{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Metoprolol+succinate&page=2", "query": { "intervention": "Metoprolol succinate", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 145, "total_pages": 15, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Metoprolol+succinate&page=3&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Metoprolol+succinate&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-01T11:23:30.590Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT04049786", "title": "Impact of Bariatric Surgery on Pharmacokinetic Study of Simvastatin and Carvedilol", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Obesity", "Bariatric Surgery", "Roux-en Y Gastric Bypass" ], "interventions": [ { "name": "Digestive biopsy", "type": "PROCEDURE" }, { "name": "Carvedilol 25mg", "type": "DRUG" }, { "name": "Serial blood sampling for PK analysis", "type": "PROCEDURE" }, { "name": "Metoprolol 100 mg for CYP2D6 phenotyping", "type": "DRUG" }, { "name": "Simvastatin 40mg", "type": "DRUG" }, { "name": "Midazolam 2 mg for CYP3A4 phenotyping", "type": "DRUG" }, { "name": "Genotyping", "type": "OTHER" } ], "intervention_types": [ "PROCEDURE", "DRUG", "OTHER" ], "sponsor": "Natalia Valadares de Moraes", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 120, "start_date": "2019-06-01", "completion_date": "2023-08", "has_results": false, "last_update_posted_date": "2022-02-08", "last_synced_at": "2026-10-01T11:23:30.590Z", "location_count": 1, "location_summary": "Orlando, Florida", "locations": [ { "city": "Orlando", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT04049786" }, { "nct_id": "NCT05745337", "title": "Atrial Fibrillation: Chronic Beta-blocker Use Versus As-needed Rate Control Guided by Implantable Cardiac Monitor", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Atrial Fibrillation", "Diastolic Dysfunction", "HFpEF - Heart Failure With Preserved Ejection Fraction" ], "interventions": [ { "name": "As needed pharmacological rate control with beta-blocker (metoprolol tartrate, metoprolol succinate) or calcium channel blocker (diltiazem, verapamil)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Vermont", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 20, "start_date": "2023-02-06", "completion_date": "2025-12-31", "has_results": false, "last_update_posted_date": "2023-03-03", "last_synced_at": "2026-10-01T11:23:30.590Z", "location_count": 1, "location_summary": "Burlington, Vermont", "locations": [ { "city": "Burlington", "state": "Vermont" } ], "official_url": "https://clinicaltrials.gov/study/NCT05745337" }, { "nct_id": "NCT00649233", "title": "Food Study of Metoprolol Tartrate/Hydrochlorothiazide Tablets 100/50 mg to Lopressor HCT® Tablets 100/50 mg", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy" ], "interventions": [ { "name": "Metoprolol Tartrate/Hydrochlorothiazide Tablets 100/50 mg", "type": "DRUG" }, { "name": "Lopressor HCT® Tablets 100/50 mg", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Mylan Pharmaceuticals Inc", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 32, "start_date": "2003-01", "completion_date": "2003-02", "has_results": false, "last_update_posted_date": "2024-04-24", "last_synced_at": "2026-10-01T11:23:30.590Z", "location_count": 1, "location_summary": "Fargo, North Dakota", "locations": [ { "city": "Fargo", "state": "North Dakota" } ], "official_url": "https://clinicaltrials.gov/study/NCT00649233" }, { "nct_id": "NCT03095313", "title": "18-F Sodium Fluoride (18F-NaF) PET for the Assessment of Bioprosthetic Aortic Valve Durability and Outcomes", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Aortic Stenosis" ], "interventions": [ { "name": "18F-NaF", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Cedars-Sinai Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "60 Years", "maximum_age": null, "sex": "ALL", "summary": "60 Years and older" }, "enrollment_count": 20, "start_date": "2017-07-23", "completion_date": "2024-02-16", "has_results": false, "last_update_posted_date": "2025-02-12", "last_synced_at": "2026-10-01T11:23:30.590Z", "location_count": 1, "location_summary": "Los Angeles, California", "locations": [ { "city": "Los Angeles", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03095313" }, { "nct_id": "NCT00077948", "title": "Enoximone Plus Extended-Release Metoprolol Succinate in Subjects With Advanced Chronic Heart Failure", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Heart Failure, Congestive" ], "interventions": [ { "name": "Enoximone", "type": "DRUG" }, { "name": "Metoprolol succinate", "type": "DRUG" }, { "name": "Placebo to match enoximone", "type": "DRUG" }, { "name": "Placebo to match metoprolol succinate", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Gilead Sciences", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 175, "start_date": "2003-07", "completion_date": "2005-06", "has_results": false, "last_update_posted_date": "2014-01-10", "last_synced_at": "2026-10-01T11:23:30.590Z", "location_count": 2, "location_summary": "Denver, Colorado • Salt Lake City, Utah", "locations": [ { "city": "Denver", "state": "Colorado" }, { "city": "Salt Lake City", "state": "Utah" } ], "official_url": "https://clinicaltrials.gov/study/NCT00077948" }, { "nct_id": "NCT01395329", "title": "Nebivolol