{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Metformin+use&page=2", "query": { "intervention": "Metformin use", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 10, "total_pages": 1, "next_page_url": null, "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Metformin+use&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-09-24T14:40:08.781Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT03751657", "title": "A Research Study to Compare Insulin 287 Once a Week to Insulin Glargine (100 Units/mL) Once a Day in People With Type 2 Diabetes.", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Diabetes Mellitus, Type 2" ], "interventions": [ { "name": "Insulin icodec", "type": "DRUG" }, { "name": "Placebo (insulin 287)", "type": "DRUG" }, { "name": "Metformin", "type": "DRUG" }, { "name": "Dipeptidyl peptidase-4 inhibitors", "type": "DRUG" }, { "name": "Insulin glargine", "type": "DRUG" }, { "name": "Placebo (insulin glargine)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Novo Nordisk A/S", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 247, "start_date": "2018-11-29", "completion_date": "2020-01-17", "has_results": true, "last_update_posted_date": "2021-04-02", "last_synced_at": "2026-09-24T14:40:08.781Z", "location_count": 14, "location_summary": "Lancaster, California • Ventura, California • Walnut Creek, California + 9 more", "locations": [ { "city": "Lancaster", "state": "California" }, { "city": "Ventura", "state": "California" }, { "city": "Walnut Creek", "state": "California" }, { "city": "Roswell", "state": "Georgia" }, { "city": "Lexington", "state": "Kentucky" } ], "official_url": "https://clinicaltrials.gov/study/NCT03751657" }, { "nct_id": "NCT05102071", "title": "Clinical Outcomes and Healthcare Cost and Resource Utilization (HCRU) in Patients With Type 2 Diabetes and Cardiovascular Disease on 2nd Line Empagliflozin Versus 2nd Line Sulfonylureas", "overall_status": "WITHDRAWN", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Diabetes Mellitus, Type 2", "Cardiovascular Diseases" ], "interventions": [ { "name": "empagliflozin", "type": "DRUG" }, { "name": "metformin", "type": "DRUG" }, { "name": "sulfonylurea", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Boehringer Ingelheim", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 0, "start_date": "2021-11-01", "completion_date": "2022-06-15", "has_results": false, "last_update_posted_date": "2022-06-01", "last_synced_at": "2026-09-24T14:40:08.781Z", "location_count": 1, "location_summary": "Ridgefield, Connecticut", "locations": [ { "city": "Ridgefield", "state": "Connecticut" } ], "official_url": "https://clinicaltrials.gov/study/NCT05102071" }, { "nct_id": "NCT05023967", "title": "Metformin and Nightly Fasting in Women With Early Breast Cancer", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Anatomic Stage I Breast Cancer AJCC v8", "Anatomic Stage II Breast Cancer AJCC v8", "Breast Ductal Carcinoma In Situ", "Invasive Breast Carcinoma" ], "interventions": [ { "name": "Biospecimen Collection", "type": "PROCEDURE" }, { "name": "Extended Release Metformin Hydrochloride", "type": "DRUG" }, { "name": "Monitoring", "type": "OTHER" }, { "name": "Nutritional Assessment", "type": "OTHER" }, { "name": "Short-Term Fasting", "type": "OTHER" } ], "intervention_types": [ "PROCEDURE", "DRUG", "OTHER" ], "sponsor": "M.D. Anderson Cancer Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "FEMALE", "summary": "18 Years and older · Female only" }, "enrollment_count": 120, "start_date": "2023-04-04", "completion_date": "2026-12-16", "has_results": false, "last_update_posted_date": "2026-01-05", "last_synced_at": "2026-09-24T14:40:08.781Z", "location_count": 1, "location_summary": "Houston, Texas", "locations": [ { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT05023967" }, { "nct_id": "NCT01524705", "title": "FLuctuATion Reduction With inSULin and Glp-1 Added togetheR (FLAT-SUGAR)", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Type 2 Diabetes" ], "interventions": [ { "name": "Insulin Glargine", "type": "DRUG" }, { "name": "Metformin", "type": "DRUG" }, { "name": "Prandial insulin", "type": "DRUG" }, { "name": "Exenatide", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Washington", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "40 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "40 Years to 75 Years" }, "enrollment_count": 102, "start_date": "2012-08", "completion_date": "2014-07", "has_results": true, "last_update_posted_date": "2023-12-29", "last_synced_at": "2026-09-24T14:40:08.781Z", "location_count": 12, "location_summary": "San Diego, California • Miami, Florida • Atlanta, Georgia + 9 more", "locations": [ { "city": "San Diego", "state": "California" }, { "city": "Miami", "state": "Florida" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Minneapolis", "state": "Minnesota" } ], "official_url": "https://clinicaltrials.gov/study/NCT01524705" }, { "nct_id": "NCT04885530", "title": "ACTIV-6: COVID-19 Study of Repurposed Medications", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Covid19" ], "interventions": [ { "name": "Ivermectin", "type": "DRUG" }, { "name": "Fluvoxamine", "type": "DRUG" }, { "name": "Fluticasone", "type": "DRUG" }, { "name": "Placebo", "type": "OTHER" }, { "name": "Montelukast", "type": "DRUG" }, { "name": "Metformin", "type": "DRUG" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Susanna