{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Methadone+placebo&page=3", "query": { "intervention": "Methadone placebo", "page": 3 }, "page_size": 10 }, "pagination": { "page": 3, "page_size": 10, "total_count": 67, "total_pages": 7, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Methadone+placebo&page=4&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Methadone+placebo&page=2&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-01T14:03:52.918Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT06544291", "title": "Combined THC and CBD for OUD and Chronic Pain", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Chronic Pain", "Opioid Use Disorder" ], "interventions": [ { "name": "CBD 300mg", "type": "DRUG" }, { "name": "CBD 600mg", "type": "DRUG" }, { "name": "Placebo 0mg", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Yale University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 147, "start_date": "2024-10-22", "completion_date": "2028-01-28", "has_results": false, "last_update_posted_date": "2026-07-16", "last_synced_at": "2026-10-01T14:03:52.918Z", "location_count": 1, "location_summary": "New Haven, Connecticut", "locations": [ { "city": "New Haven", "state": "Connecticut" } ], "official_url": "https://clinicaltrials.gov/study/NCT06544291" }, { "nct_id": "NCT01114308", "title": "A Six-Month Randomized Controlled Trial (RCT) of Probuphine Safety and Efficacy in Opioid Addiction", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Opioid Dependency" ], "interventions": [ { "name": "Probuphine (buprenorphine implant)", "type": "DRUG" }, { "name": "placebo implant", "type": "DRUG" }, { "name": "Buprenorphine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Titan Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 287, "start_date": "2010-04", "completion_date": "2011-05", "has_results": false, "last_update_posted_date": "2018-12-31", "last_synced_at": "2026-10-01T14:03:52.918Z", "location_count": 20, "location_summary": "Los Angeles, California • National City, California • Oceanside, California + 16 more", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "National City", "state": "California" }, { "city": "Oceanside", "state": "California" }, { "city": "Torrance", "state": "California" }, { "city": "Jacksonville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01114308" }, { "nct_id": "NCT01821430", "title": "Increased Sensitivity to Pain Caused by Opioids in People Who Have Abused Prescription Opioids", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Chronic Pain" ], "interventions": [ { "name": "Pregabalin", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Georgetown University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "21 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "21 Years to 65 Years" }, "enrollment_count": 4, "start_date": "2013-03", "completion_date": "2016-02", "has_results": false, "last_update_posted_date": "2017-02-09", "last_synced_at": "2026-10-01T14:03:52.918Z", "location_count": 1, "location_summary": "Washington D.C., District of Columbia", "locations": [ { "city": "Washington D.C.", "state": "District of Columbia" } ], "official_url": "https://clinicaltrials.gov/study/NCT01821430" }, { "nct_id": "NCT00790569", "title": "Varenicline or Nicotine Patch and Nicotine Gum in Helping Smokers in a Methadone Treatment Program Stop Smoking", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Bladder Cancer", "Cervical Cancer", "Esophageal Cancer", "Gastric Cancer", "Head and Neck Cancer", "Kidney Cancer", "Leukemia", "Liver Cancer", "Lung Cancer", "Pancreatic Cancer", "Tobacco Use Disorder" ], "interventions": [ { "name": "nicotine", "type": "DRUG" }, { "name": "varenicline", "type": "DRUG" }, { "name": "placebo", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Butler Hospital", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "120 Years", "sex": "ALL", "summary": "18 Years to 120 Years" }, "enrollment_count": 315, "start_date": "2008-09", "completion_date": "2012-10", "has_results": true, "last_update_posted_date": "2018-06-06", "last_synced_at": "2026-10-01T14:03:52.918Z", "location_count": 1, "location_summary": "Providence, Rhode Island", "locations": [ { "city": "Providence", "state": "Rhode Island" } ], "official_url": "https://clinicaltrials.gov/study/NCT00790569" }, { "nct_id": "NCT00838981", "title": "Pharmacotherapy & CM for Opioid and Cocaine Dependence", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1", "PHASE2" ], "conditions": [ "Cocaine Dependence" ], "interventions": [ { "name": "Modafinil", "type": "DRUG" }, { "name": "Sugar Pill", "type": "DRUG" }, { "name": "Contingency Management", "type": "BEHAVIORAL" }, { "name": "Methadone", "type": "DRUG" }, { "name": "cognitive