{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Methylprednisolone+taper", "query": { "intervention": "Methylprednisolone taper" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 135, "total_pages": 14, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Methylprednisolone+taper&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-10-30T21:52:42.981Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT04862221", "title": "TReatment for ImmUne Mediated PathopHysiology", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Acute Liver Failure", "Fulminant Hepatic Failure", "Hepatic Encephalopathy", "Acute Liver Injury", "Immune Dysregulation" ], "interventions": [ { "name": "High-dose methylprednisolone", "type": "DRUG" }, { "name": "Equine anti-thymocyte globulin", "type": "DRUG" }, { "name": "Prednisolone", "type": "DRUG" }, { "name": "Placebo for prednisolone", "type": "DRUG" }, { "name": "Placebo for infusions", "type": "DRUG" }, { "name": "Diphenhydramine", "type": "DRUG" }, { "name": "Methylprednisolone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "1 Year", "maximum_age": "18 Years", "sex": "ALL", "summary": "1 Year to 18 Years" }, "enrollment_count": 44, "start_date": "2022-02-09", "completion_date": "2027-02", "has_results": false, "last_update_posted_date": "2026-08-12", "last_synced_at": "2026-10-30T21:52:42.981Z", "location_count": 17, "location_summary": "Los Angeles, California • Palo Alto, California • San Diego, California + 14 more", "locations": [ { "city": "Los Angeles", "state": "California" }, { "city": "Palo Alto", "state": "California" }, { "city": "San Diego", "state": "California" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT04862221" }, { "nct_id": "NCT06841705", "title": "Early Vedolizumab as First-Line for Immune-Related Colitis Therapy Trial", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Immune Checkpoint Inhibitor-Related Colitis" ], "interventions": [ { "name": "Vedolizumab 300 MG Injection [Entyvio]", "type": "DRUG" }, { "name": "Prednisone (and methylprednisolone)", "type": "DRUG" }, { "name": "Prednisone Taper", "type": "DRUG" }, { "name": "Placebo Prednisone Capsules", "type": "OTHER" }, { "name": "Placebo Vedolizumab", "type": "OTHER" }, { "name": "Sulfamethoxazole-Trimethoprim", "type": "OTHER" }, { "name": "Placebo for Sulfamethoxazole-Trimethoprim", "type": "DRUG" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Shilpa Grover, MD, MPH", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 80, "start_date": "2025-07-15", "completion_date": "2026-12-31", "has_results": false, "last_update_posted_date": "2025-11-04", "last_synced_at": "2026-10-30T21:52:42.981Z", "location_count": 2, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" }, { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT06841705" }, { "nct_id": "NCT04281862", "title": "DEXTENZA Compared to Topical Prednisolone in Patients Undergoing Bilateral LASIK Surgery", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Refractive Surgery" ], "interventions": [ { "name": "Dextenza 0.4Mg Ophthalmic Insert", "type": "DRUG" }, { "name": "Topical Prednisolone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vance Thompson Vision", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 20, "start_date": "2020-01-23", "completion_date": "2020-05-01", "has_results": false, "last_update_posted_date": "2020-02-24", "last_synced_at": "2026-10-30T21:52:42.981Z", "location_count": 1, "location_summary": "West Fargo, North Dakota", "locations": [ { "city": "West Fargo", "state": "North Dakota" } ], "official_url": "https://clinicaltrials.gov/study/NCT04281862" }, { "nct_id": "NCT04658927", "title": "Dextenza With ILUX for Treatment of MGD", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Meibomian Gland Dysfunction", "Evaporative Dry Eye" ], "interventions": [ { "name": "Dexamethasone, 0.4mg", "type": "DRUG" }, { "name": "Prednisone acetate", "type": "DRUG" }, { "name": "Control", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Warrenville Eyecare", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 30, "start_date": "2021-01-04", "completion_date": "2021-05-30", "has_results": false, "last_update_posted_date": "2022-07-27", "last_synced_at": "2026-10-30T21:52:42.981Z", "location_count": 1, "location_summary": "Warrenville, Illinois", "locations": [ { "city": "Warrenville", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT04658927" }, { "nct_id": "NCT05039619", "title": "A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis and the Safety and PK of Obinutuzumab in Pediatric Participants", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Lupus Nephritis" ], "interventions": [ { "name": "Obinutuzumab", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Mycophenolate Mofetil", "type": "DRUG" }, { "name": "Acetaminophen/paracetamol", "type": "DRUG" }, { "name": "Diphenhydramine hydrochloride (HCl)", "type": "DRUG" }, { "name": "Methylprednisolone", "type": "DRUG" }, { "name": "Prednisone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Hoffmann-La Roche", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "5 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "5 Years to 17 Years" }, "enrollment_count": 40, "start_date": "2022-05-12", "completion_date": "2030-06-14", "has_results": false, "last_update_posted_date": "2026-10-06", "last_synced_at": "2026-10-30T21:52:42.981Z", "location_count": 11, "location_summary": "Loma Linda, California • San Francisco, California • Aurora, Colorado + 8 more", "locations": [ { "city": "Loma