{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Metformin+%2B+Insulin", "query": { "intervention": "Metformin + Insulin" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 223, "total_pages": 23, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Metformin+%2B+Insulin&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-10-03T15:31:37.912Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01952145", "title": "A Trial Comparing the Efficacy and Safety of Insulin Degludec/Liraglutide Versus Insulin Glargine in Subjects With Type 2 Diabetes Mellitus", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetes", "Diabetes Mellitus, Type 2" ], "interventions": [ { "name": "insulin degludec/liraglutide", "type": "DRUG" }, { "name": "insulin glargine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novo Nordisk A/S", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 557, "start_date": "2013-09-20", "completion_date": "2014-11-04", "has_results": true, "last_update_posted_date": "2019-01-03", "last_synced_at": "2026-10-03T15:31:37.912Z", "location_count": 31, "location_summary": "Fresno, California • Los Alamitos, California • Palm Springs, California + 26 more", "locations": [ { "city": "Fresno", "state": "California" }, { "city": "Los Alamitos", "state": "California" }, { "city": "Palm Springs", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Colorado Springs", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT01952145" }, { "nct_id": "NCT02072096", "title": "A Comparison of Two Treatment Strategies in Older Participants With Type 2 Diabetes Mellitus (T2DM)", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Diabetes Mellitus, Type 2" ], "interventions": [ { "name": "Glimepiride", "type": "DRUG" }, { "name": "Metformin", "type": "DRUG" }, { "name": "Pioglitazone", "type": "DRUG" }, { "name": "Acarbose", "type": "DRUG" }, { "name": "Linagliptin", "type": "DRUG" }, { "name": "Sitagliptin", "type": "DRUG" }, { "name": "Liraglutide", "type": "DRUG" }, { "name": "Insulin Glargine", "type": "DRUG" }, { "name": "Exenatide once weekly (QW)", "type": "DRUG" }, { "name": "Exenatide twice daily (BID)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Eli Lilly and Company", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "65 Years", "maximum_age": null, "sex": "ALL", "summary": "65 Years and older" }, "enrollment_count": 192, "start_date": "2014-02", "completion_date": "2015-10", "has_results": true, "last_update_posted_date": "2019-10-09", "last_synced_at": "2026-10-03T15:31:37.912Z", "location_count": 16, "location_summary": "Miami, Florida • New Port Richey, Florida • Orlando, Florida + 12 more", "locations": [ { "city": "Miami", "state": "Florida" }, { "city": "Miami", "state": "Florida" }, { "city": "New Port Richey", "state": "Florida" }, { "city": "Orlando", "state": "Florida" }, { "city": "Athens", "state": "Georgia" } ], "official_url": "https://clinicaltrials.gov/study/NCT02072096" }, { "nct_id": "NCT01392573", "title": "A Trial Comparing the Efficacy and Safety of Insulin Degludec/Liraglutide and Insulin Degludec in Subjects With Type 2 Diabetes", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetes", "Diabetes Mellitus, Type 2" ], "interventions": [ { "name": "insulin degludec/liraglutide", "type": "DRUG" }, { "name": "insulin degludec", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novo Nordisk A/S", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 413, "start_date": "2011-11-28", "completion_date": "2012-10-04", "has_results": true, "last_update_posted_date": "2019-01-03", "last_synced_at": "2026-10-03T15:31:37.912Z", "location_count": 58, "location_summary": "Huntsville, Alabama • Vestavia Hills, Alabama • Anaheim, California + 49 more", "locations": [ { "city": "Huntsville", "state": "Alabama" }, { "city": "Vestavia Hills", "state": "Alabama" }, { "city": "Anaheim", "state": "California" }, { "city": "Los Angeles", "state": "California" }, { "city": "Tustin", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01392573" }, { "nct_id": "NCT02856113", "title": "Phase 3 Alogliptin Pediatric Study", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetes Mellitus, Type 2" ], "interventions": [ { "name": "Alogliptin Benzoate", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Takeda", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "10 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "10 Years to 17 Years" }, "enrollment_count": 152, "start_date": "2016-10-14", "completion_date": "2022-02-14", "has_results": true, "last_update_posted_date": "2022-10-19", "last_synced_at": "2026-10-03T15:31:37.912Z", "location_count": 34, "location_summary": "Little Rock, Arkansas • Los Angeles, California • Palmdale, California + 31 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Los Angeles", "state": "California" }, { "city": "Palmdale", "state": "California" }, { "city": "Palo Alto", "state": "California" }, { "city": "Vallejo", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT02856113" }, { "nct_id": "NCT05414409", "title": "The Gut Microbiome in Type 1 Diabetes and Mechanism of Metformin Action", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Type 1 