and the Endothelin (ET)-1 System", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Prehypertension", "Hypertension" ], "interventions": [ { "name": "Nebivolol", "type": "DRUG" }, { "name": "Metoprolol", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "Forearm Blood Flow (FBF) response to BQ-123 (100 mol/min)", "type": "OTHER" }, { "name": "FBF response to BQ-123 (100 nmol/min)+BQ-788(50 nmol/min)", "type": "OTHER" }, { "name": "FBF response to Acetylcholine", "type": "OTHER" }, { "name": "FBF response to Sodium Nitroprusside", "type": "OTHER" }, { "name": "FBF response to BQ-123+BQ-788+ACh", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "University of Colorado, Boulder", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "45 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "45 Years to 65 Years" }, "enrollment_count": 42, "start_date": "2011-05", "completion_date": "2016-12", "has_results": true, "last_update_posted_date": "2019-01-02", "last_synced_at": "2026-10-01T11:23:30.590Z", "location_count": 1, "location_summary": "Boulder, Colorado", "locations": [ { "city": "Boulder", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT01395329" }, { "nct_id": "NCT00648895", "title": "A Study of the Effect of Nebivolol to Evaluate Its Vasodilatory Effects in Hypertensive Patients", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Hypertension" ], "interventions": [ { "name": "Nebivolol", "type": "DRUG" }, { "name": "Metoprolol ER (TM)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Forest Laboratories", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "79 Years", "sex": "ALL", "summary": "18 Years to 79 Years" }, "enrollment_count": 12, "start_date": "2007-11", "completion_date": null, "has_results": true, "last_update_posted_date": "2010-09-20", "last_synced_at": "2026-10-01T11:23:30.590Z", "location_count": 1, "location_summary": "Houston, Texas", "locations": [ { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT00648895" }, { "nct_id": "NCT05585125", "title": "A Preliminary Study for INFORMED", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Heart Failure", "Heart Failure, Diastolic", "Heart Failure With Preserved Ejection Fraction", "Cardiac Failure", "Heart Diseases" ], "interventions": [ { "name": "Beta blocker", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Weill Medical College of Cornell University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "65 Years", "maximum_age": null, "sex": "ALL", "summary": "65 Years and older" }, "enrollment_count": 18, "start_date": "2024-02-07", "completion_date": "2027-11", "has_results": false, "last_update_posted_date": "2026-08-21", "last_synced_at": "2026-10-01T11:23:30.590Z", "location_count": 1, "location_summary": "New York, New York", "locations": [ { "city": "New York", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT05585125" }, { "nct_id": "NCT02191358", "title": "YouScript IMPACT Registry", "overall_status": "COMPLETED", "study_type": "OBSERVATIONAL", "phases": [], "conditions": [ "Adverse Drug Events", "Adverse Drug Reactions", "Drug Interaction Potentiation", "Drug Metabolism, Poor, CYP2D6-RELATED", "Drug Metabolism, Poor, CYP2C19-RELATED", "Cytochrome P450 Enzyme Deficiency", "Cytochrome P450 CYP2D6 Enzyme Deficiency", "Cytochrome P450 CYP2C9 Enzyme Deficiency", "Cytochrome P450 CYP2C19 Enzyme Deficiency", "Cytochrome P450 CYP3A Enzyme Deficiency", "Poor Metabolizer Due to Cytochrome P450 CYP2C9 Variant", "Poor Metabolizer Due to Cytochrome P450 CYP2C19 Variant", "Poor Metabolizer Due to Cytochrome P450 CYP2D6 Variant" ], "interventions": [], "intervention_types": [], "sponsor": "Genelex Corporation", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "65 Years", "maximum_age": null, "sex": "ALL", "summary": "65 Years and older" }, "enrollment_count": 800, "start_date": "2014-10", "completion_date": "2015-08", "has_results": false, "last_update_posted_date": "2017-03-01", "last_synced_at": "2026-10-01T11:23:30.590Z", "location_count": 7, "location_summary": "Garden Grove, California • Denver, Colorado • Lexington, Kentucky + 3 more", "locations": [ { "city": "Garden Grove", "state": "California" }, { "city": "Denver", "state": "Colorado" }, { "city": "Lexington", "state": "Kentucky" }, { "city": "Towson", "state": "Maryland" }, { "city": "Fall River", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT02191358" }, { "nct_id": "NCT01157234", "title": "Nebivolol Effect on Nitric Oxide Levels, Blood Pressure, and Renal Function in Kidney Transplant Patients", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Hypertension" ], "interventions": [ { "name": "Nebivolol", "type": "DRUG" }, { "name": "Metoprolol", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Florida", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 32, "start_date": "2010-07", "completion_date": "2014-07", "has_results": true, "last_update_posted_date": "2024-11-06", "last_synced_at": "2026-10-01T11:23:30.590Z", "location_count": 1, "location_summary": "Gainesville, Florida", "locations": [ { "city": "Gainesville", "state": "Florida" } ], "official_url": "https://clinicaltrials.gov/study/NCT01157234" } ] }