{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Naproxen+Sodium",
    "query": {
      "intervention": "Naproxen Sodium"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 215,
    "total_pages": 22,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Naproxen+Sodium&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-09-04T18:11:45.385Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT03566979",
      "title": "Efficacy and Safety Study of a Test Naproxen Sodium 220mg Tablet in Postoperative Dental Pain",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Post-operative Dental Pain"
      ],
      "interventions": [
        {
          "name": "Test naproxen sodium tablet",
          "type": "DRUG"
        },
        {
          "name": "Commercial naproxen sodium tablet",
          "type": "DRUG"
        },
        {
          "name": "Commercial naproxen sodium liquid gels capsule",
          "type": "DRUG"
        },
        {
          "name": "Placebo tablet",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "17 Years",
        "maximum_age": "50 Years",
        "sex": "ALL",
        "summary": "17 Years to 50 Years"
      },
      "enrollment_count": 501,
      "start_date": "2018-08-13",
      "completion_date": "2019-04-15",
      "has_results": true,
      "last_update_posted_date": "2020-04-09",
      "last_synced_at": "2026-09-04T18:11:45.385Z",
      "location_count": 1,
      "location_summary": "Salt Lake City, Utah",
      "locations": [
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03566979"
    },
    {
      "nct_id": "NCT01118273",
      "title": "Evaluate Analgesic/Sedative Efficacy of Naproxen Sodium and Diphenhydramine",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Sleep"
      ],
      "interventions": [
        {
          "name": "Naproxen Sodium 440 mg (BAYH6689) / DPH 50mg",
          "type": "DRUG"
        },
        {
          "name": "Naproxen Sodium 440 mg (BAYH6689)",
          "type": "DRUG"
        },
        {
          "name": "Naproxen Sodium 220 mg (BAYH6689) / DPH 50mg",
          "type": "DRUG"
        },
        {
          "name": "Naproxen Sodium 220 mg (BAYH6689)",
          "type": "DRUG"
        },
        {
          "name": "DPH 50mg",
          "type": "DRUG"
        },
        {
          "name": "Ibuprofen 400 mg / Diphenhydramine citrate 76 mg",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Bayer",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": "45 Years",
        "sex": "ALL",
        "summary": "16 Years to 45 Years"
      },
      "enrollment_count": 162,
      "start_date": "2008-01",
      "completion_date": "2008-02",
      "has_results": true,
      "last_update_posted_date": "2015-06-08",
      "last_synced_at": "2026-09-04T18:11:45.385Z",
      "location_count": 1,
      "location_summary": "Salt Lake City, Utah",
      "locations": [
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01118273"
    },
    {
      "nct_id": "NCT05485805",
      "title": "A Study to Learn How Well a Single Dose of the Study Treatment Naproxen Sodium and Caffeine Combined in One Tablet (Fixed-dose Combination) Works to Relieve Pain After Dental Surgeries Compared to the Single Ingredients and to Placebo",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Postoperative Dental Pain"
      ],
      "interventions": [
        {
          "name": "Naproxen sodium and caffeine (BAY2880376)",
          "type": "DRUG"
        },
        {
          "name": "Naproxen sodium (Aleve)",
          "type": "DRUG"
        },
        {
          "name": "Caffeine",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Bayer",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "16 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "16 Years and older"
      },
      "enrollment_count": 541,
      "start_date": "2022-09-21",
      "completion_date": "2024-01-29",
      "has_results": true,
      "last_update_posted_date": "2025-03-25",
      "last_synced_at": "2026-09-04T18:11:45.385Z",
      "location_count": 1,
      "location_summary": "Salt Lake City, Utah",
      "locations": [
        {
          "city": "Salt Lake City",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05485805"
    },
    {
      "nct_id": "NCT01165307",
      "title": "Medical Therapy Versus Radiofrequency Endometrial Ablation in the Initial Treatment of Menorrhagia",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Menorrhagia"
      ],
      "interventions": [
        {
