{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Methylene+Blue&page=2",
    "query": {
      "intervention": "Methylene Blue",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Methylene+Blue&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-09-25T08:45:23.147Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT02221232",
      "title": "Efficacy Study to Evaluate Antimicrobial Effectiveness of ZuraPrep™",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Surgical Site Infection"
      ],
      "interventions": [
        {
          "name": "Chloraprep",
          "type": "DRUG"
        },
        {
          "name": "ZuraPrep",
          "type": "DRUG"
        },
        {
          "name": "ZuraPrep Vehicle",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Zurex Pharma, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 64,
      "start_date": "2014-08",
      "completion_date": "2014-10",
      "has_results": false,
      "last_update_posted_date": "2016-07-18",
      "last_synced_at": "2026-09-25T08:45:23.147Z",
      "location_count": 1,
      "location_summary": "Bozeman, Montana",
      "locations": [
        {
          "city": "Bozeman",
          "state": "Montana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02221232"
    },
    {
      "nct_id": "NCT02380573",
      "title": "Effects of Methylene Blue in Healthy Aging, Mild Cognitive Impairment and Alzheimer's Disease",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Mild Cognitive Impairment",
        "MCI",
        "Aging",
        "Alzheimer's Disease",
        "AD"
      ],
      "interventions": [
        {
          "name": "Methylene Blue",
          "type": "DRUG"
        },
        {
          "name": "FD&C Blue # 2",
          "type": "DRUG"
        },
        {
          "name": "Phenazopyridine hydrochloride",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "The University of Texas Health Science Center at San Antonio",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "45 Years",
        "maximum_age": "89 Years",
        "sex": "ALL",
        "summary": "45 Years to 89 Years"
      },
      "enrollment_count": 117,
      "start_date": "2015-07",
      "completion_date": "2023-07",
      "has_results": true,
      "last_update_posted_date": "2024-09-19",
      "last_synced_at": "2026-09-25T08:45:23.147Z",
      "location_count": 1,
      "location_summary": "San Antonio, Texas",
      "locations": [
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02380573"
    },
    {
      "nct_id": "NCT07324954",
      "title": "Methylene Blue in Total Knee Arthroplasty (TKA)",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Total Knee Arthroplasty",
        "Prosthetic-joint Infection",
        "Irrigation"
      ],
      "interventions": [
        {
          "name": "Methylene Blue 10 MG/ML (intra-articular application)",
          "type": "DRUG"
        },
        {
          "name": "Revision Arthroplasty for PJI (DAIR)",
          "type": "PROCEDURE"
        },
        {
          "name": "Primary Total Knee Arthroplasty",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "PROCEDURE"
      ],
      "sponsor": "University of Miami",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 20,
      "start_date": "2026-02-04",
      "completion_date": "2027-02-01",
      "has_results": false,
      "last_update_posted_date": "2026-04-14",
      "last_synced_at": "2026-09-25T08:45:23.147Z",
      "location_count": 1,
      "location_summary": "Miami, Florida",
      "locations": [
        {
          "city": "Miami",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07324954"
    },
    {
      "nct_id": "NCT05190939",
      "title": "The Use of Dye-less Cystoscopy in Assessing Urinary Tract Integrity During Hysterectomy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hysterectomy",
        "Cystoscopy"
      ],
      "interventions": [
        {
          "name": "water as bladder distending media",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "intravenous dye",
          "type": "DIAGNOSTIC_TEST"
        },
        {
          "name": "No intervention",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "WellSpan Health",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "90 Years",
        "sex": "FEMALE",
        "summary": "18 Years to 90 Years · Female only"
      },
      "enrollment_count": 276,
      "start_date": "2018-07-01",
      "completion_date": "2019-12-29",
      "has_results": false,
      "last_update_posted_date": "2023-03-17",
      "last_synced_at": "2026-09-25T08:45:23.147Z",
      "location_count": 1,
      "location_summary": "York, Pennsylvania",
      "locations": [
        {
          "city": "York",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05190939"
    },
    {
      "nct_id": "NCT04073706",
      "title": "Sentinel Node Biopsy in Endometrial Cancer",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Endometrial Cancer Stage I",
        "Sentinel Lymph Node",
        "Surgery"
      ],
      "interventions": [
        {
          "name": "TH BSO with SNB Note: If participants (≤45yo), Grade 1 endometrial adenocarcinoma with myometrial invasion <50%, wish to retain their ovaries a BSO may be omitted",
          "type": "PROCEDURE"
        },
        {
