{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Metformin+Placebo&page=4", "query": { "intervention": "Metformin Placebo", "page": 4 }, "page_size": 10 }, "pagination": { "page": 4, "page_size": 10, "total_count": 421, "total_pages": 43, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Metformin+Placebo&page=5&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Metformin+Placebo&page=3&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-03T00:14:13.021Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01376323", "title": "A Study of GSK256073 in Subjects With Type 2 Diabetes Mellitus Who Are Being Treated With Metformin", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Diabetes Mellitus, Type 2" ], "interventions": [ { "name": "GSK256073 1mg", "type": "DRUG" }, { "name": "GSK256073 5mg", "type": "DRUG" }, { "name": "GSK256073 10mg", "type": "DRUG" }, { "name": "GSK256073 25mg", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Sitagliptin 100mg", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "GlaxoSmithKline", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "20 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "20 Years to 70 Years" }, "enrollment_count": 92, "start_date": "2011-07-13", "completion_date": "2012-09-17", "has_results": true, "last_update_posted_date": "2017-10-11", "last_synced_at": "2026-10-03T00:14:13.021Z", "location_count": 3, "location_summary": "Anniston, Alabama • Miami, Florida • Miramar, Florida", "locations": [ { "city": "Anniston", "state": "Alabama" }, { "city": "Miami", "state": "Florida" }, { "city": "Miramar", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01376323" }, { "nct_id": "NCT00386100", "title": "A Type 2 Diabetes Study of the Longer-Term Glycemic Effect of AVANDAMET vs. Metformin", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Diabetes Mellitus, Type 2" ], "interventions": [ { "name": "Avandamet 6 mg/1500 mg (ttd)", "type": "DRUG" }, { "name": "Avandamet 4 mg/1000 mg (ttd)", "type": "DRUG" }, { "name": "Avandamet 2 mg/500 mg (ttd)", "type": "DRUG" }, { "name": "Avandamet 8 mg/ 2000 mg (ttd)", "type": "DRUG" }, { "name": "Metformin 500 mg (ttd)", "type": "DRUG" }, { "name": "Metformin 1000 mg (ttd)", "type": "DRUG" }, { "name": "Metformin 1500 mg (ttd)", "type": "DRUG" }, { "name": "Metformin 2000 mg (ttd)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "GlaxoSmithKline", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 688, "start_date": "2006-10", "completion_date": "2009-09", "has_results": true, "last_update_posted_date": "2016-11-23", "last_synced_at": "2026-10-03T00:14:13.021Z", "location_count": 71, "location_summary": "Tuscaloosa, Alabama • Gilbert, Arizona • Glendale, Arizona + 65 more", "locations": [ { "city": "Tuscaloosa", "state": "Alabama" }, { "city": "Gilbert", "state": "Arizona" }, { "city": "Glendale", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT00386100" }, { "nct_id": "NCT04854512", "title": "Investigational Study of Delayed Release Metformin", "overall_status": "SUSPENDED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetes Mellitus, Type 2" ], "interventions": [ { "name": "Metformin DR", "type": "DRUG" }, { "name": "Metformin IR", "type": "DRUG" }, { "name": "Metformin DR Placebo", "type": "DRUG" }, { "name": "Metformin IR placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Anji Pharma", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "100 Years", "sex": "ALL", "summary": "18 Years to 100 Years" }, "enrollment_count": 675, "start_date": "2021-05-18", "completion_date": "2024-06-30", "has_results": false, "last_update_posted_date": "2023-03-14", "last_synced_at": "2026-10-03T00:14:13.021Z", "location_count": 33, "location_summary": "Glendale, Arizona • Mesa, Arizona • Apple Valley, California + 30 more", "locations": [ { "city": "Glendale", "state": "Arizona" }, { "city": "Mesa", "state": "Arizona" }, { "city": "Apple Valley", "state": "California" }, { "city": "Chula Vista", "state": "California" }, { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT04854512" }, { "nct_id": "NCT04885530", "title": "ACTIV-6: COVID-19 Study of Repurposed Medications", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Covid19" ], "interventions": [ { "name": "Ivermectin", "type": "DRUG" }, { "name": "Fluvoxamine", "type": "DRUG" }, { "name": "Fluticasone", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" }, { "name": "Montelukast", "type": "DRUG" }, { "name": "Metformin", "type": "DRUG" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Susanna Naggie, MD", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "30 Years", "maximum_age": null, "sex": "ALL", "summary": "30 Years and older" }, "enrollment_count": 10956, "start_date": "2021-06-08", "completion_date": "2024-04-29", "has_results": true, "last_update_posted_date": "2025-11-17", "last_synced_at": "2026-10-03T00:14:13.021Z", "location_count": 110, "location_summary": "Chandler, Arizona • Gilbert, Arizona • Mesa, Arizona + 96 more", "locations": [ { "city": "Chandler", "state": "Arizona" }, { "city": "Gilbert", "state": "Arizona" }, { "city": "Mesa", "state": "Arizona" }, { "city": "Peoria", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT04885530" }, { "nct_id": "NCT01106677", "title": "The CANTATA-D Trial (CANagliflozin Treatment and Trial Analysis - DPP-4 Inhibitor Comparator Trial)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetes Mellitus, Type 