          "name": "Estradiol 30mcg / Levonorgestrel 150mcg monophasic oral contraceptive pills",
          "type": "DRUG"
        },
        {
          "name": "Naproxen sodium pills",
          "type": "DRUG"
        },
        {
          "name": "NovaSure® Radiofrequency Endometrial Ablation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DRUG",
        "DEVICE"
      ],
      "sponsor": "Abimbola Famuyide",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "30 Years",
        "maximum_age": "55 Years",
        "sex": "FEMALE",
        "summary": "30 Years to 55 Years · Female only"
      },
      "enrollment_count": 77,
      "start_date": "2009-08",
      "completion_date": "2015-10",
      "has_results": true,
      "last_update_posted_date": "2017-01-20",
      "last_synced_at": "2026-09-04T18:11:45.385Z",
      "location_count": 1,
      "location_summary": "Rochester, Minnesota",
      "locations": [
        {
          "city": "Rochester",
          "state": "Minnesota"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01165307"
    },
    {
      "nct_id": "NCT01557816",
      "title": "Trial of Naproxen to Evaluate Various Methods of Measuring Analgesic Effect in Osteoarthritis Pain of the Knee",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Osteoarthritis, Knee"
      ],
      "interventions": [
        {
          "name": "Naproxen",
          "type": "DRUG"
        },
        {
          "name": "Placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Analgesic Solutions",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "21 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "21 Years and older"
      },
      "enrollment_count": 70,
      "start_date": "2011-12",
      "completion_date": "2012-06",
      "has_results": false,
      "last_update_posted_date": "2012-03-22",
      "last_synced_at": "2026-09-04T18:11:45.385Z",
      "location_count": 1,
      "location_summary": "Natick, Massachusetts",
      "locations": [
        {
          "city": "Natick",
          "state": "Massachusetts"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT01557816"
    },
    {
      "nct_id": "NCT00573170",
      "title": "TREXIMET® Versus Butalbital-containing Combination Medications for the Acute Treatment of Migraine in Adults",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Migraine Disorders",
        "Migraine, Acute"
      ],
      "interventions": [
        {
          "name": "TREXIMET®",
          "type": "DRUG"
        },
        {
          "name": "Butalbital-containing Combination Medications (BCM)",
          "type": "DRUG"
        },
        {
          "name": "placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "GlaxoSmithKline",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 375,
      "start_date": "2008-02",
      "completion_date": "2009-08",
      "has_results": true,
      "last_update_posted_date": "2010-12-29",
      "last_synced_at": "2026-09-04T18:11:45.385Z",
      "location_count": 107,
      "location_summary": "Chandler, Arizona • Gilbert, Arizona • Litchfield Park, Arizona + 94 more",
      "locations": [
        {
          "city": "Chandler",
          "state": "Arizona"
        },
        {
          "city": "Gilbert",
          "state": "Arizona"
        },
        {
          "city": "Litchfield Park",
          "state": "Arizona"
        },
        {
          "city": "Mesa",
          "state": "Arizona"
        },
        {
          "city": "Phoenix",
          "state": "Arizona"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00573170"
    },
    {
      "nct_id": "NCT00893737",
      "title": "\"Completeness of Response\" Following Treatment With Treximet™ for Migraine",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Migraine"
      ],
      "interventions": [
        {
          "name": "sumatriptan succinate 85 mg/naproxen sodium 500 mg (Treximet)",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Cady, Roger, M.D.",
      "sponsor_class": "INDIV",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "65 Years",
        "sex": "ALL",
        "summary": "18 Years to 65 Years"
      },
      "enrollment_count": 147,
      "start_date": "2009-06",
      "completion_date": "2010-01",
      "has_results": true,
      "last_update_posted_date": "2011-01-25",
      "last_synced_at": "2026-09-04T18:11:45.385Z",
      "location_count": 8,
      "location_summary": "San Francisco, California • Kalamazoo, Michigan • Springfield, Missouri + 5 more",