behavioral treatment", "type": "BEHAVIORAL" }, { "name": "Voucher Control", "type": "BEHAVIORAL" } ], "intervention_types": [ "DRUG", "BEHAVIORAL" ], "sponsor": "Yale University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 91, "start_date": "2008-05", "completion_date": "2014-03", "has_results": true, "last_update_posted_date": "2021-12-03", "last_synced_at": "2026-10-01T14:03:52.918Z", "location_count": 1, "location_summary": "West Haven, Connecticut", "locations": [ { "city": "West Haven", "state": "Connecticut" } ], "official_url": "https://clinicaltrials.gov/study/NCT00838981" }, { "nct_id": "NCT01210079", "title": "Hyperalgesia in Methadone-Maintained Patients: Can it be Treated?", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Opioid-Induced Hyperalgesia" ], "interventions": [ { "name": "Gabapentin;", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of California, Los Angeles", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "21 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "21 Years to 55 Years" }, "enrollment_count": 26, "start_date": "2002-09", "completion_date": "2010-05", "has_results": true, "last_update_posted_date": "2012-04-06", "last_synced_at": "2026-10-01T14:03:52.918Z", "location_count": 1, "location_summary": "Los Angeles, California", "locations": [ { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT01210079" }, { "nct_id": "NCT04316559", "title": "Biased Opioid Agonists for Treatment of Opioid Withdrawal in OUD", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Opioid-Use Disorder" ], "interventions": [ { "name": "Placebo", "type": "OTHER" }, { "name": "TRV734", "type": "DRUG" }, { "name": "Oxycodone", "type": "DRUG" } ], "intervention_types": [ "OTHER", "DRUG" ], "sponsor": "National Institute on Drug Abuse (NIDA)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "75 Years", "sex": "ALL", "summary": "18 Years to 75 Years" }, "enrollment_count": 5, "start_date": "2021-12-27", "completion_date": "2025-02-14", "has_results": true, "last_update_posted_date": "2026-06-02", "last_synced_at": "2026-10-01T14:03:52.918Z", "location_count": 1, "location_summary": "Baltimore, Maryland", "locations": [ { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT04316559" }, { "nct_id": "NCT02033707", "title": "Effects of Hallucinogens and Other Drugs on Mood and Performance", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy" ], "interventions": [ { "name": "Hallucinogens and psychoactive substances", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Johns Hopkins University", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "21 Years", "maximum_age": "50 Years", "sex": "ALL", "summary": "21 Years to 50 Years" }, "enrollment_count": 20, "start_date": "2014-04", "completion_date": "2019-02", "has_results": false, "last_update_posted_date": "2019-05-16", "last_synced_at": "2026-10-01T14:03:52.918Z", "location_count": 1, "location_summary": "Baltimore, Maryland", "locations": [ { "city": "Baltimore", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT02033707" }, { "nct_id": "NCT05693675", "title": "Postoperative Oral Methadone After Major Spine Surgery; Safety, Feasibility and Efficacy in Prevention of Progression to Chronic Opioid Usage at 3 Months", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2", "PHASE3" ], "conditions": [ "Spine Surgery" ], "interventions": [ { "name": "Postoperative methadone", "type": "DRUG" }, { "name": "Postoperative placebo", "type": "DRUG" }, { "name": "Rescue Analgesia", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "The University of Texas Health Science Center, Houston", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 0, "start_date": "2023-10-01", "completion_date": "2024-07-01", "has_results": false, "last_update_posted_date": "2025-03-10", "last_synced_at": "2026-10-01T14:03:52.918Z", "location_count": 1, "location_summary": "Houston, Texas", "locations": [ { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT05693675" }, { "nct_id": "NCT00668265", "title": "Anxiety in Recovering Opiate Dependence", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Generalized Anxiety Disorder", "Comorbid Opiate Dependence in Remission", "Status Post Methadone-Maintenance Treatment" ], "interventions": [ { "name": "Quetiapine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Beth Israel Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "21 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "21 Years to 65 Years" }, "enrollment_count": 14, "start_date": "2008-01", "completion_date": "2011-08", "has_results": true, "last_update_posted_date": "2013-02-18", "last_synced_at": "2026-10-01T14:03:52.918Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT00668265" } ] }