{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Multimodal+Non-Opioid+Analgesia&page=2", "query": { "intervention": "Multimodal Non-Opioid Analgesia", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 33, "total_pages": 4, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Multimodal+Non-Opioid+Analgesia&page=3&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Multimodal+Non-Opioid+Analgesia&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-05T00:52:56.952Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT03907176", "title": "Study of Post-Herniorrhaphy Non-opioid MMA Regimens", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Analgesia" ], "interventions": [ { "name": "HTX-011", "type": "DRUG" }, { "name": "Luer lock applicator", "type": "DEVICE" }, { "name": "Ibuprofen", "type": "DRUG" }, { "name": "Acetaminophen", "type": "DRUG" } ], "intervention_types": [ "DRUG", "DEVICE" ], "sponsor": "Heron Therapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 209, "start_date": "2019-04-04", "completion_date": "2021-11-22", "has_results": true, "last_update_posted_date": "2026-06-04", "last_synced_at": "2026-10-05T00:52:56.952Z", "location_count": 30, "location_summary": "Anaheim, California • La Mesa, California • Orange, California + 22 more", "locations": [ { "city": "Anaheim", "state": "California" }, { "city": "La Mesa", "state": "California" }, { "city": "La Mesa", "state": "California" }, { "city": "Orange", "state": "California" }, { "city": "Riverside", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03907176" }, { "nct_id": "NCT06042413", "title": "Prediction and Prevention of Postoperative Mortality and Morbidity", "overall_status": "NOT_YET_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Dementia", "Postoperative Delirium (POD)", "Postoperative Neurocognitive Disorder", "Major Adverse Cardiac and Cerebrovascular Events", "Perioperative Complications", "Postoperative Cognitive Decline" ], "interventions": [ { "name": "Personalized CPC Prehabilitation", "type": "OTHER" }, { "name": "Cognitive Training", "type": "BEHAVIORAL" }, { "name": "Meditation", "type": "BEHAVIORAL" }, { "name": "Daily Exercise", "type": "BEHAVIORAL" }, { "name": "Enhanced Social Support", "type": "BEHAVIORAL" }, { "name": "Proactive Bundle Interventions", "type": "OTHER" }, { "name": "Pre-operative Standard of Care", "type": "PROCEDURE" }, { "name": "Intra-operative Standard of Care", "type": "PROCEDURE" } ], "intervention_types": [ "OTHER", "BEHAVIORAL", "PROCEDURE" ], "sponsor": "University of Pittsburgh", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "65 Years", "maximum_age": null, "sex": "ALL", "summary": "65 Years and older" }, "enrollment_count": 1200, "start_date": "2026-10", "completion_date": "2027-12", "has_results": false, "last_update_posted_date": "2026-09-25", "last_synced_at": "2026-10-05T00:52:56.952Z", "location_count": 5, "location_summary": "Pittsburgh, Pennsylvania", "locations": [ { "city": "Pittsburgh", "state": "Pennsylvania" }, { "city": "Pittsburgh", "state": "Pennsylvania" }, { "city": "Pittsburgh", "state": "Pennsylvania" }, { "city": "Pittsburgh", "state": "Pennsylvania" }, { "city": "Pittsburgh", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT06042413" }, { "nct_id": "NCT07840183", "title": "Epidural Analgesia Versus Opioid-sparing Analgesia for Open Ventral Hernia Repair With Transversus Abdominis Release", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Ventral Hernia", "Ventral Hernia Repair", "Postoperative Pain" ], "interventions": [ { "name": "Bupivicaine", "type": "DRUG" }, { "name": "Fentanyl", "type": "DRUG" }, { "name": "Thoracic epidural analgesia", "type": "DEVICE" }, { "name": "Hydromorphone", "type": "DRUG" }, { "name": "Acetaminophen", "type": "DRUG" }, { "name": "Ketorolac", "type": "DRUG" }, { "name": "magnesium sulfate", "type": "DRUG" }, { "name": "Tramadol", "type": "DRUG" }, { "name": "Gabapentin", "type": "DRUG" }, { "name": "Cyclobenzaprine", "type": "DRUG" }, { "name": "transversus abdominis plane block", "type": "PROCEDURE" } ], "intervention_types": [ "DRUG", "DEVICE", "PROCEDURE" ], "sponsor": "Northwestern University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "18 Years to 80 Years" }, "enrollment_count": 40, "start_date": "2026-09-18", "completion_date": "2027-11", "has_results": false, "last_update_posted_date": "2026-09-24", "last_synced_at": "2026-10-05T00:52:56.952Z", "location_count": 1, "location_summary": "Chicago, Illinois", "locations": [ { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT07840183" }, { "nct_id": "NCT07153003", "title": "Efficacy And Safety Of Tramadol And Oxycodone Versus Oxycodone Monotherapy For Pain Control After Primary Total Knee And Total Hip Arthroplasty", "overall_status": "ENROLLING_BY_INVITATION", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Post Operative Pain" ], "interventions": [ { "name": "Oxycodone", "type": "DRUG" }, { "name": "Tramadol and Oxycodone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Mayo Clinic", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 560, "start_date": "2026-02-02", "completion_date": "2031-09-01", "has_results": false, "last_update_posted_date": "2026-03-18", "last_synced_at": "2026-10-05T00:52:56.952Z", "location_count": 1, "location_summary": "Rochester, Minnesota", "locations": [ { "city": "Rochester", "state": "Minnesota" } ], "official_url": "https://clinicaltrials.gov/study/NCT07153003" }, { "nct_id": "NCT04710277", "title": "Novel Multimodal Pain Control Protocol for Minimally Invasive Gynecologic