{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=NEM",
    "query": {
      "intervention": "NEM"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 9,
    "total_pages": 1,
    "next_page_url": null,
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-11T11:57:09.530Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT00750854",
      "title": "Efficacy & Safety Study of Natural Eggshell Membrane (NEM) for the Treatment of Joint & Connective Tissue Disorders",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Osteoarthritis",
        "Fibromyalgia"
      ],
      "interventions": [
        {
          "name": "NEM Formulation X",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "NEM Formulation Y",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "ESM Technologies, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "100 Years",
        "sex": "ALL",
        "summary": "18 Years to 100 Years"
      },
      "enrollment_count": 28,
      "start_date": "2003-11",
      "completion_date": "2004-04",
      "has_results": false,
      "last_update_posted_date": "2023-09-07",
      "last_synced_at": "2026-09-11T11:57:09.530Z",
      "location_count": 1,
      "location_summary": "Jenks, Oklahoma",
      "locations": [
        {
          "city": "Jenks",
          "state": "Oklahoma"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00750854"
    },
    {
      "nct_id": "NCT02146924",
      "title": "Cellular Immunotherapy in Treating Patients With High-Risk Acute Lymphoblastic Leukemia",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE1"
      ],
      "conditions": [
        "B Acute Lymphoblastic Leukemia",
        "Recurrent Acute Lymphoblastic Leukemia",
        "Refractory Acute Lymphoblastic Leukemia"
      ],
      "interventions": [
        {
          "name": "CD19CAR-CD28-CD3zeta-EGFRt-expressing Tcm-enriched T-lymphocytes",
          "type": "BIOLOGICAL"
        },
        {
          "name": "CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched T-lymphocytes",
          "type": "BIOLOGICAL"
        },
        {
          "name": "Laboratory Biomarker Analysis",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "BIOLOGICAL",
        "OTHER"
      ],
      "sponsor": "City of Hope Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 71,
      "start_date": "2014-10-16",
      "completion_date": "2027-06-17",
      "has_results": false,
      "last_update_posted_date": "2026-08-05",
      "last_synced_at": "2026-09-11T11:57:09.530Z",
      "location_count": 1,
      "location_summary": "Duarte, California",
      "locations": [
        {
          "city": "Duarte",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02146924"
    },
    {
      "nct_id": "NCT00750230",
      "title": "Pilot Study of the Efficacy & Safety of Natural Eggshell Membrane (NEM) for Joint & Connective Tissue Disorders",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Osteoarthritis",
        "Fibromyalgia"
      ],
      "interventions": [
        {
          "name": "NEM",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "ESM Technologies, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "100 Years",
        "sex": "ALL",
        "summary": "18 Years to 100 Years"
      },
      "enrollment_count": 11,
      "start_date": "2003-10",
      "completion_date": "2004-01",
      "has_results": false,
      "last_update_posted_date": "2023-09-07",
      "last_synced_at": "2026-09-11T11:57:09.530Z",
      "location_count": 1,
      "location_summary": "Carthage, Missouri",
      "locations": [
        {
          "city": "Carthage",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00750230"
    },
    {
      "nct_id": "NCT07766720",
      "title": "Effects of Eggshell Membrane and Curcumin Extract Supplementation, Separately or Combined, on Recovery From Intense Exercise",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Exercise-induced Muscle Soreness",
        "Exercise-induced Joint Pain",
        "Exercise-induced Joint Stiffness",
        "Exercise-induced Cartilage Turnover"
      ],
      "interventions": [
        {
          "name": "NEM® brand eggshell membrane powder",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "curQ+® brand highly absorbable curcumin",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "EM Placebo",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Curc Placebo",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "NEM® plus curQ+® combination",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "ESM Technologies, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "40 Years",
        "sex": "MALE",
        "summary": "18 Years to 40 Years · Male only"
      },
      "enrollment_count": 60,
      "start_date": "2026-02-01",
      "completion_date": "2026-12-31",
      "has_results": false,
      "last_update_posted_date": "2026-08-14",
      "last_synced_at": "2026-09-11T11:57:09.530Z",
      "location_count": 1,
      "location_summary": "College Station, Texas",
      "locations": [
        {
          "city": "College Station",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07766720"
    },
    {
      "nct_id": "NCT03679923",