      "locations": [
        {
          "city": "San Francisco",
          "state": "California"
        },
        {
          "city": "Kalamazoo",
          "state": "Michigan"
        },
        {
          "city": "Springfield",
          "state": "Missouri"
        },
        {
          "city": "St Louis",
          "state": "Missouri"
        },
        {
          "city": "Plainview",
          "state": "New York"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00893737"
    },
    {
      "nct_id": "NCT04285853",
      "title": "Are Opioids Needed After ACL Reconstruction",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Anterior Cruciate Ligament Rupture"
      ],
      "interventions": [
        {
          "name": "Oxycodone",
          "type": "DRUG"
        },
        {
          "name": "Placebo oral tablet",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Emory University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "14 Years",
        "maximum_age": "40 Years",
        "sex": "ALL",
        "summary": "14 Years to 40 Years"
      },
      "enrollment_count": 98,
      "start_date": "2020-09-16",
      "completion_date": "2022-09-19",
      "has_results": true,
      "last_update_posted_date": "2023-10-11",
      "last_synced_at": "2026-09-04T18:11:45.385Z",
      "location_count": 3,
      "location_summary": "Atlanta, Georgia • Tucker, Georgia",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Atlanta",
          "state": "Georgia"
        },
        {
          "city": "Tucker",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04285853"
    },
    {
      "nct_id": "NCT06291337",
      "title": "Ibuprofen Inhibits Human Sweet Taste",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Treatment of Sweet Taste Receptors Without or With an Oral Rinse of Ibuprofen Solution in Healthy Participants",
        "Treatment of Sweet Taste Receptors Without or With an Oral Rinse of Naproxen Solution in Healthy Participants"
      ],
      "interventions": [
        {
          "name": "Inhibition of Sweet Taste by Ibuprofen Oral Rinses",
          "type": "DRUG"
        },
        {
          "name": "Inhibition of Sweet Taste by Naproxen Oral Rinses",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "Rutgers, The State University of New Jersey",
      "sponsor_class": "OTHER",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": "70 Years",
        "sex": "ALL",
        "summary": "18 Years to 70 Years"
      },
      "enrollment_count": 32,
      "start_date": "2020-06-01",
      "completion_date": "2023-09-30",
      "has_results": false,
      "last_update_posted_date": "2024-03-04",
      "last_synced_at": "2026-09-04T18:11:45.385Z",
      "location_count": 1,
      "location_summary": "New Brunswick, New Jersey",
      "locations": [
        {
          "city": "New Brunswick",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06291337"
    },
    {
      "nct_id": "NCT00504127",
      "title": "Efficacy and Safety Study of Naproxcinod in Subjects With Osteoarthritis of the Knee",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Osteoarthritis"
      ],
      "interventions": [
        {
          "name": "Naproxcinod 375 mg bid",
          "type": "DRUG"
        },
        {
          "name": "Naproxcinod 750 mg bid",
          "type": "DRUG"
        },
        {
          "name": "Naproxen 500 mg bid",
          "type": "DRUG"
        },
        {
          "name": "placebo",
          "type": "DRUG"
        }
      ],
      "intervention_types": [
        "DRUG"
      ],
      "sponsor": "NicOx",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "40 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "40 Years and older"
      },
      "enrollment_count": 1020,
      "start_date": "2007-04",
      "completion_date": null,
      "has_results": false,
      "last_update_posted_date": "2011-06-17",
      "last_synced_at": "2026-09-04T18:11:45.385Z",
      "location_count": 73,
      "location_summary": "Chandler, Arizona • Tempe, Arizona • Tucson, Arizona + 70 more",
      "locations": [
        {
          "city": "Chandler",
          "state": "Arizona"
        },
        {
          "city": "Tempe",
          "state": "Arizona"
        },
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Little Rock",
          "state": "Arkansas"
        },
        {
          "city": "Anaheim",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00504127"
    }
  ]
}