          "name": "TH BSO without retroperitoneal node dissection Note: If participants (≤45yo), Grade 1 endometrial adenocarcinoma with myometrial invasion <50%, wish to retain their ovaries a BSO may be omitted",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Queensland Centre for Gynaecological Cancer",
      "sponsor_class": "OTHER_GOV",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 760,
      "start_date": "2021-01-18",
      "completion_date": "2031-02",
      "has_results": false,
      "last_update_posted_date": "2026-09-15",
      "last_synced_at": "2026-09-25T08:45:23.147Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04073706"
    },
    {
      "nct_id": "NCT01386879",
      "title": "Evaluation of Above the Cuff Suctioning During General Anesthesia",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Secretion Removal Above ETT Cuff"
      ],
      "interventions": [
        {
          "name": "methylene blue",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Thomas Jefferson University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 50,
      "start_date": "2011-07",
      "completion_date": "2012-10",
      "has_results": true,
      "last_update_posted_date": "2022-06-08",
      "last_synced_at": "2026-09-25T08:45:23.147Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01386879"
    },
    {
      "nct_id": "NCT04187053",
      "title": "Clinical and Microbiologic Outcomes of aPDT in the Non-surgical Treatment of Implant Inflammation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "DENT IMPLANTS",
        "LASER"
      ],
      "interventions": [
        {
          "name": "Conventional mechanical therapy",
          "type": "PROCEDURE"
        },
        {
          "name": "Saline",
          "type": "DRUG"
        },
        {
          "name": "Methylene Blue",
          "type": "DRUG"
        },
        {
          "name": "Light emitting laser",
          "type": "DEVICE"
        },
        {
          "name": "Non-light emitting laser",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "The University of Texas Health Science Center, Houston",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 56,
      "start_date": "2020-02-14",
      "completion_date": "2022-12-06",
      "has_results": true,
      "last_update_posted_date": "2024-02-21",
      "last_synced_at": "2026-09-25T08:45:23.147Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04187053"
    },
    {
      "nct_id": "NCT06131281",
      "title": "Comparing Reduction With ESD- Versus APC-TORe",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Obesity",
        "Roux-en-y Anastomosis Site",
        "Weight Gain"
      ],
      "interventions": [
        {
          "name": "E-TORe",
          "type": "PROCEDURE"
        },
        {
          "name": "c-TORe",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Stephen Firkins",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 70,
      "start_date": "2023-10-02",
      "completion_date": "2027-04",
      "has_results": false,
      "last_update_posted_date": "2026-03-19",
      "last_synced_at": "2026-09-25T08:45:23.147Z",
      "location_count": 1,
      "location_summary": "Cleveland, Ohio",
      "locations": [
        {
          "city": "Cleveland",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06131281"
    },
    {
      "nct_id": "NCT04234971",
      "title": "Cost Effectiveness in Alveolar Bone Grafting in Patients With Cleft Lip and Palate",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Cleft Lip and Palate"
      ],
      "interventions": [
        {
          "name": "Intervention group (DBM/BMP)",
          "type": "DRUG"
        },
        {
          "name": "Control group(autologous ICBG)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "The University of Texas Health Science Center, Houston",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "6 Years",
        "maximum_age": "15 Years",
        "sex": "ALL",
        "summary": "6 Years to 15 Years"
      },
      "enrollment_count": 40,
      "start_date": "2021-06-14",
      "completion_date": "2028-01-01",
      "has_results": false,
      "last_update_posted_date": "2026-02-19",
      "last_synced_at": "2026-09-25T08:45:23.147Z",
      "location_count": 1,
      "location_summary": "Houston, Texas",
      "locations": [
        {
          "city": "Houston",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04234971"
    },
    {
      "nct_id": "NCT03782103",
      "title": "In-vivo Efficacy of Patient Preoperative Prep, ZuraPrep (ZP)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Surgical Skin Preparation"
      ],
      "interventions": [
        {
          "name": "ZuraPrep Clear Solution",
          "type": "DRUG"
        },
        {
          "name": "ChloraPrep",
          "type": "DRUG"
        },
        {
          "name": "ZuraPrep Vehicle",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Zurex Pharma, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 156,
      "start_date": "2019-01-25",
      "completion_date": "2019-09-26",
      "has_results": true,
      "last_update_posted_date": "2023-02-08",
      "last_synced_at": "2026-09-25T08:45:23.147Z",
      "location_count": 1,
      "location_summary": "Sterling, Virginia",
      "locations": [
        {
          "city": "Sterling",
          "state": "Virginia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03782103"
    }
  ]
}