{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Megestrol&page=2", "query": { "intervention": "Megestrol", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 10, "total_pages": 1, "next_page_url": null, "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Megestrol&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-09-20T05:05:27.357Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT06979596", "title": "A Study of MK-5684 in People With Certain Solid Tumors (MK-5684-015/OMAHA-015)", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Malignant Neoplasm" ], "interventions": [ { "name": "Opevesostat", "type": "DRUG" }, { "name": "Fludrocortisone/ Fludrocortisone acetate", "type": "DRUG" }, { "name": "Dexamethasone/Dexamethasone acetate", "type": "DRUG" }, { "name": "Rescue Medications", "type": "DRUG" }, { "name": "Fulvestrant", "type": "DRUG" }, { "name": "Exemestane", "type": "DRUG" }, { "name": "Megestrol acetate/Medroxyprogesterone acetate", "type": "DRUG" }, { "name": "Tamoxifen", "type": "DRUG" }, { "name": "Letrozole", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Merck Sharp & Dohme LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 250, "start_date": "2025-08-11", "completion_date": "2027-11-04", "has_results": false, "last_update_posted_date": "2026-08-28", "last_synced_at": "2026-09-20T05:05:27.357Z", "location_count": 10, "location_summary": "Anchorage, Alaska • Miami Beach, Florida • Shreveport, Louisiana + 6 more", "locations": [ { "city": "Anchorage", "state": "Alaska" }, { "city": "Miami Beach", "state": "Florida" }, { "city": "Shreveport", "state": "Louisiana" }, { "city": "Hastings", "state": "Nebraska" }, { "city": "Hackensack", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT06979596" }, { "nct_id": "NCT01206478", "title": "Trial of Amitriptyline for Chronic Oral Food Refusal in Children 9 Months to 8 Years of Age", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Chronic Oral Food Refusal" ], "interventions": [ { "name": "Amitriptyline", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Megestrol", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Ann Davis, PhD, MPH, ABPP", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "9 Months", "maximum_age": "8 Years", "sex": "ALL", "summary": "9 Months to 8 Years" }, "enrollment_count": 21, "start_date": "2010-08", "completion_date": "2014-12", "has_results": true, "last_update_posted_date": "2016-08-15", "last_synced_at": "2026-09-20T05:05:27.357Z", "location_count": 3, "location_summary": "Kansas City, Kansas • New Orleans, Louisiana • Columbus, Ohio", "locations": [ { "city": "Kansas City", "state": "Kansas" }, { "city": "New Orleans", "state": "Louisiana" }, { "city": "Columbus", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT01206478" }, { "nct_id": "NCT00031785", "title": "Megestrol in Treating Patients Who Are Undergoing Radiation Therapy for Lung Cancer", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Anorexia", "Cachexia", "Lung Cancer" ], "interventions": [ { "name": "megestrol acetate", "type": "DRUG" }, { "name": "radiation therapy", "type": "RADIATION" } ], "intervention_types": [ "DRUG", "RADIATION" ], "sponsor": "Wake Forest University Health Sciences", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "120 Years", "sex": "ALL", "summary": "18 Years to 120 Years" }, "enrollment_count": 25, "start_date": "2000-09-01", "completion_date": "2002-09-11", "has_results": false, "last_update_posted_date": "2021-09-09", "last_synced_at": "2026-09-20T05:05:27.357Z", "location_count": 1, "location_summary": "Winston-Salem, North Carolina", "locations": [ { "city": "Winston-Salem", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT00031785" }, { "nct_id": "NCT04576104", "title": "Megestrol Acetate Compared With Megestrol Acetate and Metformin to Prevent Endometrial Cancer", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia", "Endometrial Carcinoma" ], "interventions": [ { "name": "Biopsy Procedure", "type": "PROCEDURE" }, { "name": "Extended Release Metformin Hydrochloride", "type": "DRUG" }, { "name": "Megestrol Acetate", "type": "DRUG" }, { "name": "Questionnaire Administration", "type": "OTHER" } ], "intervention_types": [ "PROCEDURE", "DRUG", "OTHER" ], "sponsor": "Northwestern University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 51, "start_date": "2021-11-29", "completion_date": "2026-06-30", "has_results": false, "last_update_posted_date": "2026-01-21", "last_synced_at": "2026-09-20T05:05:27.357Z", "location_count": 8, "location_summary": "Los Angeles, California • Denver, Colorado • Chicago, Illinois + 5 more", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "Denver", "state": "Colorado" }, { "city": "Chicago", "state": "Illinois" }, { "city": "Winfield", "state": "Illinois" }, { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT04576104" }, { "nct_id": "NCT02595723", "title": "Phenytoin for Memory Impairment Secondary to Megestrol", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Cognitive Impairment" ], "interventions": [ { "name": "Phenytoin 200 mg capsule", "type": "DRUG" }, { "name": "Megestrol 800 mg liquid", "type": "DRUG" }, { "name": "Phenytoin-matched Placebo capsule", "type": "DRUG" }, { "name": "Megestrol-matched liquid Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Texas Southwestern Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "18 Years to 50 Years" }, "enrollment_count": 