{
  "api_version": "1",
  "request": {
    "url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Nasal+intermittent+positive+pressure+ventilation+%28NIPPV%29",
    "query": {
      "intervention": "Nasal intermittent positive pressure ventilation (NIPPV)"
    },
    "page_size": 10
  },
  "pagination": {
    "page": 1,
    "page_size": 10,
    "total_count": 20,
    "total_pages": 2,
    "next_page_url": "https://clinicaltrialsfind.com/api/v1/search.json?intervention=Nasal+intermittent+positive+pressure+ventilation+%28NIPPV%29&page=2&page_size=10",
    "previous_page_url": null
  },
  "source": "remote",
  "last_synced_at": "2026-10-10T14:16:59.472Z",
  "attribution": "Data derived from public ClinicalTrials.gov records. The official record at https://clinicaltrials.gov/ remains the source of truth for current availability, contacts, and full study details.",
  "notes": [
    "This endpoint exposes only public summary fields — no participant contact emails, phone numbers, or scraped investigator contact details.",
    "For contact information and full protocol detail, follow each trial's `official_url` to the ClinicalTrials.gov record.",
    "This API is a navigational aid. It does not provide medical advice, eligibility determinations, or compensation guarantees."
  ],
  "trials": [
    {
      "nct_id": "NCT04709562",
      "title": "Clinical Stabilization of Hypercapnia: NIPPV v HVNI",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypercapnic Respiratory Failure",
        "Chronic Obstructive Pulmonary Disease",
        "Dyspnea",
        "Hypercapnic Acidosis"
      ],
      "interventions": [
        {
          "name": "High Velocity Nasal Insufflation (HVNI)",
          "type": "DEVICE"
        },
        {
          "name": "Noninvasive Positive Pressure Ventilation (NIPPV)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Vapotherm, Inc.",
      "sponsor_class": "INDUSTRY",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 68,
      "start_date": "2020-11-11",
      "completion_date": "2023-06-22",
      "has_results": true,
      "last_update_posted_date": "2024-08-09",
      "last_synced_at": "2026-10-10T14:16:59.472Z",
      "location_count": 7,
      "location_summary": "Los Angeles, California • Oxnard, California • Washington D.C., District of Columbia + 4 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "Oxnard",
          "state": "California"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Baltimore",
          "state": "Maryland"
        },
        {
          "city": "Camden",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT04709562"
    },
    {
      "nct_id": "NCT03353064",
      "title": "Telemedicine for Improving Outcome in Inner City Patient Population With Hypercapneic Respiratory Failure",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Hypercapnic Respiratory Failure",
        "Chronic Obstructive Pulmonary Disease",
        "Obesity Hypoventilation Syndrome",
        "Sleep Disordered Breathing",
        "Neuromuscular Diseases"
      ],
      "interventions": [
        {
          "name": "Vivify",
          "type": "OTHER"
        },
        {
          "name": "EMS",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Albert Einstein Healthcare Network",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 4,
      "start_date": "2017-10-18",
      "completion_date": "2018-10-26",
      "has_results": false,
      "last_update_posted_date": "2018-10-29",
      "last_synced_at": "2026-10-10T14:16:59.472Z",
      "location_count": 1,
      "location_summary": "Philadelphia, Pennsylvania",
      "locations": [
        {
          "city": "Philadelphia",
          "state": "Pennsylvania"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03353064"
    },
    {
      "nct_id": "NCT03670732",
      "title": "CPAP vs.Unsynchronized NIPPV at Equal Mean Airway Pressure",
      "overall_status": "TERMINATED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Prematurity",
        "Respiratory Distress Syndrome",
        "Apnea of Prematurity"
      ],
      "interventions": [
        {
          "name": "continuous positive airway pressure",
          "type": "OTHER"
        },
        {
          "name": "nasal intermittent positive pressure ventilation",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Women and Infants Hospital of Rhode Island",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "6 Months",
        "sex": "ALL",
        "summary": "Up to 6 Months"
      },
      "enrollment_count": 52,
      "start_date": "2017-09-30",
      "completion_date": "2020-06-30",
      "has_results": false,
      "last_update_posted_date": "2024-07-30",