Linda", "state": "California" }, { "city": "San Francisco", "state": "California" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Atlanta", "state": "Georgia" }, { "city": "Indianapolis", "state": "Indiana" } ], "official_url": "https://clinicaltrials.gov/study/NCT05039619" }, { "nct_id": "NCT00801632", "title": "Combined Kidney and Bone Marrow Transplantation to Prevent Kidney Transplant Rejection", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Kidney Transplantation", "Kidney Failure, Chronic" ], "interventions": [ { "name": "Kidney Transplantation", "type": "PROCEDURE" }, { "name": "Bone marrow transplantation", "type": "PROCEDURE" }, { "name": "MEDI-507", "type": "BIOLOGICAL" }, { "name": "cyclophosphamide", "type": "DRUG" }, { "name": "rituximab", "type": "BIOLOGICAL" }, { "name": "Tacrolimus", "type": "DRUG" }, { "name": "corticosteroids", "type": "DRUG" }, { "name": "thymic irradiation", "type": "RADIATION" } ], "intervention_types": [ "PROCEDURE", "BIOLOGICAL", "DRUG", "RADIATION" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "60 Years", "sex": "ALL", "summary": "18 Years to 60 Years" }, "enrollment_count": 5, "start_date": "2008-12", "completion_date": "2014-11", "has_results": true, "last_update_posted_date": "2015-11-10", "last_synced_at": "2026-10-30T21:52:42.981Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT00801632" }, { "nct_id": "NCT03898154", "title": "Perioperative Glucocorticoid Administration in the Treatment of Adult Distal Radius Fractures", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Distal Radius Fracture" ], "interventions": [ { "name": "Dexamethasone", "type": "DRUG" }, { "name": "Methylprednisolone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "C. Liam Dwyer", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 38, "start_date": "2019-07-10", "completion_date": "2024-12-19", "has_results": true, "last_update_posted_date": "2026-04-30", "last_synced_at": "2026-10-30T21:52:42.981Z", "location_count": 1, "location_summary": "Danville, Pennsylvania", "locations": [ { "city": "Danville", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT03898154" }, { "nct_id": "NCT01624805", "title": "Methylprednisolone, Horse Anti-Thymocyte Globulin, Cyclosporine, Filgrastim, and/or Pegfilgrastim or Pegfilgrastim Biosimilar in Treating Patients With Aplastic Anemia or Low or Intermediate-Risk Myelodysplastic Syndrome", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Aplastic Anemia", "de Novo Myelodysplastic Syndrome", "Myelodysplastic Syndrome", "Previously Treated Myelodysplastic Syndrome" ], "interventions": [ { "name": "Anti-Thymocyte Globulin", "type": "BIOLOGICAL" }, { "name": "Cyclosporine", "type": "DRUG" }, { "name": "Filgrastim", "type": "BIOLOGICAL" }, { "name": "Methylprednisolone", "type": "DRUG" }, { "name": "Pegfilgrastim", "type": "BIOLOGICAL" } ], "intervention_types": [ "BIOLOGICAL", "DRUG" ], "sponsor": "M.D. Anderson Cancer Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 140, "start_date": "2012-06-25", "completion_date": "2029-06-30", "has_results": false, "last_update_posted_date": "2026-06-22", "last_synced_at": "2026-10-30T21:52:42.981Z", "location_count": 1, "location_summary": "Houston, Texas", "locations": [ { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT01624805" }, { "nct_id": "NCT00023244", "title": "Steroid Withdrawal in Pediatric Kidney Transplant Recipients", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "End-Stage Renal Disease" ], "interventions": [ { "name": "Basiliximab", "type": "DRUG" }, { "name": "Cyclosporine", "type": "DRUG" }, { "name": "Tacrolimus", "type": "DRUG" }, { "name": "Sirolimus", "type": "DRUG" }, { "name": "Methylprednisolone", "type": "DRUG" }, { "name": "Prednisone", "type": "DRUG" }, { "name": "Bactrim", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "National Institute of Allergy and Infectious Diseases (NIAID)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "1 Day", "maximum_age": "20 Years", "sex": "ALL", "summary": "1 Day to 20 Years" }, "enrollment_count": 274, "start_date": "2001-01", "completion_date": "2005-06", "has_results": false, "last_update_posted_date": "2016-10-21", "last_synced_at": "2026-10-30T21:52:42.981Z", "location_count": 18, "location_summary": "Birmingham, Alabama • San Diego, California • Aurora, Colorado + 14 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "San Diego", "state": "California" }, { "city": "Aurora", "state": "Colorado" }, { "city": "Jacksonville", "state": "Florida" }, { "city": "Atlanta", "state": "Georgia" } ], "official_url": "https://clinicaltrials.gov/study/NCT00023244" }, { "nct_id": "NCT06489626", "title": "The Effect of a Methylprednisolone Taper on Outcomes Following Total Knee Arthroplasty", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Arthritis Knee", "Knee Osteoarthritis", "Pain, Postoperative" ], "interventions": [ { "name": "Methylprednisolone 4 milligram Tab", "type": "DRUG" }, { "name": "Dexamethasone injection", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "F. Johannes Plate", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 0, "start_date": "2025-11-01", "completion_date": "2027-12-01", "has_results": false, "last_update_posted_date": "2026-02-05", "last_synced_at": "2026-10-30T21:52:42.981Z", "location_count": 2, "location_summary": "Monroeville, Pennsylvania • Pittsburgh, Pennsylvania", "locations": [ { "city": "Monroeville", "state": "Pennsylvania" }, { "city": "Pittsburgh", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT06489626" } ] }