{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=NAC&page=2",
    "query": {
      "intervention": "NAC",
      "page": 2
    },
    "page_size": 10
  },
  "pagination": {
    "page": 2,
    "page_size": 10,
    "total_count": 10,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=NAC&page=1&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-09-03T13:44:45.730Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT06727422",
      "title": "Efficacy of Rifaximin With NAC in IBS-D",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "IBS (Irritable Bowel Syndrome)",
        "IBS-D (Diarrhea-predominant)"
      ],
      "interventions": [
        {
          "name": "rifaximin 66mg + N-acetylcysteine 560mg three times daily",
          "type": "DRUG"
        },
        {
          "name": "RNIB21 containing rifaximin 132mg + N-acetylcysteine 560mg three times daily",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Mark Pimentel, MD",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 225,
      "start_date": "2026-02-04",
      "completion_date": "2027-01-01",
      "has_results": false,
      "last_update_posted_date": "2026-04-20",
      "last_synced_at": "2026-09-03T13:44:45.730Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06727422"
    },
    {
      "nct_id": "NCT04419025",
      "title": "Efficacy of N-Acetylcysteine (NAC) in Preventing COVID-19 From Progressing to Severe Disease",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "COVID",
        "Sars-CoV2",
        "SARS-Associated Coronavirus as Cause of Disease Classified Elsewhere",
        "Oxidative Stress"
      ],
      "interventions": [
        {
          "name": "N-acetylcysteine",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Cambridge Health Alliance",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 165,
      "start_date": "2020-09-23",
      "completion_date": "2021-05-14",
      "has_results": false,
      "last_update_posted_date": "2021-05-28",
      "last_synced_at": "2026-09-03T13:44:45.730Z",
      "location_count": 4,
      "location_summary": "Cambridge, Massachusetts • Everett, Massachusetts • Somerville, Massachusetts",
      "locations": [
        {
          "city": "Cambridge",
          "state": "Massachusetts"
        },
        {
          "city": "Everett",
          "state": "Massachusetts"
        },
        {
          "city": "Somerville",
          "state": "Massachusetts"
        },
        {
          "city": "Somerville",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04419025"
    },
    {
      "nct_id": "NCT00915200",
      "title": "N-Acetylcysteine and Milk Thistle for Treatment of Diabetic Nephropathy",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Diabetic Nephropathies",
        "Proteinuria",
        "Oxidative Stress"
      ],
      "interventions": [
        {
          "name": "N-acetylcysteine",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "silibin",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "high-dose silibin",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "N-acetylcysteine placebo",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "silibin placebo",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "The University of Texas Health Science Center at San Antonio",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 114,
      "start_date": "2009-10",
      "completion_date": "2016-04",
      "has_results": false,
      "last_update_posted_date": "2016-06-27",
      "last_synced_at": "2026-09-03T13:44:45.730Z",
      "location_count": 1,
      "location_summary": "San Antonio, Texas",
      "locations": [
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00915200"
    },
    {
      "nct_id": "NCT01046136",
      "title": "Mucinex Exploratory Cold Study",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Common Cold"
      ],
      "interventions": [
        {
          "name": "guaifenesin (Mucinex)",
          "type": "DRUG"
        },
        {
          "name": "placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Reckitt Benckiser Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "12 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "12 Years and older"
      },
      "enrollment_count": 378,
      "start_date": "2009-12",
      "completion_date": null,
      "has_results": true,
      "last_update_posted_date": "2020-12-30",
      "last_synced_at": "2026-09-03T13:44:45.730Z",
      "location_count": 1,
      "location_summary": "Bellevue, Nebraska",
      "locations": [
        {
          "city": "Bellevue",
          "state": "Nebraska"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01046136"
    },
    {
      "nct_id": "NCT01381354",
      "title": "Nutrition, Neuromuscular Electrical Stimulation (NMES) and Secondary Progressive Multiple Sclerosis (SPMS)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Multiple Sclerosis"
      ],
      "interventions": [
        {
          "name": "Progressive exercise",
          "type": "OTHER"
        },
        {
          "name": "Neuromuscular electrical stimulation delivered using the electrical therapy device EMPI 300 PV",
          "type": "DEVICE"
        },
        {
          "name": "Modified paleolithic diet",
          "type": "OTHER"
        },
        {
          "name": "Omega 3 fatty acids",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Full Spectrum vitamin",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Essential - hydroxytyrosol",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Maltodextrin fiber supplement",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Mineral boost (magnesium)",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Niacinamide",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Methyl B12",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Taurine",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "creatine",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "thiamine",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "riboflavin",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "N acetylcysteine",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "alpha lipoic acid",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "L acetyl carnitine",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "methyl folate",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "coenzyme Q",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "meditation",
