{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Metafolin",
    "query": {
      "intervention": "Metafolin"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 4,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-06T03:56:54.414Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00468481",
      "title": "Efficacy and Safety Study for an Oral Contraceptive Containing Folate",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Neural Tube Defects",
        "Contraception",
        "Oral Contraceptives (OC)"
      ],
      "interventions": [
        {
          "name": "Drospirenone/Ethinylestradiol/Methyltetrahydrofolate",
          "type": "DRUG"
        },
        {
          "name": "Drospirenone/Ethinylestradiol (Yaz)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Bayer",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 40 Years · Female only"
      },
      "enrollment_count": 385,
      "start_date": "2007-04",
      "completion_date": "2008-09",
      "has_results": true,
      "last_update_posted_date": "2014-04-23",
      "last_synced_at": "2026-09-06T03:56:54.414Z",
      "location_count": 9,
      "location_summary": "Anaheim, California • San Diego, California • Baltimore, Maryland + 6 more",
      "locations": [
        {
          "city": "Anaheim",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "New York",
          "state": "New York"
        },
        {
          "city": "Morrisville",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00468481"
    },
    {
      "nct_id": "NCT01360996",
      "title": "Low Dose OC Therapy in Women With Polycystic Ovary Syndrome (PCOS): Impact of BMI on Hyperandrogenism",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Polycystic Ovary Syndrome"
      ],
      "interventions": [
        {
          "name": "3 mg DRSP/20 μg EE",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Woman's",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": "35 Years",
        "sex": "FEMALE",
        "summary": "16 Years to 35 Years · Female only"
      },
      "enrollment_count": 64,
      "start_date": "2011-08",
      "completion_date": "2015-02",
      "has_results": true,
      "last_update_posted_date": "2017-03-31",
      "last_synced_at": "2026-09-06T03:56:54.414Z",
      "location_count": 1,
      "location_summary": "Baton Rouge, Louisiana",
      "locations": [
        {
          "city": "Baton Rouge",
          "state": "Louisiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01360996"
    },
    {
      "nct_id": "NCT00348933",
      "title": "Dietary Supplements for the Treatment of Angelman Syndrome",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Angelman Syndrome",
        "Nervous System Diseases"
      ],
      "interventions": [
        {
          "name": "Betaine",
          "type": "DRUG"
        },
        {
          "name": "Creatine",
          "type": "DRUG"
        },
        {
          "name": "Metafolin",
          "type": "DRUG"
        },
        {
          "name": "Vitamin B12",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of California, San Diego",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "1 Day",
        "maximum_age": "5 Years",
        "sex": "ALL",
        "summary": "1 Day to 5 Years"
      },
      "enrollment_count": 90,
      "start_date": "2006-07",
      "completion_date": "2010-02",
      "has_results": true,
      "last_update_posted_date": "2012-09-24",
      "last_synced_at": "2026-09-06T03:56:54.414Z",
      "location_count": 4,
      "location_summary": "San Diego, California • Boston, Massachusetts • Greenwood, South Carolina + 1 more",
      "locations": [
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Greenwood",
          "state": "South Carolina"
        },
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00348933"
    },
    {
      "nct_id": "NCT01370954",
      "title": "NAC-003 P.L.U.S. Program (Progress Through Learning Understanding & Support)",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Early Memory Loss",
        "Mild Cognitive Impairment",
        "Alzheimer's Disease",
        "Vascular Dementia"
      ],
      "interventions": [
        {
          "name": "CerefolinNAC®",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Pamlab, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": "80 Years",
        "sex": "ALL",
        "summary": "50 Years to 80 Years"
      },
      "enrollment_count": 204,
      "start_date": "2011-05",
      "completion_date": "2012-12",
      "has_results": false,
      "last_update_posted_date": "2013-05-09",
      "last_synced_at": "2026-09-06T03:56:54.414Z",
      "location_count": 1,
      "location_summary": "Hickory, North Carolina",
      "locations": [
        {
          "city": "Hickory",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01370954"
    }
  ]
}