{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=N-monomethyl-L-arginine", "query": { "intervention": "N-monomethyl-L-arginine" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 31, "total_pages": 4, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=N-monomethyl-L-arginine&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-10-02T02:02:03.537Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00690534", "title": "Insulin and Sarcopenia in the Elderly", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Sarcopenia" ], "interventions": [ { "name": "Insulin Regular", "type": "DRUG" }, { "name": "L-NMMA", "type": "DRUG" }, { "name": "Sodium Nitroprusside", "type": "DRUG" }, { "name": "mixed meal", "type": "OTHER" } ], "intervention_types": [ "DRUG", "OTHER" ], "sponsor": "The University of Texas Medical Branch, Galveston", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "18 Years to 85 Years" }, "enrollment_count": 88, "start_date": "2005-09", "completion_date": "2012-08", "has_results": false, "last_update_posted_date": "2016-12-12", "last_synced_at": "2026-10-02T02:02:03.537Z", "location_count": 1, "location_summary": "Galveston, Texas", "locations": [ { "city": "Galveston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT00690534" }, { "nct_id": "NCT01701973", "title": "Effect of DPP4 Inhibition on Growth Hormone Secretion", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Obesity" ], "interventions": [ { "name": "Sitagliptin", "type": "DRUG" }, { "name": "Pegvisomant", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "L-NMMA", "type": "DRUG" }, { "name": "Exendin 9-39", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vanderbilt University", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "40 Years", "sex": "ALL", "summary": "18 Years to 40 Years" }, "enrollment_count": 44, "start_date": "2013-01", "completion_date": "2017-05", "has_results": true, "last_update_posted_date": "2018-05-29", "last_synced_at": "2026-10-02T02:02:03.537Z", "location_count": 1, "location_summary": "Nashville, Tennessee", "locations": [ { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT01701973" }, { "nct_id": "NCT01791816", "title": "Mechanisms of Vasovagal Syncope", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "EARLY_PHASE1" ], "conditions": [ "Vasovagal Syncope", "Postural Tachycardia Syndrome" ], "interventions": [ { "name": "Phenylephrine", "type": "DRUG" }, { "name": "L-Ng-monomethyl Arginine (L-NMMA)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "New York Medical College", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "14 Years", "maximum_age": "29 Years", "sex": "ALL", "summary": "14 Years to 29 Years" }, "enrollment_count": 90, "start_date": "2013-02", "completion_date": "2022-12", "has_results": false, "last_update_posted_date": "2025-05-23", "last_synced_at": "2026-10-02T02:02:03.537Z", "location_count": 1, "location_summary": "Hawthorne, New York", "locations": [ { "city": "Hawthorne", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT01791816" }, { "nct_id": "NCT00327080", "title": "Sildenafil to Treat HIV-Associated Pulmonary Hypertension", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "HIV" ], "interventions": [ { "name": "MRI", "type": "PROCEDURE" }, { "name": "L-NMMA", "type": "DRUG" }, { "name": "Acetylcholine", "type": "DRUG" } ], "intervention_types": [ "PROCEDURE", "DRUG" ], "sponsor": "National Heart, Lung, and Blood Institute (NHLBI)", "sponsor_class": "NIH", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 20, "start_date": "2006-05-12", "completion_date": "2009-03-18", "has_results": false, "last_update_posted_date": "2019-12-17", "last_synced_at": "2026-10-02T02:02:03.537Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00327080" }, { "nct_id": "NCT03236935", "title": "Phase Ib of L-NMMA and Pembrolizumab", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Non-Small Cell Lung Cancer", "Malignant Melanoma", "Head and Neck Squamous Cell Carcinoma", "Classical Hodgkin Lymphoma", "Urothelial Carcinoma Bladder", "DNA Repair-Deficiency Disorders" ], "interventions": [ { "name": "L-NMMA", "type": "DRUG" }, { "name": "Pembrolizumab", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "The Methodist Hospital Research Institute", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 