Naggie, MD", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "30 Years", "maximum_age": null, "sex": "ALL", "summary": "30 Years and older" }, "enrollment_count": 10956, "start_date": "2021-06-08", "completion_date": "2024-04-29", "has_results": true, "last_update_posted_date": "2025-11-17", "last_synced_at": "2026-09-24T14:40:08.781Z", "location_count": 110, "location_summary": "Chandler, Arizona • Gilbert, Arizona • Mesa, Arizona + 96 more", "locations": [ { "city": "Chandler", "state": "Arizona" }, { "city": "Gilbert", "state": "Arizona" }, { "city": "Mesa", "state": "Arizona" }, { "city": "Peoria", "state": "Arizona" }, { "city": "Little Rock", "state": "Arkansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT04885530" }, { "nct_id": "NCT03856632", "title": "Liraglutide Effect in Atrial Fibrillation", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Atrial Fibrillation" ], "interventions": [ { "name": "Liraglutide", "type": "DRUG" }, { "name": "RFM", "type": "OTHER" }, { "name": "Anti Arrhythmics", "type": "DRUG" }, { "name": "Afib Catheter Ablation", "type": "PROCEDURE" } ], "intervention_types": [ "DRUG", "OTHER", "PROCEDURE" ], "sponsor": "University of Miami", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 60, "start_date": "2019-03-18", "completion_date": "2026-12-31", "has_results": false, "last_update_posted_date": "2026-05-01", "last_synced_at": "2026-09-24T14:40:08.781Z", "location_count": 1, "location_summary": "Miami, Florida", "locations": [ { "city": "Miami", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT03856632" }, { "nct_id": "NCT04220021", "title": "Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "C9orf72 Amyotrophic Lateral Sclerosis (ALS)", "Frontotemporal Dementia" ], "interventions": [ { "name": "Metformin", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Florida", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 41, "start_date": "2020-01-10", "completion_date": "2027-08-31", "has_results": true, "last_update_posted_date": "2026-08-20", "last_synced_at": "2026-09-24T14:40:08.781Z", "location_count": 1, "location_summary": "Gainesville, Florida", "locations": [ { "city": "Gainesville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT04220021" }, { "nct_id": "NCT04264897", "title": "Antecedent Metabolic Health and Metformin Aging Study", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Aging", "Insulin Sensitivity", "Chronic Disease", "Mitochondria", "Insulin Resistance" ], "interventions": [ { "name": "Metformin", "type": "DRUG" }, { "name": "Placebo oral tablet", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Oklahoma Medical Research Foundation", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "40 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "40 Years to 75 Years" }, "enrollment_count": 166, "start_date": "2020-07-29", "completion_date": "2025-03-12", "has_results": true, "last_update_posted_date": "2026-07-02", "last_synced_at": "2026-09-24T14:40:08.781Z", "location_count": 2, "location_summary": "Oklahoma City, Oklahoma • Madison, Wisconsin", "locations": [ { "city": "Oklahoma City", "state": "Oklahoma" }, { "city": "Madison", "state": "Wisconsin" } ], "official_url": "https://clinicaltrials.gov/study/NCT04264897" }, { "nct_id": "NCT02981329", "title": "Fetal Hemoglobin Induction Treatment Metformin", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "EARLY_PHASE1" ], "conditions": [ "Sickle Cell Anemia", "Sickle Cell Disease", "Hemoglobin Disorder" ], "interventions": [ { "name": "Metformin", "type": "DRUG" }, { "name": "Questionnaires", "type": "BEHAVIORAL" } ], "intervention_types": [ "DRUG", "BEHAVIORAL" ], "sponsor": "Baylor College of Medicine", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "10 Years", "maximum_age": "60 Years", "sex": "ALL", "summary": "10 Years to 60 Years" }, "enrollment_count": 37, "start_date": "2017-03-02", "completion_date": "2020-07-20", "has_results": false, "last_update_posted_date": "2023-10-12", "last_synced_at": "2026-09-24T14:40:08.781Z", "location_count": 2, "location_summary": "Houston, Texas", "locations": [ { "city": "Houston", "state": "Texas" }, { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT02981329" }, { "nct_id": "NCT06096259", "title": "Preventing Injured Knees From osteoArthritis: Severity Outcomes", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Osteoarthritis, Knee", "Post-traumatic Osteoarthritis", "ACL Tear" ], "interventions": [ { "name": "Metformin", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Brigham and Women's Hospital", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "45 Years", "sex": "ALL", "summary": "18 Years to 45 Years" }, "enrollment_count": 512, "start_date": "2024-05-06", "completion_date": "2029-12", "has_results": false, "last_update_posted_date": "2025-04-29", "last_synced_at": "2026-09-24T14:40:08.781Z", "location_count": 9, "location_summary": "Atlanta, Georgia • Iowa City, Iowa • Lexington, Kentucky + 6 more", "locations": [ { "city": "Atlanta", "state": "Georgia" }, { "city": "Iowa City", "state": "Iowa" }, { "city": "Lexington", "state": "Kentucky" }, { "city": "Boston", "state": "Massachusetts" }, { "city": "Omaha", "state": "Nebraska" } ], "official_url": "https://clinicaltrials.gov/study/NCT06096259" } ] }