{ "api_version": "1", "request": { "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Naproxen+placebo&page=2", "query": { "intervention": "Naproxen placebo", "page": 2 }, "page_size": 10 }, "pagination": { "page": 2, "page_size": 10, "total_count": 115, "total_pages": 12, "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Naproxen+placebo&page=3&page_size=10", "previous_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Naproxen+placebo&page=1&page_size=10" }, "source": "remote", "last_synced_at": "2026-10-02T13:27:37.854Z", "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.", "notes": [ "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.", "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.", "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees." ], "trials": [ { "nct_id": "NCT00584870", "title": "RN624 In Adult Patients With Chronic Low Back Pain", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Low Back Pain" ], "interventions": [ { "name": "Naproxen", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" }, { "name": "PF-04383119 (RN624)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Pfizer", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "90 Years", "sex": "ALL", "summary": "18 Years to 90 Years" }, "enrollment_count": 220, "start_date": "2007-07-05", "completion_date": "2008-09-02", "has_results": true, "last_update_posted_date": "2021-07-12", "last_synced_at": "2026-10-02T13:27:37.854Z", "location_count": 38, "location_summary": "Anniston, Alabama • Birmingham, Alabama • Chandler, Arizona + 30 more", "locations": [ { "city": "Anniston", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Chandler", "state": "Arizona" }, { "city": "Scottsdale", "state": "Arizona" }, { "city": "Anaheim", "state": "California" } ], "official_url": "https://clinicaltrials.gov/study/NCT00584870" }, { "nct_id": "NCT03949673", "title": "Study to Evaluate Arthroplasty Specimens for Osteoarthritis of the Knee and Hip", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Osteoarthritis, Knee", "Osteoarthritis, Hip" ], "interventions": [ { "name": "Fasinumab", "type": "DRUG" }, { "name": "Naproxen", "type": "DRUG" }, { "name": "Diclofenac", "type": "DRUG" }, { "name": "Celecoxib", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Regeneron Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 23, "start_date": "2019-04-08", "completion_date": "2020-08-25", "has_results": true, "last_update_posted_date": "2023-10-17", "last_synced_at": "2026-10-02T13:27:37.854Z", "location_count": 6, "location_summary": "Phoenix, Arizona • Littleton, Colorado • Jacksonville, Florida + 3 more", "locations": [ { "city": "Phoenix", "state": "Arizona" }, { "city": "Littleton", "state": "Colorado" }, { "city": "Jacksonville", "state": "Florida" }, { "city": "Chicago", "state": "Illinois" }, { "city": "Brooklyn", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT03949673" }, { "nct_id": "NCT05868122", "title": "A Study to Evaluate a Fixed Combination of Acetaminophen/Naproxen Sodium in Acute Postoperative Pain Following Bunionectomy", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Pain" ], "interventions": [ { "name": "Acetaminophen/Naproxen Sodium Fixed Combination", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Johnson & Johnson Consumer Inc. (J&JCI)", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "16 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "16 Years to 65 Years" }, "enrollment_count": 143, "start_date": "2023-09-07", "completion_date": "2024-05-30", "has_results": false, "last_update_posted_date": "2026-05-04", "last_synced_at": "2026-10-02T13:27:37.854Z", "location_count": 4, "location_summary": "New Providence, New Jersey • Bellaire, Texas • Houston, Texas + 1 more", "locations": [ { "city": "New Providence", "state": "New Jersey" }, { "city": "Bellaire", "state": "Texas" }, { "city": "Houston", "state": "Texas" }, { "city": "San