2" ], "interventions": [ { "name": "Placebo", "type": "DRUG" }, { "name": "Canagliflozin", "type": "DRUG" }, { "name": "Sitagliptin", "type": "DRUG" }, { "name": "Metformin immediate release", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Janssen Research & Development, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 1284, "start_date": "2010-05", "completion_date": "2012-05", "has_results": true, "last_update_posted_date": "2013-07-30", "last_synced_at": "2026-10-03T00:14:13.021Z", "location_count": 45, "location_summary": "Little Rock, Arkansas • Fountain Valley, California • National City, California + 42 more", "locations": [ { "city": "Little Rock", "state": "Arkansas" }, { "city": "Fountain Valley", "state": "California" }, { "city": "National City", "state": "California" }, { "city": "Northridge", "state": "California" }, { "city": "Colorado Springs", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT01106677" }, { "nct_id": "NCT02033876", "title": "Ursodiol on Insulin Sensitivity, Gastric Emptying and Body Weight With Type 2 Diabetes on Metformin", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Type 2 Diabetes Mellitus" ], "interventions": [ { "name": "Ursodiol", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Mayo Clinic", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 24, "start_date": "2013-10", "completion_date": "2017-03", "has_results": true, "last_update_posted_date": "2019-05-08", "last_synced_at": "2026-10-03T00:14:13.021Z", "location_count": 1, "location_summary": "Rochester, Minnesota", "locations": [ { "city": "Rochester", "state": "Minnesota" } ], "official_url": "https://clinicaltrials.gov/study/NCT02033876" }, { "nct_id": "NCT02420652", "title": "Metformin Hydrochloride and Aspirin in Treating Patients With Hormone-Dependent Prostate Cancer That Has Progressed After Surgery or Radiation Therapy", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Recurrent Prostate Carcinoma", "Stage I Prostate Cancer", "Stage IIA Prostate Cancer", "Stage IIB Prostate Cancer", "Stage III Prostate Cancer" ], "interventions": [ { "name": "Aspirin", "type": "DRUG" }, { "name": "Laboratory Biomarker Analysis", "type": "OTHER" }, { "name": "Metformin Hydrochloride", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Rutgers, The State University of New Jersey", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "MALE", "summary": "18 Years and older · Male only" }, "enrollment_count": 27, "start_date": "2015-06-23", "completion_date": "2019-12-01", "has_results": true, "last_update_posted_date": "2023-02-08", "last_synced_at": "2026-10-03T00:14:13.021Z", "location_count": 1, "location_summary": "New Brunswick, New Jersey", "locations": [ { "city": "New Brunswick", "state": "New Jersey" } ], "official_url": "https://clinicaltrials.gov/study/NCT02420652" }, { "nct_id": "NCT00286442", "title": "Efficacy and Safety of Alogliptin Combined With Metformin in Participants With Type 2 Diabetes Mellitus", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetes Mellitus" ], "interventions": [ { "name": "Alogliptin and metformin", "type": "DRUG" }, { "name": "Metformin", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Takeda", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 527, "start_date": "2006-03", "completion_date": "2007-06", "has_results": true, "last_update_posted_date": "2012-02-03", "last_synced_at": "2026-10-03T00:14:13.021Z", "location_count": 40, "location_summary": "Phoenix, Arizona • Anaheim, California • Artesia, California + 37 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Anaheim", "state": "California" }, { "city": "Artesia", "state": "California" }, { "city": "Fresno", "state": "California" }, { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00286442" }, { "nct_id": "NCT02308228", "title": "Metformin to Augment Strength Training Effective Response in Seniors (MASTERS)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "EARLY_PHASE1" ], "conditions": [ "Aging" ], "interventions": [ { "name": "Progressive Resistance Training", "type": "BEHAVIORAL" }, { "name": "Metformin", "type": "DRUG" } ], "intervention_types": [ "BEHAVIORAL", "DRUG" ], "sponsor": "Philip Kern", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "65 Years", "maximum_age": null, "sex": "ALL", "summary": "65 Years and older" }, "enrollment_count": 109, "start_date": "2015-01-14", "completion_date": "2018-06-28", "has_results": true, "last_update_posted_date": "2019-09-17", "last_synced_at": "2026-10-03T00:14:13.021Z", "location_count": 2, "location_summary": "Birmingham, Alabama • Lexington, Kentucky", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Lexington", "state": "Kentucky" } ], "official_url": "https://clinicaltrials.gov/study/NCT02308228" }, { "nct_id": "NCT00682448", "title": "Metformin for the Prevention of the Metabolic Side-effects of Zyprexa", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Metabolic Complications" ], "interventions": [ { "name": "Metformin", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Rush University Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 25, "start_date": "2007-08", "completion_date": "2011-08", "has_results": true, "last_update_posted_date": "2021-02-02", "last_synced_at": "2026-10-03T00:14:13.021Z", "location_count": 1, "location_summary": "Chicago, Illinois", "locations": [ { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT00682448" } ] }