      "last_synced_at": "2026-10-10T14:16:59.472Z",
      "location_count": 1,
      "location_summary": "Providence, Rhode Island",
      "locations": [
        {
          "city": "Providence",
          "state": "Rhode Island"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT03670732"
    },
    {
      "nct_id": "NCT05869825",
      "title": "HFNC vs NIPPV Following Extubation",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Congenital Heart Disease"
      ],
      "interventions": [
        {
          "name": "High Flow Nasal Canula following extubation",
          "type": "PROCEDURE"
        },
        {
          "name": "Non-Invasive Positive Pressure Ventilation following extubation",
          "type": "PROCEDURE"
        }
      ],
      "intervention_types": [
        "PROCEDURE"
      ],
      "sponsor": "Emory University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "1 Year",
        "sex": "ALL",
        "summary": "Up to 1 Year"
      },
      "enrollment_count": 200,
      "start_date": "2025-02-27",
      "completion_date": "2027-03",
      "has_results": false,
      "last_update_posted_date": "2026-07-14",
      "last_synced_at": "2026-10-10T14:16:59.472Z",
      "location_count": 1,
      "location_summary": "Atlanta, Georgia",
      "locations": [
        {
          "city": "Atlanta",
          "state": "Georgia"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT05869825"
    },
    {
      "nct_id": "NCT02743936",
      "title": "Mask Leak With Nasal Cannula in Noninvasive Positive Pressure Ventilation",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Mechanical Ventilation Pressure High"
      ],
      "interventions": [
        {
          "name": "Nasal cannula",
          "type": "DEVICE"
        },
        {
          "name": "Non-invasive positive pressure ventilation",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Brooke Army Medical Center",
      "sponsor_class": "FED",
      "healthy_volunteers": true,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 64,
      "start_date": "2016-04",
      "completion_date": "2016-05",
      "has_results": true,
      "last_update_posted_date": "2016-09-26",
      "last_synced_at": "2026-10-10T14:16:59.472Z",
      "location_count": 1,
      "location_summary": "San Antonio, Texas",
      "locations": [
        {
          "city": "San Antonio",
          "state": "Texas"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02743936"
    },
    {
      "nct_id": "NCT06849596",
      "title": "Manual T-piece Versus Ventilator Positive Pressure Ventilation During Resuscitation of Extremely Premature Neonates",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Neonatal Resuscitation",
        "Apnea Neonatal"
      ],
      "interventions": [
        {
          "name": "Ventilator derived positive pressure ventilation - V-PPV",
          "type": "DEVICE"
        },
        {
          "name": "T-piece resuscitator (TPR)",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Michelle Baczynski",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "25 Weeks",
        "maximum_age": "29 Weeks",
        "sex": "ALL",
        "summary": "25 Weeks to 29 Weeks"
      },
      "enrollment_count": 780,
      "start_date": "2025-12-01",
      "completion_date": "2029-01-01",
      "has_results": false,
      "last_update_posted_date": "2026-10-09",
      "last_synced_at": "2026-10-10T14:16:59.472Z",
      "location_count": 1,
      "location_summary": "Los Angeles, California",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT06849596"
    },
    {
      "nct_id": "NCT07558265",
      "title": "WIN Ratio Analysis to Determine a Strategy of Non- Invasive SUpport for Respiratory Failure in the EmeRgency Department",
      "overall_status": "RECRUITING",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Acute Hypoxic Respiratory Failure",
        "Acute Respiratory Distress Syndrome (ARDS)"
      ],
      "interventions": [
        {
          "name": "Non-Invasive Positive Pressure Ventilation",
          "type": "DEVICE"
        },
        {
          "name": "High Flow Nasal Oxygen",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "Ohio State University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 500,
      "start_date": "2026-08-18",
      "completion_date": "2031-08",
      "has_results": false,
      "last_update_posted_date": "2026-10-01",
      "last_synced_at": "2026-10-10T14:16:59.472Z",
      "location_count": 6,
      "location_summary": "Tucson, Arizona • Ann Arbor, Michigan • Columbus, Ohio + 2 more",
      "locations": [
        {
          "city": "Tucson",
          "state": "Arizona"
        },