          "type": "BEHAVIORAL"
        },
        {
          "name": "self massage",
          "type": "BEHAVIORAL"
        },
        {
          "name": "learning",
          "type": "BEHAVIORAL"
        },
        {
          "name": "Coconut oil",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "OTHER",
        "DEVICE",
        "DIETARY_SUPPLEMENT",
        "BEHAVIORAL"
      ],
      "sponsor": "University of Iowa",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 38,
      "start_date": "2010-10",
      "completion_date": "2016-05",
      "has_results": false,
      "last_update_posted_date": "2018-06-26",
      "last_synced_at": "2026-09-03T13:44:45.730Z",
      "location_count": 1,
      "location_summary": "Iowa City, Iowa",
      "locations": [
        {
          "city": "Iowa City",
          "state": "Iowa"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01381354"
    },
    {
      "nct_id": "NCT00397735",
      "title": "N-acetylcysteine in Intra-amniotic Infection/Inflammation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "Labor, Premature",
        "Preterm Premature Rupture of the Membranes",
        "Infection",
        "Inflammation",
        "Chorioamnionitis"
      ],
      "interventions": [
        {
          "name": "amniocentesis",
          "type": "PROCEDURE"
        },
        {
          "name": "N-acetylcysteine or placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "PROCEDURE",
        "DRUG"
      ],
      "sponsor": "Ohio State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 68,
      "start_date": "2006-10-01",
      "completion_date": "2018-08-01",
      "has_results": false,
      "last_update_posted_date": "2018-10-10",
      "last_synced_at": "2026-09-03T13:44:45.730Z",
      "location_count": 2,
      "location_summary": "New Haven, Connecticut • Columbus, Ohio",
      "locations": [
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "Columbus",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00397735"
    },
    {
      "nct_id": "NCT03220776",
      "title": "Imaging GABAergic/Glutamatergic Drugs in Bipolar Alcoholics Alcoholics",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Alcohol Use Disorder",
        "Bipolar Disorder"
      ],
      "interventions": [
        {
          "name": "N-Acetylcysteine",
          "type": "DRUG"
        },
        {
          "name": "Gabapentin",
          "type": "DRUG"
        },
        {
          "name": "Placebo Oral Tablet",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Medical University of South Carolina",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 54,
      "start_date": "2017-08-07",
      "completion_date": "2022-11-21",
      "has_results": true,
      "last_update_posted_date": "2023-12-13",
      "last_synced_at": "2026-09-03T13:44:45.730Z",
      "location_count": 1,
      "location_summary": "Charleston, South Carolina",
      "locations": [
        {
          "city": "Charleston",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03220776"
    },
    {
      "nct_id": "NCT01962961",
      "title": "N-acetylcysteine to Reduce Oxidative Stress and Improve Endothelial Function in HIV-infected Older Adults",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1",
        "PHASE2"
      ],
      "conditions": [
        "HIV",
        "Endothelial Dysfunction",
        "Oxidative Stress"
      ],
      "interventions": [
        {
          "name": "PharmaNAC (N-acetylcysteine)",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Matching placebo",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "Indiana University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "50 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "50 Years and older"
      },
      "enrollment_count": 24,
      "start_date": "2013-10",
      "completion_date": "2015-10",
      "has_results": true,
      "last_update_posted_date": "2016-02-08",
      "last_synced_at": "2026-09-03T13:44:45.730Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01962961"
    },
    {
      "nct_id": "NCT01675661",
      "title": "Achieving Cannabis Cessation-Evaluating N-Acetylcysteine Treatment",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Cannabis Dependence"
      ],
      "interventions": [
        {
          "name": "N-Acetylcysteine",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Medical University of South Carolina",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "18 Years to 50 Years"
      },
      "enrollment_count": 302,
      "start_date": "2014-01",
      "completion_date": "2015-08",
      "has_results": true,
      "last_update_posted_date": "2018-05-24",
      "last_synced_at": "2026-09-03T13:44:45.730Z",
      "location_count": 6,
      "location_summary": "Los Angeles, California • New Haven, Connecticut • Lexington, Kentucky + 3 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "New Haven",
          "state": "Connecticut"
        },
        {
          "city": "Lexington",
          "state": "Kentucky"
        },
        {
          "city": "Portland",
          "state": "Oregon"
        },
        {
          "city": "Pickens",
          "state": "South Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01675661"
    },
    {
      "nct_id": "NCT00586092",
      "title": "A Phase I Study of ABT-510 in Combination With Bevacizumab in Advanced Solid Tumors",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "Solid Tumors"
      ],
      "interventions": [
        {
          "name": "bevacizumab, ABT-510",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Herbert Hurwitz",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 45,
      "start_date": "2005-09",
      "completion_date": "2013-02",
      "has_results": false,
      "last_update_posted_date": "2013-04-08",
      "last_synced_at": "2026-09-03T13:44:45.730Z",
      "location_count": 1,
      "location_summary": "Durham, North Carolina",
      "locations": [
        {
          "city": "Durham",
          "state": "North Carolina"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00586092"
    }
  ]
}