{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Naloxegol", "query": { "intervention": "Naloxegol" }, "page_size": 10 }, "pagination": { "page": 1, "page_size": 10, "total_count": 29, "total_pages": 3, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Naloxegol&page=2&page_size=10", "previous_page_url": null }, "source": "remote", "last_synced_at": "2026-09-10T14:26:50.768Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT01336205", "title": "Assessment of Long-term Safety in Patients With Non-cancer-related Pain and Opioid-induced Constipation", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Opioid-Induced Constipation (OIC)" ], "interventions": [ { "name": "NKTR-118", "type": "DRUG" }, { "name": "Usual care", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AstraZeneca", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "84 Years", "sex": "ALL", "summary": "18 Years to 84 Years" }, "enrollment_count": 844, "start_date": "2011-04", "completion_date": "2012-12", "has_results": true, "last_update_posted_date": "2014-10-20", "last_synced_at": "2026-09-10T14:26:50.768Z", "location_count": 169, "location_summary": "Athens, Alabama • Birmingham, Alabama • Huntsville, Alabama + 166 more", "locations": [ { "city": "Athens", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Huntsville", "state": "Alabama" }, { "city": "Mobile", "state": "Alabama" }, { "city": "Pell City", "state": "Alabama" } ], "official_url": "https://clinicaltrials.gov/study/NCT01336205" }, { "nct_id": "NCT02977286", "title": "Naloxegol to Prevent Lower Gastrointestinal Paralysis in Critically Ill Adults Administered Opioids", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Constipation" ], "interventions": [ { "name": "Naloxegol Oral Tablet", "type": "DRUG" }, { "name": "Placebo Oral Tablet", "type": "DRUG" }, { "name": "Docusate Sodium 100 Mg oral capsule [Colace]", "type": "DRUG" }, { "name": "Senna 217 Mg Oral Tablet", "type": "DRUG" }, { "name": "Polyethylene Glycols", "type": "DRUG" }, { "name": "Bisacodyl 10 mg Suppository", "type": "DRUG" }, { "name": "Magnesium Citrate Oral Liquid Product", "type": "DRUG" }, { "name": "Methylnaltrexone", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Tufts Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 12, "start_date": "2017-01-01", "completion_date": "2019-10-09", "has_results": true, "last_update_posted_date": "2023-02-16", "last_synced_at": "2026-09-10T14:26:50.768Z", "location_count": 1, "location_summary": "Boston, Massachusetts", "locations": [ { "city": "Boston", "state": "Massachusetts" } ], "official_url": "https://clinicaltrials.gov/study/NCT02977286" }, { "nct_id": "NCT01323790", "title": "Assessment of Efficacy and Safety in Patients With Non-cancer-related Pain and Opioid-induced Constipation", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Opioid-Induced Constipation (OIC)" ], "interventions": [ { "name": "NKTR-118", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AstraZeneca", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "84 Years", "sex": "ALL", "summary": "18 Years to 84 Years" }, "enrollment_count": 700, "start_date": "2011-03", "completion_date": "2012-09", "has_results": true, "last_update_posted_date": "2015-06-02", "last_synced_at": "2026-09-10T14:26:50.768Z", "location_count": 68, "location_summary": "Mobile, Alabama • Pell City, Alabama • Mesa, Arizona + 65 more", "locations": [ { "city": "Mobile", "state": "Alabama" }, { "city": "Pell City", "state": "Alabama" }, { "city": "Mesa", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Sun Lakes", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT01323790" }, { "nct_id": "NCT01392807", "title": "Open-label Study to Assess the Pharmacokinetics of NKTR-118 in Patients With Impaired Hepatic Function", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Hepatic; Functional Disturbance" ], "interventions": [ { "name": "NKTR-118", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AstraZeneca", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 24, "start_date": "2011-07", "completion_date": "2011-11", "has_results": false, "last_update_posted_date": "2014-10-15", "last_synced_at": "2026-09-10T14:26:50.768Z", "location_count": 1, "location_summary": "Overland Park, Kansas", "locations": [ { "city": "Overland Park", "state": "Kansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT01392807" }, { "nct_id": "NCT03060512", "title": "To Evaluate Patient Preference of Movantik and Polyethylene Glycol 3350 for Opioid Induced Constipation", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Opioid Induced Constipation" ], "interventions": [ { "name": "Polyethylene Glycol 3350", "type": "DRUG" }, { "name": "Movantik", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AstraZeneca", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "84 Years", "sex": "ALL", "summary": "18 Years to 84 