{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=NaF&page=9",
    "query": {
      "intervention": "NaF",
      "page": 9
    },
    "page_size": 10
  },
  "pagination": {
    "page": 9,
    "page_size": 10,
    "total_count": 219,
    "total_pages": 22,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=NaF&page=10&page_size=10",
    "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=NaF&page=8&page_size=10"
  },
  "source": "remote",
  "last_synced_at": "2026-10-20T17:42:17.643Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT07225478",
      "title": "Clinical Study to Evaluate the Tooth Whitening Efficacy of a New NextGen In-office Whitening System",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Health Adult Subjects"
      ],
      "interventions": [
        {
          "name": "Beaming White",
          "type": "DRUG"
        },
        {
          "name": "Philips Zoom Professional Whitening Treatment",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "Opalescence Boost PF",
          "type": "COMBINATION_PRODUCT"
        },
        {
          "name": "Fluoride Toothpaste",
          "type": "DRUG"
        },
        {
          "name": "Soft Manual Toothbrush",
          "type": "DEVICE"
        },
        {
          "name": "CP LED",
          "type": "DEVICE"
        },
        {
          "name": "Gingival Barrier",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "COMBINATION_PRODUCT",
        "DEVICE"
      ],
      "sponsor": "Colgate Palmolive",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 180,
      "start_date": "2025-10-31",
      "completion_date": "2025-12-21",
      "has_results": false,
      "last_update_posted_date": "2026-01-08",
      "last_synced_at": "2026-10-20T17:42:17.643Z",
      "location_count": 1,
      "location_summary": "Melbourne, Florida",
      "locations": [
        {
          "city": "Melbourne",
          "state": "Florida"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07225478"
    },
    {
      "nct_id": "NCT03527199",
      "title": "Prostate Cancer Patients With Biochemical Recurrence",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Patients With Prostate Cancer"
      ],
      "interventions": [
        {
          "name": "Pelvic CT or MRI + MDP bone scan + or - 18F-NaF PET/CT(SOC)",
          "type": "DIAGNOSTIC_TEST"
        }
      ],
      "intervention_types": [
        "DIAGNOSTIC_TEST"
      ],
      "sponsor": "Medhat Osman",
      "sponsor_class": "FED",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "89 Years",
        "sex": "MALE",
        "summary": "18 Years to 89 Years · Male only"
      },
      "enrollment_count": 65,
      "start_date": "2018-12-18",
      "completion_date": "2023-04-10",
      "has_results": false,
      "last_update_posted_date": "2023-04-11",
      "last_synced_at": "2026-10-20T17:42:17.643Z",
      "location_count": 1,
      "location_summary": "St Louis, Missouri",
      "locations": [
        {
          "city": "St Louis",
          "state": "Missouri"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03527199"
    },
    {
      "nct_id": "NCT01641237",
      "title": "Effect of Fluoride in a Dentifrice on Remineralization of Erosive Lesions",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Enamel Erosion"
      ],
      "interventions": [
        {
          "name": "sodium fluoride",
          "type": "DRUG"
        },
        {
          "name": "no added fluoride in a silica base",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "GlaxoSmithKline",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 72,
      "start_date": "2012-03",
      "completion_date": "2012-05",
      "has_results": true,
      "last_update_posted_date": "2014-07-24",
      "last_synced_at": "2026-10-20T17:42:17.643Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01641237"
    },
    {
      "nct_id": "NCT03970759",
      "title": "Meta-analysis of Stannous Fluoride and the Effects on Gingival Health",
      "overall_status": "COMPLETED",
      "study_type": "OBSERVATIONAL",
      "phases": [],
      "conditions": [
        "Gingivitis"
      ],
      "interventions": [
        {
          "name": "Stannous Fluoride Dentifrice",
          "type": "DRUG"
        },
        {
          "name": "Positive control dentifrice",
          "type": "DRUG"
        },
        {
          "name": "Negative control dentifrice",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Procter and Gamble",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 2890,
      "start_date": "2018-01-08",
      "completion_date": "2018-11-30",
      "has_results": false,
      "last_update_posted_date": "2019-06-17",
      "last_synced_at": "2026-10-20T17:42:17.643Z",
      "location_count": 1,
      "location_summary": "Cincinnati, Ohio",
      "locations": [
        {
          "city": "Cincinnati",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03970759"
    },
    {
      "nct_id": "NCT02598778",
      "title": "Comparing Mouth Rinses (and Chewing Gum) in Regard to Streptococcus Mutans Reduction",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Dental Caries"
      ],
      "interventions": [
        {
          "name": "Chlorhexidine gluconate (0.12%)",
          "type": "DRUG"
        },
        {
          "name": "Sodium Fluoride (0.05%)",
          "type": "DRUG"
        },
        {
          "name": "Paraffin wax chewing gum (sugar-free)",
          "type": "OTHER"
        },
        {
          "name": "Deionized water",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "DRUG",
        "OTHER"
      ],
      "sponsor": "Montefiore Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "6 Years",
        "maximum_age": "12 Years",
        "sex": "ALL",
