{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Metformin+and+Sulfonylurea&page=2", "query": { "intervention": "Metformin and Sulfonylurea", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 80, "total_pages": 8, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Metformin+and+Sulfonylurea&page=3&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Metformin+and+Sulfonylurea&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-08T00:12:02.357Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT02128932", "title": "Efficacy and Safety of Semaglutide Once Weekly Versus Insulin Glargine Once Daily as add-on to Metformin With or Without Sulphonylurea in Insulin-naïve Subjects With Type 2 Diabetes", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetes", "Diabetes Mellitus, Type 2" ], "interventions": [ { "name": "semaglutide", "type": "DRUG" }, { "name": "insulin glargine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novo Nordisk A/S", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 1089, "start_date": "2014-08-04", "completion_date": "2015-09-03", "has_results": true, "last_update_posted_date": "2019-06-13", "last_synced_at": "2026-10-08T00:12:02.357Z", "location_count": 136, "location_summary": "Birmingham, Alabama • Ozark, Alabama • Tuscumbia, Alabama + 117 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Ozark", "state": "Alabama" }, { "city": "Tuscumbia", "state": "Alabama" }, { "city": "Gilbert", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT02128932" }, { "nct_id": "NCT05161429", "title": "BESTMED: Observational Evaluation of Second Line Therapy Medications in Diabetes", "overall_status": "UNKNOWN", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Diabetes Mellitus, Type 2" ], "interventions": [ { "name": "DPP4", "type": "DRUG" }, { "name": "GLP-1 receptor agonist", "type": "DRUG" }, { "name": "Basal Insulin", "type": "DRUG" }, { "name": "SLGT2", "type": "DRUG" }, { "name": "SU", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Brigham and Women's Hospital", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "30 Years", "maximum_age": null, "sex": "ALL", "summary": "30 Years and older" }, "enrollment_count": 550000, "start_date": "2021-07-01", "completion_date": "2024-06-30", "has_results": false, "last_update_posted_date": "2023-06-22", "last_synced_at": "2026-10-08T00:12:02.357Z", "location_count": 5, "location_summary": "Wilmington, Delaware • Lexington, Kentucky • Boston, Massachusetts + 2 more", "locations": [ { "city": "Wilmington", "state": "Delaware" }, { "city": "Lexington", "state": "Kentucky" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Beachwood", "state": "Ohio" }, { "city": "Dallas", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT05161429" }, { "nct_id": "NCT02269098", "title": "The Synergy to Control Emergency Department Hyperglycemia Program for Type 2 Diabetes", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Diabetes Mellitus, Type 2", "Medication Adherence", "HYPERGLYCEMIA" ], "interventions": [ { "name": "Diabetes medication management", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Medstar Health Research Institute", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 101, "start_date": "2012-02", "completion_date": "2013-12", "has_results": true, "last_update_posted_date": "2017-01-09", "last_synced_at": "2026-10-08T00:12:02.357Z", "location_count": 1, "location_summary": "Washington D.C., District of Columbia", "locations": [ { "city": "Washington D.C.", "state": "District of Columbia" } ], "official_url": "https://clinicaltrials.gov/study/NCT02269098" }, { "nct_id": "NCT03893422", "title": "Placebo-Controlled Clinical Nutrition Study of the Safety and Metabolic Effects of Two Medical Foods in Type 2 Diabetes", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Type 2 Diabetes Mellitus" ], "interventions": [ { "name": "WB-010", "type": "OTHER" }, { "name": "WB-011", "type": "OTHER" }, { "name": "Placebo", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Pendulum Therapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 76, "start_date": "2017-10-22", "completion_date": "2018-09-14", "has_results": false, "last_update_posted_date": "2020-02-27", "last_synced_at": "2026-10-08T00:12:02.357Z", "location_count": 5, "location_summary": "Torrance, California • Tustin, California • Youngstown, Ohio + 2 more", "locations": [ { "city": "Torrance", "state": "California" }, { "city": "Tustin", "state": "California" }, { "city": "Youngstown", "state": "Ohio" }, { "city": "Mt. Pleasant", "state": "South Carolina" }, { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT03893422" }, { "nct_id": "NCT00968812", "title": "CANagliflozin Treatment And Trial Analysis-Sulfonylurea (CANTATA-SU) SGLT2 Add-on to Metformin Versus Glimepiride", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Diabetes Mellitus, Type 2" ], "interventions": [ { "name": "Glimepiride", "type": "DRUG" }, { "name": "Canagliflozin (JNJ-28431754)", "type": "DRUG" }, { "name": "Metformin", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Janssen Research & Development, LLC", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 1452, "start_date": "2009-09", "completion_date": "2013-01", "has_results": true, "last_update_posted_date": "2017-01-30", "last_synced_at": "2026-10-08T00:12:02.357Z", "location_count": 43, "location_summary": "Calera, Alabama • Gilbert, Arizona • Mesa, Arizona + 40 more", "locations": [ { "city": "Calera", "state": "Alabama" }, { "city": "Gilbert", "state": "Arizona" }, { "city": "Mesa", "state": "Arizona" }, { "city": "Tucson", "state": "Arizona" }, { "city": "Jonesboro", "state": "Arkansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT00968812" }, { "nct_id": "NCT01658501", "title": "Phase 2b Multicenter, Randomized, Double-Blind, Placebo- and Active-Controlled, Parallel-Group Study to Assess the PD Response and Safety of Three Dose Levels of (PB1023) Injection Following 20 Weeks of Weekly SC Dosing in Adults With T2DM", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Type 2 Diabetes Mellitus" ], "interventions": [ { "name": "50 mg PB1023", "type": "DRUG" }, { "name": "70 mg PB1023", "type": "DRUG" }, { "name": "100 mg PB1023", "type": "DRUG" }, { "name": "Placebo (0.9% Sodium Chloride)", "type": "DRUG" }, { "name": "Victoza®", "type": "DRUG" }, { "name": "Diet and Exercise", "type": "OTHER" }, { "name": "Metformin", "type": "DRUG" }, { "name": "Sulfonylurea", "type": "DRUG" }, { "name": "Metformin and Sulfonylurea", "type": "DRUG" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "PhaseBio Pharmaceuticals Inc.", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 593, "start_date": "2012-07", "completion_date": "2013-07", "has_results": false, "last_update_posted_date": "2015-12-07", "last_synced_at": "2026-10-08T00:12:02.357Z", "location_count": 93, "location_summary": "Anniston, Alabama • Birmingham, Alabama • Gulf Shores, Alabama + 90 more", "locations": [ { "city": "Anniston", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Gulf Shores", "state": "Alabama" }, { "city": "Huntsville", "state": "Alabama" }, { "city": "Mobile", "state": "Alabama" } ], "official_url": "https://clinicaltrials.gov/study/NCT01658501" }, { "nct_id": "NCT00649454", "title": "Fasting Study of Glipizide and Metformin HCl Tablets 5 mg/500 mg to Metaglip® Tablets 5 mg/500 mg", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy" ], "interventions": [ { "name": "Glipizide and Metformin HCl Tablets 5 mg/500 mg", "type": "DRUG" }, { "name": "Metaglip® Tablets 5 mg/500 mg", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Mylan Pharmaceuticals Inc", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 36, "start_date": "2005-06", "completion_date": "2005-06", "has_results": false, "last_update_posted_date": "2024-04-24", "last_synced_at": "2026-10-08T00:12:02.357Z", "location_count": 1, "location_summary": "Fargo, North Dakota", "locations": [ { "city": "Fargo", "state": "North Dakota" } ], "official_url": "https://clinicaltrials.gov/study/NCT00649454" }, { "nct_id": "NCT01033773", "title": "Stop Emergency Room Visits for Hyperglycemia Project - District of Columbia (DC)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Type 2 Diabetes Mellitus" ], "interventions": [ { "name": "Antihyperglycemic medication guideline for management of uncontrolled hyperglycemia presenting to the ED using metformin, sulfonylurea and/or insulin", "type": "DRUG" }, { "name": "Diabetes survival skills self-management education", "type": "BEHAVIORAL" } ], "intervention_types": [ "DRUG", "BEHAVIORAL" ], "sponsor": "Medstar Health Research Institute", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 86, "start_date": "2007-09", "completion_date": "2009-01", "has_results": true, "last_update_posted_date": "2020-10-05", "last_synced_at": "2026-10-08T00:12:02.357Z", "location_count": 1, "location_summary": "Washington D.C., District of Columbia", "locations": [ { "city": "Washington D.C.", "state": "District of Columbia" } ], "official_url": "https://clinicaltrials.gov/study/NCT01033773" }, { "nct_id": "NCT00269061", "title": "Study In Patients With Type 2 Diabetes Who Are Taking Metformin And Sulfonylurea, Metformin And Insulin, Or Insulin", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Non-Insulin-Dependent Diabetes Mellitus" ], "interventions": [ { "name": "pioglitazone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "GlaxoSmithKline", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 32, "start_date": "2006-01", "completion_date": null, "has_results": false, "last_update_posted_date": "2008-10-16", "last_synced_at": "2026-10-08T00:12:02.357Z", "location_count": 1, "location_summary": "Belmont, Massachusetts", "locations": [ { "city": "Belmont", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT00269061" }, { "nct_id": "NCT01329016", "title": "Glyburide and Metformin for Gestational Diabetes Mellitus (GDM)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Gestational Diabetes Mellitus" ], "interventions": [ { "name": "Glyburide", "type": "DRUG" }, { "name": "Metformin", "type": "DRUG" }, { "name": "Glyburide-Metformin combination", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)", "sponsor_class": "NIH", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "FEMALE", "summary": "18 Years to 45 Years · Female only" }, "enrollment_count": 177, "start_date": "2011-07", "completion_date": "2015-02-28", "has_results": false, "last_update_posted_date": "2026-05-11", "last_synced_at": "2026-10-08T00:12:02.357Z", "location_count": 4, "location_summary": "Indianapolis, Indiana • Pittsburgh, Pennsylvania • Galveston, Texas + 1 more", "locations": [ { "city": "Indianapolis", "state": "Indiana" }, { "city": "Pittsburgh", "state": "Pennsylvania" }, { "city": "Galveston", "state": "Texas" }, { "city": "Seattle", "state": "Washington" } ], "official_url": "https://clinicaltrials.gov/study/NCT01329016" } ] }