": "Exercise",
          "type": "OTHER"
        },
        {
          "name": "Health Education",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Exercise Compliance",
          "type": "OTHER"
        },
        {
          "name": "Calorie-Restricted Diet",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Behavioral Modification",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Weight-Loss Compliance",
          "type": "OTHER"
        },
        {
          "name": "Dietary Counseling",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER",
        "BEHAVIORAL",
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Wake Forest University Health Sciences",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "40 Years and older"
      },
      "enrollment_count": 38,
      "start_date": "2018-03-21",
      "completion_date": "2020-04-10",
      "has_results": true,
      "last_update_posted_date": "2021-11-23",
      "last_synced_at": "2026-09-27T23:19:25.252Z",
      "location_count": 1,
      "location_summary": "Winston-Salem, North Carolina",
      "locations": [
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03423238"
    },
    {
      "nct_id": "NCT00704912",
      "title": "Treatment of Hyperandrogenism Versus Insulin Resistance in Infertile Polycystic Ovary Syndrome (PCOS) Women",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Polycystic Ovary Syndrome"
      ],
      "interventions": [
        {
          "name": "Orlistat/Meal Replacement/Lifestyle Modification",
          "type": "DRUG"
        },
        {
          "name": "Loestrin 1/20",
          "type": "DRUG"
        },
        {
          "name": "Combination of treatments",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Milton S. Hershey Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 40 Years · Female only"
      },
      "enrollment_count": 217,
      "start_date": "2008-09",
      "completion_date": "2014-03",
      "has_results": true,
      "last_update_posted_date": "2016-11-07",
      "last_synced_at": "2026-09-27T23:19:25.252Z",
      "location_count": 2,
      "location_summary": "Hershey, Pennsylvania • Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Hershey",
          "state": "Pennsylvania"
        },
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00704912"
    },
    {
      "nct_id": "NCT01729117",
      "title": "A Trial of Meal Replacement at a Community Diabetes Clinic Serving a Low Socioeconomic Hispanic Population",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Type 2 Diabetes",
        "Obesity"
      ],
      "interventions": [
        {
          "name": "Meal Replacement",
          "type": "OTHER"
        },
        {
          "name": "Standard Care",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Southern California",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 30,
      "start_date": "2009-05",
      "completion_date": "2012-04",
      "has_results": false,
      "last_update_posted_date": "2012-11-20",
      "last_synced_at": "2026-09-27T23:19:25.252Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01729117"
    },
    {
      "nct_id": "NCT01702012",
      "title": "Almased Multi-Center Diabetes Intervention Trial",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Type 2 Diabetes",
        "Obesity"
      ],
      "interventions": [
        {
          "name": "Almased Meal Replacement Powder",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Group-Based Lifestyle Intervention",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT",
        "BEHAVIORAL"
      ],
      "sponsor": "Wake Forest University Health Sciences",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 240,
      "start_date": "2013-01",
      "completion_date": "2015-05",
      "has_results": false,
      "last_update_posted_date": "2020-01-31",
      "last_synced_at": "2026-09-27T23:19:25.252Z",
      "location_count": 1,
      "location_summary": "Winston-Salem, North Carolina",
      "locations": [
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01702012"
    },
    {
      "nct_id": "NCT05139420",
      "title": "Risk of Metabolic Adaptation After Weight Loss",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Weight Loss",
        "Obesity"
      ],
      "interventions": [
        {
          "name": "lifestyle intervention with meal replacement program",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Medical College of Wisconsin",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 60,
      "start_date": "2022-09-10",
      "completion_date": "2031-11",
      "has_results": false,
      "last_update_posted_date": "2026-02-11",
      "last_synced_at": "2026-09-27T23:19:25.252Z",
      "location_count": 1,
      "location_summary": "Milwaukee, Wisconsin",
      "locations": [
        {
          "city": "Milwaukee",
          "state": "Wisconsin"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05139420"
    },
    {
      "nct_id": "NCT02869659",
      "title": "Valued EpiGenetic Glycemic ImprovEments Through Weight Loss",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Obesity",
        "Pre-diabetes"
      ],
      "interventions": [
        {
          "name": "Weight Loss Group",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Delayed Weight Loss",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "Wake Forest University Health Sciences",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "40 Years to 65 Years"
      },
      "enrollment_count": 138,
      "start_date": "2016-11-01",
      "completion_date": "2020-12-02",
      "has_results": false,
      "last_update_posted_date": "2020-12-31",
      "last_synced_at": "2026-09-27T23:19:25.252Z",
      "location_count": 1,
      "location_summary": "Winston-Salem, North Carolina",
      "locations": [
        {
          "city": "Winston-Salem",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02869659"
    },
    {
      "nct_id": "NCT03156660",
      "title": "Efficacy of Two Novel Behavioral Post-cessation Weight Gain Interventions",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Weight Change, Body",
        "Smoking Cessation"
      ],
      "interventions": [
        {
          "name": "Weight gain prevention (Group 1)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Weight loss intervention (Group 2)",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Self-guided intervention (Group 3)",
          "type": "BEHAVIORAL"
        }
      ],
      "intervention_types": [
        "BEHAVIORAL"
      ],
      "sponsor": "University of Tennessee",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 305,
      "start_date": "2017-11-30",
      "completion_date": "2022-03-12",
      "has_results": true,
      "last_update_posted_date": "2023-04-21",
      "last_synced_at": "2026-09-27T23:19:25.252Z",
      "location_count": 1,
      "location_summary": "Memphis, Tennessee",
      "locations": [
        {
          "city": "Memphis",
          "state": "Tennessee"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03156660"
    }
  ]
}