Surgery", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Postoperative Pain", "Narcotic Use", "Cryotherapy Effect" ], "interventions": [ { "name": "Opioid-sparing multimodal pain management", "type": "OTHER" }, { "name": "Usual care", "type": "OTHER" } ], "intervention_types": [ "OTHER" ], "sponsor": "Ohio State University", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "FEMALE", "summary": "18 Years and older · Female only" }, "enrollment_count": 54, "start_date": "2021-04-19", "completion_date": "2022-10-20", "has_results": false, "last_update_posted_date": "2023-05-12", "last_synced_at": "2026-10-05T00:52:56.952Z", "location_count": 1, "location_summary": "Columbus, Ohio", "locations": [ { "city": "Columbus", "state": "Ohio" } ], "official_url": "https://clinicaltrials.gov/study/NCT04710277" }, { "nct_id": "NCT07439666", "title": "NEUROCUPLE™ as an Opioid Alternative Following Total Knee Arthroplasty", "overall_status": "NOT_YET_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Total Knee Arthroplasty Postoperative Pain", "Opioid Reduction After TKA" ], "interventions": [ { "name": "NEUROCUPLE™ Patch", "type": "DEVICE" }, { "name": "Sham patch", "type": "DEVICE" }, { "name": "Enhanced Recovery After Surgery (ERAS) Standard of Care", "type": "OTHER" } ], "intervention_types": [ "DEVICE", "OTHER" ], "sponsor": "Jacques E. Chelly", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 274, "start_date": "2026-12", "completion_date": "2027-11", "has_results": false, "last_update_posted_date": "2026-07-06", "last_synced_at": "2026-10-05T00:52:56.952Z", "location_count": 3, "location_summary": "Pittsburgh, Pennsylvania", "locations": [ { "city": "Pittsburgh", "state": "Pennsylvania" }, { "city": "Pittsburgh", "state": "Pennsylvania" }, { "city": "Pittsburgh", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT07439666" }, { "nct_id": "NCT07348627", "title": "Opioid-Sparing Joint Replacement", "overall_status": "RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Pain Management", "Opioid Consumption" ], "interventions": [ { "name": "Placebo", "type": "DRUG" }, { "name": "Oxycodone 5 mg", "type": "DRUG" }, { "name": "Multimodal Non-Opioid Analgesia", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "Emory University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 120, "start_date": "2026-03-19", "completion_date": "2028-08", "has_results": false, "last_update_posted_date": "2026-04-17", "last_synced_at": "2026-10-05T00:52:56.952Z", "location_count": 1, "location_summary": "Atlanta, Georgia", "locations": [ { "city": "Atlanta", "state": "Georgia" } ], "official_url": "https://clinicaltrials.gov/study/NCT07348627" }, { "nct_id": "NCT03928015", "title": "Evaluation of Dronabinol For Acute Pain Following Traumatic Injury", "overall_status": "WITHDRAWN", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Traumatic Injury", "Pain, Acute" ], "interventions": [ { "name": "Adjunctive dronabinol", "type": "DRUG" }, { "name": "Systemic analgesics", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "CommonSpirit Health", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 0, "start_date": "2019-10-01", "completion_date": "2021-06-29", "has_results": false, "last_update_posted_date": "2022-07-28", "last_synced_at": "2026-10-05T00:52:56.952Z", "location_count": 1, "location_summary": "Lakewood, Colorado", "locations": [ { "city": "Lakewood", "state": "Colorado" } ], "official_url": "https://clinicaltrials.gov/study/NCT03928015" }, { "nct_id": "NCT03974932", "title": "Total Knee Arthroplasty (TKA) Study of HTX-011 in an Multimodal Analgesic Regimen (MMA) Regimen", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Analgesia" ], "interventions": [ { "name": "HTX-011", "type": "DRUG" }, { "name": "Ibuprofen", "type": "DRUG" }, { "name": "Acetaminophen", "type": "DRUG" }, { "name": "Celecoxib", "type": "DRUG" }, { "name": "+/- Bupivacaine HCl", "type": "DRUG" }, { "name": "Luer Lock Applicator", "type": "DEVICE" } ], "intervention_types": [ "DRUG", "DEVICE" ], "sponsor": "Heron Therapeutics", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 116, "start_date": "2019-06-05", "completion_date": "2021-01-07", "has_results": true, "last_update_posted_date": "2026-03-02", "last_synced_at": "2026-10-05T00:52:56.952Z", "location_count": 6, "location_summary": "Sheffield, Alabama • Tamarac, Florida • Dayton, Ohio + 3 more", "locations": [ { "city": "Sheffield", "state": "Alabama" }, { "city": "Tamarac", "state": "Florida" }, { "city": "Dayton", "state": "Ohio" }, { "city": "Bellaire", "state": "Texas" }, { "city": "Plano", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT03974932" }, { "nct_id": "NCT04003350", "title": "The Effect of Prolonged Multimodal Analgesic Regimen on Post Hospital Discharge Opioid Use and Pain Control After Primary Total Knee Arthroplasty", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Osteo Arthritis Knee" ], "interventions": [ { "name": "Oxycodone", "type": "DRUG" }, { "name": "Tramadol", "type": "DRUG" }, { "name": "Tylenol", "type": "DRUG" }, { "name": "Meloxicam", "type": "DRUG" }, { "name": "Gabapentin", "type": "DRUG" }, { "name": "Metaxalone", "type": "DRUG" }, { "name": "Esomeprazole 20mg", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Rothman Institute Orthopaedics", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 216, "start_date": "2017-12-21", "completion_date": "2019-03-15", "has_results": false, "last_update_posted_date": "2019-07-01", "last_synced_at": "2026-10-05T00:52:56.952Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT04003350" } ] }