12, "start_date": "2018-08-27", "completion_date": "2022-04-22", "has_results": true, "last_update_posted_date": "2026-04-09", "last_synced_at": "2026-10-02T02:02:03.537Z", "location_count": 1, "location_summary": "Houston, Texas", "locations": [ { "city": "Houston", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT03236935" }, { "nct_id": "NCT00759707", "title": "Endothelial Function in Lower Extremity Bypass Grafts", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Peripheral Arterial Disease" ], "interventions": [ { "name": "L-N^G monomethyl arginine (L-NMMA)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Brigham and Women's Hospital", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 19, "start_date": "2006-04", "completion_date": "2009-12", "has_results": true, "last_update_posted_date": "2017-05-16", "last_synced_at": "2026-10-02T02:02:03.537Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT00759707" }, { "nct_id": "NCT01122407", "title": "Pathophysiology of Cardiometabolic Risk Factors in African Americans", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Obesity", "Hypertension" ], "interventions": [ { "name": "L-NMMA", "type": "DRUG" }, { "name": "Trimethaphan", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vanderbilt University Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "30 Years", "maximum_age": "50 Years", "sex": "FEMALE", "summary": "30 Years to 50 Years · Female only" }, "enrollment_count": 34, "start_date": "2010-01", "completion_date": "2016-11", "has_results": false, "last_update_posted_date": "2017-01-18", "last_synced_at": "2026-10-02T02:02:03.537Z", "location_count": 1, "location_summary": "Nashville, Tennessee", "locations": [ { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT01122407" }, { "nct_id": "NCT00356265", "title": "Alpha-Adrenoceptor Vascular Function In Chronic Kidney Disease Focus On The Role Of Endothelial Nitric Oxide", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Chronic Kidney Disease", "Hypertension" ], "interventions": [ { "name": "Procedure: Regional phenylephrine arterial infusion", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Michigan", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 18, "start_date": "2006-07", "completion_date": "2010-11", "has_results": true, "last_update_posted_date": "2018-01-23", "last_synced_at": "2026-10-02T02:02:03.537Z", "location_count": 1, "location_summary": "Ann Arbor, Michigan", "locations": [ { "city": "Ann Arbor", "state": "Michigan" } ], "official_url": "https://clinicaltrials.gov/study/NCT00356265" }, { "nct_id": "NCT00685945", "title": "Renin-Angiotensin Aldosterone System and Fibrinolysis Interaction in Humans-Specific Aim 3", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Obesity" ], "interventions": [ { "name": "Control (bradykinin)", "type": "DRUG" }, { "name": "L-NMMA + bradykinin", "type": "DRUG" }, { "name": "Isosorbide + L-NMMA + bradykinin", "type": "DRUG" }, { "name": "Sildenafil + L-NMMA + bradykinin", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Vanderbilt University", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "70 Years", "sex": "ALL", "summary": "18 Years to 70 Years" }, "enrollment_count": 24, "start_date": "2007-12", "completion_date": "2009-01", "has_results": true, "last_update_posted_date": "2013-02-25", "last_synced_at": "2026-10-02T02:02:03.537Z", "location_count": 1, "location_summary": "Nashville, Tennessee", "locations": [ { "city": "Nashville", "state": "Tennessee" } ], "official_url": "https://clinicaltrials.gov/study/NCT00685945" }, { "nct_id": "NCT00009581", "title": "Nitric Oxide to Improve Blood Flow in Sickle Cell Disease", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Sickle Cell Anemia" ], "interventions": [ { "name": "L-NMMA", "type": "DRUG" }, { "name": "Acetylcholine", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "National Institutes of Health Clinical Center (CC)", "sponsor_class": "NIH", "healthy_volunteers": true, "eligibility": { "minimum_age": null, "maximum_age": null, "sex": "ALL", "summary": "Not listed" }, "enrollment_count": 65, "start_date": "2001-01", "completion_date": "2003-01", "has_results": false, "last_update_posted_date": "2008-03-04", "last_synced_at": "2026-10-02T02:02:03.537Z", "location_count": 1, "location_summary": "Bethesda, Maryland", "locations": [ { "city": "Bethesda", "state": "Maryland" } ], "official_url": "https://clinicaltrials.gov/study/NCT00009581" } ] }