Diabetes", "Obesity" ], "interventions": [ { "name": "Metformin", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Heba M. Ismail", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "11 Years", "maximum_age": "18 Years", "sex": "ALL", "summary": "11 Years to 18 Years" }, "enrollment_count": 114, "start_date": "2022-09-30", "completion_date": "2027-03-01", "has_results": false, "last_update_posted_date": "2026-08-21", "last_synced_at": "2026-10-03T15:31:37.912Z", "location_count": 1, "location_summary": "Indianapolis, Indiana", "locations": [ { "city": "Indianapolis", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT05414409" }, { "nct_id": "NCT00755287", "title": "A Study of the Safety, Tolerability and Effect on Glycemic Control of Taspoglutide Versus Insulin Glargine in Insulin Naive Type 2 Diabetic Patients Inadequately Controlled With Metformin Plus Sulphonylurea.", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetes Mellitus Type 2" ], "interventions": [ { "name": "insulin glargine", "type": "DRUG" }, { "name": "metformin", "type": "DRUG" }, { "name": "taspoglutide", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Hoffmann-La Roche", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 1072, "start_date": "2008-11", "completion_date": "2010-12", "has_results": false, "last_update_posted_date": "2016-07-29", "last_synced_at": "2026-10-03T15:31:37.912Z", "location_count": 74, "location_summary": "Phoenix, Arizona • Searcy, Arkansas • Concord, California + 63 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Searcy", "state": "Arkansas" }, { "city": "Concord", "state": "California" }, { "city": "Huntington Beach", "state": "California" }, { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00755287" }, { "nct_id": "NCT01421459", "title": "A Study in Adults With Type 2 Diabetes", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetes Mellitus, Type 2" ], "interventions": [ { "name": "LY2963016", "type": "DRUG" }, { "name": "Lantus", "type": "DRUG" }, { "name": "OAMs", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Eli Lilly and Company", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 759, "start_date": "2011-09", "completion_date": "2012-09", "has_results": true, "last_update_posted_date": "2014-12-18", "last_synced_at": "2026-10-03T15:31:37.912Z", "location_count": 28, "location_summary": "Montgomery, Alabama • Brooksville, Florida • Fort Lauderdale, Florida + 25 more", "locations": [ { "city": "Montgomery", "state": "Alabama" }, { "city": "Brooksville", "state": "Florida" }, { "city": "Fort Lauderdale", "state": "Florida" }, { "city": "New Port Richey", "state": "Florida" }, { "city": "Oviedo", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01421459" }, { "nct_id": "NCT02069379", "title": "Endogenous Opioid Activity and Affective State in Insulin Resistant Women", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Depression", "Insulin Resistance", "Metabolic Syndrome" ], "interventions": [ { "name": "Metformin", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Michigan", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "40 Years", "sex": "FEMALE", "summary": "18 Years to 40 Years · Female only" }, "enrollment_count": 42, "start_date": "2014-07", "completion_date": "2017-09", "has_results": true, "last_update_posted_date": "2018-11-08", "last_synced_at": "2026-10-03T15:31:37.912Z", "location_count": 1, "location_summary": "Ann Arbor, Michigan", "locations": [ { "city": "Ann Arbor", "state": "Michigan" } ], "official_url": "https://clinicaltrials.gov/study/NCT02069379" }, { "nct_id": "NCT01095822", "title": "Effects of Valsartan and Aliskiren on Hemostatic Indices in Hypertensive Diabetics", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Diabetes Mellitus" ], "interventions": [ { "name": "Aliskiren + Valsartan", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "HeartDrug Research LLC", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "21 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "21 Years to 65 Years" }, "enrollment_count": 50, "start_date": "2010-03", "completion_date": "2011-03", "has_results": false, "last_update_posted_date": "2010-03-30", "last_synced_at": "2026-10-03T15:31:37.912Z", "location_count": 1, "location_summary": "Baltimore, Maryland", "locations": [ { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT01095822" }, { "nct_id": "NCT03960333", "title": "Immunometabolism in Pediatric Obesity", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Obesity", "Type 2 Diabetes Mellitus", "Insulin Resistance" ], "interventions": [], "intervention_types": [], "sponsor": "Arkansas Children's Hospital Research Institute", "sponsor_class": "OTHER", "healthy_volunteers": null, "eligibility": { "minimum_age": "5 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "5 Years to 17 Years" }, "enrollment_count": 82, "start_date": "2019-04-25", "completion_date": "2024-06-30", "has_results": false, "last_update_posted_date": "2025-02-13", "last_synced_at": "2026-10-03T15:31:37.912Z", "location_count": 1, "location_summary": "Little Rock, Arkansas", "locations": [ { "city": "Little Rock", "state": "Arkansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT03960333" } ] }