        {
          "city": "Ann Arbor",
          "state": "Michigan"
        },
        {
          "city": "Columbus",
          "state": "Ohio"
        },
        {
          "city": "Columbus",
          "state": "Ohio"
        },
        {
          "city": "Murray",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT07558265"
    },
    {
      "nct_id": "NCT00433212",
      "title": "Nasal Intermittent Positive Pressure Ventilation in Premature Infants (NIPPV)",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE3"
      ],
      "conditions": [
        "Respiratory Insufficiency of Prematurity"
      ],
      "interventions": [
        {
          "name": "nCPAP",
          "type": "DEVICE"
        },
        {
          "name": "NIPPV",
          "type": "DEVICE"
        }
      ],
      "intervention_types": [
        "DEVICE"
      ],
      "sponsor": "McMaster University",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": null,
        "maximum_age": "28 Days",
        "sex": "ALL",
        "summary": "Up to 28 Days"
      },
      "enrollment_count": 1011,
      "start_date": "2007-04",
      "completion_date": "2011-12",
      "has_results": false,
      "last_update_posted_date": "2014-12-05",
      "last_synced_at": "2026-10-10T14:16:59.472Z",
      "location_count": 14,
      "location_summary": "Washington D.C., District of Columbia • Boston, Massachusetts • Voorhees Township, New Jersey + 6 more",
      "locations": [
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Washington D.C.",
          "state": "District of Columbia"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Boston",
          "state": "Massachusetts"
        },
        {
          "city": "Voorhees Township",
          "state": "New Jersey"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00433212"
    },
    {
      "nct_id": "NCT00486850",
      "title": "Synchronized Intermittent Mandatory Ventilation (SIMV) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) In Preterm Infants With Respiratory Distress",
      "overall_status": "COMPLETED",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "PHASE4"
      ],
      "conditions": [
        "Respiratory Distress Syndrome, Newborn"
      ],
      "interventions": [
        {
          "name": "Extubation to Nasal IPPV",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "University of Southern California",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "10 Minutes",
        "maximum_age": "120 Minutes",
        "sex": "ALL",
        "summary": "10 Minutes to 120 Minutes"
      },
      "enrollment_count": 110,
      "start_date": "2006-10",
      "completion_date": "2009-01",
      "has_results": false,
      "last_update_posted_date": "2009-07-10",
      "last_synced_at": "2026-10-10T14:16:59.472Z",
      "location_count": 4,
      "location_summary": "Los Angeles, California • San Diego, California • Augusta, Georgia + 1 more",
      "locations": [
        {
          "city": "Los Angeles",
          "state": "California"
        },
        {
          "city": "San Diego",
          "state": "California"
        },
        {
          "city": "Augusta",
          "state": "Georgia"
        },
        {
          "city": "Oklahoma City",
          "state": "Oklahoma"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT00486850"
    },
    {
      "nct_id": "NCT02961933",
      "title": "Utah Study Evaluating Apneic Oxygenation for Emergency Department Intubation",
      "overall_status": "UNKNOWN",
      "study_type": "INTERVENTIONAL",
      "phases": [
        "NA"
      ],
      "conditions": [
        "Intubation"
      ],
      "interventions": [
        {
          "name": "Apneic oxygenation",
          "type": "OTHER"
        },
        {
          "name": "Pre-oxgenation with NRB, NIPPV, BVM",
          "type": "OTHER"
        }
      ],
      "intervention_types": [
        "OTHER"
      ],
      "sponsor": "Intermountain Health Care, Inc.",
      "sponsor_class": "OTHER",
      "healthy_volunteers": false,
      "eligibility": {
        "minimum_age": "18 Years",
        "maximum_age": null,
        "sex": "ALL",
        "summary": "18 Years and older"
      },
      "enrollment_count": 500,
      "start_date": "2016-12",
      "completion_date": "2020-06",
      "has_results": false,
      "last_update_posted_date": "2020-02-11",
      "last_synced_at": "2026-10-10T14:16:59.472Z",
      "location_count": 1,
      "location_summary": "Murray, Utah",
      "locations": [
        {
          "city": "Murray",
          "state": "Utah"
        }
      ],
      "official_url": "https://clinicaltrials.gov/study/NCT02961933"
    }
  ]
}