        "summary": "6 Years to 12 Years"
      },
      "enrollment_count": 12,
      "start_date": "2015-11-01",
      "completion_date": "2016-04-01",
      "has_results": true,
      "last_update_posted_date": "2022-10-31",
      "last_synced_at": "2026-10-20T17:42:17.643Z",
      "location_count": 1,
      "location_summary": "The Bronx, New York",
      "locations": [
        {
          "city": "The Bronx",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02598778"
    },
    {
      "nct_id": "NCT02127073",
      "title": "Pilot Study of Oxytocin and microRNA Identification in NAF, Serum, and Tissue in Women With Breast Cancer",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Breast Cancer",
        "Ductal Carcinoma in Situ"
      ],
      "interventions": [
        {
          "name": "Intranasal Oxytocin",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Montefiore Medical Center",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "FEMALE",
        "summary": "18 Years and older · Female only"
      },
      "enrollment_count": 8,
      "start_date": "2015-01-30",
      "completion_date": "2017-09-18",
      "has_results": true,
      "last_update_posted_date": "2023-11-09",
      "last_synced_at": "2026-10-20T17:42:17.643Z",
      "location_count": 1,
      "location_summary": "New York, New York",
      "locations": [
        {
          "city": "New York",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02127073"
    },
    {
      "nct_id": "NCT00708305",
      "title": "Evaluation of Plaque Fluid Fluoride Retention From Fluoride Toothpastes",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Dental Caries"
      ],
      "interventions": [
        {
          "name": "Sodium Fluoride (NaF)",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "GlaxoSmithKline",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 65,
      "start_date": "2008-06",
      "completion_date": "2008-10",
      "has_results": true,
      "last_update_posted_date": "2015-01-01",
      "last_synced_at": "2026-10-20T17:42:17.643Z",
      "location_count": 1,
      "location_summary": "Indianapolis, Indiana",
      "locations": [
        {
          "city": "Indianapolis",
          "state": "Indiana"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00708305"
    },
    {
      "nct_id": "NCT04255251",
      "title": "Effectiveness Silver Diamine Fluoride Versus Sodium Fluoride in Arresting Caries Around Crown Margins in Older Adults",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "EARLY_PHASE1"
      ],
      "conditions": [
        "Caries Roots",
        "Flouride Varnish",
        "Caries; Dentin",
        "Caries Arrested"
      ],
      "interventions": [
        {
          "name": "Silver Diammine Fluoride",
          "type": "DRUG"
        },
        {
          "name": "Fluoride Varnishes",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "University of New England",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "65 Years",
        "maximum_age": "85 Years",
        "sex": "ALL",
        "summary": "65 Years to 85 Years"
      },
      "enrollment_count": 200,
      "start_date": "2021-06-26",
      "completion_date": "2024-01-03",
      "has_results": false,
      "last_update_posted_date": "2021-10-05",
      "last_synced_at": "2026-10-20T17:42:17.643Z",
      "location_count": 1,
      "location_summary": "Portland, Maine",
      "locations": [
        {
          "city": "Portland",
          "state": "Maine"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04255251"
    },
    {
      "nct_id": "NCT03173924",
      "title": "18F-DCFPyL PSMA- Versus 18F-NaF-PET Imaging for Detection of Metastatic Prostate Cancer",
      "overall_status": "ACTIVE_NOT_RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE2"
      ],
      "conditions": [
        "Metastatic Prostate Cancer",
        "Prostatic Neoplasms",
        "Prostate Cancer",
        "Prostatic Cancer",
        "Prostate Neoplasms"
      ],
      "interventions": [
        {
          "name": "18F-NaF",
          "type": "DRUG"
        },
        {
          "name": "18F-DCFPyL",
          "type": "DRUG"
        },
        {
          "name": "18F-FDG",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "National Cancer Institute (NCI)",
      "sponsor_class": "NIH",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "MALE",
        "summary": "18 Years and older · Male only"
      },
      "enrollment_count": 96,
      "start_date": "2017-06-06",
      "completion_date": "2028-02-06",
      "has_results": false,
      "last_update_posted_date": "2026-10-16",
      "last_synced_at": "2026-10-20T17:42:17.643Z",
      "location_count": 1,
      "location_summary": "Bethesda, Maryland",
      "locations": [
        {
          "city": "Bethesda",
          "state": "Maryland"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03173924"
    },
    {
      "nct_id": "NCT03546491",
      "title": "Evaluate Dental Plaque Benefit of a Preventive Treatment Gel",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Dental Plaque"
      ],
      "interventions": [
        {
          "name": "Preventive Gel",
          "type": "DRUG"
        },
        {
          "name": "Marketed Control",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Procter and Gamble",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 32,
      "start_date": "2018-05-08",
      "completion_date": "2018-06-22",
      "has_results": true,
      "last_update_posted_date": "2019-09-04",
      "last_synced_at": "2026-10-20T17:42:17.643Z",
      "location_count": 1,
      "location_summary": "Mason, Ohio",
      "locations": [
        {
          "city": "Mason",
          "state": "Ohio"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03546491"
    }
  ]
}