Years" }, "enrollment_count": 276, "start_date": "2017-03-02", "completion_date": "2017-08-23", "has_results": true, "last_update_posted_date": "2018-07-13", "last_synced_at": "2026-09-10T14:26:50.768Z", "location_count": 53, "location_summary": "Huntsville, Alabama • Phoenix, Arizona • Anaheim, California + 46 more", "locations": [ { "city": "Huntsville", "state": "Alabama" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Anaheim", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT03060512" }, { "nct_id": "NCT02737059", "title": "Effect of Naloxegol on Gastric, Small Bowel, and Colonic Transit in Healthy Subjects", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Constipation Drug Induced" ], "interventions": [ { "name": "Naloxegol", "type": "DRUG" }, { "name": "Codeine", "type": "DRUG" }, { "name": "codeine placebo", "type": "DRUG" }, { "name": "naloxegol placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Michael Camilleri", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 72, "start_date": "2016-07-01", "completion_date": "2017-05-10", "has_results": false, "last_update_posted_date": "2017-08-30", "last_synced_at": "2026-09-10T14:26:50.768Z", "location_count": 1, "location_summary": "Rochester, Minnesota", "locations": [ { "city": "Rochester", "state": "Minnesota" } ], "official_url": "https://clinicaltrials.gov/study/NCT02737059" }, { "nct_id": "NCT01325415", "title": "A Placebo-controlled Four Way Crossover Study to Asses the Effect of a Single Oral Dose of NKTR-118 on QTc Interval in Healthy Male Subjects", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Amount of NKTR-118 in Blood", "Variation in the Heart's Electrical Cycle" ], "interventions": [ { "name": "NKTR-118", "type": "DRUG" }, { "name": "moxifloxacin", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AstraZeneca", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "50 Years", "sex": "MALE", "summary": "18 Years to 50 Years · Male only" }, "enrollment_count": 45, "start_date": "2011-04", "completion_date": "2011-07", "has_results": false, "last_update_posted_date": "2014-10-15", "last_synced_at": "2026-09-10T14:26:50.768Z", "location_count": 1, "location_summary": "Overland Park, Kansas", "locations": [ { "city": "Overland Park", "state": "Kansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT01325415" }, { "nct_id": "NCT02998606", "title": "Movantik for Opioid-Related Esophageal Disorders", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Opioid-Induced Disorders", "Esophagus Disorder" ], "interventions": [ { "name": "Naloxegol", "type": "DRUG" }, { "name": "Placebo Oral Capsule", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Temple University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "85 Years", "sex": "ALL", "summary": "18 Years to 85 Years" }, "enrollment_count": 2, "start_date": "2017-01", "completion_date": "2018-10", "has_results": false, "last_update_posted_date": "2018-12-24", "last_synced_at": "2026-09-10T14:26:50.768Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT02998606" }, { "nct_id": "NCT01533870", "title": "Study in Healthy Volunteers to Investigate the Effects of Rifampin on the Pharmacokinetics of NKTR-118", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Drug Induced Constipation" ], "interventions": [ { "name": "NKTR-118", "type": "DRUG" }, { "name": "Rifampin", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AstraZeneca", "sponsor_class": "INDUSTRY", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "55 Years", "sex": "ALL", "summary": "18 Years to 55 Years" }, "enrollment_count": 22, "start_date": "2012-03", "completion_date": "2012-05", "has_results": false, "last_update_posted_date": "2014-10-15", "last_synced_at": "2026-09-10T14:26:50.768Z", "location_count": 1, "location_summary": "Overland Park, Kansas", "locations": [ { "city": "Overland Park", "state": "Kansas" } ], "official_url": "https://clinicaltrials.gov/study/NCT01533870" }, { "nct_id": "NCT01309841", "title": "Assessment of Efficacy and Safety in Patients With Non-cancer-related Pain and Opioid-induced Constipation", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Opioid-Induced Constipation (OIC)" ], "interventions": [ { "name": "NKTR-118", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "AstraZeneca", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "84 Years", "sex": "ALL", "summary": "18 Years to 84 Years" }, "enrollment_count": 652, "start_date": "2011-03", "completion_date": "2012-08", "has_results": true, "last_update_posted_date": "2015-06-01", "last_synced_at": "2026-09-10T14:26:50.768Z", "location_count": 91, "location_summary": "Birmingham, Alabama • Calera, Alabama • Glendale, Arizona + 88 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Calera", "state": "Alabama" }, { "city": "Glendale", "state": "Arizona" }, { "city": "Mesa", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT01309841" } ] }