Antonio", "state": "Texas" } ], "official_url": "https://clinicaltrials.gov/study/NCT05868122" }, { "nct_id": "NCT05463367", "title": "Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure", "overall_status": "ACTIVE_NOT_RECRUITING", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Opioid Use", "Opioid Dependence", "Opioid-use Disorder", "Narcotic Use", "Back Pain", "Back Injuries", "Chronic Pain", "Chronic Low-back Pain", "Pain, Chronic", "Pain;Back Low;Chronic", "Pain, Back" ], "interventions": [ { "name": "Carbidopa-Levodopa 25 Mg-100 Mg Oral Tablet", "type": "DRUG" }, { "name": "Naproxen 500 Mg", "type": "DRUG" }, { "name": "Opioids", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Northwestern University", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 60, "start_date": "2021-01-01", "completion_date": "2025-06-01", "has_results": false, "last_update_posted_date": "2024-11-27", "last_synced_at": "2026-10-02T13:27:37.854Z", "location_count": 1, "location_summary": "Chicago, Illinois", "locations": [ { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT05463367" }, { "nct_id": "NCT01587274", "title": "A Randomized Study of Three Medication Regimens for Acute Low Back Pain", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE4" ], "conditions": [ "Acute Low Back Pain" ], "interventions": [ { "name": "Naproxen", "type": "DRUG" }, { "name": "Cyclobenzaprine", "type": "DRUG" }, { "name": "Oxycodone/ acetaminophen", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Montefiore Medical Center", "sponsor_class": "OTHER", "healthy_volunteers": false, "eligibility": { "minimum_age": "21 Years", "maximum_age": "64 Years", "sex": "ALL", "summary": "21 Years to 64 Years" }, "enrollment_count": 323, "start_date": "2012-04", "completion_date": "2014-12", "has_results": true, "last_update_posted_date": "2018-07-31", "last_synced_at": "2026-10-02T13:27:37.854Z", "location_count": 1, "location_summary": "The Bronx, New York", "locations": [ { "city": "The Bronx", "state": "New York" } ], "official_url": "https://clinicaltrials.gov/study/NCT01587274" }, { "nct_id": "NCT00843024", "title": "Migraine Study in Adolescent Patients", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Migraine Disorders" ], "interventions": [ { "name": "Sumatriptan and Naproxen Sodium", "type": "DRUG" }, { "name": "Placebo", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "GlaxoSmithKline", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "12 Years", "maximum_age": "17 Years", "sex": "ALL", "summary": "12 Years to 17 Years" }, "enrollment_count": 589, "start_date": "2008-12", "completion_date": "2010-06", "has_results": true, "last_update_posted_date": "2017-01-18", "last_synced_at": "2026-10-02T13:27:37.854Z", "location_count": 79, "location_summary": "Gilbert, Arizona • Litchfield Park, Arizona • Phoenix, Arizona + 71 more", "locations": [ { "city": "Gilbert", "state": "Arizona" }, { "city": "Litchfield Park", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" }, { "city": "Phoenix", "state": "Arizona" } ], "official_url": "https://clinicaltrials.gov/study/NCT00843024" }, { "nct_id": "NCT00780325", "title": "Effects of Dual Cyclooxygenase-2 and Carbonic Anhydrase Inhibition", "overall_status": "TERMINATED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE1" ], "conditions": [ "Healthy Volunteers" ], "interventions": [ { "name": "CG100649 (2 mg)", "type": "DRUG" }, { "name": "Celecoxib", "type": "DRUG" }, { "name": "Placebo capsules", "type": "DRUG" }, { "name": "Naproxen", "type": "DRUG" }, { "name": "Acetazolamide", "type": "DRUG" }, { "name": "CG100649 (8 mg)", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "University of Pennsylvania", "sponsor_class": "OTHER", "healthy_volunteers": true, "eligibility": { "minimum_age": "18 Years", "maximum_age": "60 Years", "sex": "ALL", "summary": "18 Years to 60 Years" }, "enrollment_count": 