21, "start_date": "2015-07", "completion_date": "2016-12", "has_results": true, "last_update_posted_date": "2019-09-09", "last_synced_at": "2026-09-20T05:05:27.357Z", "location_count": 1, "location_summary": "Dallas, Texas", "locations": [ { "city": "Dallas", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT02595723" }, { "nct_id": "NCT01200602", "title": "Megestrol Acetate in Treating Weight Loss or Anorexia in Young Patients With Malignancies Who Are Undergoing Radiation Therapy and/or Chemotherapy", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Anorexia", "Weight Changes" ], "interventions": [ { "name": "megestrol acetate", "type": "DRUG" }, { "name": "clinical observation", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Mayo Clinic", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": null, "maximum_age": "21 Years", "sex": "ALL", "summary": "Up to 21 Years" }, "enrollment_count": 1, "start_date": "2011-03", "completion_date": "2012-01", "has_results": true, "last_update_posted_date": "2015-11-25", "last_synced_at": "2026-09-20T05:05:27.357Z", "location_count": 1, "location_summary": "Rochester, Minnesota", "locations": [ { "city": "Rochester", "state": "Minnesota" } ], "official_url": "https://clinicaltrials.gov/study/NCT01200602" }, { "nct_id": "NCT00001079", "title": "A Study of Megestrol Acetate Alone or in Combination With Testosterone Enanthate Drug in the Treatment of HIV-Associated Weight Loss", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "HIV Infections", "HIV Wasting Syndrome" ], "interventions": [ { "name": "Testosterone enanthate", "type": "DRUG" }, { "name": "Megestrol acetate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 80, "start_date": null, "completion_date": "2002-12", "has_results": false, "last_update_posted_date": "2021-11-01", "last_synced_at": "2026-09-20T05:05:27.357Z", "location_count": 21, "location_summary": "Los Angeles, California • San Francisco, California • Aurora, Colorado + 12 more", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "San Francisco", "state": "California" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Washington D.C.", "state": "District of Columbia" } ], "official_url": "https://clinicaltrials.gov/study/NCT00001079" }, { "nct_id": "NCT00002067", "title": "A Study Comparing Megestrol Acetate at 800 mg/Day, and Placebo in AIDS Patients With Anorexia and Cachexia", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Anorexia", "Cachexia", "HIV Infections" ], "interventions": [ { "name": "Megestrol acetate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Bristol-Myers Squibb", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": null, "start_date": null, "completion_date": null, "has_results": false, "last_update_posted_date": "2007-10-02", "last_synced_at": "2026-09-20T05:05:27.357Z", "location_count": 14, "location_summary": "Los Angeles, California • Oakland, California • Palo Alto, California + 10 more", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "Oakland", "state": "California" }, { "city": "Palo Alto", "state": "California" }, { "city": "Rancho Mirage", "state": "California" }, { "city": "Sacramento", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00002067" }, { "nct_id": "NCT00006799", "title": "Megestrol to Limit Weight Loss and Improve Quality of Life in Treating Patients With Head and Neck Cancer", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Anorexia", "Cachexia", "Head and Neck Cancer", "Quality of Life" ], "interventions": [ { "name": "megestrol acetate", "type": "DRUG" }, { "name": "quality-of-life assessment", "type": "PROCEDURE" } ], "intervention_types": [ "DRUG", "PROCEDURE" ], "sponsor": "Wake Forest University Health Sciences", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "120 Years", "sex": "ALL", "summary": "18 Years to 120 Years" }, "enrollment_count": 13, "start_date": "2000-10-01", "completion_date": "2002-09-06", "has_results": false, "last_update_posted_date": "2021-09-09", "last_synced_at": "2026-09-20T05:05:27.357Z", "location_count": 1, "location_summary": "Winston-Salem, North Carolina", "locations": [ { "city": "Winston-Salem", "state": "North Carolina" } ], "official_url": "https://clinicaltrials.gov/study/NCT00006799" }, { "nct_id": "NCT00002680", "title": "Sequential High-Dose Chemotherapy and Stem Cell Transplantation in Treating Patients With Chemotherapy-Sensitive Metastatic Breast Cancer", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Breast Cancer" ], "interventions": [ { "name": "filgrastim", "type": "BIOLOGICAL" }, { "name": "cyclophosphamide", "type": "DRUG" }, { "name": "megestrol acetate", "type": "DRUG" }, { "name": "melphalan", "type": "DRUG" }, { "name": "tamoxifen citrate", "type": "DRUG" }, { "name": "thiotepa", "type": "DRUG" }, { "name": "conventional surgery", "type": "PROCEDURE" }, { "name": "peripheral blood stem cell transplantation", "type": "PROCEDURE" }, { "name": "radiation therapy", "type": "RADIATION" } ], "intervention_types": [ "BIOLOGICAL", "DRUG", "PROCEDURE", "RADIATION" ], "sponsor": "Yale University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 40, "start_date": "1994-02", "completion_date": "2000-12", "has_results": false, "last_update_posted_date": "2013-07-24", "last_synced_at": "2026-09-20T05:05:27.357Z", "location_count": 1, "location_summary": "New Haven, Connecticut", "locations": [ { "city": "New Haven", "state": "Connecticut" } ], "official_url": "https://clinicaltrials.gov/study/NCT00002680" } ] }