      "title": "NEM® Versus Placebo in Exercised-induced Joint Pain, Stiffness, & Cartilage Turnover in Healthy Men & Women",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Exercise-induced Joint Pain",
        "Exercise-induced Joint Stiffness",
        "Exercise-induced Joint Cartilage Turnover"
      ],
      "interventions": [
        {
          "name": "NEM® brand eggshell membrane",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "ESM Technologies, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "40 Years to 75 Years"
      },
      "enrollment_count": 84,
      "start_date": "2018-09-20",
      "completion_date": "2018-11-13",
      "has_results": false,
      "last_update_posted_date": "2024-09-19",
      "last_synced_at": "2026-09-11T11:57:09.530Z",
      "location_count": 1,
      "location_summary": "Springfield, Missouri",
      "locations": [
        {
          "city": "Springfield",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03679923"
    },
    {
      "nct_id": "NCT03769857",
      "title": "NEM® + BIOCURC® Versus Placebo in Exercised-induced Joint Pain, Stiffness, & Cartilage Turnover in Healthy Men & Women",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Exercise-induced Joint Pain",
        "Exercise-induced Joint Stiffness",
        "Exercise-induced Joint Cartilage Turnover"
      ],
      "interventions": [
        {
          "name": "NEM® + BIOCURC®",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "ESM Technologies, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "40 Years to 75 Years"
      },
      "enrollment_count": 84,
      "start_date": "2019-01-13",
      "completion_date": "2019-04-15",
      "has_results": false,
      "last_update_posted_date": "2019-07-18",
      "last_synced_at": "2026-09-11T11:57:09.530Z",
      "location_count": 1,
      "location_summary": "Springfield, Missouri",
      "locations": [
        {
          "city": "Springfield",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03769857"
    },
    {
      "nct_id": "NCT01407991",
      "title": "Nasogastric/Oral Gastric Tube Placement in Infants: Comparing 2 Measurement Methods",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Enteral Tube Placement"
      ],
      "interventions": [
        {
          "name": "enteral tube placement accuracy",
          "type": "OTHER"
        },
        {
          "name": "NEM method for NG/OG tube placement",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Children's Hospital of Philadelphia",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "6 Months",
        "sex": "ALL",
        "summary": "Up to 6 Months"
      },
      "enrollment_count": 9,
      "start_date": "2011-07",
      "completion_date": "2015-11",
      "has_results": false,
      "last_update_posted_date": "2015-11-10",
      "last_synced_at": "2026-09-11T11:57:09.530Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01407991"
    },
    {
      "nct_id": "NCT04215198",
      "title": "NEM® + KD PUR® Fish Oil Versus Placebo in Exercised-induced Joint Pain, Stiffness, & Cartilage Turnover in Healthy Men & Women",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Exercise-induced Joint Pain",
        "Exercise-induced Joint Stiffness",
        "Exercise-induced Joint Cartilage Turnover"
      ],
      "interventions": [
        {
          "name": "Move3™ (NEM® brand eggshell membrane + KD PUR® brand fish oil)",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "ESM Technologies, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": "75 Years",
        "sex": "ALL",
        "summary": "40 Years to 75 Years"
      },
      "enrollment_count": 85,
      "start_date": "2018-09-20",
      "completion_date": "2019-01-16",
      "has_results": false,
      "last_update_posted_date": "2024-04-30",
      "last_synced_at": "2026-09-11T11:57:09.530Z",
      "location_count": 1,
      "location_summary": "Springfield, Missouri",
      "locations": [
        {
          "city": "Springfield",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04215198"
    },
    {
      "nct_id": "NCT00750477",
      "title": "Efficacy & Safety Study Evaluating Natural Eggshell Membrane (NEM) in the Treatment of Osteoarthritis",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Osteoarthritis"
      ],
      "interventions": [
        {
          "name": "NEM",
          "type": "DIETARY_SUPPLEMENT"
        },
        {
          "name": "Placebo",
          "type": "DIETARY_SUPPLEMENT"
        }
      ],
      "intervention_types": [
        "DIETARY_SUPPLEMENT"
      ],
      "sponsor": "ESM Technologies, LLC",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 67,
      "start_date": "2004-12",
      "completion_date": "2006-05",
      "has_results": false,
      "last_update_posted_date": "2016-02-15",
      "last_synced_at": "2026-09-11T11:57:09.530Z",
      "location_count": 3,
      "location_summary": "Cuba, Missouri • Kirksville, Missouri • Springfield, Missouri",
      "locations": [
        {
          "city": "Cuba",
          "state": "Missouri"
        },
        {
          "city": "Kirksville",
          "state": "Missouri"
        },
        {
          "city": "Springfield",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00750477"
    }
  ]
}