26, "start_date": "2008-10", "completion_date": "2013-07", "has_results": false, "last_update_posted_date": "2014-02-06", "last_synced_at": "2026-10-02T13:27:37.854Z", "location_count": 1, "location_summary": "Philadelphia, Pennsylvania", "locations": [ { "city": "Philadelphia", "state": "Pennsylvania" } ], "official_url": "https://clinicaltrials.gov/study/NCT00780325" }, { "nct_id": "NCT01160822", "title": "To Determine the Safety, Tolerability, Pharmacokinetics and Effect on Pain of a Single Intra-articular Administration of Canakinumab in Patients With Osteoarthritis in the Knee", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE2" ], "conditions": [ "Osteoarthritis" ], "interventions": [ { "name": "Canakinumab", "type": "BIOLOGICAL" }, { "name": "Placebo to canakinumab", "type": "DRUG" }, { "name": "Naproxen", "type": "DRUG" }, { "name": "Placebo to Naproxen", "type": "DRUG" } ], "intervention_types": [ "BIOLOGICAL", "DRUG" ], "sponsor": "Novartis Pharmaceuticals", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "40 Years", "maximum_age": "80 Years", "sex": "ALL", "summary": "40 Years to 80 Years" }, "enrollment_count": 169, "start_date": "2010-04", "completion_date": "2011-07", "has_results": true, "last_update_posted_date": "2012-10-30", "last_synced_at": "2026-10-02T13:27:37.854Z", "location_count": 8, "location_summary": "Anniston, Alabama • Mesa, Arizona • San Diego, California + 5 more", "locations": [ { "city": "Anniston", "state": "Alabama" }, { "city": "Mesa", "state": "Arizona" }, { "city": "San Diego", "state": "California" }, { "city": "Westlake Village", "state": "California" }, { "city": "Chicago", "state": "Illinois" } ], "official_url": "https://clinicaltrials.gov/study/NCT01160822" }, { "nct_id": "NCT00837044", "title": "Treximet in Acute Migraine Headache: Assessing Cognitive Function", "overall_status": "UNKNOWN", "study_type": "INTERVENTIONAL", "phases": [ "NA" ], "conditions": [ "Migraine Headache", "Cognitive Impairment" ], "interventions": [ { "name": "Treximet", "type": "DRUG" }, { "name": "Migraine rescue medication of choice", "type": "DRUG" } ], "intervention_types": [ "DRUG" ], "sponsor": "Neurological Research Center", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": "65 Years", "sex": "ALL", "summary": "18 Years to 65 Years" }, "enrollment_count": 30, "start_date": "2009-02", "completion_date": "2009-09", "has_results": false, "last_update_posted_date": "2009-02-05", "last_synced_at": "2026-10-02T13:27:37.854Z", "location_count": 1, "location_summary": "Bennington, Vermont", "locations": [ { "city": "Bennington", "state": "Vermont" } ], "official_url": "https://clinicaltrials.gov/study/NCT00837044" }, { "nct_id": "NCT02528188", "title": "Long Term Safety and Efficacy Study of Tanezumab in Subjects With Osteoarthritis of the Hip or Knee", "overall_status": "COMPLETED", "study_type": "INTERVENTIONAL", "phases": [ "PHASE3" ], "conditions": [ "Chronic Pain", "Osteoarthritis, Hip", "Osteoarthritis, Knee" ], "interventions": [ { "name": "NSAID", "type": "DRUG" }, { "name": "Tanezumab 2.5 mg", "type": "BIOLOGICAL" }, { "name": "Tanezumab 5 mg", "type": "BIOLOGICAL" } ], "intervention_types": [ "DRUG", "BIOLOGICAL" ], "sponsor": "Pfizer", "sponsor_class": "INDUSTRY", "healthy_volunteers": false, "eligibility": { "minimum_age": "18 Years", "maximum_age": null, "sex": "ALL", "summary": "18 Years and older" }, "enrollment_count": 3021, "start_date": "2015-07-21", "completion_date": "2019-02-27", "has_results": true, "last_update_posted_date": "2020-01-10", "last_synced_at": "2026-10-02T13:27:37.854Z", "location_count": 299, "location_summary": "Birmingham, Alabama • Huntsville, Alabama • Mobile, Alabama + 187 more", "locations": [ { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Birmingham", "state": "Alabama" }, { "city": "Huntsville", "state": "Alabama" } ], "official_url": "https://clinicaltrials.gov/study/NCT02528188" } ] }